Jian Zhang

• Rogers Corporation

Copper-based materials-mediated persulfate activation for pollutant degradation has attracted great interest, with copper species playing a crucial role in generating reactive species. However, the mechanism behind copper valence transformation during the catalytic activation of different persulfates, peroxydisulfate (PDS) and peroxymonosulfate (PM...

The effects of various amendments on soil health, particularly regarding metal immobilization efficacy and micro-ecological health, have been insufficiently investigated in agricultural soil remediation. Synthetic humic-like acid (SHLA) possesses controllable structures and higher functional group densities than natural humic acid, making SHLA-base...

Correction for ‘TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3 H )-ones from 2-aminobenzamides and isothiocyanates’ by Jingbin Huang et al. , Org. Biomol. Chem. , 2025, 23 , 4860–4865, https://doi.org/10.1039/d5ob00410a.

Aim: To construct and validate a multitask deep learning (DL) model based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) contrast-enhanced magnetic resonance imaging (MRI) for predicting microvascular invasion (MVI) plus cytokeratin 19 (CK19) positivity in patients with hepatocellular carcinoma (HCC). Methods: A total...

A practical protocol has been established to access 2-aminoquinazolin-4(3H)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C−N bonds under mild...

Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia. Recent studies suggest that promoting \{beta}-arrestin-biased signaling in NTSR1 may diminish drugs of abuse, such as psychostimulants, there...

Background Osimertinib resistance remains a major challenge in the treatment of lung adenocarcinoma. Long non-coding RNAs (lncRNAs) have emerged as key regulators of drug resistance, but their roles in osimertinib resistance are poorly understood. This study aimed to identify lncRNAs driving osimertinib resistance and elucidate their molecular mech...

Allostery governs‌ the functional dynamics of proteins by regulating their conformational transitions. ‌The development of allosteric modulators has emerged as a promising therapeutic strategy‌, leveraging their superior target specificity ‌and reduced off-target effects compared to orthosteric compounds‌. ‌A critical barrier in this field remains‌...

Venetoclax (VEN)--based induction therapy has demonstrated considerable promise in treating acute myeloid leukemia (AML); however, the optimal VEN-based combination therapy remains to be established. This study evaluated the efficacy and safety of the venetoclax-homoharringtonine-cytarabine (VHA) regimen in patients with newly diagnosed (ND) AML. A...

Background As the objective overall response rate to immune checkpoint inhibitors (ICIs) is less than 30% in late stage or metastatic bladder cancer (BLCA), elucidating the intrinsic mechanisms of immune evasion is of great importance for the discovery of predictive and prognostic biomarkers and the exploration of novel targets for intervention. Re...

To explore clinical and pathological characteristics of tubal isthmic pregnancy. A single-center, retrospective clinicopathological cohort study was conducted in women diagnosed with tubal pregnancy that underwent salpingectomy in International Peace Maternal and Child Health Care Hospital from January 2018 to April 2023. A total of 598 eligible wo...

Selenium (Se), a potentially toxic trace element, undergoes complex biogeochemical cycling in the environment, largely driven by microbial activity. The reduction in selenate or selenite to elemental selenium is an environmentally beneficial process, as it decreases both Se toxicity and mobility. This reduction is catalyzed by enzymes encoded by va...

Lower respiratory tract microbiome constitutes a unique immune microenvironment for advanced non-small cell lung cancer as one of dominant localized microbial components. However, there exists little knowledge on the associations between this regional microbiome and clinical responses to anti-PD-1 immunotherapy from clinical perspectives. Here, we...

Engineering active sites on catalyst surface to enhance selective oxidation pathways in advanced oxidation processes (AOPs) is key to the efficient removal of pollutants. In this work, a method of loading bimetallic ions and simultaneously activating the surface of swine manure biochar using cetyltrimethylammonium bromide (CTAB) was developed. By a...

Purpose To compare the anatomical changes of the uterine niche in women before and after hysteroscopic niche resection (HNR) and to investigate the correlation between these changes and the improvement in postoperative spotting symptoms by thin-slice MRI. Methods This prospective observational study enrolled women with symptomatic uterine niches b...

Background Abdominal aortic aneurysm (AAA) is a severe aortic disease for which no pharmacological interventions have yet been developed. This investigation focused on identifying protein‐based therapeutic targets and assessing how proteins mediate the interplay between modifiable risk factors and AAA development. Methods Causal inferences between...

Glycogen accumulation is a typical feature in clear cell renal cell carcinoma (ccRCC). It has been reported that glycogen metabolism-related genes can promote the progression of ccRCC, but its role in molecular typing, prognosis, immune infiltration, and immunotherapy response has rarely been reported. We applied an unsupervised clustering approach...

Aims We aimed to develop Ferroptosis-Related Gene (FRG) signatures to predict overall survival (OS) along with disease-free survival (DFS) in individuals with colorectal cancer (CRC). Background Prediction of CRC prognosis is challenging. Ferroptosis constitutes a newly reported kind of cell death, and its association with CRC prognosis remains un...

The CRISPR-associated endonuclease Streptococcus pyogenes Cas9 (SpCas9) enables site-specific DNA cleavage by transitioning from a pre-catalytic conformation to a catalytically active state, yet how its HNH catalytic domain undergoes an approximately 40 Å displacement towards the target DNA has remained elusive. Here, we combined extensive unbiased...

Background Psoriasis is a common autoimmune inflammatory disease. Vitamin B6 is crucial for the body’s inflammatory response, yet the relationship between pyridoxal 5'-phosphate (PLP), 4-pyridoxic acid (4-PA), and vitamin B6 turnover (4-PA/PLP) in psoriasis remains unexplored. Objective To investigate the relationship of PLP, 4-PA and vitamin B6 c...

Ovarian cancer is one of the deadliest gynecological malignancies due to its late diagnosis and easy recurrence. Therefore, it is urgent to develop novel therapeutics for ovarian cancer treatment. In this study, we evaluated the anti-ovarian cancer effects of sempervirine in vitro and in vivo. CCK8 assays showed that sempervirine dose-dependently i...

In vitro fertilization-embryo transfer (IVF-ET) stands as one of the most prevalent treatments for infertility. During an IVF-ET cycle, the time interval between trigger shot and oocyte pickup (OPU) is a pivotal period for follicular maturation, which determines mature oocytes yields and impacts the success of subsequent procedures. However, accura...

Tamoxifen is one of the most frequently used endocrine medications for the treatment of estrogen receptor‐positive (ER + ) breast cancer (BC). Unfortunately, tamoxifen resistance (TR) brings more challenges to the clinical treatment, and the mechanisms of TR have not yet been fully clarified. HGF/c‐Met is closely associated with cancer metastasis,...

Constructed wetland (CW) technology has attracted much attention due to its economical and environmentally friendly features. The low dissolved oxygen (DO) and low carbon/nitrogen (C/N) ratio in the wetland influent water affect the treatment performance of CW, resulting in a decrease in the removal efficiency of ammonia nitrogen (NH 4 ⁺ -N) and ni...

Background Gut microbiome on predicting clinical responses to immune checkpoint inhibitors (ICIs) has been discussed in detail for decades, while microecological features of the lower respiratory tract within advanced non‐small‐cell lung cancer (NSCLC) are still relatively vague. Methods During this study, 26 bronchoalveolar lavage fluids (BALF) f...

The precise mechanisms behind early embryonic arrest due to sperm‐related factors and the most effective strategies are not yet fully understood. Here, we present two cases of male infertility linked to novel TDRD6 variants, associated with oligoasthenoteratozoospermia (OAT) and early embryonic arrest. To investigate the underlying mechanisms and p...

A solvent-controlled C2/C3-regioselective ring-opening/coupling strategy was developed to synthesize two types of 2-aminoethyl dithiocarbamates from aziridines, amines, and CS 2 .

A convenient methodology for the synthesis of benzo[c]naphthyridinone derivatives was developed via Rh(III)-catalyzed and Cu(I)-oxidized annulation of 3-diazooxindoles with 3-aryl-5-isoxazolones. This transformation involves in situ generation of tricyclic core through...

Individual organic components namely cellulose, xylan and lignin are fundamental and essential factors for generation of bio-based monocyclic aromatic hydrocarbons (MAHs) from pyrolysis of lignocellulosic biomass. In this study, the...

Extreme-environment temperature sensing above 2000°C represents a critical technological challenge for next-generation nuclear reactors, hypersonic propulsion systems, and deep-earth energy extraction. This study pioneers the development of novel mixed sesquioxide...

Generative drug design opens new avenues for discovering novel compounds within the vast chemical space rather than conventional screening against limited compound libraries. However, the practical utility of the generated molecules is frequently constrained, as many designs prioritize a narrow range of pharmacological properties while neglecting p...

The coastal wetland of the Yellow River Estuary, one of China’s largest wetlands, is essential for biodiversity conservation and ecosystem services. Ecological water replenishment, a typical wetland restoration measure in the Yellow River Delta, has significantly impacted the habitat of zoobenthos, which are critical indicators of ecosystem health...

Occupational and unintentional exposure of zinc oxide nanoparticles (ZnONPs) raises concerns regarding their neurotoxic potential and there is an urgent need for the development of effective agents to protect against the toxic effects of ZnONPs. Astragalus memeranaceus (AM), a famous Traditional Chinese Medicine, as well as its bioactive components...

Background Breast cancer remains the most prevalent malignancy in women. Chemotherapy is the primary systemic treatment modality, and the effectiveness of treatment is often hampered by chemoresistance. Autophagy has been implicated in promoting chemoresistance, as elevated autophagic flux supports tumor cell survival under therapeutic stress. Sinc...

Cell division cycle 37 (CDC37) is a member of the molecular chaperone family and acts as a cochaperone of heat shock protein 90 (HSP90), which is overexpressed in many cancer types as a regulator of protein kinase maturation. In this process, CDC37 selectively recognizes and stabilizes protein kinases by forming a HSP90‐CDC37‐kinase chaperone compl...

Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T-cell (CAR T-cell) therapy has exhibited remarkable efficacy in refractory or relapsed multiple myeloma (R/R MM), but recurrence and rapid progression of disease are still observed within a short time after treatment. Long-term pomalidomide therapy, which potentiates T-...

Ferroptosis represents a newly programmed cell death, and the process is usually accompanied with iron-dependent lipid peroxidation. Importantly, ferroptosis is implicated in a myriad of diseases. Recent literature suggests a potential position of ferroptosis in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD), the m...

Rupture of advanced carotid atherosclerotic plaques increases the risk of ischaemic stroke, which has significant global morbidity and mortality rates. However, the specific characteristics of immune cells with dysregulated function and proven biomarkers for the diagnosis of atherosclerotic plaque progression remain poorly characterised. Our study...

Cell division cycle 37 (CDC37) is a member of the molecular chaperone family and acts as a cochaperone of heat shock protein 90 (HSP90), which is overexpressed in many cancer types as a regulator of protein kinase maturation. In this process, CDC37 selectively recognizes and stabilizes protein kinases by forming a HSP90‐CDC37‐kinase chaperone compl...

Background : Rituximab is a monoclonal antibody that targets CD20 and can significantly improve the prognosis of patients with CD20-positive B-cell non-Hodgkin lymphoma (B-NHL). Nonetheless, a significant number of patients experience disease progression or relapse post-rituximab therapy. CD19-chimeric antigen receptor (CAR) T cells have demonstrat...

Introduction In patients with relapsed or refractory acute myeloid leukemia (R/R AML), FMS-like tyrosine kinase 3 (FLT3) gene mutation portends a poorer prognosis and survival. Gilteritinib, as a novel type I inhibitor, is a kind of highly selective and potent FLT3 inhibitor. It has been recommended by NCCN and ESMO guidelines for the treatment of...

Introduction The combination of venetoclax with hypomethylating agent (HMA) showed synergistic effects and most of the adverse events were manageable in preclinical studies of high-risk myelodysplastic syndromes (HR MDS), which provides a new therapeutic option for intermediate- and high- risk MDS patients. In addition, venetoclax-based combination...

The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....