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October 2024 - present
October 2022 - August 2024
Publications
Publications (9)
Cognitive dysfunction in Alzheimer’s disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly at elevated risk of AD, we investigated four cerebrospinal (CSF) markers of synaptic dysfunction and degeneration. Thr...
Mandarin Chinese is typologically unusual among the world’s languages in having flexible word order despite a near absence of inflectional morphology. These features of Mandarin challenge conventional linguistic notions such as subject and object and the divide between syntax and semantics. In the present study, we tested monolingual processing of...
Genetic analysis results for synaptic proteins and cognitive performance show a promising connection between synaptic gene regulation and cognitive ability.
CSF synaptic protein levels show promising correlations with emerging cognitive deficits and provide insights toward a possible compensatory mechanism in the early presymptomatic phase of the d...
Background: Synaptic proteins in the cerebrospinal fluid (CSF) may reveal changes in the pre-symptomatic stages of Alzheimer’s disease (AD), thus may be candidate biomarkers for early detection of the disease.
Method: The PREVENT-AD cohort includes symptom-free (upon enrolment) elderly participants who are at risk of developing AD from their family...
Mandarin Chinese is typologically unusual among the world’s languages in having flexible word order despite a near absence of inflectional morphology. These features of Mandarin challenge conventional linguistic notions such as subject and object and the divide between syntax and semantics. In the present study, we tested monolingual processing of...
Background
The heterogeneous etiology of “sporadic” Alzheimer’s disease (sAD) includes genetic influences. To better understand synaptic dysfunction in AD pathogenesis, we used protein quantitative train loci (pQTL) assessments and a polygenic risk score (PRS) to examine the relationship between synaptic integrity and longitudinal cognitive perform...
Background
Synaptic proteins in the cerebrospinal fluid (CSF) may reveal changes in the pre‐symptomatic stages of Alzheimer’s disease (AD), thus may be candidate biomarkers for early detection of the disease.
Method
The PREVENT‐AD cohort includes symptom‐free (upon enrolment) elderly participants who are at risk of developing AD from their family...
Late learners of Mandarin (L1 is English) can obtain qualitative native-like profiencey in processing mechansim of Mandarin sentences .
