Jie Pan

Peking University School of Stomatology · department of general dentistry

Background Hydrogen peroxide (H 2 O 2 ) is the commonly used bleaching agent for teeth. But it is highly corrosive to teeth for the high concentration. The cold atmospheric pressure plasma has been witnessed a novel tooth bleaching technology and could help strengthen the bleaching effect when combined with H 2 O 2 . However, the efficacy and safet...

Streptococcus mutans (S. mutans) has been implicated as the primary cariogenic species of dental caries in humans. The purpose of this study was to explore the inhibition effects of plasma activated water (PAW) on S. mutans biofilm and the mechanisms. S. mutans biofilm model was established on bovine enamel discs in vitro. Both 12 h old and 48 h ol...

Enterococcus faecalis (E. faecalis) is the species which can cause life-threatening infections in human beings and exhibit highly antibacterial resistance in the nosocomial environment. The purpose of this study was to evaluate the inhibition effect and the mechanisms of ultra-low dose reactive oxygen species produced by plasma activated water (PAW...

The changes of denture base acrylic resin surface properties under cold plasma and the relationships with time were investigated. Cold plasma treated the specimens for 30 s, 60 s, 90 s, and 120 s, respectively. Water contact angles were measured immediately after the treatment, 48 h, 15 days and 30 days later. Surface roughness was measured with 3-...

Atmospheric-pressure cold plasma was applied to process the surface of heat-polymerized acrylic resin. Changes to the physical properties and early adherence of Candida albicans were investigated. Alternating current cold plasma with Ar/O2 as working gas was used. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) were em...

Although endodontic infection is caused by multi-bacteria species, Enterococcus faecalis is usually isolated in chronic apical periodontitis. The aim of this study was to evaluate the effectiveness and mechanical safety of cold plasma therapy in disinfecting 3-week E. faecalis biofilms. Teeth with 3-week E. faecalis biofilm were treated with AC arg...

The aim of this paper was to assess the effectiveness, safety, stability, and mechanism of tooth whitening using a direct current cold atmospheric pressure air plasma microjet (PMJ) with the assistance of whitening gels (blank or containing 3% H2O2). The results were compared with those obtained from teeth treated with blank gel only and with gel c...

This chapter presents a summary of selected recent research efforts devoted to the use of low-temperature (or non-thermal) atmospheric-pressure plasmas in various dental applications. Areas of application that will be discussed here in some depth include the surface modification and functionalization of selected dental surfaces and materials, plasm...

Adenoid cystic carcinoma (ACC) is one of the most common malignant neoplasms in salivary glands. To evaluate the therapeutic effects of nanosecond pulsed electric field (nsPEF) combined with pingyangmycin (PYM) on salivary gland adenoid cystic carcinoma (SACC), ACC high metastatic cell line (SACC-LM) and low metastatic cell line (SACC‑83) were test...

form only given. Dental caries and periodontal disease are common oral diseases worldwide, and 60-90% of school children and nearly 100% of adults have dental cavities. The world health organization has put the incidence of periodontal disease as the tumor, cardiovascular morbidity after the third. Actually, those two diseases are caused by bacteri...

Heat curing acrylic resin is an important kind of material in the prosthetic dentistry, which has been widely used in dentar e base, and the oral cavity is colonized with Candida albicans among approximately 75% of persons with dentures. In this study, alternating-current (AC) atmospheric-pressure Ar/O2 (2%) cold plasma was applied to treat the sur...

form only given. Since early 1980s, the incidence of invasive and opportunistic mycoses has significantly increased, resulting in excessive mortality and morbidity. As a species of fungi and one of the major oral pathogens, Candida Albicans can get adhered to prosthesis and easily lead to denture stomatitis, which is a common recurring disease obse...

To investigate the tooth bleaching effect of a low con-centration hydrogen peroxide (H 2 O 2) assisted by a nonthermal plasma, extracted human teeth were treated by a nonthermal plasma in the presence of varying concentrations of hydrogen peroxide gel. The results showed that combining plasma treatment with a low concentration hydrogen peroxide (6%...

Complete sterilization of an infected root canal is an important challenge in endodontic treatment. Traditional methods often cannot achieve high-efficiency sterilization because of the complexity of the root canal system. The objective of the study was to investigate in vitro the feasibility of using a cold plasma treatment of a root canal infecte...

Introduction: Complete sterilization of an infected root canal is an important challenge in endodontic treatment. Traditional methods often cannot achieve high-efficiency sterilization because of the complexity of the root canal system. The objective of the study was to investigate in vitro the feasibility of using a cold plasma treatment of a root...

The purpose of this study is to evaluate the changes in dental enamel (morphology, elemental composition, microhardness, and roughness) after applying hydrogen peroxide in conjunction with a nonthermal plasma to bleach the teeth. Extracted human teeth were randomly placed in six groups. Two control groups (one group with no bleaching agent and no p...

Treatment of cancer often involves uses of multiple therapeutic strategies with different mechanisms of action. In this study we investigated combinations of nanosecond pulsed electric fields (nsPEF) with low concentrations of gemcitabine on human oral cancer cells. Cells (Cal-27) were treated with pulse parameters (20 pulses, 100 ns in duration, i...

Department of Applied Science and Technology and Center for Microplasma Science and Technology, Saint Peter's College, New Jersey, USA, 07306 In dental clinics, caries is one of the highest incidence diseases in human, and Streptococcus mutans (S. mutans) is the most contributing cariogenic bacteria in oral environment. The primary step in the occu...

Aesthetics of teeth, including tooth color, is of great importance to people. Conventional clinical tooth-whitening treatments are mainly based on hydrogen peroxide (H2O2), while some studies demonstrate that the bleaching process can be accelerated when enhanced by heat or light (laser, cold light). The dependence on H2O2 may lead to sensitivity o...

form only given. Eating habits, smoking, drugs and chemicals can cause undesirable staining of teeth. Tooth whitening has become a popular dental practice to remove stains from the tooth surface for aesthetic or therapeutic purposes. Traditional in-office tooth whitening involves applying dental gel (active compound: H2O2) on patients teeth for sev...

A direct current, cold, atmospheric-pressure Ar/O 2 (2%) plasma microjet (PMJ) was used to disinfect root canals in single-rooted extracted human teeth. Results showed that 98.8% Enterococcus faecalis (E. faecalis) was inactivated in 8 min. However, the seemingly cleaned root canal was reinfected after a week, possibly due to the hard-to-reach infe...

We reported in this paper the tooth-whitening effect by a direct-current cold atmospheric-pressure air plasma microjet (PMJ) and saline solution (0.9%). All teeth were randomly divided into three groups, treated for 20 min with an air blow and saline solution, a PMJ and saline solution, and 35% hydrogen peroxide gel, respectively. Compared with the...

We reported in this paper the tooth-whitening effect by a direct-current cold atmospheric-pressure air plasma micro-jet (PMJ) and saline solution (0.9%). All teeth were randomly divided into three groups, treated for 20 min with an air blow and saline solution, a PMJ and saline solution, and 35% hydrogen peroxide gel, respectively. Compared with th...

A tooth-whitening process using hydrogen peroxide (H₂O₂) enhanced by a direct-current cold atmospheric-pressure plasma microjet (PMJ) is presented. Compared with the conventional clinical method of using H₂O₂ alone, a significant improvement of the tooth-whitening process was observed when the PMJ was use...

A tooth-whitening process using hydrogen peroxide (H 2 O 2) enhanced by a direct-current cold atmospheric-pressure plasma microjet (PMJ) is presented. Compared with the conven-tional clinical method of using H 2 O 2 alone, a significant improve-ment of the tooth-whitening process was observed when the PMJ was used in the process. The tooth-surface...

Summary form only given. Eating habits, smoking, drugs and chemicals can cause undesirable staining of teeth. Tooth bleaching has become a popular dental practice to remove stains from the tooth surface for aesthetic or therapeutic purposes. Clinical teeth-whitening involves the application of H2O2 gel (35%), which might be harmful after prolonged...

form only given. Formocresol and calcium hydroxide are commonly used as the clinical disinfectant of root canals. Although they have strong chemical disinfection properties, their cytotoxic effects have always been a concern. E. faecalis, which is responsible for root canal failure, can also cause life-threatening infections in humans, especially i...

E. faecalis grow within dentinal tubules, re-infect the obturated root canal and cause endodontic failure, which is the major reason for the failure of treatment of endodontic. Moreover, the biofilm of E. faecalis which have strong cantibiotic-resistance than planktonic bacteria, can also cause life-threatening infections in humans, especially in t...