Jibon Kotoky

Jibon Kotoky
National Institute Of Pharmaceutical Research And Education

PhD

About

82
Publications
49,652
Reads
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1,465
Citations
Additional affiliations
March 1992 - present
Institute of Advanced Study in Science and Technology
Position
  • Professor

Publications

Publications (82)
Article
Full-text available
The present investigation was intended to characterize pigments for the first time from Rhodotorula taiwanensis (LC011412) yeast isolated from the ethic fermentation starter culture source meant to evaluate its carotenoid contents for beneficial applications. The pigments were extracted by an optimized solvent system, purified by flash chromatograp...
Conference Paper
The study was undertaken to identify the phenolic compounds present in Hydrocotyle sibthorpioides (HS) extracts and investigate their respective antioxidant and antihyperlipidemic activities. Herein, an UPLC-MS/MS analytical method has been developed for the separation and systematic characterization of the phenolic compounds in HS extracts and was...
Article
Several active compounds from ‘Mother Nature’ have been found to be tailor-made therapeutics for the better management of numerous chronic ailments, with fewer adverse side effects. Zerumbone is one such molecule isolated from the rhizomes of Zingiber zerumbet (L.) Smith, a Zingiberaceae plant with significant medicinal values that has been used tr...
Conference Paper
The aim of the study was to identify the phenolic compounds present in Hydrocotyle sibthorpioides (HS), Centella asiatica (CA) and Amaranthus viridis (AV) extracts and investigate their respective antioxidant activities. Herein, an ultra-high pressure liquid chromatography-mass spectrometer (UPLC-MS/MS) analytical method has been developed for the...
Article
Background: Breast cancer is one of the most common cancers diagnosed among women. It is now recognized that two receptors mediate estrogen action and the presence of estrogen receptor alpha (ERα) correlates with better prognosis and the likelihood of response to hormonal therapy. ERα is an attractive target for the treatment of breast cancer. Most...
Article
A rapid rise in cancer cases worldwide, especially breast cancer in females, instigates the need for more effective and less side effect causing drugs from natural origin. Thereby, in the present study, Garcinia morella fruit was investigated for antioxidant, anti-inflammatory and anti-breast cancer activity. Preliminary antioxidant and anticancer...
Article
Full-text available
In this study we have reported an efficient antibacterial hybrid fabricated through surface functionalization of lysozyme capped gold nanoclusters (AUNC-L) with β-lactam antibiotic ampicillin (AUNC-L-Amp). The prepared hybrid not only reverted the MRSA resistance towards ampicillin but also demonstrated enhanced antibacterial activity against non-r...
Article
Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine. Non-toxic herbal carbazole alkaloids occur in the edible part of Murraya koenigii, Micromelum minutum, M. zeylanicum, and M. euchrestiolia. Mahanine and girinimbine are the major potent compounds from these species. In fact, they interfered with...
Article
Full-text available
Prostate Cancer (PCa) is one of the major causes of death in men worldwide. Prostate-Specific Antigen (PSA) test and Digital Rectal Examination (DRE) improves the detection rate of prostate cancer. There are several types of hormone and chemotherapy drugs that are used for the treatment of prostate cancer. Enzalutamide is a non-steroidal, orally bi...
Article
Full-text available
In this study, a glycogen–gold nanohybrid was fabricated to enhance the potency of a promising hepatoprotective agent silymarin (Sly) by improving its solubility and gut permeation. By utilizing a facile green chemistry approach, biogenic gold nanoparticles were synthesized from Annona reticulata leaf phytoconstituents in combination with Sly (SGNP...
Article
The present study displays the biodegradation capacities of native bacteria toward polycyclic aromatic hydrocarbons (PAHs) with particular emphasis to anthracene. A total of 23 bacterial strains were isolated from hydrocarbon contaminated sites of Guwahati city; using anthracene as the carbon source. Among all these isolates, one Gram-positive stra...
Article
Treatment by androgen receptor (AR) antagonists is one of the regimens for prostate cancer. The prolonged treatment with AR antagonist leads to the expression of point mutation in the ligand binding domain of the AR. This point mutation causes resistance to AR antagonist by converting them into an agonist. The T887A mutated AR was frequently expres...
Article
Full-text available
Background: Androgen receptor is an attractive target for the treatment of prostate cancer. The 1,3- thiazolidine-2,4-diones possess a wide diversity of important biochemical effects and interesting pharmacological properties. Objective: The aim of the study is to find the experimental and computational methods to investigate the interference of...
Article
Full-text available
The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the p...
Data
The single crystal of the compound was developed by slow evaporation of ethyl acetate. The XRD data for a good quality single crystal (0.40 X 0.34 X 0.22 mm3) was collected at 296K temperature with a Bruker 3-circle diffractometer (Bruker Nonius SMART APEX 2) equipped with CCD area detector. Bruker SMART software was used for data collection and al...
Article
Full-text available
Methicillin-resistant Staphylococcus aureus (MRSA) and Candida co-infections in the context of burn wounds, leads to morbidity and mortality. Eradication of such difficult to treat complex infection needs concomitant effective topical administration of an antibiotic–antifungal cocktail. Application of the broad-spectrum antibiotic chloramphenicol (...
Article
Background: Gold nanoparticles (GNPs) are of tremendous interest due to their wide application range in the field of therapeutics and diagnostics. However, its potential is limited by its mode of synthesis utilizing different chemicals which are costly, hazardous and often labor-intensive. Nevertheless, the GNPs synthesized through green methods by...
Article
Full-text available
The study aimed to identify the phenolic compounds present in Centella asiatica (L.) (C. asiatica) extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-dip...
Article
Full-text available
Breast cancer is the most prominent cause of cancer death in women worldwide. The highlights of this review are to provide an overview of the targeted therapeutic agents, challenges with metastatic breast cancer (MBCa), mechanisms of action through Hedgehog/Gli 1 signaling pathway and future prospective. Over a decade of success, several drugs have...
Article
Full-text available
The tribal communities of North Eastern India rely on herbal medicine to cure various disease conditions. Ziziphus jujuba Mill. (Rhamnaceae) is one of such medicinal plants used for curing liver ailments, insomnia, anemia, diarrhea, diabetic complications, cancer and loss of appetite. The present study was aimed to describe the protective ability o...
Article
Full-text available
We report a robust biofilm with antimicrobial properties fabricated from chitosan-iron oxide coated graphene oxide nano-composite hydrogel. For the first time, the co-precipitation method was used for the successful synthesis of iron oxide coated graphene oxide (GIO) nanomaterial. Following this, the films were fabricated by gel casting technique a...
Article
Full-text available
Randia dumetorum Lam. (RD) (Rubiaceae) is traditionally used by some tribes of Assam and Manipur of North East India for the treatment of liver ailments. In this context, to scientifically validate this indigenous traditional knowledge, we have evaluated the antioxidant and hepatoprotective activity of RD leaf and bark. The methanol extracts of RD...
Article
Full-text available
Soil pollution in Guwahati city, Assam, India has become a major concern since the last few decades. To study the impact of automobile and industrial emission, distribution patterns of 16 different polycyclic aromatic hydrocarbons (PAHs) and eight heavy metals were investigated in the soil samples collected from 15 different sites. Higher concentra...
Article
Full-text available
Poor wound healing is one of the major complication of diabetic patients which arises due to different factors like hyperglycemia, oxidative stress, vascular insufficiency and microbial infections. Candidiasis of diabetic wounds is a difficult to treat condition and potentially can lead to organ amputation. There are a few number of medications ava...
Article
Full-text available
Herbal medicine is popularized worldwide due to its ability to cure the diseases with lesser or no side effects. North Eastern part of India comes under one of the world biodiversity hotspots which is very rich in traditional herbal medicine. Annona reticulata L. (Annonaceae) is one such plant used for the treatment of inflammatory diseases, liver...
Conference Paper
Full-text available
Traditional knowledge (TK) based medicines have gained worldwide attention and recently the scientific community is focusing in proper pharmacological validation and identification of lead compounds for the treatment of various diseases. The North Eastern region of India is the heritage of valuable traditional herbal remedies. Garcinia morella Desr...
Article
The quest for developing an ideal suture material prompted our interest to develop a novel suture with advantageous characters to market available ones. From natural origin only silk, cotton and linen fibers are presently available in market as non-absorbable suture biomaterials. In this study, we have developed a novel, cost-effective, and biocomp...
Article
Full-text available
Articular cartilage damage represents one of the most perplexing clinical problems of musculoskeletal therapeutics due to its limited self-repair and regenerative capabilities. In this study, 3D porous silk fibroin scaffolds derived from non-mulberry muga silkworm; Antheraea assamensis were fabricated and examined for its ability to support cartila...
Article
Full-text available
Folklore studies have revealed that Musa balbisiana Colla (MB; Family: Musaceae) has high medicinal properties. The purpose of the present study is to evaluate antihyperglycemic, and antioxidant activity of MB extracts in streptozotocin (STZ) induced diabetic rats. In vitro antioxidant and antidiabetic activity of MB extracts, i.e., root extract (R...
Article
In this study, we have described the biosynthesis of biocompatible gold nanoparticles (GNPs) from aqueous extract of the aerial parts of a pteridophyte, “Adiantum philippense” by microwave irradiation and its surface functionalization with broad spectrum beta lactam antibiotic, amoxicillin (Amox). The functionalization of amoxicillin on GNPs (GNP-A...
Article
Full-text available
Antiandrogens are a novel class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis in various cell lines. To find the lead compound from the oxobenzimidazole derivatives, receptor-ligand docking studies were initially performed using Schrödinger software. The best fit molecules were synthesized and characterized throug...
Article
Akt kinase is a serine threonine kinase that exists in three isoforms located in different chromosomes and has distinct sites of expression which orchestrates diverse cellular processes required for normal functioning of the cell. Though, these Akt isoforms have some overlapping actions but they also have specific roles and interestingly, sometimes...
Article
Low temperature plasma can effectively tailor the surface properties of natural polymeric biomaterials according to the need for various biomedical applications. Non-mulberry silk, Antherarea assama silk fibroin (AASF) is a natural polymer having excellent biocompatibility and mechanical strength yet unlike mulberry silk, Bombyx mori silk fibroin,...
Article
The aim of the study was to identify the phenolic compounds present in Hydrocotyle sibthorpioides (HS), Centella asiatica (CA) and Amaranthus viridis (AV) extracts and investigate their respective antioxidant activities. Herein, an ultra-high pressure liquid chromatography–mass spectrometer (UPLC-MS/MS) analytical method has been developed for the...
Article
Background: The quest for developing silk fibroin as a biomaterial for drug release systems continues to draw research interest owing to its impressive mechanical properties as well as biocompatibility and biodegradability. The aim of this study is to develop low-temperature O2 plasma-treated muga (Antheraea assama) silk fibroin (AASF) yarn impreg...
Article
Despite the consistent and significant advancements made in the treatment of head and neck cancer (HNSCC), it remains one of the most devastating cancers globally killing approximately 350,000 people every year. Both clinical and basic research revealed that the transcription factor NF-κB, is constitutively expressed in HNSCC and this persistent ex...
Article
Full-text available
Traditional knowledge (TK) based medicines have gained worldwide attention and presently the scientific community is focussing on proper pharmacological validation and identification of lead compounds for the treatment of various diseases. The North East region of India is the home of valuable traditional herbal remedies. Garcinia morella Desr. (Gu...
Article
Full-text available
Purpose: To evaluate the antioxidant and antifungal activities of polyphenol-rich extracts of the dried fruit pulp of Garcinia pedunculata (GP) and Garcinia morella (GM) to determine their traditional claims of therapeutic activity against certain diseases. Methods: Analysis of total phenolic (TP) and flavonoid (TF) contents of the extracts were pe...
Article
Phoebe goalparensis Hutch., belonging to the family- Lauraceae, is traditionally used in Assam to treat diseases which are related to cancer. The bark of the plant was collected, cleaned, shade dried and extracted with methanol for 72 hours in an orbital shaker. Preliminary phytochemical estimation of P. goalparensis showed the presence of importan...
Conference Paper
Full-text available
Unimolecular reactivities of different 2, 6-(substituted) diphenylpiperidone derivatives cations were investigated by electrospray ionization orbitrap mass spectrometry. All the collision-induced dissociation spectra of cations show similar ions at phenyl anions, neutral loss of piperidones. Electrospray ionization (ESI) mass spectrometry combined...
Article
Full-text available
Ten ethno-medicinally important plants of North East India were selected to evaluate their in vitro antioxidant activity. In vitro antioxidant activity of the methanolic extract of the leaves of these medicinal plants was tested using two wellestablised methods, DPPH free radical scavenging activity and reducing power assay. Polyphenol content of t...
Patent
A method for extraction of cymbopogon nardus essential oil extract for healing of fungal infected diabetic wounds comprising hydrodistilling the desired mass of grass of cymbopogon nardus, in a suitable apparatus using 4 to 5 litres of de-ionized water for about 3 hours and obtaining the essential oil extract. The invention also relates to cymbopog...
Article
Full-text available
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) infection has increased precipitously over the past several decades, with far-reaching health care and societal costs. MRSA infections in the context of burn wounds lead to invasive disease that could potentially cause mortality. Chloramphenicol is a well-known broad-spectrum bacte...
Article
Full-text available
In the title compound, C 23 H 26 ClNO 2 , the piperidin-4-one ring adopts a distorted boat conformation. The two p -tolyl rings are nearly normal to each other, making a dihedral angle of 83.33 (10)°. They are inclined to the mean plane of the piperidine ring by 73.2 (1) and 87.22 (9)°. In the crystal, there are no significant intermolecular intera...
Article
Full-text available
The main focus of this review is to discuss the discoveries and developments of various therapies for prostate cancer. The AR has played an important role in prostate cancer growth and functions. This review discusses several groups of drugs that have sparingly good anti-cancer activities, as well as a similar structure and behaviour. A recent new-...
Article
Full-text available
The Solanum genus (Solanaceae family) comprised of one thousand five hundred species and most of the members of the genus are widely used as food and traditional medicine. Diabetes mellitus is a common and serious metabolic disorder throughout the world. Traditionally used medicinal plants play an important role as alternative medicine due to less...
Article
Full-text available
The single crystal of the compound was developed by slow evaporation of chloroform and alcohol (1:1 ratio). The XRD data for a good quality single crystal (0.40 X 0.34 X 0.22 mm3) was collected at 296K temperature with a Bruker 3-circle diffractometer (Bruker Nonius SMART APEX 2) equipped with CCD area detector. Bruker SMART software was used for d...
Article
ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. The obtained acetyl-CoA is required for lipid synthesis during membrane biogenesis, as well as for histone acetylation reactions to regulate the expression of certai...
Conference Paper
Full-text available
Breast and Prostate cancers are the most common invasive cancers that affect women and men respectively. Androgen receptor (AR) is a DNA-binding transcription factor, belonging to nuclear receptor subfamily, which regulates gene expression. AR antagonists, such as cyproterone acetate, flutamide, nilutamide and bicalutamide have been used to block t...
Conference Paper
Dermatophytes are one of the primary agents responsible for skin diseases of man and other animals. Tropical countries like India are facing so many problems due to repeated infections of dermatophytes. In the present investigation, in vitro antidermatophytic activity of crude extracts prepared from Cascabela thevetia L. leaves were evaluated again...