Jianying Hu

Jianying Hu
Peking University | PKU · College of Urban and Environmental Sciences

PhD

About

237
Publications
29,471
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9,989
Citations

Publications

Publications (237)
Article
Owing to increasing concerns about the toxicity of alkyl organophosphate triesters (OPTEs), it is necessary to comprehensively profile alkyl OPTEs in the environment. In this study, we conducted a nontarget analysis using high-resolution mass spectrometry to newly identify alkyl OPTEs in house dust samples collected in North China. Data-independent...
Article
Background: Abnormal placental development may result in adverse pregnancy outcomes and metabolic diseases in adulthood; however, it remains unknown whether and how xenobiotics affect human placentation. Objectives: This study aimed to screen and identify placentation-disrupting chemicals in commonly used organophosphate flame retardants (OPFRs)...
Article
Full-text available
Organophosphate esters (OPEs) are frequently detected in the environment and human samples, bringing potential adverse effects to ecosystems and human health. Aryl OPEs (AOPEs), which are widely used in industrial and consumer products, are regarded as emerging endocrine disrup-tors. Taking triphenyl phosphate, 2-ethyl-hexyl diphenyl phosphate, tri...
Article
North China is among the most polluted regions in the country, and human exposure to PM2.5 (particulate matter with an aerodynamic diameter less than 2.5 μm) in this region has led to severe health consequences. The region has also benefited the most from emission reductions in recent years. It is of interest to understand to what extent and throug...
Article
The broad-spectrum insecticide p,p′-dichlorodiphenyltrichloroethane (p,p′-DDT) has been banned in most countries since the 1970s on account of its environmental persistence as well as the high biomagnification of its major metabolite 1,1-dichloro-2,2-bis(4-chorophenyl)ethylene (p,p′-DDE). However, the information on the bioaccumulation and behavior...
Article
As tricresyl phosphate (TCrP) is commonly found in global water sources, its potential reproductive toxicity to fish is of increasing concern. Japanese medaka larvae were exposed to TCrP at 657.9, 1,511, and 4042 ng/L for 100 days. We identified significant fertilization inhibition (6.9%–12.8%) in all exposure groups. Intersex was significantly ind...
Article
Full-text available
Sulfur dioxide (SO2) is a major atmospheric pollutant and precursor of sulfate aerosols, which influences air quality, cloud microphysics, and climate. Therefore, better understanding the conversion of SO2 to sulfate is essential to simulate and predict sulfur compounds more accurately. This study evaluates the effects of in-cloud aqueous-phase che...
Article
Retinoic acid receptors (RARs) control reproduction and development in vertebrates, but little attention has been paid to anthropogenic chemicals exhibiting RAR agonistic/antagonistic activity. Here we applied a His-RARα pull-down assay combined with high-resolution mass spectrometry to identify chemicals with RARα activity in house dust. After scr...
Article
Rural residential energy switching from solid fuels to electricity and natural gas has resulted in substantial health benefits in China. Here, we quantitatively estimated the environmental and health benefits of stove upgrading, energy switching, and the interaction of stove upgrading and energy switching in rural mainland China during the period o...
Article
Although concerns have been raised about the adverse effects of triphenyl phosphate (TPhP) on female fertility, its risk to ovarian functioning remains unknown. In this study, female C57BL/6 mice at postnatal day 21 were exposed on a daily basis to TPhP dose of 2, 10, and 50 mg/kg for 40 days. A significant delay in pubertal timing was observed in...
Preprint
Full-text available
Sulfur dioxide (SO2) is a major atmospheric pollutant and precursor of sulfate aerosols, which influences air quality, cloud microphysics and climate. Therefore, better understanding the conversion of SO2 to sulfate is essential to simulate and predict sulfur compounds more accurately. This study evaluates the effects of in-cloud aqueous-phase chem...
Article
Full-text available
This study investigated the association between house cleaning frequency and the risk of miscarriage in a case control sample of Chinese population. We recruited 59 pregnant women with clinical pregnancy loss as cases and 122 women who chose to conduct induced abortion as controls. All participants were aged 20~40 years and completed a questionnair...
Article
Coal abatement actions for pollution reduction often target total coal consumption. The health impacts of coal uses, however, vary extensively among sectors. Here, we modeled the sectorial contributions of coal uses to emissions, outdoor and indoor PM2.5 (particulate matter with an aerodynamic diameter of less than 2.5 mm) concentrations, exposures...
Article
2-Ethylhexyl diphenyl phosphate (EHDPP) has been detected in wild fish with high concentrations, which may pose a risk in the embryo development considering its potential maternal transfer. In this study, EHDPP was demonstrated to elicit antagonistic activity to medaka retinoic acid receptor (mRAR) and retinoic X receptor (mRXR) with 50% inhibitory...
Article
Air pollution is a major environmental issue in China and imposes severe health burdens on Chinese citizens. Consequently, China has deployed a series of control measures to mitigate fine particulate matter (PM2.5). However, the extent to which these measures have been effective is obscured by the existence of confounding meteorological effects. He...
Article
Exposure to environmental pollutants is an important factor contributing to the development and severity of thrombosis. However, the important physiological molecules in the thrombotic processes affected by environmental exposures remain unknown. In this study, we show that exposure to environmental chemicals disrupts the equilibrium of cardiolipin...
Article
Traffic pollution threatens both human health and climate stability. The Chinese government issued the “Mid- and Long-term Railway Network Plan” and the “National Highway Network Plan (2013-2030)” in 2004 and 2013, respectively, aiming at building a national railway network and a national highway network with reasonable layout, wide coverage and ec...
Article
Several haloalkyl organophosphate triester (OPTE) flame retardants have been restricted in some countries due to their potential health risks, but the usage of alternative haloalkyl OPTEs is of concern. In this study, we comprehensively screened for haloalkyl OPTEs in house dust using high-resolution mass spectrometry. Through halogenation-guided n...
Article
Indoor air pollution has significant adverse health impacts, but its spatiotemporal variations and source contributions are not well quantified. In this study, we used low-cost sensors to measure PM2.5 concentrations in a typical apartment in Beijing. The measurements were conducted at 15 indoor sites and one outdoor site on 1-minute temporal resol...
Article
Full-text available
Chlorinated paraffins (CPs) have been extensively examined to identify their components. Short-chain CPs with a carbon number of 10-13 have been strictly restricted or banned due to their addition to the list of Persistent Organic Pollutants in the world. However, more constituents with potential toxicities in these complicated mixtures are still u...
Article
The identified components of fine particulate matter with dynamic diameters less than 2.5 μm (PM2.5) suggests the remarkable increase in Cl⁻ in PM2.5 during autumn and winter over North China. Anthropogenic chlorine emissions, including those from biomass burning, coal combustion and biofuel burning, are the main sources of Cl⁻, which could potenti...
Article
Full-text available
Residential contribution to air pollution–associated health impacts is critical, but inadequately addressed because of data gaps. Here, we fully model the effects of residential energy use on emissions, outdoor and indoor PM2.5 concentrations, exposure, and premature deaths using updated energy data. We show that the residential sector contributed...
Article
Full-text available
Gonadal intersex has been observed in wild fishes and attributed to endocrine-disrupting chemicals but the specific causes remain controversial. Here, a forensic analysis utilizing field and laboratory studies was conducted to explore the causal agent(s). In a 2008-2009 survey of Liaodong Bay, China, 20.7%-33.3% incidences of gonadal intersex was o...
Article
While high concentrations of 2-ethylhexyl diphenyl phosphate (EHDPP) have been detected in wild fish, its reproductive toxicity in fish remains unclear. In this study, we for the first time observed EHDPP elicited androgen receptor (AR) antagonistic activity with 50% inhibitory concentration of 37.5 μM. 2-Ethyl-5-hydroxyhexyl diphenyl phosphate was...
Article
Although huge interspecies differences in the response to dioxins have been acknowledged, toxic equivalency factors derived from rodent studies are often used to assess human health risk. To determine interspecies differences, we first developed a toxicokinetic model in humans by measuring dioxin concentrations in environmental and biomonitoring sa...
Article
Antibiotic resistance genes (ARGs) can survive the water treatment process. However, the prevalence patterns, key drivers, and relationships with opportunistic pathogens of the antibiotic resistome harbored in drinking water sources remain unclear. Herein, 53 drinking water samples collected across a large geographical scale in China were character...
Article
Although triphenyl phosphate (TPHP) has been reported to disrupt lipid metabolism, the effect of TPHP on lipid saturation remains unexplored. In this study, a lipidomic analysis demonstrated decreases in the levels of poly-unsaturated phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in RAW264.7 murine macrophage...
Article
A variety of anthropogenic chemicals can disrupt the equilibrium of intrinsic biological metabolites in organisms, leading to metabolic disorders and an increased risk of metabolic syndromes. However, exposure to pollutants which induce metabolic disorders in wildlife as a cause of adverse effects is unknown. In this study, approximately 3108 compo...
Article
Wastewater reclamation and reuse is considered an attractive and practical method for coping with water scarcity. However, the presence of micropollutants in reclaimed water, including endocrine disrupting chemicals (EDCs), is a major public health concern. This study attempted to identify unknown EDCs with liver X receptor (LXRα) agonist/antagonis...
Article
Full-text available
Since triphenyl phosphate (TPhP) elicits both anti-estrogenic activity via blocking estrogen receptor (ER) and estrogenic activity by elevating 17β-estradiol (17β-E2) synthesis, its adverse effects on female reproduction is uncertain. In this study, we exposed Japanese medaka to TPhP at 131, 363, and 1773 ng/L for 100 days following hatching. TPhP...
Article
Chlorinated paraffins (CPs) are chemicals with high production volumes that can accumulate at high levels in general populations. The pharmacokinetics of CPs as pollutants is unknown, and there is no evidence that the MCCPs and LCCPs are safe replacements for SCCPs. In this study, SCCPs, MCCPs and LCCPs were firstly in vivo and in vitro exposed to...
Article
Full-text available
Background: Atherosclerotic cardiovascular disease has become the leading cause of death worldwide, and environmental pollutants are increasingly recognized as risk factors for atherosclerosis. Liver X receptors (LXRs) play a central role in atherosclerosis; however, LXR activity of organic pollutants and associated potential risk of atheroscleros...
Article
Full-text available
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), commonly referred to simply as "dioxin", is a persistent environmental pollutant. Because of its high environmental persistence and biological accumulation, humans and animals are often exposed to TCDD. Therefore, the harmful effects on humans and animals is a major concern. Although studies have elucidat...
Article
There is growing evidence that aryl organophosphate flame retardants (aryl-OPFRs) can disrupt lipid metabolism in animals. However, epidemiologic studies of this possible phenomenon are lacking. In this study, we explored the association between urinary concentrations of three aryl-OPFRs (triphenyl phosphate (TPHP), tricresyl phosphate, and 2-ethyl...
Article
Oligomeric organophosphorus flame retardants (o-OPFRs) are extensively used as substitutes for decabromodiphenyl ether. However, little is currently known about their occurrence in aquatic environments, their bioaccumulation, or their trophic transfer. In this study, concentrations of two o-OPFRs, bisphenol A bis(diphenyl phosphate) (BPA-BDPP) and...
Article
Constant elimination half-life is usually used in first-order one-compartment pharmacokinetic models to assess human exposure to dioxin-like polychlorinated biphenyls (PCBs). However, hepatic clearance rates are usually lower for elders than for young people. In this study, levels of 12 dioxin-like PCBs were determined in blood samples collected in...
Article
Full-text available
In regions with heavily contaminated drinking water, a significant contribution of drinking water to overall human perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) exposure has been well documented. However, the relationship of PFOA/PFOS blood concentrations in the general population to routine drinking water exposure is not well char...
Article
Although phthalates (PAEs)are ubiquitous in drinking water, and phthalate monoesters (MPAEs)have been recognized as the bioactive metabolites of PAEs, little information is available regarding the occurrence of MPAEs in drinking water and the contributions of PAEs and MPAEs to human exposure. In this study, the concentrations of PAEs and MPAEs in 1...
Article
Full-text available
While monomeric aryl organophosphate flame retardants (m-aryl-OPFRs) are used worldwide in a variety of consumer products, specific biomarkers for epidemiologic studies are lacking. To explore the potential of urinary hydroxylated metabolites of m-aryl-OPFRs as the biomarkers, we detected triphenyl phosphate (TPHP), 2-ethylhexyl diphenyl phosphate...
Article
While the phytoestrogen metabolite equol has been reported to exist in surface water, its behavior in drinking water treatment plants remains unrevealed. In this study, eight products including four chlorinated equols (monochloro-equol, dichloro-equol, trichloro-equol, and tetrachloro-equol) were identified in an aqueous chlorinated equol solution...
Article
Despite increasing use of organophosphorus flame retardants (OPFRs), their food web transfer behavior is not well known. In this study, concentrations of fourteen OPFRs were measured in 17 species from Taihu Lake, China, and their trophodynamics were assessed. Of the 14 OPFRs, nine were detected in at least 70% of the food web samples, including tr...
Article
While phthalates monoesters have been recognized as the bioactive metabolites of phthalates, the knowledge on their environmental occurrence and sources is limited. In this study, monomethyl phthalate (MMP), monoethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), and mono-2-ethylhexyl phthalate (MEHP) were frequen...
Article
Full-text available
Considering triclosan (TCS) is ubiquitous in surface water and wild fish at relatively high concentrations, its adverse effects on gonadal development and reproduction were evaluated. After exposure for 100 days from hatching, the lowest observable effective concentrations (LOEC) of TCS to significantly induce gonadal intersex in male Japanese meda...
Article
Corn oil, sesame oil, and 10% ethanol in corn oil are commonly used as dosing vehicles in toxicology studies. Since these vegetable oils contain bioactive compounds, it is important for toxicology studies to characterize the toxicities of the dosing vehicles themselves. It has been recently proposed that the width of the genital tubercle (GT), the...
Article
While (N-ethyl perfluorooctanesulfonamido ethanol)-based phosphates (SAmPAPs) have been proposed as a group of perfluorooctanesulfonate (PFOS) precursors, investigation of their occurrence and fate has been limited to SAmPAP diester. In this study, SAmPAP diester and triester were simultaneously determined in freshwater sediment from Taihu Lake usi...
Article
Fluorotelomer alcohols (FTOHs) are the most well-known precursors of perfluoroalkyl carboxylic acids (PFCAs), but limited information is available on their occurrence and fate in municipal wastewater treatment plants (WWTPs). The occurrence of FTOHs was investigated in influent, secondary effluent and sludge of 12 municipal WWTPs in nine cities of...
Article
Metabolism is an organism's primary defense against xenobiotics, yet it also increases the production of toxic metabolites. It is generally recognized that phenolic xenobiotics, a group of ubiquitous endocrine disruptors, undergo rapid phase II metabolism to generate more water-soluble glucuronide and sulfate conjugates as a detoxification pathway....
Article
The potential for prenatal exposure has recently raised concerns over the health risks of endocrine disruptors; however, knowledge about human prenatal exposure to organophosphorus flame retardants (OPFRs) is lacking. In this study, 2-ethylhexyl diphenyl phosphate (EHDPP), tributyl phosphate (TBP), triphenyl phosphate (TPHP), and tris(2-chloroethyl...
Article
The impacts of triphenyltin (TPT) on ecological health are of particular concern due to the unexpectedly high levels found in wild fish around the world. Here, zebrafish embryos were exposed to TPT via in ovo nano-injection to study its toxicity on the development of retinal axons in fish. Lipophilic dye labeling revealed obvious defects in retinal...
Article
Concerns over the adverse reproductive outcomes in human have been raised, more evidence including the underlying mechanism are required. Since extravillous trophoblast (EVT) invasion is an important physiological step during early development, the effects of mono-2-ethylhexyl phthalate (MEHP), the bioactive metabolite of DEHP, on EVT invasion were...
Article
Full-text available
Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water samples from ten drinking water treat...
Article
The potential health effects of toxic chemicals (e.g. heavy metals) emitted by municipal solid waste incinerators (MSWIs) are of great concern to local residents, however there have been few studies on the contributions of different exposure pathways and their subsequent effects on the body burden of residents living near MSWIs. In this study, mult...
Article
2-Ethylhexyl diphenyl phosphate (EHDPP), an organophosphate flame retardants (OPFRs), is frequently detected in human blood. In this study, sensitive dual-luciferase reporter gene assay and molecular docking were used to investigate the activation of EHDPP to human peroxisome proliferator-activated receptor gamma (PPARG). Results show that EHDPP ex...
Article
Full-text available
Bisphenol A (BPA) is used in the production of plastic but has oestrogenic activity. Therefore, BPA substitutes, such as fluorene-9-bisphenol (BHPF), have been introduced for the production of so-called ‘BPA-free’ plastics. Here we show that BHPF is released from commercial ‘BPA-free’ plastic bottles into drinking water and has anti-oestrogenic eff...
Data
Supplementary figures, supplementary tables and supplementary notes.
Article
The industrial chlorinated paraffins (CPs) are comprised of short-chain (SCCPs), medium chain (MCCPs), and long chain (LCCPs) CPs. Although SCCPs and MCCPs are environmentally ubiquitous, little is known about CPs in humans. This study established a method for simultaneous determination of 261 SCCP, MCCP, and LCCP congener groups in one injection b...
Article
Full-text available
While a recent toxicological study has shown that organophosphorus flame retardants (OPFRs) may disrupt sphingolipid homeostasis, epidemiologic evidence is currently lacking. In this study, a total of 257 participants were recruited from Shenzhen, China. Eleven OPFRs were for the first time simultaneously determined in the human blood samples by ul...
Article
Full-text available
Equol is present in the aquatic environment via livestock waste and runoff discharge; however, it remains unclear whether it can induce gonadal intersex in fish at environmentally relevant concentrations. This study evaluated adverse effects of equol on gonadal development by exposing transgenic Japanese medaka (Oryzias latipes) from hatching for 1...
Article
The use of trophic magnification factors (TMFs) to characterize the bioaccumulation potentials of chemicals was encouraged, however the method for assessment of trophic magnification potentials is still lacking. We optimized the in vitro assays used for the measurement of intrinsic clearance in liver microsomes by incorporating benzo[a]pyrene [B(a)...
Article
The present study applied non-targeted screening techniques as a novel approach to evaluate the tap water samples collected during the "4.11" tap water pollution incident occurred on April 11, 2014 in Lanzhou in west China. Multivariate analysis (PCA and OPLS-DA) of about 3000 chemical features obtained in extracts of tap water samples by ultrahigh...
Article
While the U.S. EPA has issued a draft report with a 1% TCDD effective dose (ED01) of 87.9pg/kg/day based on continuous integration of key scientific evidence, a detailed and comprehensive uncertainty analysis has not been well documented. In this study, a new estimate for ED01 was derived based on uncertainty analysis by quantitatively assessing th...
Article
Prenatal exposure has recently raised concerns over the health risks of endocrine disruptors; however, little is known about their extent and mechanisms of maternal transfer in the embryo stage. In this study, bisphenol A (BPA), nonylphenol (NP), and their six chlorinated derivatives were quantified in decidua samples from 25 pregnant women and the...