Jianfeng Yang

• Medical Doctor at Shaoxing University

Cholangiocarcinoma (CCA) is a malignant tumor that originates from the bile duct epithelium and with a poor outcome due to lack of effective early diagnostic methods. Surgical resection is the preferred method for cure, but treatment options are limited for advanced diseases, such as distant metastatic or locally progressive tumors. Therefore, it i...

Background The rising incidence of hilar malignant bile duct strictures poses challenges for diagnosis and treatment. While endoscopic treatment is essential for relieving obstruction, it carries a high risk of postoperative cholangitis. Sequential cutting of nasobiliary tubes as an alternative to stent placement after nasobiliary drainage may emer...

Acute pancreatitis (AP) is characterized by autodigestion of the pancreas, and some patients may rapidly progress to systemic inflammation, pancreatic necrosis, and multi-organ failure. Numerous studies have detailed the bidirectional communication networks between the pancreas and the intestinal microbiota, as well as its metabolites. Such crossta...

In China, the balanced fertilization was neglected in jackfruit orchards from lack of monitoring nutrient status. Therefore, for identification deficiency or excess of nutrients and determination the order of nutrient requirement, the jackfruit diagnosis and recommendation integrated system (DRIS) was provided. The jackfruit DRIS norms about N, P,...

Introduction Peritoneal metastasis often predicts advanced progression and a poor prognosis in colorectal cancer (CRC). However, peritoneal metastases are extremely difficult to predict or diagnose by routine diagnostic methods. Material and methods In this study, a microarray containing 30 samples from peritoneal metastasis and their matched CRC...

Background Endoscopic radiofrequency ablation (RFA) is used for the treatment of unresectable malignant biliary obstruction (MBO). The postoperative adverse events associated with RFA treatment have gained importance. Objective To investigate the early adverse events and their risk factors associated with RFA for the treatment of MBO. Design Obse...

Acute pancreatitis (AP) is associated with a high mortality rate, and thereby AP therapy is still a challenge. Pancreatic enzymes overproduction-induced pancreas self-digestion and persistent oxidative stress-associated pancreas pyroptosis have been identified two root causes against current AP therapy. Herein, single-atom nanozymes of Co-based SAE...

The Hard X-ray Imager (HXI) aboard the Advanced Space-based Solar Observatory (ASO-S) is an instrument designed to observe hard X-ray (HXR) spectra and images of solar flares. Having 91 subcollimators to modulate incident X-rays, HXI can obtain 91 modulation data and 45 visibilities to reconstruct images with a spatial resolution as high as \docume...

The ASO-S/HXI is a bi-grids modulating instrument for solar hard X-ray imaging, whose collimator contains 91 pairs of tungsten grids. Since the solar disk is invisible in hard X-rays, a Solar Aspect System (SAS) is required to provide the pointing of hard X-ray imager (HXI) for locating X-ray sources on the solar disk. In addition, the knowledge of...

Background Endoscopic retrograde cholangiopancreatography (ERCP) has become a routine endoscopic procedure that is essential for diagnosing and managing various conditions, including gallstone extraction and the treatment of bile duct and pancreatic tumors. Despite its efficacy, post-ERCP infections – particularly those caused by carbapenem-resista...

Video

In this study, a topology optimization method is proposed to design the layout of the radar absorbing coatings (RACs) outside the surface. The radar cross section (RCS) of a structure with RACs is evaluated by the physical optics method. A material interpolation model oriented to the relative permittivity and relative permeability of RACs is establ...

Papillary adenomas, known precursors to papillary adenocarcinoma, warrant close monitoring due to their malignant potential. Historically, surgical resection represented the mainstay of treatment for papillary adenomas with intraductal extension. However, recent advancements in endoscopic techniques have facilitated the adoption of endoscopic papil...

Background Collagen (COL) genes, play a key role in tumor invasion and metastasis, are involved in tumor extracellular matrix (ECM)-receptor interactions and focal adhesion pathways. However, studies focusing on the diagnostic value of the COL4 family in stomach adenocarcinoma (STAD) are currently lacking. Methods The TCGA database was employed to...

Abnormal activation of ferroptosis worsens the severity of acute pancreatitis and intensifies the inflammatory response and organ damage, but the detailed underlying mechanisms are unknown. Compared with other types of pancreatitis, hyperlipidemic acute pancreatitis (HLAP) is more likely to progress to necrotizing pancreatitis, possibly due to peri...

Acute pancreatitis (AP) is an inflammatory disease characterized by localized pancreatic injury and a systemic inflammatory response. Fatty acids (FAs), produced during the breakdown of triglycerides (TGs) in blood and peripancreatic fat, escalate local pancreatic inflammation to a systemic level by damaging pancreatic acinar cells (PACs) and trigg...

Background Cuproptosis is a novel type of mediated cell death strongly associated with the progression of several cancers and has been implicated as a potential therapeutic target. However, the role of cuproptosis in cholangiocarcinoma for prognostic prediction, subgroup classification, and therapeutic strategies remains largely unknown. Methods A...

Background Previously, our investigations have underscored the potential of hyperthermia to improve the therapeutic efficacy of gemcitabine (GEM) in pancreatic cancer (PC). Nonetheless, the precise underlying mechanisms remain elusive. Methods We engineered two GEM-resistant PC cell lines (BxPC-3/GEM and PANC-1/GEM) and treated them with GEM along...

For a long time, myeloid-derived suppressor cells (MDSCs) dilated in circulation system of colorectal cancer (CRC) patients have been puzzling clinicians. Various evidence shows that MDSCs constitute the bulk of immunosuppression in CRC, which is related to tumor growth, adhesion, invasion, metastasis, and immune escape. However, the mechanisms und...

Objective The dysregulation of the human high-temperature requirement A (HtrA) family of serine proteases is associated with many malignancies. However, there are few reports on HtrAs in head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the expression, prognostic value, and biological functions of HtrAs in HNSC...

Aims: Primary choledocholithiasis is a common digestive disease with high morbidity and relapse. However, the compositions and functions of the bile microbial ecosystem and the pathogenesis of microfloral regulation of host metabolism resulting in stone formation are poorly understood. Main methods: Biliary samples collected from patients with a...

Background Cholangiocarcinoma (CCA) is a malignant epithelial tumor characterized by a dismal prognosis. Given the lack of therapeutic strategies and durable treatment options currently available, identifying innovative treatments for CCA is an urgent unmet clinical need. Cucurbitacin C (CuC) is a distinct variant of the cucurbitacin family, displa...

Background Cuproptosis is a novel type of mediated cell death strongly associated with the progression of several cancers and has been implicated as a potential therapeutic target. However, the role of cuproptosis in cholangiocarcinoma (CCA) for prognostic prediction, subgroup classification, and therapeutic strategies remains largely unknown. Met...

Background With the increasing number of critically ill patients in the gastroenterology department (GED), infections associated with Carbapenem resistant gram-negative bacteria (CR-GNB) are of great concern in GED. As the turn-around time (TAT) for a positive screening culture result is slow, contact precaution and pre-emptive isolation, cohorting...

Introduction Acute pancreatitis (AP) is an inflammatory disease with very poor outcomes. However, the order of induction and coordinated interactions of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) and the potential mechanisms in AP are still unclear. Methods An integrative analysis was...

Background The optimal timing of enteral nutrition (EN) initiation in predicted severe acute gallstone pancreatitis (SAGP) and its influence on disease outcomes are not well known. Methods We conducted a retrospective study of patients with predicted SAGP treated with endoscopic retrograde cholangiopancreatography and EN. The patients were classif...

The Multispectral Camera (MSCam) onboard the Zhurong rover, collecting eight band images in the visible and near-infrared wavelengths, aims to investigate the morphological characteristics and mineralogic properties of the Martian surface. Due to the perturbation of Martian atmosphere, accurate reflectance calibration for the MSCam data is crucial...

The distribution range, time-varying characteristics, and sources of lunar water are still controversial. Here we show the Chang’E-5 in-situ spectral observations of lunar water under Earth’s magnetosphere shielding and relatively high temperatures. Our results show the hydroxyl contents of lunar soils in Chang’E-5 landing site are with a mean valu...

Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedbac...

Background: Cholangiocarcinoma (CCA) is a rare malignant carcinoma characterized by high mortality, challenging diagnosis, and poor prognosis. A powerful prediction biomarker is urgently needed for the early diagnosis and individualized treatment of CCA patients. Methods: A systematic bioinformatics analysis was conducted based on mRNA expression d...

Background and aims Endoscopic papillectomy is the preferred approach for management of ampullary adenomas. Endobiliary radiofrequency ablation (RFA) is an ablative therapy that has been used to treat malignant biliary strictures. The aim of this study was to evaluate the safety and efficacy of endoscopic papillectomy combined with endobiliary RFA...

The Moon has experienced an intense bombardment history since its formation1. Fragments of the impactor can remain on the lunar surface2–4 and can provide evidence of the evolution of the impactor composition and impact population in the Earth–Moon system3–5. However, the retained impactor fragments previously identified in the Apollo samples have...

In the early morning on December 17, 2020 Beijing time, China's chang'E-5 probe successfully returned to the Earth with 1731 grams of lunar samples after completing drilling, shoveling, packaging of lunar soil and scientific exploration on lunar surface. It is the successful completion of the third phase of China's lunar exploration project, namely...

China’s first Mars exploration mission (HuoXing-1) has been named as ‘Tianwen-1’ meaning Heaven Inquiry. Tianwen-1 was launched on July 23, 2020. In this paper, the scientific objectives of earlier and current Mars exploration missions worldwide are reviewed, and the scientific objectives, payloads and preliminary scientific investigation plan of C...

The biliary microbiota is related to the pathogenesis of human bile duct stones. However, the extent to which a history of invasive endoscopic sphincterotomy (EST) affects the biliary bacterial community remains largely unknown. We collected bile samples from the common bile duct of 100 choledocholithiasis patients. We performed 16S rRNA sequencing...

The South Pole–Aitken (SPA) basin is the oldest and largest impact structure on the Moon, and it gives particular insight on the lunar interior composition1–3. However, the surface of the SPA basin has been substantially modified by consequent impacts and basalt flooding. The exploration of the surficial material and the substructure of the SPA bas...

True-color image of Mars is important for mineral analysis. The working light source of the Mars exploration multi-spectral camera is different from the laboratory calibration light source, so that the commonly used RGB calibration method has a large color difference in correcting the on-orbit images. After analyzing the influence of light source l...

The present paper investigates the effects of CO2-saturation and confining pressures on the fracture toughness of carbon dioxide saturated bituminous coals. Three-point bending experiments were performed with semi-circular coal specimens (SCB) after they were immersed in different CO2 pressures. The experimental results show that the pure modes I a...

Chang'E-4, with the Yutu-2 rover, is the first lunar probe to successfully land and conduct a tour on the far side of the Moon from early 2019. We analyze the physical and mechanical characteristics of lunar soil through the in situ terrain data collected by the panoramic camera onboard the Yutu-2 rover. With the slip ratio and wheel sinkage obtain...

Coal bed formation is widely considered a potential reservoir for CO 2 geological storage. The injection of CO 2 into coalbed formations is beneficial for reducing the CO 2 concentration in the atmosphere and enhancing the recovery of coalbed methane, which is a clean fuel. Natural coal mass is a complex system comprising fractures and matrixes. Ho...

This paper describes the scientific objectives and payloads of Tianwen-1, China’s first exploration mission to Mars. An orbiter, carrying a lander and a rover, lifted-off in July 2020 for a journey to Mars where it should arrive in February 2021. A suite of 13 scientific payloads, for in-situ and remote sensing, autonomously commanded by integrated...

The present work conducted laboratory experiments of fracturing in fat coals, anthracites, and mudstones. Three different fluids were selected as the fracturing fluids, including water, liquid CO 2 (L-CO 2 ), and supercritical CO 2 (Sc-CO 2 ). The resulting fracture morphologies and fracture apertures of the coal specimens were investigated using 3...

Spectral calibration is an essential step in the calibration process of multispectral camera for Mars exploration. The precision of spectral calibration has a direct impact on the accuracy of Mars multispectral data inversion. The most common method for determining the central wavelength and spectral bandwidth of a multispectral camera is to fit th...

The affiliations of the first three authors of the paper have been updated. See the PDF file for details.

The Yutu‐2 rover of the Chang’E‐4 spacecraft observed many meter‐sized shallow pits fully covered with small fragments, distinct from the typical rock‐free impact craters with comparable sizes in the landing area. The unique morphology of the pits and the visible and near‐infrared spectra of the fragments suggest that the fragments are broken piece...

The Chang'E-4 spacecraft successfully landed in Von Kármán crater inside the South Pole-Aitken basin on the lunar far side on January 3, 2019 and the Yutu-2 Rover has performed explorations on the lunar surface for nine lunar days as of September 2019. Our earlier analysis of the visible and near-infrared spectrometer measurements made by the Yutu-...

Background and Aims Endoscopic radiofrequency ablation (RFA) is a new ablative treatment for unresectable extrahepatic cholangiocarcinoma (EHCC). A novel 5-fluorouracil compound (S-1TM) has been widely used as one of the key drugs with first-line or second-line chemotherapy for the treatment of advanced cholangiocarcinoma. The aim of this study is...

The South Pole–Aitken (SPA) basin, located between the South Pole and Aitken crater on the far side of the Moon, is the largest confirmed lunar impact structure. The pre-Nectarian SPA basin is a 2400 × 2050 km elliptical structure centered at 53°S, 191°E, which should have exposed lower crust and upper mantle due to the enormous excavation depth. O...

Background/aims: The aim of this study is to evaluate serum mucin 3A (MUC3A) as a candidate biomarker for extrahepatic cholangiocarcinoma (EHCC). Patients and methods: 35 Patients with EHCC, 30 patients with pancreatic cancer, 35 patients with gallbladder carcinoma and 78 patients with benign biliary disease were enrolled during January 2015 to...

For precision machinery, the measurement of the relative in-plane displacement of two parallel planes that are separated by several meters is important. In this paper, a theoretical model for measuring the relative in-plane microdisplacement between two parallel planes was developed on the basis of secondary diffraction. Based on this method, we em...

Objective: The aim of the study was to investigate the clinical efficacy and safety of ketotifen for the treatment of irritable bowel syndrome with diarrhea (IBS-D). Methods: A total of 108 enrolled IBS-D patients were randomly divided into a ketotifen group (n = 55) and a control (placebo) group (n = 53). The patients in the ketotifen group rec...

Chang'e‐4 (CE‐4) achieved the first farside landing in Von Kármán crater. In the landing site, linear features have been identified previously from SLDEM and considered to be ejecta from the neighboring Finsen crater. The 5 cm grid spacing digital elevation model of the landing site, generated from the rover's panoramic images, provides more detail...

Chang’E-4 landed in the South Pole-Aitken (SPA) Basin, providing a unique chance to probe the composition of the lunar interior. Its landing site is located on ejecta strips in Von Kármán crater that possibly originate from the neighboring Finsen crater. A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by...

Microservice architecture is a promising architectural style. It decomposes monolithic software into a set of loosely coupled containerized microservices and associates them into multiple microservice chains to serve service requests. The new architecture creates flexibility for service provisioning but also introduces increased energy consumption...

The control plane of Software-Defined Networking (SDN) is the key component for overseeing and managing networks. As a software entity, the control plane is inevitable to involve design or logic flaws in its policy enforcement and network control, which can cause it to behave incorrectly and induce network anomalies. Existing approaches mainly focu...

With the tremendous increment of traffic in the next generation mobile networks, device to device (D2D) communication is proposed to relieve the traffic burden of the base station and improve the overall network capacity. It supports direct communications between devices and could reuse the resources of cellular users (CUs). Despite the advantages,...

S-polarization light and p-polarization light are mutually cross orthogonal, which can be used as signal light for emitting and receiving in the polarization-modulated space laser communication, respectively. Due to the retro reflection characteristics of the corner cube retroreflector (CCR), it is widely used as a calibration reflector system in t...

Favorable isolation performance in optical transmitting-receiving (T/R) channels is key to establishing full-duplex bi-directional laser communication links when designing mono-wavelength laser communication terminals. This study proposes a novel design scheme for T/R channels that use a single laser wavelength. The system includes measures such as...

To investigate the influence of geometric characteristics of deformable rough fractures under confining stresses on the behaviors of non-Darcy flow, four fractured sandstone specimens were used for hydraulic tests in the experiments. According to the experimental results of the relationships between the hydraulic gradient and the flow rate, it is d...

This chapter discusses the benefits of Ti‐Ti bonding on the formation of the lateral conductive path in the TiO2110 surface. The geometry optimization and energy are calculated on spin‐polarized DFT methods as implemented in the DMoI package. The basis set of double numerical plus polarization of 3.5 are used for the geometry optimizations as well...

Pancreatic cancer (PC) is a highly aggressive type of cancer. Gemcitabine (GEM) is a standard chemotherapeutic treatment of advanced PC; however, it requires improvement, and more effective therapeutic methods must be further explored. In the present study, hyperthermia combined with GEM was used on the PC cell line SW1990. The results revealed tha...

Black pepper plants maintain synchronous vegetative growth and flowering during their lifetimes, even in the juvenile phase. How to limit the duration of flowering, facilitate a return to vegetative development should be studied. Light intensity has been reported to affect the levels of stored carbohydrates in some horticultural trees. However, it...

Software-defined networking (SDN) has emerged as a new network paradigm that promises control/data plane separation and centralized network control. While these features simplify network management and enable innovative networking, they give rise to persistent concerns about reliability. The new paradigm suffers from the disadvantage that various n...

Providing reliable transmission for real-time traffic in wireless cellular networks is a great challenge due to the unreliable wireless links. This paper concentrates on the resource allocation problem aiming to improve the real-time throughput. First, the resource allocation problem is formulated as a Markov Decision Process and thus the optimal r...