Jiang Qiu

• Southwest University

Alexithymia is a subclinical condition that affects individuals’ processing of emotions. Emerging evidence suggests that alexithymia results from a multidomain and multidimensional interoceptive failure. Although extensive research has examined the relationship between alexithymia and interoception, less is known about how alexithymia modulates the...

Early adversity experiences have been linked to poor mental health outcomes in both adolescence and adulthood. This study investigates the interplay of the family social environment (FSE) with emotional regulation, mental health, and stress-sensitive brain structures, as well as the development of these brain structures during young adulthood. A to...

Background The emotion regulation network (ERN) in the brain provides a framework for understanding the neuropathology of affective disorders. Although previous neuroimaging studies have investigated the neurobiological correlates of the ERN in major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC)...

Creativity is hypothesized to arise from a mental state which balances spontaneous thought and cognitive control, corresponding to functional connectivity between the brain’s Default Mode (DMN) and Executive Control (ECN) Networks. Here, we conduct a large-scale, multi-center examination of this hypothesis. Employing a meta-analytic network neurosc...

Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified into joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic ac...

While the hyper- and hypo- reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, the lack of an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from the Allen Human Bra...

Objective Everyday creativity is fundamental to human existence and improved well‐being. Beyond recent attention regarding how contextual, lifestyle, personality, and neurobiological differences might foster everyday creativity, empathy may also constitute an intriguing connection. However, this potential relationship has not yet been systematicall...

Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to char...

Background In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unifie...

Background: Previous studies have demonstrated that mind wandering during incubation phases enhances post-incubation creative performance. Recent empirical evidence, however, has highlighted a specific form of mind wandering closely related to creativity, termed freely moving mind wandering (FMMW). In this study, we examined the behavioral and neur...

Mounting evidence suggests hierarchical psychopathology factors underlying psychiatric comorbidity. However, the exact neurobiological characterizations of these multilevel factors remain elusive. In this study, leveraging the brain-behavior predictive framework with a 10-year longitudinal imaging-genetic cohort (IMAGEN, ages 14, 19 and 23, N = 1,7...

Creativity is typically operationalized as divergent thinking (DT) ability, a form of higher-order cognition which relies on memory, attention, and other component processes. Despite recent advances, creativity neuroscience lacks a unified framework to model its complexity across neural, genetic, and cognitive scales. Using task-based fMRI from two...

Semantic memory offers a rich repository of raw materials (e.g., various concepts and connections between concepts) for creative thinking, represented as a semantic network. Similar to other networks, the semantic network exhibits a modular structure characterized by modules with dense internal connections and sparse connections between them. This...

Creative thinking is a unique higher-order human capacity that leads to novel and appropriate products or ideas. Researchers have increasingly turned to transcranial direct current stimulation (tDCS), employing weak electrical stimulation to augment individual creative performance. Despite these efforts, the field grapples with inconsistent finding...

Since there are many sources of unconscious information in our minds, there is a possibility that multiple channels of unconscious information can affect a response at the same time. However, this question has been largely ignored by researchers. In the present study, we presented two opposite pointing arrows as the masked primes followed by a targ...

Previous studies in small samples have identified inconsistent cortical abnormalities in major depressive disorder (MDD). Despite genetic influences on MDD and the brain, it is unclear how genetic risk for MDD is translated into spatially patterned cortical vulnerability. Here, we initially examined voxel-wise differences in cortical function and s...

Structural neuroimaging data have been used to compute an estimate of the biological age of the brain (brain‐age) which has been associated with other biologically and behaviorally meaningful measures of brain development and aging. The ongoing research interest in brain‐age has highlighted the need for robust and publicly available brain‐age model...

Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood. In the present study, we aim to distinguish behavioral and neural bases of novelty and appropriateness of creative idea generation. In alignment with...

The COVID-19 pandemic has presented an unprecedented challenge for individual mental health. In this study, we examined the lasting impact of the pandemic on mental health among Chinese college students and tested whether different coping dimensions contributed to resilience. Using a 2-year longitudinal design with four waves, we identified four co...

Thought control ability (TCA) plays an important role in individuals' health and happiness. Previous studies demonstrated that TCA was closely conceptually associated with happiness. However, empirical research supporting this relationship was limited. In addition, the neural basis underlying TCA and how this neural basis influences the relationshi...

At present there is little knowledge on whether and how multiple pieces of unconscious information can simultaneously affect a single conscious response. In the present study, we manipulated the congruency relation between a masked prime arrow and the target arrow, as well as that between masked flankers and the target arrow. The results demonstrat...

Previous studies pay more attention to the cognitive control in classical cognitive conflict task but the time-course of the expectation violation in a social comparison context remains unknown. Event-related potentials (ERPs) were recorded to explore the electrophysiological correlates of expectation violation by using a reward feedback paradigm i...

cingulate cortex (vACC) and the bilateral parahippocampal gyrus during the congruent versus incongruent condition, as compared to the control group. Depressive symptoms were positively correlated with left vACC activation during the congruent condition. Moreover, psychophysiologi-cal interaction results showed that the survivor group had stronger f...

Internet addiction symptomatology (IAS) is characterized by persistent and involuntary patterns of compulsive Internet use, leading to significant impairments in both physical and mental well-being. Here, a connectome-based predictive modeling approach was applied to decode IAS from whole-brain resting-state functional connectivity in healthy popul...

Previous studies have explored the neural bases of forgiveness, however, the neural associations of decisional and emotional forgiveness remain unclear. Regional homogeneity (ReHo) and functional connectivity (FC) measured by resting-state functional magnetic resonance imaging (fMRI) were used to investigate the neural associations of individual di...

From childhood to adulthood, the human brain develops highly specialized yet interacting neural modules that give rise to nuanced attention and other cognitive functions. Each module can specialize over development to support specific functions, yet also coexist in multiple neurobiological modes to support distinct processes. Advances in cognitive...

Objective Overweight and obesity, as commonly indicated by a higher BMI, are associated with functional alterations in the brain, which may potentially result in cognitive decline and emotional illness. However, the manner in which these detrimental impacts manifest in the brain's dynamic characteristics remains largely unknown. Methods Based on t...

Transdiagnostic factors are considered promising in elucidating the etiological underpinnings of psychiatric comorbidities, especially in anxiety and depression. However, their symptom-centered neurobiological substrates, encompassing the genetic macro-micro-molecular brain functional landscape, remain elusive. Here, we develop edge-centric functio...

Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Our objective was to identify the neuroanatomical dimensions that characterize MDD and predict treatment response to selective serotonin reuptake inhibitor (SSRI) antidepressants or placebo. In the COORDINATE-MDD consortium, raw M...

Background Emerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus might play a crucial role in the interplay between sleep disturbance and depressive symptomatology, e.g., hippocampal atrophy is typically seen in both insomnia disorder and depression. Thus, examining the role of hippo...

Major depressive disorder (MDD) is a globally prevalent and highly disabling disease characterized by dysfunction of large-scale brain networks. Previous studies have found that static functional connectivity is not sufficient to reflect the complicated and time-varying properties of the brain. The underlying dynamic interactions between brain func...

Emotions rely on bodily states, and perceiving the emotions of others depends on awareness of one’s own emotional state. However, the intercorrelations among interoception, alexithymia, and empathy are not well understood, and the neural mechanisms behind this connection are also largely unknown. To address these issues, 297 college students partic...

Background and Hypothesis Schizotypy has been conceptualized as a continuum of symptoms with marked genetic, neurobiological, and sensory-cognitive overlaps to schizophrenia. Hierarchical organization represents a general organizing principle for both the cortical connectome supporting sensation-to-cognition continuum and gene expression variabilit...

Curiosity, an innate and intrinsic motivation to explore, makes vital contributions to learning in individuals of various ages. Epistemic curiosity centers on the drive to close information gaps and can be classified a joyous exploration and interest (I) and deprivation sensitivity (D) types. Each subtype is associated with different academic achie...

Major depressive disorder (MDD) is recognized as a severe mental illness with imbalanced interactions among brain networks. However, the detailed mechanisms of large-scale network dysfunction and their clinical implications are not fully understood. To explore the neurological basis of altered connectivity within the brain, the current study aims t...

Background Despite previous studies highlighting the benefits of social media use during the COVID-19 pandemic, particularly under lockdown, limited research has identified the potential detrimental consequences of social media use during lockdown. Therefore, the purpose of this study is to examine the effects of social media on mental health in pa...

Novelty and appropriateness are two fundamental components of creativity. However, the way in which novelty and appropriateness are separated at behavioral and neural levels remains poorly understood. In the present study we aimed to distinguish behavioral and neural bases of novelty and appropriateness of creative idea generation. In alignment wit...

Suicidal behavior is a major concern for patients who suffer from major depressive disorder (MDD). However, dynamic alterations and dysfunction of resting-state networks (RSNs) in MDD patients with suicidality have remained unclear. Thus, we investigated whether subjects with different severity of suicidal ideation and suicidal behavior may have di...

Sleep health is both conceptually and operationally a composite concept containing multiple domains of sleep. In line with this, high dependence and interaction across different domains of sleep health encourage a transition in sleep health research from categorical to dimensional approaches that integrate neuroscience and sleep health. Here, we se...

Background Rumination impedes problem solving and is one of the most important factors in the onset and maintenance of multiple psychiatric disorders. The current study aims to investigate the impact of social rejection on rumination and explore the underlying neural mechanisms involved in this process. Methods We utilized psychological questionna...

Complex cognitive processes, like creative thinking, rely on interactions among multiple neurocognitive processes to generate effective and innovative behaviors on demand, for which the brain’s connector hubs play a crucial role. However, the unique contribution of specific hub sets to creative thinking is unknown. Employing three functional magnet...

The investigation of similarities and differences in the mechanisms of verbal and visuospatial creative thinking has long been a controversial topic. Prior studies found that visuospatial creativity was primarily supported by the right hemisphere, whereas verbal creativity relied on the interaction between both hemispheres. However, creative thinki...

The functional connectome of the human brain represents the fundamental network architecture of neural activity, but its normative growth trajectory over the life course remains unknown. Here, we aggregate the largest, quality-controlled multimodal neuroimaging dataset across 119 global sites, including 33,809 task-free fMRI and structural MRI scan...

Adolescence is the peak period for the onset of generalized anxiety disorder (GAD). Brain networks of cognitive and affective control in adolescents are not well developed when their exposure to external stimuli suddenly increases. Reasonable parental monitoring is especially important during this period. To examine the role of parental monitoring...

During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focus...

Emerging evidence increasingly suggests that poor sleep quality is associated with depressive symptoms. The hippocampus plays a crucial role in the interplay between sleep disturbance and depressive symptomatology e.g., accelerated hippocampal atrophy is typically seen in both insomnia disorder and depression. Hence, it is critical to examine the p...

Background: Major depressive disorder (MDD) is complicated by population heterogeneity, motivating the investigation of biotypes through imaging-derived phenotypes. However, neuromorphic heterogeneity in MDD remains unclear, and how the correlated gene expression (CGE) connectome constrains these neuromorphic anomalies in MDD biotypes has not yet...

Background: Passive coping style (CS) and perceived stress play significant roles as influencing factors in the development of anxiety. However, the underlying neurobiological mechanism linking passive CS and perceived stress to anxiety susceptibility remains elusive. Thus, we aimed to investigate the relationships among passive CS, brain function...

Background: Adult studies have reported atypicalities in the hippocampus and subfields in patients with schizophrenia (SCZ) and major depressive disorder (MDD). Both affective and psychotic disorders typically onset in adolescence, when human brain develops rapidly and shows increased susceptibility to adverse environments. However, few in vivo st...

Previous studies have demonstrated the benefits of multicultural experience (ME), especially its impact on creativity. However, the neural association of ME in the brain and its effect on domain-specific creativity is unclear. In this study, we selected the ventral medial prefrontal cortex (VMPFC), inferior parietal lobule, and inferior frontal gyr...

Background: Major depressive disorder (MDD) is a highly heterogeneous disorder that typically emerges in adolescence and can occur throughout adulthood. Quantitatively uncovering the heterogeneity of individual functional connectome abnormalities in MDD and identifying reproducibly distinct neurophysiological MDD subtypes across the lifespan, whic...

The cognitive and behavioral development of children and adolescents is closely related to the maturation of brain morphology. Although the trajectory of brain development has been depicted in detail, the underlying biological mechanism of normal cortical morphological development in childhood and adolescence remains unclear. By combining the Allen...

Thought control ability (TCA) refers to the ability to exclude unwanted thoughts. There has been consistent evidence on the protective effect of TCA on anxiety, that higher TCA is associated with lower anxiety. However, the underlying neural mechanism remains unclear. In this study, with a large sample (N = 495), we investigated how seed-based rest...

During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013-2022), a ten-year pilot stage of the lifespan CCNP (2013-2032), is an ongoing project focusing...

Nothing ventured, nothing gained. To succeed one must take risks, and more importantly, take risks wisely, which depends on individual ability to exploit risk. Here, we explore neural substrates for the ability to exploit risk by using voxel-based morphometry (VBM). First, we carried out structural magnetic resonance imaging and measured individual...

The univariate obesity-brain associations have been extensively explored, while little is known about the multivariate associations between obesity and resting-state functional connectivity. We therefore utilized machine learning and resting-state functional connectivity to develop and validate predictive models of 4 obesity phenotypes (i.e. body f...

Background The subgenual anterior cingulate cortex (sgACC) appears to play a central role in the pathophysiology of major depressive disorder (MDD). To wit, its functional interactive profile with the left dorsal lateral prefrontal cortex (DLPFC) has been shown to be related to treatment outcomes with transcranial magnetic stimulation (TMS) treatme...

Background: The transition from late adolescence to early adulthood is a period that experiences a surge of life changes and brain reorganization caused by internal and external factors, including negative affect, personality, and social conditions. Methods: Non-imaging phenotype and structural brain variables were available on 497 healthy parti...

Major depressive disorder (MDD) is the most burdensome psychiatric disorder characterized by remarkably heterogeneous clinical phenotypes. It remains challenging to delineate the heterogeneity of neurobiological abnormalities underlying the clinical variance and, on this basis, to identify neurophysiological subtypes of MDD patients. Here, using a...

Normal sleepers may be at risk for insomnia during COVID-19. Identifying psychological factors and neural markers that predict their insomnia risk, as well as investigating possible courses of insomnia development, could lead to more precise targeted interventions for insomnia during similar public health emergencies. Insomnia severity index of 306...

Existing research has consistently supported a relationship between creative achievement and specific personality traits (e.g., openness to experience). However, such work has largely focused on univariate associations, potentially obscuring complex interactions among multiple personality factors, rendering an incomplete picture of the creative per...

Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources of most serotonergic neurons that project throughout the brain. Incorporating measurements of activity within the raphe nuclei into the analysis of connectivity characteristics may contribu...

Forgiveness is a positive and prosocial manner of reacting to transgressions and is strongly associated with mental health and well-being. Despite recent studies exploring the neural mechanisms underlying forgiveness, a model capable of predicting trait forgiveness at the individual level has not been developed. Herein, we applied a machine-learnin...

Background Efforts to develop neuroimaging-based biomarkers in major depressive disorder (MDD), at the individual level, have been limited to date. As diagnostic criteria are currently symptom-based, MDD is conceptualized as a disorder rather than a disease with a known etiology; further, neural measures are often confounded by medication status an...

Objective: This study aimed to examine whether baseline gray matter (GM) volume and structural covariance patterns could predict body fat gain over 1 to 2 years in a relatively large sample. Methods: Voxel-based morphometry (VBM) analysis was applied to examine the association between baseline GM volume and body fat gain in 502 participants over...

Schizotype has been conceptualized as a continuum with symptoms of schizophrenia with marked genetic, neurobiological, sensory-cognitive overlaps. Hierarchical organization represents a general organizing principle for both the brain connectome supporting sensation-to-cognition continuum and gene expression patterns. However, the underlying changes...

Sleep health is both conceptually and operationally a composite concept containing multiple domains of sleep. In line with this, high dependence and interaction across different domains of sleep health encourage a transition in sleep health research from categorical to dimensional approaches that integrate neuroscience and sleep health. Here, we se...

Poetry composition is an ecologically valid approach for investigating creative processes. However, little is known about how the brain creates poetry and about the role of knowledge during poetry composition. Here, we identified patterns of task-based functional connectivity during poetry composition by experts and novices under two experimental c...

Creativity is critical to economic growth and societal progress. However, assessing creativity using objective approaches remains a challenge. To address this, we employ three objective indicators based on semantic distance to quantify the originality and appropriateness of creativity by analyzing long texts in a story‐writing experiment. Global an...

It is important for mental health to be able to control unwanted intrusive memories. Previous studies suggest that middle frontal gyrus (MFG) down regulates pathways underlie the suppression of retrieval of general memories. However, the neural basis of motivated forgetting of autobiographical memories is unclear. Therefore, this study used two sam...

Mirror-touch synaesthesia (MTS) refers to tactile sensations people have on their own body when they see another person being touched. This trait has been linked to individual differences in computing body awareness and ownership (e.g., on questionnaires, cognitive tests) as well as differences in the brain. Here it is assessed for the first time i...

Importance: Major depressive disorder (MDD) is a heterogeneous clinical syndrome with widespread subtle neuroanatomical correlates. Identifying neuroimaging-based biomarkers might aid in defining the disease-related dimensions that characterize MDD and predict treatment response. Objective: To investigate the neuroanatomical dimensions that charact...

Self‐control is a core psychological construct for human beings and it plays a crucial role in the adaptation to society and achievement of success and happiness for individuals. Although progress has been made in behavioral studies examining self‐control, its neural mechanisms remain unclear. In this study, we employed a machine‐learning approach—...

Insofar as the autistic-like phenotype presents in the general population, it consists of partially dissociable traits, such as social and sensory issues. Here, we investigate individual differences in cortical organisation related to autistic-like traits. Connectome gradient decomposition based on resting state fMRI data reliably reveals a princip...

Creativity, the ability to generate original and valuable products, has long been linked to semantic retrieval processes. The associative theory of creativity posits flexible retrieval ability as an important basis for creative idea generation. However, there is insufficient research on how flexible memory retrieval acts on creative activities. Thi...

Background Despite increasing knowledge on the neuroimaging patterns of eating disorder (ED) symptoms in non-clinical populations, studies using whole-brain machine learning to identify connectome-based neuromarkers of ED symptomatology are absent. This study examined the association of connectivity within and between large-scale functional network...