Jianfeng Li

Jianfeng Li
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine · Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai

Doctor of Philosophy

About

40
Publications
4,564
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469
Citations
Introduction
Jianfeng Li currently works at the Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine. Jianfeng does research in leukemia and bioinformatics.
Education
September 2015 - July 2018
Shanghai Jiao Tong University School of Medicine
Field of study
  • Biochemistry and molecular biology
September 2011 - July 2015
Harbin Institute of Technology
Field of study
  • Bioengineering

Publications

Publications (40)
Article
Recurrent MEF2D fusions with poor prognosis have been identified in B-cell precursor ALL (BCP-ALL). The molecular mechanisms underlying the pathogenic function of MEF2D fusions are poorly understood. Here, we showed that MEF2D-HNRNPUL1 (MH) knock-in mice developed a progressive disease from impaired B-cell development at pre-pro-B stage to pre-leuk...
Article
Full-text available
Significance We provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expressi...
Preprint
Full-text available
Modern web techniques provide an unprecedented opportunity for leveraging complex biomedical data generating in clinical, omics, and mechanism experiments. Currently, the functions for carrying out publication-ready biomedical data visualization represent primary technical hurdles in the state-of-art omics-based web services, whereas the demand for...
Article
Full-text available
Background: Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors that are classified into seven histological subtypes, including lactotroph, somatotroph, corticotroph, thyrotroph, gonadotroph, null cell, and plurihormonal PitNETs. However, the molecular characteristics of these types of PitNETs are not completely clear. Method...
Preprint
Full-text available
Cox analysis is a common clinical data analysis technique to link valuable variables to clinical outcomes including dead and relapse. In the omics era, Cox model batch processing is a basic strategy for screening clinically relevant variables, biomarker discovery and gene signature identification. However, all such analyses have been implemented wi...
Article
Full-text available
UCSC Xena platform provides huge amounts of processed cancer omics data from large cancer research projects (e.g. TCGA, CCLE and PCAWG) or individual research groups and enables unprecedented research opportunities. However, a graphical user interface (GUI) based tool for interactively analyzing UCSC Xena data and generating elegant plots is still...
Article
Full-text available
Background The rapidly increasing dimensionality and throughput of flow and mass cytometry data necessitate new bioinformatics tools for analysis and interpretation, and the recently emerging single-cell-based algorithms provide a powerful strategy to meet this challenge. Results Here, we present CytoTree, an R/Bioconductor package designed to ana...
Article
Full-text available
B cell precursor acute lymphoblastic leukemia (BCP-ALL) is a blood cancer that originates from the abnormal proliferation of B-lymphoid progenitors. Cell population components and cell–cell interaction in the bone marrow microenvironment are significant factors for progression, relapse, and therapy resistance of BCP-ALL. In this study, we identifie...
Article
Full-text available
Therapeutic agents for refractory prolactinomas that are resistant to dopamine agonists (DAs) are troublesome, and surgery often only removes a large part of the tumor without complete remission. Among the various second-line treatment regimens, the treatment effect of the alkylating agent temozolomide (TMZ) is only effective for approximately half...
Article
Full-text available
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with high heterogeneity. Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology. Most of these profiles are associated with recurrent non-overlapping rearrangements o...
Article
Full-text available
Background: A virus community is the spectrum of viral strains populating an infected host, which plays a key role in pathogenesis and therapy response in viral infectious diseases. However automatic and dedicated pipeline for interpreting virus community sequencing data has not been developed yet. Results: We developed Quasispecies Analysis Pac...
Article
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes of NKTCL based on genomic structural alterations and EBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosed NKTCL and de...
Article
Full-text available
Generation of hematopoietic stem/progenitor cells (HSPCs) via cell expansion or cell reprogramming has been widely achieved by overexpression of transcription factors. Herein, it is reported that without introducing exogenous genes, mouse fibroblasts can be reprogrammed into hemogenic cells based on lineage tracing analysis, which further develop i...
Poster
Full-text available
Background B-precursor acute lymphoblastic leukemia (B-ALL) represents a heterogeneous group of hematological malignancies. Previous studies have identified distinctive gene expression profiles for several molecular subtypes of B-ALL with both biological and clinical importance. However, a proportion of B-ALL has remained poorly characterized with...
Article
Background B-precursor acute lymphoblastic leukemia (B-ALL) represents a heterogeneous group of hematological malignancies. Previous studies have identified distinctive gene expression profiles for several molecular subtypes of B-ALL with both biological and clinical importance. However, a proportion of B-ALL have remained poorly characterized with...
Article
Full-text available
The increase in bioinformatics resources such as tools/scripts and databases poses a great challenge for users seeking to construct interactive and reproducible biological data analysis applications. Here, we propose an open-source, comprehensive, flexible R package named BioInstaller that consists of the R functions, Shiny application, the HTTP re...

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Projects

Project (1)
Project
Establish a comprehensive data visualization platform for biomedicine research.