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Introduction
Polymer chemistry and Biotechnology
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Publications
Publications (5)
Copper (Cu) is a transition metal that plays crucial roles in cellular metabolism. Cu⁺ homeostasis is upregulated in many cancers and contributes to tumorigenesis. However, therapeutic strategies to target Cu⁺ homeostasis in cancer cells are rarely explored because small molecule Cu⁺ chelators have poor binding affinity in comparison to the intrace...
Copper (Cu) is a transition metal that plays crucial roles in cellular metabolism. Cu+ homeostasis is upregulated in many cancers and contributes to tumorigenesis. However, therapeutic strategies to target Cu+ homeostasis in cancer cells are rarely explored because small molecule Cu+ chelators have poor binding affinity in comparison to the intrace...
The merits of nanomedicines are significantly impacted by the surrounding biological environment. Similar to the protein corona generated on the surface of nanoparticles in the circulation system, the intracellular protein corona (IPC) might be formed on nanoparticles when transported inside the cells. However, little is known currently about the f...
Overcoming the epithelial barriers to enhance drug transport is a focused topic for gastrointestinal, intratracheal, intranasal, vaginal and intrauterine delivery. Nanomedicines with targeting functionization promote such a process owing to specific ligand-receptor interaction. However, compared to the cell uptake of targeting nano-therapies, curre...
