Jianping Wu

• University of Alberta

Osteoporosis, the most prevalent metabolic bone disorder, is a major public health issue. Previous studies indicated the potential of food components in mitigating the risks of osteoporosis. The study aimed to evaluate the potential of canola protein hydrolysates (CPH) on osteoclastogenesis using a pre‐osteoblast cell MC3T3‐E1. Twenty‐two CPHs were...

Taste‐active peptides (TAPs) impart significant organoleptic attributes of food products. Their diverse taste profiles, such as umami, bitter, sweet, salty, sour, and kokumi, hold great potential for various food and nutraceutical applications. The perception of taste is influenced by TAPs' interactions with taste receptors, which are governed by t...

Brewer’s spent grain (BSG) is the primary byproduct of the beer industry, accounting for nearly 85% of the total solids generated. BSG mainly consists of barley grain husks retained as a solid residue after wort production. It is a rich source of protein and fibre; however, it remains underutilized, primarily being used as low-value animal feed. Co...

Bioactive peptides from edible bird’s nest (EBN) represent a unique natural source that exhibits various attractive bioactivities. Four EBN peptides (P1: LFWSPSVYLK, P2: GWPHLEDNYLDW, P3: NPPADLHK and P4: GDLAYLDQGHR) were previously identified with potential antioxidant and anti-inflammatory activities. However, their bioactivities at cellular lev...

Egg whites contain a variety of biologically active proteins and are a good source of bioactive peptides. Egg white hydrolysate prepared by thermoase (EWH) possesses antihypertensive effects. Our recent study showed that egg white proteins, after depleting ovotransferrin, also contained many angiotensin-converting enzyme (ACE)-inhibitory peptides a...

Antimicrobial resistance (AMR) poses a global public health concern. Recognizing the critical role of bacterial adhesion in pathogenesis of infection, anti-adhesive therapy emerges as a promising approach to impede initial bacterial attachment, thus preventing pathogenic colonization and infection. Natural anti-adhesive agents derived from food sou...

Ovotransferrin, an iron-binding glycoprotein, accounting for approximately 12% of egg white protein, is a member of transferrin fam ily. Our previous studies showed that ovotransferrin stimulates the proliferation and differentiation of osteoblasts, while inhibits osteoclastogenesis and resorption activity. The work aims to study the efficacy of or...

Angiotensin-converting enzyme 2 (ACE2) is a key enzyme in the renin-angiotensin system (RAS), also serving as an amino acid transporter and a receptor for certain coronaviruses. Its primary role is to protect the cardiovascular system via the ACE2/Ang (1–7)/MasR cascade. Given the critical roles of ACE2 in regulating numerous physiological function...

One of the most consistent epidemiological associations between diet and human disease risk is the impact of consuming red meat and processed meat products. In recent years, the health concerns surrounding red meat and processed meat have gained worldwide attention. The fact that humans have lost the ability to synthesize N‐glycolylneuraminic acid...

Scope This study aims to investigate the antihypertensive effect of four chicken muscle‐derived angiotensin (Ang)‐converting enzymes (ACE)‐regulating peptides: Val‐Arg‐Pro (VRP, ACE inhibition), Leu‐Lys‐Tyr and Val‐Arg‐Tyr (LKY and VRY, ACE inhibition and ACE2 upregulation), and Val‐Val‐His‐Pro‐Lys‐Glu‐Ser‐Phe (VVHPKESF [V‐F], ACE2 upregulation) in...

Dry-fermented sausages are a good source of bioactive peptides, whose stability against gastrointestinal (GI) digestion determines their bioaccessibility. This study focused on evaluating the effect of peptide extracts from sausages fermented with Staphylococcus simulans QB7 during in vitro simulated GI digestion, including peptide profiles and ant...

The demand for plant-based meat analogs (PBMA) is on the rise as a strategy to sustain the food protein supply while mitigating environmental change. In addition to supplying essential amino acids and energy, food proteins are known sources of bioactive peptides. Whether protein in PBMA affords similar peptide profiles and bioactivities as real mea...

Eggs are considered an excellent source of nutrients including high quality protein and a substantial amount of essential fatty acids, vitamins, and minerals. In addition to supporting embryo development, providing nutrients to humans, and using as a versatile food ingredient, egg white is regarded as a rich and inexpensive source of bioactive prot...

Non-alcoholic fatty liver disease (NAFLD) the hepatic manifestation of the metabolic syndrome, remains without approved pharmacological treatment, with lifestyle modifications being the first line of therapy. Alternative approaches, including food-derived bioactive peptides can aid in the management of metabolic conditions including hypertension, o...

Bioadhesives applied on human organs are promising soft implants for interventional diagnostics and therapeutics. However, the conventional bioadhesive interfaces on organs typically lack apical–basal polarity to resemble the surface functions of original organ epithelia. To overcome the bioadhesive-induced dysfunction on treated organs, we have de...

Angiotensin-converting enzyme (ACE) catalyzes the formation of angiotensin II (Ang II), a vasoconstrictor, whereas its homologue ACE2 degrades Ang II into angiotensin (1-7) (Ang (1-7)), a vasodilator. Given the similarities in structure and their interconnected roles in the regulation of cardiovascular system, this study aims to investigate if ACE-...

Osteoporosis is the most common bone disorder, characterized by low bone mineral density and microarchitectural deterioration of the bone tissue, which increases the susceptibility to fracture. In the past decade, emerging research findings reported the implication of gut microbiota on bone health and osteoporosis pathology. Osteoporotic patients o...

This study aimed to understand how specific cell-bound receptors influence ACE2 activation by IRW. Our results showed that G protein-coupled receptor 30 (GPR30), a 7-transmembrane domain protein, was involved in IRW-mediated ACE2 increase. IRW treatment (50 μM) significantly increased the GPR30 pool levels (3.2 ± 0.5 folds) (p < 0.001). IRW treatme...

Obesity-induced adipose chronic inflammation is closely related to the development of insulin resistance and T2DM. Tripeptides l-valyl-l-prolyl-l-proline (VPP) and l-isoleucyl-l-prolyl-L-proline (IPP) derived from bovine casein have been reported to prevent inflammatory changes and mitigate insulin resistance in adipocytes. In this study, we aimed...

Simple Summary Metabolic syndrome refers to a cluster of various risk factors commonly associated with cardiovascular diseases and diabetes. Upregulation of angiotensin-converting enzyme 2 (ACE2), a key member of the renin–angiotensin system (RAS), is in general protective against cardiovascular diseases and diabetes. Peptide IRW was previously sho...

Type 2 diabetes mellitus is a chronic metabolic disease, characterized by persistent hyperglycemia, the prevalence of which is on the rise worldwide. Fermented soybean products (FSP) are rich in diverse functional ingredients which have been shown to exhibit therapeutic properties in alleviating hyperglycemia. This review summarizes the hypoglycemi...

The demand for plant-based meat analogs (PBMA) is on the rise as a strategy to sustain the food protein supply while mitigating environmental change. In addition to supplying essential amino acids and energy, food proteins are known sources of bioactive peptides. Whether protein in PBMA affords similar peptide profiles and bioactivities as real mea...

Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a global health problem. Currently, no pharmacological treatment is approved for NAFLD. Natural health products, including bioactive peptides, are potential candidates to aid in the management of metabolic syndrome-related conditions, including insuli...

Proteases, especially microbial proteases, are widely used in food processing. The purpose of this study was aimed to purify an extracellular protease produced by the strain Staphylococcus simulans QB7 and to evaluate its ability in hydrolyzing meat proteins and generating antioxidant and anti-inflammatory peptides. The optimal conditions for produ...

Spent hen are egg-laying hens reaching the end of their laying cycles; billions of spent hens are produced globally each year. Differences in people’s attitudes towards spent hen as foods lead to their different fates among countries. While spent hens are consumed as raw or processed meat products in Asian countries such as China, India, Korea, and...

Soybean is a rich source of high-quality proteins and an excellent food source of bioactive peptides. A tripeptide, Leu–Ser–Trp (LSW), was previously identified from soybean as an angiotensin-converting enzyme inhibitory peptide. In the present work, we further studied its antioxidant and anti-inflammatory activities in human vascular endothelial c...

Coronavirus disease 2019 (COVID-19), the current global pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Various pharmaceuticals are being developed to counter the spread of the virus. The strategy of repurposing known drugs and bioactive molecules is a rational approach. A previously described molecule, Ile-Arg-T...

Leu-Arg-Trp (LRW), a pea-derived tripeptide, is an isomer of Ile-Arg-Trp (IRW), an egg-derived tripeptide possessing various health benefits including antihypertensive activity. Since LRW and IRW are structural analogs, we hypothesized that LRW can significantly reduce blood pressure in spontaneously hypertensive rats. LRW showed a more potent in v...

A phenylalanine (Phe)-restricted diet is indispensable for individuals suffering from phe-nylketonuria (PKU). Our previous study reported a low-Phe-containing whey protein hydrolysate (LPH) prepared from a selected whey protein hydrolysate (TA2H). This study aimed to investigate the osteogenic activity of LPH and TA2H in MC3T3-E1 preosteoblast cell...

Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health. Through modulation of mitochondrial function, the kidneys are able to sustain or recover acute kidney injury (AKI), chronic kidney disease (CKD), nephrotoxicity, nephropathy, a...

Insulin resistance leads to impaired glucose metabolism by disrupting both insulin secretion and sensitivity. Insulin resistance plays a key role in the pathophysiology of type 2 diabetes and metabolic syndrome. Reviews on the mechanisms of action of bioactive peptides on glucose homeostasis and insulin resistance are scarce. The recent discoveries...

Multiple strategies including the use of bioactive peptides and other nutraceuticals are being adopted to maintain bone health. This study provides an improved and deeper understanding of the pharmacological effects that a bioactive peptide IRW (Ile-Arg-Trp) extends on bone health. Our results showed that IRW treatment protects osteoblasts against...

Scope: This study aimed to investigate the protective effects of four chicken muscle-derived peptides (Val-Arg-Pro (VRP), Leu-Lys-Tyr (LKY), Val-Arg-Tyr (VRY), and Val-Val-His-Pro-Lys-Glu-Ser-Phe [VVHPKESF (V-F)] on tumor necrosis factor alpha (TNFα)-induced endothelial inflammation and oxidative stress in human vascular endothelial EA.hy926 cells...

IRW (Isoleucine–Arginine–Tryptophan), has antihypertensive and anti-inflammatory properties in cells and animal models and prevents angiotensin-II- and tumor necrosis factor (TNF)-α-induced insulin resistance (IR) in vitro. We investigated the effects of IRW on body composition, glucose homeostasis and insulin sensitivity in a high-fat diet (HFD) i...

This study aimed to evaluate the modulatory effects of four chicken muscle-derived peptides [VRP, LKY, VRY, and VVHPKESF (V-F)] on angiotensin II (Ang II)-induced inflammation in rat vascular smooth muscle A7r5 cells. Only V-F could significantly attenuate Ang II-stimulated inflammation via the inhibition of NF-κB and p38 MAPK signaling, being depe...

Spent hens are egg‐laying chicken reaching the end of their egg‐laying cycle and are seen as a by‐product to the egg industry. A spent hen muscle protein hydrolysate prepared by food‐grade thermoase PC10F (SPH‐T) has previously shown antihypertensive potential. In the present work, we further investigated its antihypertensive effect and underlying...

Diabetes mellitus, a group of metabolic disorders characterized by persistent hyperglycemia, affects millions of people worldwide and is on the rise. Dietary proteins, from a wide range of food sources, are rich in bioactive peptides with antidiabetic properties. Notable examples include AGFAGDDAPR, a black tea-derived peptide, VRIRLLQRFNKRS, a β-c...

Dasatinib, a small-molecule drug used as a treatment for chronic myeloid leukemia induces mitochondrial damage in embryonic kidney (293T) cells (p<0.05). This dasatinib induced mitochondrial injury in kidney cells was mitigated by H3K36me3 activating ovotransferrin-derived peptides GWN and GW. Pre-treatment of kidney cells with GWN and GW lead to e...

MOTS‐c (mitochondrial ORF of the twelve S-c) is a 16-amino-acid mitochondrial peptide that has been shown to counter insulin resistance and alleviate obesity in vivo. However, the mechanisms involved in the pharmacological action of MOTS-c remain elusive. Based on the ability of MOTS-c to improve insulin resistance and promote cold adaptation, we h...

Polysaccharides can form interfacial complexes with proteins to form emulsions with enhanced stability. We assessed the effect of adding gum guar or gum arabic to egg yolk/fish oil emulsions. The emulsions were produced using simple or high-pressure homogenization, stored for up to 10 days at 45 °C, and characterized for their particle size and dis...

Processing red tilapia (Oreochromis sp.) yields a large quantity of scale, a byproduct of the aquaculture industry. This study focuses on evaluating the potential of scale as a source of antioxidant peptides. Scale was ground and enzymatically hydrolyzed by Alcalase® 2.4 L. The hydrolysate obtained was fractionated to purify and identify the antiox...

Egg yolk can be fractionated into two fractions, plasma and granule, at high centrifugation force. This work was designed to study the influence of using low centrifugal forces (2000 to 6000 ×g) for a short time (5 min) on the fractionation efficiency. The chemical composition and emulsifying properties (oil droplet size and stability against cream...

Phosvitin (PV) is an egg protein. Our recent study showed both phosvitin and phosvitin hydrolysate (PVH) could promote osteoblast differentiation in osteoblast cells. The objective of the study was to investigate the effects of PV and PVH on osteoclastogenesis and possible signalling pathways in RAW264.7 cells. Both PV and PVH inhibited osteoclasto...

VPP (Val-Pro-Pro) and IPP (Ile-Pro-Pro) are two famous antihypertensive peptides with possible benefits for type 2 diabetes mellitus (T2DM). The study was aimed to investigate the effect of peptide analogues of VPP and IPP on glucose uptake activity in L6 myotubes. The analogues were designed by replacing the N-terminal, middle, or C-terminal amino...

The traditional low-alcoholic beverages, such as grape wine, sake, and rice wine, have been consumed all over the world for thousands of years, each with their unique methods of production that have been practiced for centuries. Moderate consumption of wine is generally touted as beneficial for health, although there is ongoing debate for the respo...

Low molecular weight (LMW) collagen peptides show skin and bone health benefits for human. However, the production of LMW collagen peptides from land vertebrate sources remains challenging due to the presence of advanced glycation end products (AGEs) cross-links. In this study, the effect of α-amylase pre-treatment on proteolytic production of LMW...

Spent hens are egg-laying hens reaching the end of their egg-laying cycles, being a major byproduct of the egg industry. Recent studies have been focusing on finding new value-added uses for spent hens. We have previously identified four bioactive peptides from spent hen muscle proteins, including three angiotensin-converting enzyme (ACE) inhibitor...

Background Bioactive peptides derived from food proteins have great potential for uses as functional food ingredients or nutraceuticals. Bioactive peptides are prepared mainly by enzymatic hydrolysis. High specificity, mild conditions, a lack of residual organic solvents and toxic chemicals in the final peptide preparations have positioned enzymati...

Nicotinamide adenine dinucleotide (NAD+) plays a vital role in cellular processes that govern human health and disease. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in NAD+ biosynthesis. Thus, boosting NAD+ level via an increase in NAMPT levels is an attractive approach for countering the effects of aging and metabolic d...

Bone is a dynamic organ under constant metabolism (or remodeling), where a delicate balance between bone resorption and bone formation is maintained. Disruption of this coordinated bone remodeling results in bone diseases, such as osteoporosis, the most common bone disorder characterized by decreased bone mineral density and microarchitectural dete...

With the enhanced consumers’ awareness about food and health, the development of functional foods for specific health effects is on the rise. Bioactive peptides are one category of functional foods holding the promise of prevention or treatment of many chronic diseases including type 2 diabetes. Antidiabetic peptides have been identified from a var...

Manipulation of the genome is an objective sought by many, with applications from the laboratory to the bedside. The discovery of CRISPR–Cas systems as genome editors has spurred a scientific revolution, heralding the dawn of a new era in biological and medical research. Combined with the rapid expansion of tailored genomic information, CRISPR–Cas...

Cells are the building blocks of life. Cell culture technique can recapitulate many fundamental physiological systems in the laboratory, and the effects of bioactive peptides can be successfully tested in cultured cells, prior to animal study. In this chapter, we first provide the practical knowledge on safety management in a cell culture facility,...

IRW (Ile-Arg-Trp) was identified as an inhibitor of angiotensin converting enzyme (ACE) from egg white protein ovotransferrin through an integrated in silico digestion and quantitative structure and activity relationship prediction in 2011. Oral administration of IRW to spontaneously hypertensive rats (SHRs) can significantly reduce blood pressure,...

Egg white is a rich source of bioactive proteins that are essential to provide protection to the embryo in yolk. There is an ongoing interest in identifying novel egg white proteins; it is not known however if peptides are also present in egg white. The objectives of the study were to identify low molecular peptides occurring naturally in egg white...

The study explored the use of spent hen, a major egg industry byproduct, as the starting material for preparing antihypertensive peptides. While previous studies were focused mainly on ACE inhibitory (ACEi) peptides, this work also studied peptides with ACE2 upregulating (ACE2u) activity, an emerging target for treating hypertension. Spent hen musc...

Spent hens are a major byproduct of the egg industry but are rich in muscle proteins that can be enzymatically transformed into bioactive peptides. The present study aimed to develop a spent hen muscle protein hydrolysate (SPH) with antihypertensive activity. Spent hen muscle proteins were hydrolyzed by nine enzymes, either individually or in combi...

COVID-19 (Coronavirus disease 2019) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. This virus has emerged as a threat to global health, social stability, and the global economy. This pandemic continues to cause rampant mortality worldwide with the dire urgency to develop nove...

Phosphorylated proteins from food sources have been investigated as regulators of bone formation with potential benefits in treating osteoporosis. Egg, a cheap and nutritious food, is also the source of various proteins and bioactive peptides with applications in human health. Egg yolk is rich in phosvitin, the most phosphorylated protein in nature...

Ovotransferrin, a major protein in egg white induces osteoblast proliferation and survival in vitro. However, it is unclear which receptor(s) drive beneficial activities of this bioactive glycoprotein. We examined the role of the lipoprotein receptor-related proteins 1 (LRP1) in the actions of ovotransferrin on osteoblasts. Here we showed that LRP1...

The carapace from the Chinese soft-shelled turtle (Pelodiscus sinensis) is used as a traditional Chinese medicine. Acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) from turtle carapace were isolated and characterized to screen novel collagen material in this study. Yields of 1.0% and 2.8% were obtained for ASC and PSC which contained g...

Enzymatic treatment of egg yolk with phospholipases can enhance its emulsifying properties and thermal stability. Additionally, a two-step process (primary and secondary homogenization) could form emulsions with better stability. Thus, in this study we used a split-split-plot in time design to assessed the effect of enzymatic treatment, processing,...

A low-phenylalanine (Phe) diet is indispensable for phenylketonuria patients. The objectives of this study were to develop a two-step enzymatic method to effectively release Phe from whey protein, and then to prepare a low-Phe hydrolysate (LPH) by using adsorbent. Thermolysin (T) or Pancreatin (P) combined with Protease A2SD (A2) showed the degree...

Food protein-derived bioactive peptides, particularly antihypertensive peptides, are important constituents of functional foods or nutraceuticals. Most antihypertensive are identified as the inhibitors of angiotensin converting enzyme (ACE), a key enzyme responsible for the generation of angiotensin II (Ang II), which is a vasoconstricting peptide....

Excessive bone resorption, due to increased osteoclastic activity, is a key underlying cause of osteolytic disorders. Lipopolysaccharide (LPS) is a potent factor to stimulate osteoclastic activity by inducing inflammatory stress. Egg-derived tripeptide IRW (Ile-Arg-Trp) was previously shown to exert anti-inflammatory activity. The overall objective...

Food protein-derived bioactive peptides have been recognized as a promising candidate for the development of functional foods or nutraceuticals. Peptides exhibiting antioxidant, anti-proliferative and anti-hypertensive activities have been characterized from corn proteins while the knowledge on the presence of immunomodulatory peptides in corn prot...

In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also plays a key role in the onset and development of insulin resistance, which is central to metabolic syndrome (MetS). Due to the interplay between RAS and insulin resistance, antihypertensive compounds may exert beneficial effects in the management of MetS. Food-...

Vascular oxidative stress, inflammatory response, and proliferation are crucial mediators of vascular dysfunction that contribute to the pathology of hypertension. A tripeptide, LRW (Leu-Arg-Trp), was characterized from pea protein legumin, and its previously studied isomer IRW (Ile-Arg-Trp) was reported to exhibit antihypertensive activity via act...

With improvements in healthcare and lifestyle, the proportion of the aging population is rising steadily across the world. Many physiological functions are altered during aging and resemble those occurring in disease conditions involving metabolic and mitochondrial disturbances. Thus, there is an urge to better develop dietary or medicinal interven...

The polymorphism of buffalo αs1-casein has been reported, but little is known about their effect on the biological properties. The objective of this study was to investigate the effect of αs1-casein polymorphism on the digestive properties and bioactivities of buffalo milk protein in simulated gastrointestinal digestion. In this study, two variants...

Collagen hydrolysate (CH) and peptides may have anti-aging properties on skin. In this study, CH prepared from the skin of porcine, bovine, tilapia, and hen were supplemented to human dermal fibroblasts (HDF) with UVA-exposure. Bovine CH inhibited matrix metalloproteinases (MMP)-1 synthesis. Tilapia CH promoted cell viability and pro-collagen I pro...

Background Bioactive peptides derived from food proteins are continuing gain the momentum as an important constituent of functional food ingredients and nutraceuticals. Although there is a burgeoning body of literature about preparation, characterization and activity study of food-derived bioactive peptides and several bioactive peptides have been...

Egg yolk is well known for its excellent emulsifying property. In this article, egg yolk was used as the encapsulating matrix to prevent the oxidation of n‐3 long‐chain polyunsaturated fatty acids from fish oil. A 2 × 2 × 5 complete block design with three replications was used. Two levels of fish oil (1% and 5%) and two levels of esterification ty...

Vascular inflammation and oxidative stress are the major causes of endothelial dysfunction leading to cardiovascular disease. Previously, we have reported the anti-inflammatory activity of zein hydrolysate and its-derived peptides. However, the underlying mechanisms have not been understood. In this study, we report that zein hydrolysate and its de...

Ovotransferrin, a member of the transferrin family, is the second main protein found in egg white. Ovotransferrin was reported to have antimicrobial, antioxidant, and immunomodulating activities. The aim of this work was to characterize the cellular and molecular functions of egg white ovotransferrin on osteoclasts differentiation and function. Ost...

Angiotensin converting enzyme 2 (ACE2) degrades vasoconstricting angiotensin II (Ang II) into angiotensin (1–7), exerting protective effects in cardiovascular system; thus, ACE2 is considered as a novel target for cardiovascular therapy. The objectives of this study were to identify ACE2 up-regulating peptides from pea protein hydrolysate based on...

PurposeExcessive formation of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, has been implicated in the development of insulin resistance in obesity and type-2 diabetes. In skeletal muscle, chronic exposure to TNF-α impairs insulin-stimulated glucose uptake and insulin signaling. The aim of this study is to investigate the effects of...

Collagen hydrolysates (peptides) derived from food processing byproducts have been used to produce commercially valuable food ingredients due to their potential to trigger certain desirable physiological responses in the body. Low-molecular-weight (LMW) collagen hydrolysates are generally thought to exert better bioactivities than their larger coun...

Ile‐Pro‐Pro and Val‐Pro‐Pro are two most well‐known food‐derived bioactive peptides, initially identified as inhibitors of angiotensin I‐converting enzyme (ACE) from a sample of sour milk. These two peptides were identified in fermented and enzymatic hydrolyzed cow and non‐cow (that is, goat, sheep, buffalo, yak, camel, mare, and donkey) milk, as w...

Egg proteins are recognized as excellent sources of bioactive peptides, such as angiotensin-converting enzyme inhibitory (ACEi) peptides. Oral administration of a thermolysin-digested egg white hydrolysate (T-EWH) caused a significant blood pressure reduction in spontaneously hypertensive rats; a further ACEi assay implied that its ACEi activity wa...

Often described as ‘nature’s perfect food’, perceptions of egg consumption and human health have evolved substantially over the past decades, in particular dietary guidelines no longer include a limit for dietary cholesterol and recommend eggs as part of healthy eating patterns. This book presents the opportunities for processing eggs to produce va...

Often described as ‘nature’s perfect food’, perceptions of egg consumption and human health have evolved substantially over the past decades, in particular dietary guidelines no longer include a limit for dietary cholesterol and recommend eggs as part of healthy eating patterns. This book presents the opportunities for processing eggs to produce va...

Agents that block the renin-angiotensin system (RAS) improve glucoregulation in the Metabolic Syndrome disorder. We evaluated the effects of egg white hydrolysate (EWH), previously shown to modulate the protein abundance of RAS component in vivo , on glucose homeostasis in diet-induced insulin resistant rats. Sprague Dawley rats were fed a high fat...

Background: Osteoblasts maintain the structural integrity of bone via differentiation and mineralization; therefore, their malfunction or reduced activity can cause serious bone disorders. Although studies have demonstrated the association between nutrients and bone, research on food-derived bioactive peptides and bone health are scanty. Methods:...