Jianmin Zhou

• Wenzhou Medical College

Background: ALI/ARDS is characterized by severe hypoxemic respiratory failure attributed to inflammatory tissue injury. There are no treatment modalities able to prevent/reverse the dire pathological sequelae in these patients. Evidence links the inflammatory lung injury to uncontrolled activation of the immune signaling complex, TLR4-MD2 (Toll-li...

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), pose a major clinical challenge. The major driving force in this syndrome is pulmonary inflammation. Recent studies have shown that the naturally occurring flavonoid kaempferol (KPF) reduces endotoxin-induced inflammatory responses in mice. However, the mechani...

Acute lung injury (ALI) is primarily driven by inflammation that severely impacts lung function. Novel 2-sulfonylindoles were recently shown to exhibit anti-inflammatory activity through the inhibition of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production. Here, we synthesized 31 compounds which contained 2-sulfonylindole structure...

The activation and overexpression of fibroblast growth factor receptors (FGFRs) are highly correlated with a variety of cancers. Most small molecule inhibitors of FGFRs selectively target FGFR1-3, but not FGFR4. Hence, designing highly selective inhibitors towards FGFR4 remains a great challenge because FGFR4 and FGFR1 have a high sequence identity...

It is recognized that myeloid differentiation protein 2 (MD-2), a coreceptor of toll-like receptor 4 (TLR4) for innate immunity, plays an essential role in activation of the lipopolysaccharide signaling pathway. MD-2 is known as a neoteric and suitable therapeutical target. Therefore, there is great interest in the development of a potent MD-2 inhi...

Video S2 50 ns of xanthohumol/MD-2 complex molecular dynamics simulation. Notes: Xanthohumol was stable in the hydrophobic cavity of MD-2. MD-2 and xanthohumol were shown as cartoon and sticks, respectively. The sticks of upper left and lower right corner were TYR-102 and ARG-90. Abbreviation: MD-2, myeloid differentiation protein 2.

Video S1 50 ns of apo MD-2 protein molecular dynamics simulation. Note: The cavity of MD-2 closes rapidly in the absence of any ligand. Abbreviation: MD-2, myeloid differentiation protein 2.

Background Colon cancer is the third most commonly diagnosed cancer and the second leading cause of cancer mortality worldwide. Chalcone and its derivatives are reported to exhibit anti-cancer effects in several cancer cell lines, including colon cancer cells. In addition, chalcones have advantages such as poor interaction with DNA and low risk of...

Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. It has been reported that both resveratrol and chalcone derivatives could ameliorate lung injury induced by inflammation. A series of paralleled Aza resveratrol-chalcone compounds (5a-5m, 6a-6i) were designed, synthesized and screened for anti-inflamma...

37 acetylenic chalcones were designed, synthesized by the Pd/Cu catalyzed Sonogashira coupling reaction, and evaluated for anti-inflammatory activities. A majority of these compounds showed remarkable inhibitions of the expression of inflammatory cytokines in LPS-stimulated macrophages. Six of them demonstrated the dose-dependent inhibition of infl...

Acute lung injury (ALI) is a leading cause of morbidity and mortality in critically-ill patients. Previously, we reported that a symmetric mono-carbonyl analog of curcumin, (C66), exhibits enhanced stability and was found to have efficacy and be involved in potential cytokines inhibition. In the present study, a series of novel asymmetric C66 analo...

Extensive researches within the last decade have supported the anti-inflammatory properties of curcumin. However, the development and clinical application of curcumin have been limited significantly by its instability and poor metabolic property resulting from the β-diketone moiety decomposition and phenolic glucuronides. In this paper, a curcumin...

Using MCM-41 as the supporter, a series of MCM-41 supported amino-palladium complexes has been prepared and characterized by XRD (X-ray diffraction) and XPS (X-ray photoelectron spectroscopy), etc. The XRD and XPS results indicate that the Pd coordinates with the -NH2 groups on the MCM-41 surface, and the structure of MCM-41 has been not damaged. I...

Three Y zeolites supported CeO2 catalysts (CeO2/USY, CeO2/HY, CeO2/SSY) were prepared and used for deep oxidation of 1,2-dichloroethane (DCE) in low concentration (about 1,000 ppm). The catalysts were characterized by XRD, N2 adsorption/desorption and H2-TPR. The results showed that the catalytic activity of the supported CeO2 catalysts was much hi...

A new MCM-41 supported aminopropylsiloxane palladium(0) complex was prepared and characterized. The catalyst is highly active and stereoselective for Heck reaction at 70 °C.