Jiayu Zhou

• PhD
• Professor (Associate) at Michigan State University

Background Mild Cognitive Impairment (MCI) is the prodromal stage of dementia, including Alzheimer’s Disease (AD). Early identification and accurate assessment of MCI are critical for clinical trial enrichment as well as the early intervention of AD. Digital makers offered a unique opportunity for ecologically valid and affordable early detection a...

Background Mild Cognitive Impairment (MCI) is the prodromal stage of dementia, including Alzheimer’s Disease (AD). Early identification and accurate assessment of MCI are critical for clinical trial enrichment as well as the early intervention of AD. Digital makers offered a unique opportunity for ecologically valid and affordable early detection a...

Independent and identically distributed (i.i.d.) data is essential to many data analysis and modeling techniques. In the medical domain, collecting data from multiple sites or institutions is a common strategy that guarantees sufficient clinical diversity, determined by the decentralized nature of medical data. However, data from various sites are...

Advancements in large language models (LLMs) have shown their effectiveness in multiple complicated natural language reasoning tasks. A key challenge remains in adapting these models efficiently to new or unfamiliar tasks. In-context learning (ICL) provides a promising solution for few-shot adaptation by retrieving a set of data points relevant to...

Cell surface proteins serve as primary drug targets and cell identity markers. The emergence of techniques like CITE-seq has enabled simultaneous quantification of surface protein abundance and transcript expression for multimodal data analysis within individual cells. The published data have been utilized to train machine learning models for predi...

Independent and identically distributed (i.i.d.) data is essential to many data analysis and modeling techniques. In the medical domain, collecting data from multiple sites or institutions is a common strategy that guarantees sufficient clinical diversity, determined by the decentralized nature of medical data. However, data from various sites are...

The ultra-low latency requirements of 5G/6G applications and privacy constraints call for distributed machine learning systems to be deployed at the edge. With its simple yet effective approach, federated learning (FL) is a natural solution for massive user-owned devices in edge computing with distributed and private training data. FL methods based...

We develop SPIDER, a zero-shot model which can predict the abundance for a large scale (>2,000) of surface proteins from single-cell transcriptomes in various contexts. This is to overcome the challenges in current single-cell protein abundance quantification tools (e.g., flow cytometry, CITE-seq) and computational models (e.g., totalVI, Seurat, cT...

Mild cognitive impairment (MCI) represents the early stage of dementia including Alzheimer's disease (AD) and is a crucial stage for therapeutic interventions and treatment. Early detection of MCI offers opportunities for early intervention and significantly benefits cohort enrichment for clinical trials. Imaging and in vivo markers in plasma and c...

Federated learning (FL) learns a model jointly from a set of participating devices without sharing each other’s privately held data. The characteristics of non-i.i.d. data across the network, low device participation, high communication costs, and the mandate that data remain private bring challenges in understanding the convergence of FL algorithm...

Gene expression profiling of new or modified cell lines becomes routine today; however, obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines, including those derived from underrepresented groups, is not trivial when resources are minimal. Using gene expression to predict other measurements has been a...

Training a high-performance deep neural network requires large amounts of data and computational resources. Protecting the intellectual property (IP) and commercial ownership of a deep model is challenging yet increasingly crucial. A major stream of watermarking strategies implants verifiable backdoor triggers by poisoning training samples, but the...

Blood transfusion is a commonly used, life-saving medical thera-peutics worldwide. A significant challenge is the high variability of supply and demand in blood products, making it difficult to maintain a balance between preventing shortages of blood products and preventing wastage. Recent studies used data-driven methods on demand forecasting for...

Reinforcement learning is a learning paradigm for solving sequential decision-making problems. Recent years have witnessed remarkable progress in reinforcement learning upon the fast development of deep neural networks. Along with the promising prospects of reinforcement learning in numerous domains such as robotics and game-playing, transfer learn...

Deep Neural Networks (DNNs) possess powerful prediction capability thanks to their over-parameterization design, although the large model complexity makes it suffer from noisy supervision. Recent approaches seek to eliminate impacts from noisy labels by excluding data points with large loss values and showing promising performance. However, these a...

Federated learning (FL) emerges as a popular distributed learning schema that learns a model from a set of participating users without sharing raw data. One major challenge of FL comes with heterogeneous users, who may have distributionally different (or non-iid) data and varying computation resources. As federated users would use the model for pre...

Federated learning has gained popularity for distributed learning without aggregating sensitive data from clients. But meanwhile, the distributed and isolated nature of data isolation may be complicated by data quality, making it more vulnerable to noisy labels. Many efforts exist to defend against the negative impacts of noisy labels in centralize...

Data-free knowledge distillation (KD) helps transfer knowledge from a pre-trained model (known as the teacher model) to a smaller model (known as the student model) without access to the original training data used for training the teacher model. However, the security of the synthetic or out-of-distribution (OOD) data required in data-free KD is la...

Federated learning provides a promising privacy-preserving way for utilizing large-scale private edge data from massive Internet-of-Things (IoT) devices. While existing research extensively studied optimizing the learning process, computing efficiency, and communication overhead, one important and often overlooked aspect is that participants contri...

Increasing concerns have been raised on deep learning fairness in recent years. Existing fairness-aware machine learning methods mainly focus on the fairness of in-distribution data. However, in real-world applications, it is common to have distribution shift between the training and test data. In this paper, we first show that the fairness achieve...

Federated learning (FL) is a distributed and privacy-preserving learning framework for predictive modeling with massive data generated at the edge by Internet of Things (IoT) devices. One major challenge preventing the wide adoption of FL in IoT is the pervasive power supply constraints of IoT devices due to the intensive energy consumption of batt...

The recent decade witnessed a surge of increase in financial crimes across the public and private sectors, with an average cost of scams of \$102m to financial institutions in 2022. Developing a mechanism for battling financial crimes is an impending task that requires in-depth collaboration from multiple institutions, and yet such collaboration im...

The ultra-low latency requirements of 5G/6G applications and privacy constraints call for distributed machine learning systems to be deployed at the edge. With its simple yet effective approach, federated learning (FL) is proved to be a natural solution for massive user-owned devices in edge computing with distributed and private training data. Mos...

Clinical trials are increasingly focused on pre‐manifest and early Alzheimer’s disease (AD). Accurately predicting those who transit from normal to MCI or from MCI to dementia/AD (true positives) versus non‐progressors (false positives) is challenging. Biomarker positivity and comorbidity information are often not sufficient to identify those who a...

Deep neural networks (DNNs) are vulnerable to backdoor attacks. Previous works have shown it extremely challenging to unlearn the undesired backdoor behavior from the network, since the entire network can be affected by the backdoor samples. In this paper, we propose a brand-new backdoor defense strategy, which makes it much easier to remove the ha...

As deep learning blooms with growing demand for computation and data resources, outsourcing model training to a powerful cloud server becomes an attractive alternative to training at a low-power and cost-effective end device. Traditional outsourcing requires uploading device data to the cloud server, which can be infeasible in many real-world appli...

Unsupervised Domain Adaptation (UDA) provides a promising solution for learning without supervision, which transfers knowledge from relevant source domains with accessible labeled training data. Existing UDA solutions hinge on clean training data with a short-tail distribution from the source domain, which can be fragile when the source domain data...

As deep learning blooms with growing demand for computation and data resources, outsourcing model training to a powerful cloud server becomes an attractive alternative to training at a low-power and cost-effective end device. Traditional outsourcing requires uploading device data to the cloud server, which can be infeasible in many real-world appli...

Deep neural networks (DNNs) are vulnerable to backdoor attacks. Previous works have shown it extremely challenging to unlearn the undesired backdoor behavior from the network, since the entire network can be affected by the backdoor samples. In this paper, we propose a brand-new backdoor defense strategy, which makes it much easier to remove the ha...

Leveraging computational methods to generate small molecules with desired properties has been an active research area in the drug discovery field. Towards real-world applications, however, efficient generation of molecules that satisfy multiple property requirements simultaneously remains a key challenge. In this paper, we tackle this challenge usi...

Federated Learning (FL) has recently received significant interests thanks to its capability of protecting data privacy. However, existing FL paradigms yield unsatisfactory performance for a wide class of human activity recognition (HAR) applications since they are oblivious to the intrinsic relationship between data of different users. We propose...

Increasing concerns have been raised on deep learning fairness in recent years. Existing fairness-aware machine learning methods mainly focus on the fairness of in-distribution data. However, in real-world applications, it is common to have distribution shift between the training and test data. In this paper, we first show that the fairness achieve...

The rise of Federated Learning (FL) is bringing machine learning to edge computing by utilizing data scattered across edge devices. However, the heterogeneity of edge network topologies and the uncertainty of wireless transmission are two major obstructions of FL's wide application in edge computing, leading to prohibitive convergence time and high...

Reinforcement learning (RL) has demonstrated its superiority in solving sequential decision-making problems. However, heavy dependence on immediate reward feedback impedes the wide application of RL. On the other hand, imitation learning (IL) tackles RL without relying on environmental supervision by leveraging external demonstrations. In practice,...

Density estimation is a widely used method to perform unsupervised anomaly detection. By learning the density function, data points with relatively low densities are classified as anomalies. Unfortunately, the presence of anomalies in training data may significantly impact the density estimation process, thereby imposing significant challenges to t...

Protecting privacy in learning while maintaining the model performance has become increasingly critical in many applications that involve sensitive data. Private Gradient Descent (PGD) is a commonly used private learning framework, which noises gradients based on the Differential Privacy protocol. Recent studies show that dynamic privacy schedules...

Gene expression profiling of new or modified cell lines becomes routine today; however, obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines, including those derived from underrepresented groups, is not trivial when resources are minimal. Using gene expression to predict other measurements has been a...

Gene expression profiling of new or modified cell lines becomes routine today; however, obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines, including those derived from underrepresented groups, is not trivial when resources are minimal. Using gene expression to predict other measurements has been a...

The analytical research has recently indicated that the computational resources of Connected Autonomous Vehicles (CAVs) have been wasted since almost all vehicles spend over 95% of their time in parking lots. This paper presents a collaborative computing framework to efficiently offload online computational tasks to parked vehicles (PVs) during pea...

Federated learning (FL) provides a distributed learning framework for multiple participants to collaborate learning without sharing raw data. In many practical FL scenarios, participants have heterogeneous resources due to disparities in hardware and inference dynamics that require quickly loading models of different sizes and levels of robustness....

In recent years, behavioral markers such as spoken language and lexical preferences have been studied in the early detection of mild cognitive impairment (MCI) using conversations. While the combination of linguistic and acoustic signals have been shown to be effective in detecting MCI, they have generally been restricted to structured conversation...

Due to the outstanding performance in reducing the cost of annotation, unsupervised domain adaptation (UDA) has gained considerable interests in cross-modal medical image classification and segmentation. To bridge the gap between the two domains, the most common strategy puts focus on matching the marginal distributions in the feature space through...

Background In recent years, speech‐related behavioral markers such as spoken language and lexical preferences have been studied in the early detection of mild cognitive impairment (MCI). While the combination of linguistic and acoustic signals has been shown to be effective in detecting MCI, they have generally been restricted to structured convers...

In this paper we define and investigate the problem of \emph{persona authentication}: learning a conversational policy to verify the consistency of persona models. We propose a learning objective and prove (under some mild assumptions) that local density estimators trained under this objective maximize the mutual information between persona informa...

Alzheimer's disease (AD) is a neurodegenerative syndrome which affects tens of millions of elders worldwide. Although there is no treatment currently available, early recognition can improve the lives of people with AD and their caretakers and families. To find a cost-effective and easy-to-use method for dementia detection and address the dementia...

Federated learning is a distributed learning framework that is communication efficient and provides protection over participating users' raw training data. One outstanding challenge of federate learning comes from the users' heterogeneity, and learning from such data may yield biased and unfair models for minority groups. While adversarial learning...

Recent years have seen a rapid growth of utilizing graph neural networks (GNNs) in the biomedical domain for tackling drug-related problems. However, like any other deep architectures, GNNs are data hungry. While requiring labels in real world is often expensive, pretraining GNNs in an unsupervised manner has been actively explored. Among them, gra...

Unsupervised anomaly detection plays a crucial role in many critical applications. Driven by the success of deep learning, recent years have witnessed growing interests in applying deep neural networks (DNNs) to anomaly detection problems. A common approach is using autoencoders to learn a feature representation for the normal observations in the d...

Federated Learning (FL) is a decentralized machine-learning paradigm in which a global server iteratively aggregates the model parameters of local users without accessing their data. User heterogeneity has imposed significant challenges to FL, which can incur drifted global models that are slow to converge. Knowledge Distillation has recently emerg...

Training deep neural models in the presence of corrupted supervision is challenging as the corrupted data points may significantly impact the generalization performance. To alleviate this problem, we present an efficient robust algorithm that achieves strong guarantees without any assumption on the type of corruption, and provides a unified framewo...

Federated learning (FL) emerges as a popular distributed learning schema that learns a model from a set of participating users without requiring raw data to be shared. One major challenge of FL comes from heterogeneity in users, which may have distributionally different (or non-iid) data and varying computation resources. Just like in centralized l...

Recent analytical research has pointed out that almost all vehicles spend over 95\% of their time in parking lots where their powerful computing resources are wasted. In this paper, we propose a novel collaborative computing paradigm that efficiently offloads online heterogeneous computation tasks to parked vehicles (PVs) during peak hours. A cont...

Recent years have seen a rapid growth of utilizing graph neural networks (GNNs) in the biomedical domain for tackling drug-related problems. However, like any other deep architectures, GNNs are data hungry. While requiring labels in real world is often expensive, pretraining GNNs in an unsupervised manner has been actively explored. Among them, gra...

Federated Learning (FL) is a decentralized machine-learning paradigm, in which a global server iteratively averages the model parameters of local users without accessing their data. User heterogeneity has imposed significant challenges to FL, which can incur drifted global models that are slow to converge. Knowledge Distillation has recently emerge...

Protecting privacy in gradient-based learning has become increasingly critical as more sensitive information is being used. Many existing solutions seek to protect the sensitive gradients by constraining the overall privacy cost within a constant budget, where the protection is hand-designed and empirically calibrated to boost the utility of the re...

The advances of sensor technology enable people to monitor air quality through widely distributed low-cost sensors. However, measurements from these sensors usually encounter high biases and require a calibration step to reach an acceptable performance in down-streaming analytical tasks. Most existing calibration methods calibrate one type of senso...

DNN-based face recognition models require large centrally aggregated face datasets for training. However, due to the growing data privacy concerns and legal restrictions, accessing and sharing face datasets has become exceedingly difficult. We propose FedFace, a federated learning (FL) framework for collaborative learning of face recognition models...

To bridge the gap between the source and target domains in unsupervised domain adaptation (UDA), the most common strategy puts focus on matching the marginal distributions in the feature space through adversarial learning. However, such category-agnostic global alignment lacks of exploiting the class-level joint distributions, causing the aligned d...

Learning from Observations (LfO) is a practical reinforcement learning scenario from which many applications can benefit through the reuse of incomplete resources. Compared to conventional imitation learning (IL), LfO is more challenging because of the lack of expert action guidance. In both conventional IL and LfO, distribution matching is at the...

Training deep neural models in the presence of corrupted supervision is challenging as the corrupted data points may significantly impact the generalization performance. To alleviate this problem, we present an efficient robust algorithm that achieves strong guarantees without any assumption on the type of corruption and provides a unified framewor...

Protecting privacy in learning while maintaining the model performance has become increasingly critical in many applications that involve sensitive data. Private Gradient Descent (PGD) is a commonly used private learning framework, which noises gradients based on the Differential Privacy protocol. Recent studies show that \emph{dynamic privacy sche...

Learning with curriculum has shown great effectiveness in tasks where the data contains noisy (corrupted) labels, since the curriculum can be used to re-weight or filter out noisy samples via proper design. However, obtaining curriculum from a learner itself without additional supervision or feedback deteriorates the effectiveness due to sample sel...

Background Early identification and accurate assessment of Mild Cognitive Impairment (MCI) is critical for clinical‐trial enrichment as well as the early intervention of the neurodegenerative disease. Continuous home‐based measurements of functions using simple embedded sensors and devices could provide an opportunity to improve the sensitivity and...

Background The search for early biomarkers of mild cognitive impairment (MCI) has been central to Alzheimer's Disease (AD) and the dementia research community in recent years. While there exist in‐vivo biomarkers (e.g., beta‐amyloid and tau) that can serve as indicators of pathological progression toward AD, biomarker screenings are prohibitively e...

As most vehicles spend over 95% of their time in the parking lots, the powerful computing resources of parked vehicles (PVs) are underutilized, that can be considered as available computing nodes to run tasks as well as an extension of the existing infrastructure. In this paper, we propose EdgePV, a collaborative computing paradigm to efficiently i...

Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the expression of entry genes ACE2 and TMPRSS2 , host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment. Using over 220,000 human...

Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clini...

This paper surveys the field of transfer learning in the problem setting of Reinforcement Learning (RL). RL has been the key solution to sequential decision-making problems. Along with the fast advance of RL in various domains. including robotics and game-playing, transfer learning arises as an important technique to assist RL by leveraging and tra...

Multi-task learning (MTL) refers to the paradigm of learning multiple related tasks together. In contrast, in single-task learning (STL) each individual task is learned independently. MTL often leads to better-trained models because they can leverage the commonalities among related tasks. However, because MTL algorithms can "leak" information from...

Federated learning (FL) learns a model jointly from a set of participating devices without sharing each other's privately held data. The characteristics of non-iid data across the network, low device participation, and the mandate that data remain private bring challenges in understanding the convergence of FL algorithms, particularly in regards to...

Although ecosystems respond to global change at regional to continental scales (i.e., macroscales), model predictions of ecosystem responses often rely on data from targeted monitoring of a small proportion of sampled ecosystems within a particular geographic area. In this study, we examined how the sampling strategy used to collect data for such m...

With the proliferation of blockchain projects and applications, cryptocurrency exchanges, which provides exchange services among different types of cryptocurrencies, become pivotal platforms that allow customers to trade digital assets on different blockchains. Because of the anonymity and trustlessness nature of cryptocurrency, one major challenge...

With the proliferation of blockchain projects and applications, cryptocurrency exchanges, which provides exchange services among different types of cryptocurrencies, become pivotal platforms that allow customers to trade digital assets on different blockchains. Because of the anonymity and trustlessness nature of cryptocurrency, one major challenge...

In this work, we proposed a DDI detection method based on molecular structures using graph convolutional networks and deep sets. We proposed a more discriminative convolutional layer compared to conventional GCN and achieved permutation invariant prediction without losing the capability of capturing complicated interactions.

Model-free deep reinforcement learning (RL) has demonstrated its superiority on many complex sequential decision-making problems. However, heavy dependence on dense rewards and high sample-complexity impedes the wide adoption of these methods in real-world scenarios. On the other hand, imitation learning (IL) learns effectively in sparse-rewarded t...

The search for early biomarkers of mild cognitive impairment (MCI) has been central to the Alzheimer’s Disease (AD) and dementia research community in recent years. To identify MCI status at the earliest possible point, recent studies have shown that linguistic markers such as word choice, utterance and sentence structures can potentially serve as...

Aquatic scientists require robust, accurate information about nutrient concentrations and indicators of algal biomass in unsampled lakes in order to understand and predict the effects of global climate and land‐use change. Historically, lake and landscape characteristics have been used as predictor variables in regression models to generate nutrien...

Predictive modeling of large-scale spatio-temporal data is an important but challenging problem as it requires training models that can simultaneously predict the target variables of interest at multiple locations while preserving the spatial and temporal dependencies of the data. In this paper, we investigate the effectiveness of applying a multi-...