Jiaru Bai

• Doctor of Philosophy
• Assistant Professor with Robinson-Lightcap Faculty Fellow at Wake Forest University

Applications of government subsidies to speed up consumer trade‐ins of used products can be commonly observed in practice. This paper studies the design of such trade‐in subsidy programs and aims to provide implementable insights for practice. In particular, we focus on two open problems in the literature, (i) how to optimally allocate the subsidy...

Background Olaparib was approved on December 19, 2014 by the US FDA as 4th-line therapy (and beyond) for patients with germline BRCA1/2 mutations; rucaparib was approved on December 19, 2016 as 3rd-line therapy (and beyond) for germline or somatic BRCA1/2-mutated recurrent disease. On October 23, 2019, niraparib was approved for treatment of women...

Markov modeling allows medical prognosis to be modeled with health state transitions over time and is particularly useful for decisions regarding diseases where uncertain events and outcomes may occur. To provide sufficient detail for operations researchers to carry out a Markov analysis, we present a detailed example of a Markov model with five he...

5545 Background: With the December 19, 2018 regulatory approval by the US FDA of olaparib tablets as maintenance therapy for women with deleterious or suspected deleterious germline or somatic BRCAmut advanced ovarian carcinoma, it becomes important to clarify the role of PARP inhibitors in this disease. We evaluated cost-effectiveness of olaparib...

Many on-demand service platforms use a fixed payout ratio (i.e., the percentage of the platform’s revenue that is paid to the providers) regardless of the customer demand and the number of participating providers that tend to vary over time. In this chapter, we examine the implications of time-based payout ratios. To do so, we first present a queue...

We consider an on-demand service platform using earning-sensitive independent providers with heterogeneous reservation price (for work participation) to serve its time and price-sensitive customers with heterogeneous valuation of the service. As such, the supply and demand are “endogenously” dependent on the price the platform charges its customers...

5516 Background: Unlike approved IV administered therapies, Medicare is under no obligation to cover prescription medicines. We sought to evaluate the cost-effectiveness of the two FDA-approved orally administered PARP inhibitors (PARPi), olaparib and rucaparib. Methods: A Markov model was created in TreeAge Pro 2015 with nodes in the chain allowin...

Markov processes (or Markov chains) are used for modeling a phenomenon in which changes over time of a random variable comprise a sequence of values in the future, each of which depends only on the immediately preceding state, not on other past states. A Markov process (PM) is completely characterized by specifying the finite set S of possible stat...

We consider a situation in which a home improvement project contractor has a team of regular crew members who receive compensation even when they are idle. Because both projects arrivals and the completion time of each project are uncertain, the contractor needs to manage the utilization of his crews carefully. One common approach adopted by many h...

To evaluate the cost-effectiveness of bevacizumab in recurrent/persistent and metastatic cervical cancer using recently reported updated survival and toxicology data. A Markov decision tree based on the Gynecologic Oncology Group 240 randomized trial was created. The 2013 MediCare Services Drug Payment Table and Physician Fee Schedule provided cost...

In this paper, we study the dynamical behavior of a prey-dependent digestive model with a state-dependent impulsive effect. Using the Poincaré map and the Lambert W-function, we find the analytical expression of discrete mapping. Sufficient conditions are established for transcritical bifurcation and period-doubling bifurcation through an analytica...