Jianlin Shi

Jianlin Shi
Chinese Academy of Sciences | CAS

Ph.D

About

722
Publications
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53,624
Citations

Publications

Publications (722)
Article
Emerging cancer cell ferroptosis features the direct depletion of glutathione (GSH) and resultant chemical inhibition on glutathione peroxidase 4 (GPX4) bioactivity, which, unfortunately, is counteracted considerably by nicotinamide adenine dinucleotide phosphate (NADPH)-enabled regeneration of antioxidant GSH. Herein, a Pt-MIL-101 (Fe)-based nanoc...
Article
Immunogenic cell death (ICD) based on endoplasmic reticulum (ER) stress has been widely studied as the fundamentals of cancer immunotherapy. However, the currently available ICD inducers are still very rare and mostly highly toxic chemotherapeutic drugs. Herein, a novel ICD modality based on mitochondrial heat stress by magnetic hyperthermia treatm...
Article
Full-text available
Tumor associated bacteria (TAB) plays a critically important role in regulating the microenvironment of tumor, which consequently greatly deteriorates the therapeutic effects by chemo- and, radiotherapy deactivation, and more considerably, leads to substantial immunosuppression. On the contrary, herein we propose a nanocatalytic tumor-immunotherape...
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Strategies to manipulate immune cell co-inhibitory or co-activating signals have revolutionized immunotherapy. However, certain immunologically cold diseases, such as bacterial biofilm infections of medical implants are hard to target due to the complexity of the immune co-stimulatory pathways involved. Here we show that two-dimensional manganese c...
Preprint
Full-text available
Using hydrazine oxidation reaction (HzOR) substituting for oxygen evolution reaction can realize hydrogen production at largely reduced energy consumption. While the HzOR mechanism and the electrochemical utilization rate of hydrazine are still ambiguous. Herein, a bimetallic phosphide heterostructure nanoarrays (Ni-Co-P/NF) fabricated by an interf...
Article
The bacterial pneumonia has been demonstrated to cause acute and severe pathological lung injury as well as the uncontrollable oxidative cytokine storms. The effective therapeutics against bacterial pneumonia demands highly efficient pathogen elimination, oxidative stress alleviation and anti-inflammation. Nevertheless, current therapeutics fail to...
Article
As an emerging therapeutic gas, hydrogen (H2) is gifted with excellent biosafety, high tissue permeability, and radical-trapping capacity and is extensively considered as a highly promising antioxidant in clinics. However, a facile and effective strategy of H2 production for major inflammatory disease treatments is still lacking. In this study, by...
Article
Developing efficient electrocatalysts is of significance for hydrogen production in acid electrolyte. In this work, we report a facile decoration of ruthenium species onto tungsten oxides to construct the Mott-Schottky heterojunction electrocatalyst for hydrogen evolution. The resultant Ru-WO2.72 hybrid exhibits a superior Ru-based mass activity of...
Article
Earth-abundant MoS2 has attracted great attentions as a promising hydrogen evolution reaction (HER) electrocatalyst, but it is limited by sluggish water dissociation and strong adsorption of the oxygen-containing intermediates in alkaline media. Herein, an interfacial engineering strategy to fabricate Co-doped 1T-MoS2 coupling with V2C MXene was re...
Article
The performance of oxygen reduction reaction (ORR) on Fe-N-C single-atom catalysts (SACs) is still less satisfactory due to the rather low atom-utilization of active sites. Here, a novel acetate thermolysis-assisted route is proposed to create hierarchical carbon nanocages of Fe-N-C SACs (FeSA-N/Cs-OAc) by selective cleavage of carbon layers, which...
Article
Developing efficient and highly sensitive diagnostic techniques for the early detections of pathogenic viruses such as SARS‐CoV‐2 are vitally important for preventing its widespread. However, the conventional polymerase chain reaction (PCR)‐based detection features high complexity, excessive time‐consumption and labor‐intensiveness, while viral pro...
Article
Programmed cell death (PCD) plays an important role in triggering the cell death fate against tumor in biomedical frontier. However, malignant tumor cells are often resistant to the commonly used apoptosis-inducing anticancer drugs due to the multi-drug resistance of cancer. Considering the mitochondria as the origin of the aerobic respiration and...
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Tumor targeting and effective immunomodulation are of critical significance during tumor treatment by sonodynamic therapy (SDT). Herein, the probiotic engineering of the clinically approved sonosensitizer (hematoporphyrin monomethyl ether (HMME)) is reported onto the probiotic bacterium Bifidobacteria Longum (BiL) for sonosensitive bifidobacterium...
Article
Osteoporosis is a kind of global chronic bone disease characterized by progressive loss of bone mass and bone quality reduction, leading to a largely increased risk of bone fragility. In clinics, the current treatment of osteoporosis relies on the inhibition of bone damage by osteoclasts but ignores the function of immune cells in the progress of o...
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The spontaneous reaction between Zn and H2O is of critical importance and could plausibly be used to produce H2 gas, especially under neutral conditions. However, this reaction has long been overlooked owing to its sluggish kinetics and Zn consumption. Herein, we report a unique self‐co‐electrolysis system (SCES), using a Zn anode, a CoP‐based cata...
Article
Glucose and glutamine are two principal nutrients in mammalian cells that provide energy and biomass for cell growth and proliferation. Especially in cancer cells, glutamine could be a main alternative for energy and biomass supply once glucose metabolism is suppressed. Therefore, single inhibition of enzymes in either glucose metabolism or glutami...
Article
A novel Zn‐Fe flow battery featuring Fe3+ reduction reaction (Fe3+RR)‐coupled zinc oxidation, and a Fe2+ oxidation reaction (Fe2+OR)‐coupled hydrogen evolution reaction (HER) system as well, were established for the first time, and such a battery is capable of driving two Fe2+OR‐coupled HER systems in series based on the above Fe2+/Fe3+ cycling, fo...
Article
A novel Zn‐Fe flow battery featuring Fe3+ reduction reaction (Fe3+RR)‐coupled zinc oxidation, and a Fe2+ oxidation reaction (Fe2+OR)‐coupled hydrogen evolution reaction (HER) system as well, were established for the first time, and such a battery is capable of driving two Fe2+OR‐coupled HER systems in series based on the above Fe2+/Fe3+ cycling, fo...
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Full-text available
Constructing nanomaterials mimicking the coordination environments of natural enzymes may achieve biomimetic catalysis. Here we construct a two-dimensional (2D) metal-organic framework (MOF) nanosheet catalyst as an artificial antioxidase for nanocatalytic rheumatoid arthritis treatment. The 2D MOF periodically assembles numbers of manganese porphy...
Article
The intrinsic sluggish conversion kinetics and severe shuttle effect in lithium—sulfur (Li-S) batteries are responsible for their poor reversible capacity and cycling longevity, which have greatly hindered their practical applications. To address these drawbacks, herein, we design and construct a heterostructured Ni/Ni2P embedded in a mesoporous ca...
Article
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Mild hyperthermia is greatly beneficial to the healing of bone defects; however, how to generat hyperthermia directly at the bone defect site remains an unsolved problem due to the poor thermal conversion capability of currently commercially available materials and the thickness of soft tissues. Herein, we applied mild magnetic hyperthermia therapy...
Article
Owing to the special structural characteristics and maximized efficiency, atomically dispersed catalysts (ADCs) with different atom sizes ranged from the single atom to clusters can bridge the gap between heterogeneous and homogeneous catalysis. Tremendous progress has been made in ADCs including developing advanced synthesis strategies, promoting...
Article
Full-text available
Nanocatalysts with enzyme-like catalytic activities, such as oxidase mimics, are extensively used in biomedicine and environmental treatment. Searching for enzyme-like nanomaterials, clarifying the origins of the catalytic activity and developing activity assessment methodologies are therefore of great significance. Here, we report that oxidase cat...
Article
Fenton reactions have been recently applied in tumor catalytic therapy, whose efficacy suffers from the unsatisfactory reaction kinetics of Fe3+ to Fe2+ conversion. Here we introduce a co‐catalytic concept in tumor catalytic therapy by using a two‐dimensional molybdenum disulfide (MoS2) nanosheet atomically dispersed with Fe species. The single‐ato...
Article
Fenton reactions have been recently applied in tumor catalytic therapy, whose efficacy suffers from the unsatisfactory reaction kinetics of Fe3+ to Fe2+ conversion. Here we introduce a co‐catalytic concept in tumor catalytic therapy by using a two‐dimensional molybdenum disulfide (MoS2) nanosheet atomically dispersed with Fe species. The single‐ato...
Article
The electrosynthesis of ammonia by nitrogen reduction reaction is one of the most attractive research fields; however, it suffers from both extremely low NH3 yield, poor faradic efficiency and the sluggish kinetics of anodic oxygen evolution reaction. Herein, a novel nitrogen-methanol co-electrolysis system has been established to reduce the overal...
Article
Fe‐N‐C electrocatalysts have been demonstrated to be the most promising substitutes for benchmark Pt/C for oxygen reduction reaction (ORR). Herein, we report that, a N‐doped carbon materials with trace amount of iron (0‐0.08 wt.%) show excellent ORR activity and durability comparable and even superior to those of Pt/C in both alkaline and acidic me...
Article
Fe‐N‐C electrocatalysts have been demonstrated to be the most promising substitutes for benchmark Pt/C for oxygen reduction reaction (ORR). Herein, we report that, a N‐doped carbon materials with trace amount of iron (0‐0.08 wt.%) show excellent ORR activity and durability comparable and even superior to those of Pt/C in both alkaline and acidic me...
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Full-text available
Pursuing and developing effective methodologies to construct highly active catalytic sites to maximize the atomic and energy efficiency by material engineering are attractive. Relative to the tremendous researches of carbon-based single atom systems, the construction of bio-applicable single atom materials is still in its infancy. Herein, we propos...
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Chemotherapy remains one of the most prevailing regimens hitherto in the fight against cancer, but its development has been being suffering from various fatal side effects associated with the non-specific toxicity of common chemical drugs. Advances in biomedical application of nanomedicine have been providing alternative but promising approaches fo...
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Cardiovascular diseases caused by ischemia are attracting considerable attention owing to its high morbidity and mortality worldwide. Although numerous agents with cardioprotective benefits have been identified, their clinical outcomes are hampered by their low bioavailability, poor drug solubility, and systemic adverse effects. Advances in nanosci...
Article
Surfactant-directed block copolymer(BCP) particles have gained intensive attention owing to their attractive morphologies and ordered domains. However, their controllable fabrication suffers several limitations including complex design and synthesis of multiple surfactant systems, limited choices of block copolymers, and time-consuming post-process...
Article
Siloxene features abundant functional groups and oxygen vacancies, which facilitates the ultrafine platinum nanoparticles loading for catalyzing hydrogen evolution reaction (HER). Herein, a siloxene-p-Pt-2h composite has been fabricated with an ultralow platinum loading on siloxene (0.56 wt.%), which shows greatly enhanced HER activity featuring an...
Article
Due to the strong bonding between Ti and O atoms, creating oxygen vacancy in stable TiO2 usually involves harsh synthetic conditions. In this work, inspired by DFT calculation results that much lower energy is required to dissociate Ti-OH bond than Ti-O bond, we report a facile approach by simply calcining TiOx(OH)y precursor in inertia atmosphere,...
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Full-text available
The binary co-assembly systems consisting of amphiphilic block copolymers and surfactants have provided us a versatile platform for materials design and structural regulation. In this review (Article number 2021, e49), Shi, Li, and co-workers comprehensively discussed the main three amphiphilic co-assembly systems and their potential biological app...
Article
The efficient and low-cost electro-catalysts towards hydrogen oxidation reaction (HOR) are vitally important to the commercialization of fuel cells, which, however, have been rarely paid attentions. Herein, NiW nano-alloy electro-catalysts (∼3 nm) grown in-situ on carbon paper (NiW/CP) have been designed and synthesized by a facile and rapid (in 14...
Article
Current major electrocatalytic reactions, such as hydrogen evolution reaction, carbon dioxide reduction reaction, and nitrogen reduction reaction, focus on single-target chemical production, which suffers from strong competitive reactions at the same electrodes and/or high energy barrier reactions at the counterpart electrodes. The co-electrolysis...
Article
Polymeric carbon nitride (PCN) has initiated another wave of studies on its properties and behavior since the discovery of its photocatalytic ability. However, pristine PCN is unable to cope with the growing varieties of applications. Making PCN more adaptive to evolving conditions is one of the greatest challenges. Molecular engineering strategy p...
Article
Silicon, a highly biocompatible and ubiquitous chemical element in living systems, exhibits great potentials in biomedical applications. However, the silicon-based nanomaterials such as silica and porous silicon have been largely limited to only serving as carriers for delivery systems, due to the lack of intrinsic functionalities of silicon. This...
Article
Neuronal microenvironment imbalance is associated with successive and irreversible pathophysiological changes and insufficient functional restoration after peripheral nerve injury. Conventional neural-supporting scaffolds result in unsatisfactory curative effects due to lack of biomimetic nanotechnology designs and biochemical or physicochemical mo...
Article
Ferroptosis, an emerging type of cell death found in the past decades, features specifically lipid peroxidation during the cell death process commonly by iron accumulation. Unfortunately, however, the direct delivery of iron species may trigger undesired detrimental effects such as anaphylactic reactions in normal tissues. Up to date, reports on th...
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Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy (PDT). Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT, but is limited by scant penetration depth and efficiency of external light. Herein, aiming at the dual purposes of reducing bi...
Article
Photodynamic therapy (PDT) has attracted tremendous attention due to its advantages such as high safety and effectiveness compared to traditional radiotherapy and chemotherapy. However, the intratumoral hypoxic microenvironment will inevitably compromise the PDT effect of the highly oxygen‐dependent type II photosensitizers, implicating the urgent...
Article
Recently, the therapeutic efficacy of reactive oxygen species (ROS)-mediatedphotodynamic therapy (PDT) involving laser irradiation or chemodynamic therapy (CDT) hasbeen limited by low laser penetration depth and insufficient O2 supply in PDT, and modest ROS production in CDT. To address these, we develop a facile“ reductant-free reduction ”strategy...
Article
Full-text available
Metal–nitrogen–carbon (M–N–C) material with specifically coordinated configurations is a promising alternative to costly Pt‐based catalysts. In the past few years, great progress is made in the studies of M–N–C materials, including the structure modulation and local coordination environment identification via advanced synthetic strategies and chara...
Article
Armed with both hydroxyl and carboxyl groups, glycolic acid is an especially high-value-added chemical applied in diverse areas. However, its large-scale production suffers heavily from harsh synthetic conditions and poor selectivity. Here, an electrocatalytic approach has been developed for glycolic-acid production by electro-oxidation of ethylene...
Article
Electrocatalytic hydrogen production under acidic conditions is of great importance for industrialization in comparison to that in alkaline media, which, unfortunately, still remains great challenges due to the lack of earth-abundant, cost-effective and highly active anodic electrocatalysts that can be used durably under strongly acidic conditions....
Article
The goddess Venus has been known for her armless beauty. Such a unique artistic effect teaches us that the imperfection in one aspect may result in a great aesthetics in another aspect. The existence of structural defects in nanomaterials (substitutional impurities and vacancies) endows them with diverse and fascinating physicochemical properties,...
Article
Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between cr...
Article
Advanced and tremendous researches in two-dimensional (2D) materials have unlocked valuable capabilities that lead a new materials era. Silicene, as a rising‐star 2D material, that features multifaceted properties such as high specific surface area, excellent optical properties, unique electronic properties and desirable biocompatibility and biodeg...
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Full-text available
Solar-driven photoelectrochemical (PEC) technology has been widely recognized as a green and sustainable approach to produce fossil-fuel-alternative energy sources, whereas currently its feasibility is still a great challenge due to the lack of high-performance photoanodes. Herein, two-dimensional trimetallic CoNiFe-layered double hydroxides (CoNiF...
Article
This work reports a strategy of using a low-cost acidic aqueous solution of alcohols for efficient hydrogen/chemical co-production. The as-prepared non-precious metal MnO2/carbon paper electrocatalyst in coordination with alcohol oxidation demonstrates a significantly decreased total energy input for hydrogen production and ultra-high durability in...
Article
Photosynthesis of organic compounds in coupling with promoted hydrogen evolution under mild conditions of light irradiation is considered as one of the most efficient and promising approach to obtain high purity hydrogen and value-added chemicals concurrently by utilizing green solar energy. Here, we report the synthesis of NiS nanoparticle-modifie...
Preprint
Full-text available
The development of bacterial vaccines for inducing immunoresponse against infectious diseases such as osteomyelitis is of great significance and importance. However, the responsiveness of bacterial immunotherapy remains far from being satisfactory largely due to the erratic antigen epitopes of bacteria. Herein, we report an in situ vaccination stra...
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Full-text available
The iron gall ink-triggered chemical corrosion of hand-written documents is a big threat to Western cultural heritages, which was demonstrated to result from the iron gall (GA-Fe) chelate-promoted reactive oxygen species generation. Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. In this work,...
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Full-text available
The therapeutic outcomes of noninvasive sonodynamic therapy (SDT) are always compromised by tumor hypoxia, as well as inherent protective mechanisms of tumor. Herein, we report a simple cascade enzymatic approach of the concurrent glucose depletion and intratumoral oxygenation for starvation-sensitized and oxygenation-amplified sonodynamic therapy...
Preprint
Nanocatalysts with enzyme-like catalytic activities, such as oxidase-mimics, are extensively used in biomedicine and environmental treatment. Searching enzyme-like nanomaterials, clarifying the origins of catalytic activity and developing activity assessment methodologies are therefore of great significance. Here we report that the oxidase- and oxy...