Jiantao Liu

Henan Provincial People’s Hospital · Department of spine and spinal cord surgery

There are various internal fixation methods in treating lumbosacral spinal tuberculosis. The study compared the stability and stress distribution in surrounding tissues/implants, such as discs, endplates and screw-rod internal fixation system, etc. when applying three different lumbar internal fixation methods to treat lumbosacral spinal tuberculos...

Introduction: Ti6Al4V titanium alloy is widely used in producing orthopedic and maxillofacial implants, but drawbacks include high elastic modulus, poor osseointegration performance, and toxic elements. A new medical titanium alloy material with better comprehensive performance is urgently needed in the clinic. Methods: Ti10Mo6Zr4Sn3Nb titanium all...

Nanodynamic therapy (NDT) based on reactive oxygen species (ROS) production has been envisioned as an effective cancer treatment. However, the efficacy is limited by the hypoxia, insufficient hydrogen peroxide conversion, and high glutathione (GSH) levels in the tumor microenvironment (TME). To solve these issues, we proposed and designed a biocomp...

Oxidation behavior of a novel powder metallurgy superalloy was investigated at 900 oC under minor tension of 0, 30, 50, and 70 MPa, respectively. Minor tensile stress was proved helpful in enhancing the oxidation resistance of superalloy. With increasing stress, oxide scale became thinner, more compact, more continuous and flatter. This was also ac...

In this work, the quantification of key microstructural features like γ′ size morphology distribution, grain size, and localized stress distribution, especially near a fracture, were coupled with mechanical properties under various temperatures in Ni-base powder metallurgy superalloys subjected to sub-solvus or super-solvus heat treatments. Compare...

Influence of Co on the coarsening behavior of γ’ phase in Ni-base superalloy was investigated. Long term thermal exposure at 750 oC and 850 oC were carried out on alloys with Co contents of 10, 20, 25 wt.%. The coarsening rates of γ’ phase were observed to decrease gradually with increasing Co content ascribed to the lower interfacial energy betwee...

Oxidation of a novel Ni-19Cr-17W-2Al-0.5Ti superalloy was investigated in air at 800–1100 °C. In spite of the local spallation of external oxide scale after prolonged oxidation at high temperature, the alloy maintains excellent oxidation resistance. The excellent oxidation resistance is related to continuous external Ti-rich oxide covering on Cr2O3...

In spine biomechanics, follower loads are used to mimic the in vivo muscle forces acting on a human spine. However, the effects of the follower load on the continuous biomechanical responses of the subaxial cervical spines (C2-T1) have not been systematically clarified. This study aims at investigating the follower load effects on the continuous bi...

Influence of Nb addition on the internal oxidation of a novel powder metallurgy superalloy was studied. The results indicated that higher Nb concentration leads to deeper internal oxidation but narrower γ’ phase depletion region. Nb enhanced the partition of more Al into γ’ phase, which slows down the outward diffusion of Al and hence promotes the...

Purpose. This was an in vivo study to develop a novel movable lumbar artificial vertebral complex (MLVC) in a goat model. The purpose of this study was to evaluate clinical and biomechanical characteristics of MLVC and to provide preclinical data for a clinical trial in the future. Methods. According to the preoperative X-ray and CT scan data of th...

Effect of Ti addition on oxidation behavior of Ni-Cr-W alloys was systematically investigated by isothermal oxidation in air. The oxidation rate is accelerated by Ti addition, due to that Cr2O3 vacancy density is increased by Ti⁴⁺ occupies Cr³⁺ position, which promotes the formation of Cr2O3 scales. Ti addition induced the formation of TiO2 but inh...

A near-full dense Cu-36.8Fe alloy was manufactured by selective laser melting (SLM). The as-SLMed Cu-Fe alloy exhibits an excellent combination of both high strength and superior ductility. The exceptional mechanical performances are associated with the unique hierarchical microstructures, including molten pools, sub-micron cellular bi-phasic struc...

A novel Co-Ni-based superalloy was manufactured by powder metallurgy (PM) process. The microstructure and mechanical properties of PM alloy were analyzed in detail and compared with the corresponding casting alloy. After cold swaging to 66% and subsequent aging for 800 °C for 3 h on solution treated (ST) PM alloy, the yield strengths of PM superall...

Studies have indicated that collagen α-1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types of malignant tumor. However, its role in the development of glioma has remained elusive. Therefore, the present study sought to determine the association between the expression levels of COL4A1 a...

Background Clavicular hook plates are frequently used in clinical orthopedics to treat acromioclavicular joint dislocation. However, patients often exhibit acromial osteolysis and peri-implant fracture after hook plate fixation. To solve the above problems, we developed a novel double-hook clavicular plate and used finite element analysis (FEA) to...

The aim of the study was to evaluate the biomechanical properties of a novel nonfused artificial vertebral body in treating lumbar diseases and to compare with those of the fusion artificial vertebral body. An intact finite element model of the L1–L5 lumbar spine was constructed and validated. Then, the finite element models of the fusion group and...

Objective: To compare the biomechanical properties of a new memory compression alloy plate and traditional titanium plate after anterior cervical discectomy and fusion (ACDF). Methods: A finite element model of the C3-7 segments was developed and validated. The C5-6 disc was removed, and an intervertebral cage made of peek material was implanted...

MicroRNAs (miRNAs) function as gene expression switches, and participate in diverse pathophysiological processes of spinal cord injury (SCI). Olfactory ensheathing cells (OECs) can alleviate pathological injury and facilitate functional recovery after SCI. However, the mechanisms by which OECs restore function are not well understood. This study ai...

Objective To design a novel prosthesis, a movable artificial lumbar complex (MALC), for non-fusion reconstruction after lumbar subtotal corpectomy and to evaluate the stability, range of motion and load-bearing strength in the human cadaveric lumbar spine. Methods Biomechanical tests were performed on lumbar spine specimens from 15 healthy cadaver...

Background/aims: Zinc Finger Protein 281 (ZNF281) was recently identified as a novel oncogene in several human carcinomas. However, the clinical significance of ZNF281 in colorectal cancer (CRC) and the molecular mechanisms by which ZNF281 promotes the growth and metastasis of CRC remain unknown. Methods: ZNF281 expression in CRC tissues was ass...

Background: Although various surgical methods are used to treat lumbosacral tuberculosis, no unified surgical approach exists. Thus, exploring an optimal operation method has substantial clinical importance. Evaluate the initial stability of a new surgical method, a one-stage anterior debridement and cage implantation combined with anterior-latera...

Objective: To study and measure the anatomic structure of lumbar vertebral endplate structure in healthy adults by computed tomography(CT) technique in order to provide a useful guidance for the optimal design and clinical application of lumbar prostheses. Methods: Sixty healthy adults (male and female equals) were recruited for full-waist CT sc...

The cervical screw fixation has been used widely in the clinic setting due to the high fusion rate, immediate fixation of the surgical segment and good correction of the deformity. However, owing to the variation of anatomical structures and the narrow pedicle screws, it's rather difficult to implant the screws through traditional methods. The perf...

Background The aim of this study was to compare renal function in children with congenital scoliosis and congenital anomalies of the kidney and urinary tract, with healthy children. Material/Methods Biochemical tests were performed before surgery (pre-therapy) and after surgery (post-therapy) in 16 children with congenital scoliosis and congenital...

Objective: To study the anatomical measurement of goat lumbar vertebrae and to compare with human lumbar vertebrae, so as to build the foundation for establishing animal models of lumbar prosthesis. Methods: The anatomical parameters of the vertebral body, pedicle and intervertebral disc in the fresh lumbar vertebrae of Boer goat and the lumbar...

Objective: To explore the feasibility and the attention of perioperative management of goat lumbar fusion model for individualized 3D printing technology. Methods: According to preoperative X-ray and CT three dimensional reconstruction data of 10 males Boer goat's lumbar(1-2 years old, weight 35-45 kg), the preoperative open height were determin...

Ebselen is a fat-soluble small molecule and organic selenium compound that regulates the activity of glutathione peroxidase to alleviate mitochondrial oxidative stress and improve mitochondrial function. In the present study, we aimed to investigate the effects of ebselen on mitochondrial oxidative stress response, mitochondrial apotosis, and motor...

Objective: To evaluate renal function in congenital spinal deformities patients with urinary malformations. Methods: We prospectively enrolled patients diagnosed with congenital spinal deformities combined with urinary malformation as well as age- and weight-matched healthy individuals and divided them into three groups: renal malformations group,...

Objective: To systematically evaluate the clinical effect of high frequency repeated transcranial magnetic stimulation(HF rTMS)therapy on dyskinesia in patients with incomplete spinal cord injury. Methods: Randomized controlled trials(RCTs) about HF rTMS therapy on patients with motor incomplete spinal cord injury were searched electronically in...

Artificial vertebral body has achieved good results in treating spinal tumors, tuberculosis, fracture and other diseases. Currently, artificial vertebral body with variety of kinds and pros and cons, is generally divided into two types: fusion type and movable type. The former according to whether the height could be adjusted and strength of self-s...

Objective: In this study, we aimed to design a movable artificial lumbar complex (MALC) prosthesis for non-fusion reconstruction after lumbar subtotal corpectomy and to establish an in vitro anterolateral lumbar corpectomy non-fusion model for evaluating the biomechanical stability, preservation of segment movements and influence on adjacent inter...

Background The aim of this study was to evaluate the clinical and radiological outcomes of the use of a new 3D-printed anatomy-adaptive titanium mesh cage (AA-TMC) for single-level anterior cervical corpectomy and fusion (ACCF) in patients with cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL). Ma...

Background Olfactory ensheathing cell transplantation is a promising treatment for spinal cord injury. Diffusion tensor imaging has been applied to assess various kinds of spinal cord injury. However, it has rarely been used to evaluate the beneficial effects of olfactory ensheathing cell transplantation. This study aimed to explore the feasibility...

Objective: To research the effects of olfactory ensheathing cells (OECs) on the proliferation of neural stem cells (NSCs). Methods: OECs and NSCs were separated and cultured in vitro. The proliferation of NSCs was observed by means of co-culture and two-chamber shared medium culture with OECs. For investigating the mechanism of the proliferation of...