Jian Wang

Southwest University in Chongqing | SWU · College of Pharmaceutical Sciences

Objective The long-term impact of COVID-19 on patient health has been a recent focus. This study aims to determine the persistent symptoms and psychological conditions of patients hospitalized with COVID-19 15 months after onset, that patients first developed symptoms. The potential risk factors were also explored. Methods A cohort of COVID-19 pat...

The molecular mechanisms underlying restrictive cardiomyopathy (RCM) are not fully understood. Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) is a vital element of Endosomal sorting required for transport (ESCRT), which mediates protein sorting for degradation and is crucial for protein homeostasis (proteostasis) maintenance. Ho...

Background COVID‐19 has caused an ongoing worldwide pandemic. Much remains unknown about detailed symptomatic features of COVID‐19 onset and rehabilitation. Methods In this retrospective cohort study, 932 hospitalized patients with COVID‐19 in Wuhan were enrolled, including 52 severe cases and 880 non‐severe cases. The symptomatic features were an...

Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims to investigate the early detection of white matter structural network changes in T2DM patients with MCI and assess the relationship between...

Type 2 diabetes mellitus (T2DM) patients are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. In this study, we performed a battery of neuropsychological tests and high-resolution sagittal T1-weighted structural imaging to explore how T2DM affects white...

Background Much remains unknown about COVID-19 onset and rehabilitation's symptomatic features, especially the long-term health consequences of patients with COVID-19 who have been discharged from the hospital. Methods In this cohort study, we collected the first pandemic data of hospitalized patients in Wuhan from February 20 to March 31, 2020. Al...

The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the efficacy of targeted therapies is often limited due to drug resistance. The relevant signaling pathways in PTEN-deficient cancer cells treated with the PI3K/mTOR inhibitor BEZ235 w...

Background The precise physiopathological association between the courses of neurodegeneration and cognitive decline in type 2 diabetes mellitus (T2DM) remains unclear. This study sought to comprehensively investigate the distribution characteristics of gray matter atrophy in middle-aged T2DM patients with newly diagnosed mild cognitive impairment...

Human adenovirus infection is a common cause of upper and lower respiratory illness and easily breaks out in schools and the army. In an adenovirus epidemic, a large number of samples would be collected for laboratory diagnosis, and it is urgent to optimize the current sampling strategy. We researched the application of laboratory detection in the...

We investigate the transient behavior of the quantum transport in mesoscopic systems under a quantum quench within the Caroli scheme. Using the nonequilibrium Green's function approach, an exact solution of the transient electric current, energy current, and their fluctuations in the presence of both external bias and temperature gradient are prese...

The study aimed to investigate the aberration of brain spontaneous activity and synchronization in type 2 diabetes mellitus (T2DM) patients homozygous for the apolipoprotein E (APOE)-ε3 allele. In the APOE-ε3 homozygotes, 37 T2DM patients and 37 well-matched healthy controls (HC) were included to acquire blood sample measurements, neuropsychologica...

Efficient performance prediction at the source code level is essential in reducing the turnaround time of software development. In this paper, we introduce a new prediction model, which combines several machine learning algorithms, such as KNN, clustering, similarity, sample and attribute weighting with multiple linear regression techniques, to pre...

The monotonicity of depth in a geometric constraint based absolute phase unwrapping is analyzed and a monotonic discriminant of Δ(uc,vc) is presented in this paper. The sign of the discriminant determines the distance selection for the virtual plane to create the artificial absolute phase map for a given structured light system. As Δ(uc,vc) ≥ 0 at...

Spinal fusion serves an important role in the reconstruction of spinal stability via restoration of the normal spinal sequence and relief of pain. Studies have demonstrated that the fusion rate is mainly associated with the osteogenic capacity of the implanted graft. Mesenchymal stem cells (MSCs) have been successfully isolated from human degenerat...

In a structured-light system, lens distortion of the camera and projector is the main source of 3D measurement error. In this Letter, a new approach, to the best of our knowledge, of using deep neural networks to address this problem is proposed. The neural network consists of one input layer, five densely connected hidden layers, and one output la...

Background: Amblyopia is generally considered a neurodevelopmental disorder that results from abnormal visual experiences in early childhood and may persist to adulthood. The neural basis of amblyopia has been a matter of interest for many decades, but the critical neural processing sites in amblyopia are not entirely understood. Although many fun...

To predict transport properties of disordered systems, especially ac transport properties, one has to calculate the disorder average of the correlation of the multiple Green's function at different energies. To avoid brute force calculation, diagrammatic perturbation expansion must be used along with the coherent potential approximation (CPA). In t...

The mTORC1 inhibitors, such as rapamycin and its analogs, show limited antitumor activity in clinic, reasons for which have not been clearly elucidated. Here, we undertook an effort to uncover the mechanisms underlying the limited efficacy of rapamycin, and found that the transit suppression of 4EBP1 phosphorylation led to cap-dependent translation...

Purpose Postoperative infection has seriously affected the prognosis of cancer patients, while probiotics have been increasingly used to prevent postoperative infection in clinical practice. This study aimed to evaluate the preventive effect of probiotics on infection after colorectal cancer (CRC) surgery. Methods Related clinical trial reports we...

Recently, numerous identity-based proxy signature (IDPS) schemes are constructed by direct methods or generic methods. However, most of them are proved only to be secure in the random oracle model or are involved high computational cost. In this paper, we present a novel and generic construction method of IDPS scheme secure in the standard model fr...

Purpose The study aimed to investigate the abnormal alterations of both the intra-regional brain activity and inter-regional functional connectivity (FC) in patients with subjective tinnitus (ST) using resting-state functional MRI (rs-fMRI) methods. Methods Twenty-five ST patients and 25 normal controls (NCs) were included and underwent resting-st...

Samarium doped ZnO porous nanosheets were prepared via a hydrothermal approach and well characterized by X-ray diffraction (XRD), Raman spectroscopy, transition electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photoluminescence spectroscopy (PL) and UV–vis absorption spectroscopy. With increasing the Sm³⁺ doping concentrations, th...

Using nonequilibrium Green’s function combined with density functional theory, we investigate the spin-related current generated by the photogalvanic effect (PGE) in monolayer zigzag SiC nanoribbons (ZSiCNRs) from first-principles calculations. Due to its unique atomic structure and bandstructure properties, we find that 100% spin polarized photocu...

Eph receptor tyrosine kinases and their ephrin ligands, mediate an important cell communication system both in normal and oncogenic development, and play central roles in a series of processes including angiogenesis, stem cell maintenance and cancer metastasis. Eph receptor A3 (EphA3), commonly overexpressed in a broad range of cancers, including g...

[This corrects the article DOI: 10.1371/journal.pone.0108124.].

Cooler electrons for transistors The operating power of field-effect transistors is constrained in part by the minimum change in voltage needed to change the current output. This subthreshold swing (SS) limit is caused by hotter electrons from a thermal electron source leaking over the potential of the gate electrode. Qiu et al. show that graphene...

Power consumption of today's integrated circuit is very difficult to reduce because the MOSFET is subjected to the thermal limit of 60 mV/decade for the subthreshold swing (SS). In this paper, we show that this SS limit of thermionic current can be conquered--thus power consumption drastically reduced by density of states (DOS) engineering at the s...

Type 2 diabetes mellitus (T2DM) affects a vast population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in T2DM patients have not been unraveled. Research on the basic units (nodes or hubs and edges) of the brain functional network on the basis of neuroimaging may advance our understanding of t...

Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been shown to be a promising technique for assessing lung lesions. However, DCE-MRI often suffers from motion artifacts and insufficient imaging speed. Therefore, highly accelerated free-breathing DCE-MRI is of clinical interest for lung exams. Purpose: To test the pe...

The designed synthesis of advanced ZnO heterostructures in a simple and mild way is of great significance, for the purpose of improving their photocatalytic performance and large-scale applications. Herein, a magnetic hierarchical microsphere Fe3O4@SiO2@[email protected] (FSZA) was successfully synthesized by multistep chemical methods, in which ma...

Here, a new three-dimensional (3D) multi-shell Fe3O4/SiO2/ZnO/ZnSe (FSZ-ZnSe) photocatalyst with a type II heterostructure was successfully produced by a convenient synthetic route. The amount of ZnSe particles can be regulated by varying the reactant concentration, and five kinds of FSZ-ZnSe samples (FSZ-ZnSe0, FSZ-ZnSe1, FSZ-ZnSe2, FSZ-ZnSe3 and...

Background Influenza is an acute respiratory infectious disease with a high incidence rate in the Chinese army, which directly disturbs military training and affects soldiers’ health. Influenza surveillance systems are widely used around the world and play an important role in influenza epidemic prevention and control. Methods As a theater centers...

Parkinson’s disease (PD) can be classified into tremor-dominant and akinetic-rigid subtypes, each of which exhibits a unique clinical course and prognosis. The neural basis for these disparate manifestations is not well-understood, however. This study comprehensively investigated the altered functional connectivity patterns of these two subtypes. T...

Quantum transport is a stochastic process in nature. As a result, the conductance is fully characterized by its average value and fluctuations, i.e., characterized by full counting statistics (FCS). Since disorders are inevitable in nanoelectronic devices, it is important to understand how FCS behaves in disordered systems. The traditional approach...

By employing the nonequilibrium Green's function (NEGF) method, the transient current and the transient behavior of the spin transfer torque (STT) of the magnetic layered system are investigated within the framework of density functional theory (DFT). To reduce the huge computational cost of the transient calculation, especially when the dense mesh...

Neurological impairment plays an important role in the development of Ankylosing spondylitis (AS). Early diagnosis and detection of it may stop the progress of neurological complications and improve the quality of patients’ lives greatly. Somatosensory evoked potential (SSEP) and magnetic motor evoked potentials (MEP) have been proved useful to det...

After the publication of the article, the authors notified the PLOS ONE Editors that an error in the data analyses had been detected following a reanalysis of the data. While there are no concerns about the data themselves, the experimental and control groups were inadvertently switched during the original analysis. This error unfortunately lead to...

In order to meet the application requirement of a certain long wavelength infrared (LWIR) seeker, a small volume, light weight and passively athermalized infrared (IR) objective is designed in this paper. The two-lens telephoto structure is adopted by merely using aluminum alloy as the housing material. By balancing the thermo-optical coefficient a...

A high frequency surface wave radar (HFSWR) system with improved performance. Two or more transmitters including separate transmitting antennas (120, 122, 410) are used to improve the performance of the HFSWR over the performance of a comparable system with a single transmitter. In one embodiment, two transmitters are used, and configured to transm...

PurposeAltered brain functional connectivity has been reported in patients with amblyopia by recent neuroimaging studies. However, relatively little is known about the alterations in interhemispheric functional connectivity in amblyopia. The present study aimed to investigate the functional connectivity patterns between homotopic regions across hem...

A simple synthetic approach based on solvothermal technique and hydrogenation was developed for preparation of TiO2 nanocrystals with different morphologies such as elongated rhombic, dog-bone, oval and core-shell structured oval. The effect of oleic acid (OA) and oleylamine (OM) as two capping surfactants on the growth of TiO2 nanocrystals was inv...

ZnSe photocatalytic films made of \( \left\{ {000 1} \right\} \)-ended microdisks and \( \left\{ {2\overline{1} \overline{1} 0} \right\} \)-ended nanobelts have been successfully synthesized via a solvothermal route followed by annealing in Ar atmosphere. Zn foils are used as both the Zn source and the substrate, Se powder as the Se source, and eth...

The multidrug resistance 1 gene (MDR1) encodes for P-glycoprotein (P-gp), which plays a pathophysiological role in the development of autoimmune diseases, including systemic lupus erythematosus (SLE). Herein, we aimed to investigate the relationship between MDR1 gene polymorphisms and SLE susceptibility in the Chinese Guangxi population. The genoty...

The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 ag...

Transient current calculation is essential to study the response time and capture the peak transient current for preventing meltdown of nanochips in nanoelectronics. Its calculation is known to be extremely time consuming with the best scaling TN3 where N is the dimension of the device and T is the number of time steps. The dynamical response of th...

Here, unique Fe3O4/SiO2/mTiO2 (FST) composites were fabricated, which are composed of a Fe3O4 core with a strong response to magnetic field, an intermediate SiO2 layer as an electronic barrier, and an outer mesoporous TiO2 (mTiO2) as the active layer for degradation of organic contaminants. The distinctive approach involved TiO2 shell coating on th...

Most of the strong designated verifier signature (SDVS) schemes cannot tell the real signature generator when the signer and the designated verifier dispute on a signature. In other words, most of the SDVS schemes do not have the undeniability property. In this paper, we propose two SDVS schemes which hold the undeniability property, namely, strong...

We report the calculated fundamental band gaps of \emph{wurtzite} ternary alloys Zn$_{1-x}$M$_x$O (M=Mg, Cd) and the band offsets of the ZnO/Zn$_{1-x}$M$_x$O heterojunctions, these II-VI materials are important for electronics and optoelectronics. Our calculation is based on density functional theory within the linear muffin-tin orbital (LMTO) appr...

In a strong designated verifier signature with message recovery (SDVSWMR) scheme, only the designated receiver has the capability to recover and validate the message-signature pair. In 2015, using the bilinear pairing, Islam and Biswas presented an SDVSWMR scheme (we call it: IsBi-SDVSWMR) with non-delegatability, which has better performance than...

We report an extensive first-principles investigation of impurity-induced device-to-device variability of spin-polarized quantum tunneling through Fe/MgO/Fe magnetic tunnel junctions (MTJ). In particular, we calculated the tunnel magnetoresistance ratio (TMR) and the average values and variances of the currents and spin transfer torque (STT) of an...

The androgen receptor (AR) is not only a ligand-dependent transcription factor, but also functions as a licensing factor, a component of DNA replication, which is degraded during mitosis. Furthermore, the deregulation of AR activity is involved in the initiation of prostate cancer and contributes to castration resistant prostate cancer (CRPC). Whil...

Diffraction effects play a significant role in the digital micromirror device (DMD)-based scene projectors in the long-wave infrared (IR) band (8–12 μm). The contrast provided by these projector systems can become noticeably worse because of the diffraction characteristics of the DMD. We apply a diffraction grating model of the DMD based on the sca...

Radiotherapy is promising and effective for treating prostate cancer but the addition of a tumor cell radiosensitizer would improve therapeutic outcomes. PC-1/ PrLZ, a TPD52 protein family member is frequently upregulated in advanced prostate cancer cells and may be a biomarker of aggressive prostate cancer. Therefore, we investigated the potential...

Background Overgrowth syndromes represent clinically and genetically heterogeneous conditions characterized by a wide spectrum of malformations, tall stature, intellectual disability and/or macrocephaly. Results In a cohort of four clinically characterized patients with overgrowth syndrome without known causative gene mutation, we performed an Ill...

Introduction Several types of stem cells have been successfully demonstrated to exist in the human degenerated intervertebral disc (IVD), which is composed of annulus fibrosus (AF), nucleus pulposus (NP) and cartilage endplate (CEP). However, the differences in the biological characteristics among these and bone marrow derived mesenchymal stem cell...

Type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment. However, its neurological mechanism remains elusive. Combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, the present study aimed to investigate brain functional alterations in middle-aged T2DM patients, which could provide complementary infor...

Identity-based proxy signature (IDBPSE) has attracted many researchers and scholars since it can simplify key management procedure of certificate-based public key setting. Recently, some IDBPSE schemes are constructed in the standard model. However, most of them have very loose security reductions. And they cannot resist the attack from the delegat...

Study design: Retrospective analysis of the clinical outcomes of eight patients with the lumbar pars interarticulars defects treated by direct repair with the aid of intraoperative O-arm based navigation and microendoscopic techniques. Objective: To investigate the efficacy and safety of direct screw repair by using minimally invasive surgery fo...

Identity-based batch verification (IBBV) scheme is very desirable to solve efficiency, security and privacy preservation issues for vehicular ad hoc network (VANET). In 2015, Tzeng et al. proposed an IBBV scheme which was published in IEEE Transaction on Vehicular Technology. Their scheme has superior performance than other existing similar schemes...

The agglomeration mechanism of SiO2, TiO2, and ZnO nanoparticles by adding coarse fluid catalytic cracking (FCC) particles is studied. The core-shell structure of agglomerates is revealed on the basis of experimental analyses. Nanoparticles can be fluidized by forming agglomerates of the core-shell structure with coarse FCC particles. The porosity...

Diffraction effects play a significant role in scene projectors by digital micromirror devices (DMDs) in the long-wave infrared (IR) band (8 to 12 μm). The contrast provided by these projector systems can become noticeably worse because of the diffraction characteristics of the DMD. The actual diffraction characteristics of the DMD deviate signific...

Quantum transport properties of negative capacitance transistors (NC-FETs) with monolayer black phosphorus (ML-BP) are theoretically studied. Our calculations show that atomistic thin ML-BP can enhance the amplification effect of the ferroelectric layer, and subthreshold swing is effectively reduced to 27 mV per decade in ML-BP NC-FETs. Device perf...

Black phosphorus (BP) tunneling transistors (TFETs) using heterojunction (He) are investigated by atomistic quantum transport simulations. It is observed that edge states have a great impact on transport characteristics of BP He-TFETs, which result in the potential pinning effect and deteriorate the gate control. While, on-state current can be effe...

ZnSe(en)0.5 (en = ethylenediamine) nanosheets were successfully synthesized via a facile solvothermal method using en-water mixture as solvent. When ZnSe(en)0.5 composite were calcined at 300 °C in air atmosphere, ZnSe(en)0.5 nanosheets first converted to ZnSe nanosheets. When the calcination temperature was increased to 400 °C, ZnSe nanosheets com...

Amyotrophic lateral sclerosis (ALS) is a rare degenerative disorder characterized by loss of upper and lower motor neurons. Neuroimaging has provided noticeable evidence that ALS is a complex disease, and shown that anatomical and functional lesions extend beyond precentral cortices and corticospinal tracts, to include the corpus callosum; frontal,...

Aims: The H19 lncRNA, a highly abundant and conserved imprinted gene, has been implicated in many essential biological processes and diseases. However, the function of H19 in the heart remains unknown. In this study, we investigated the function and underlying mechanism of H19 in regulating cardiomyocyte hypertrophy. Methods and results: We firs...

With continuous scaling of semiconductor devices , the number of atoms in transistors becomes countable. Various effects related to the device atomic structure, such as random dopants, edge roughness, and channel-oxide interface, have great impact on device performance. Therefore, it is valuable to study material electronic properties and device tr...

A photoinduced current of a layered MoS2-based transistor is studied from first-principles. Under the illumination of circular polarized light, a valley-polarized current is generated, which can be tuned by the gate voltage. For monolayer MoS2, the valley-polarized spin-up (down) electron current at K ([Formula: see text]) points is induced by the...

Aims: Overexpression of either member of the miR-199 family, miR-199a-5p or miR-199b-5p (hereinafter referred to as miR-199a or miR-199b), promotes pathological cardiac hypertrophy, but little is known about the role of endogenous miR-199 in cardiac development and disease. Our study aimed to determine the physiological function of the endogenous...

Herein, we developed the design and synthesis of urchin-like Fe3O4@SiO2@ZnO/CdS core shell microspheres, in which the multiple functional components were integrated successful into a single microcomposite. Morphology, composition, optical and magnetic property of those core shell microspheres were characterized by various analytical techniques. Pho...

In the study the response time of ultrafast transistor and peak transient current to prevent melt down of nano-chips, the first principles transient current calculation plays an essential role in nanoelectronics. The first principles calculation of transient current through nano-devices for a period of time T is known to be extremely time consuming...

The present work is focused on the fluidization behavior of different mixed binary nanoparticles (Fe2O3 + SiO2, Fe2O3 + TiO2, and Fe2O3 + ZnO) under the influence of a vibrated field. The results reveal that the iron-containing nanoparticles mixtures with different mass fractions can achieve uniform fluidization in the initial bed height of 40 mm,...

We propose and theoretically investigate a class of stable zigzag graphene nanoribbon (ZGNR) based molecular magnetic tunneling junctions (MTJs). For those junctions having pentagon-connecting formation, huge tunnel magneto-resistance (TMR) is found. Different from most of the other proposed molecular junctions, the huge TMR in our structures is ge...

Objectives To perform a meta-analysis to evaluate the diagnostic efficacy of diffusion-weighted imaging (DWI) in differentiating malignant from benign thyroid nodules. Design A meta-analysis. Data sources and study selection Medical and scientific literature databases were searched for original articles published up to August 2015. Studies were sel...

Fluidization behavior of the mixture of SiO2 and TiO2 nanoparticles by adding FCC coarse particles was investigated. The results showed that the fluidization quality of the mixture system can be obviously improved with adding FCC coarse particles. The size and mass percentage of FCC coarse particles are very important to the fluidization behavior o...

The agglomerating fluidization behavior of different binary mixtures of SiO2/TiO2, SiO2/ZnO and TiO2/ZnO nanoparticles in vibro-fluidized bed (VFB) was performed. The results showed that the bed of nanoparticles existed obviously channeling and crack formation at lower gas velocities and slowly disappeared with increasing superficial gas velocity,...

ZnO nanopowders with different morphologies were successfully synthesized via hydrothermal method. By using different surfactants and controlling the concentration of surfactant in the reaction mixture, ZnO nanoparticles and nanoplates were obtained at 160. °C. The analysis of photoluminescence spectra shows that there exist more oxygen vacancies i...

The transport of picosecond laser generated fast electrons in a nanowire array is studied with two-dimensional particle-in-cell simulations. Our simulations show that a fast electron beam is initially guided and collimated by strong magnetic filaments in the array. Subsequently, after the decomposition of the structure of nanowire array due to plas...

Purpose: To determine the optimal hepatobiliary delay time after Gd-EOB-DTPA injection for lesion characterization in cirrhosis patients with different liver function. Materials and methods: Ninety consecutive patients with liver cirrhosis who underwent Gd-EOB-DTPA-enhanced MRI for the evaluation of known or suspected focal liver lesions were en...

Certificateless cryptography avoids the key escrow problem in identity-based crytosystems and certificate management in traditional public-key crytosystems, it has been researched by many scholars and many certificateless signature schemes have been proposed. However, most of them exist some security drawbacks and are insecure for some kinds of att...

Ballistic transport characteristics of transition metal dichalcogenide (TMDC) tunneling FETs (TFETs) are investigated by atomistic simulations using nonequilibrium Green's function. It is revealed that TMDC TFETs have crystal orientation-dependent transport properties: larger current but smaller utmost limit of ION/IOFF ratio in the zigzag directio...

We report a theoretical investigation of ballistic transport in multilayer black phosphorus (BP) tunneling transistors (TFETs) with HfO2 as the gate oxide. First-principles calculations show that monolayer BP can be preserved well on HfO2 (111) surface. For a better device performance, the optimum layer and transport direction at different channel...

Background: Interleukin (IL)-17 has been shown to play an important role in tissue inflammation and in the pathogenesis of immune-related liver damage. Genetic variations in IL-17 gene may be associated with the development of hepatitis B virus (HBV) infection. However, literature is scanty regarding their association. Methods: We conducted a ca...