Jian Gu

Jian Gu
The University of Arizona | UA · Department of Basic Medical Sciences

About

27
Publications
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890
Citations
Introduction
Skills and Expertise

Publications

Publications (27)
Article
A major hindrance to advances in the care of patients with malignant gliomas is the presence of the blood brain barrier (BBB) and blood-brain tumor barrier (BBTB) that greatly restricts drug access from the plasma to the tumor cells. Bubble-assisted Focused Ultrasound (BAFUS) has proven effective in opening the BBB for treatment of glial tumors in...
Article
Full-text available
Biological materials can be shipped off-site for diagnostic, therapeutic and research purposes. They usually are kept in certain environments for their final application during transportation. However, active reagent handling during transportation from a collection site to a laboratory or biorepository has not been reported yet. In this paper, we s...
Article
Full-text available
We report a shipping container that enables a disruptive logistics for cytogenetic biodosimetry for radiation countermeasures through pre-processing cell culture during transportation. The container showed precise temperature control (< 0.01 °C) with uniform sample temperature (< 0.1 °C) to meet the biodosimetry assay requirements. Using an existin...
Article
Full-text available
We report the development of system for packaging critical components of the traditional collection kit to make an integrated fingerstick blood collector for self-collecting blood samples of 100 μl or more for radiation countermeasures. A miniaturized vacuum tube system (VacuStor system) has been developed to facilitate liquid reagent storage, simp...
Article
Full-text available
Currently, the standard method for identifying biological agents of potential threats to national security and public health, such as pathogens, virus, and toxins, mainly rely on microbiological cultivation. This method is time-consuming and it requires sophisticated equipment and well-trained personnel, which are often unavailable in remote areas...
Article
The demand for polymer based electrochromic device is increasing in recent years due to not only the advantages of conjugated electrochromic polymers such as high color versatility, large optical contrasts, but also their potential applications in flexible devices. In this review, we focus on the state-of-the-art research activities related to the...
Article
Advances in molecular techniques have improved discovery of biomarkers associated with radiation exposure. Gene expression techniques have been demonstrated as effective tools for biodosimetry, and different assay platforms with different chemistries are now available. One of the main challenges is to integrate the sample preparation processing of...
Article
Dynamics of methanol and acetic acid (3:1, v/v) fixative sessile drop is important for metaphase chromosomal spreads in cytogenetic assays. However, it has not been well characterized by biologists from a physical science point of view. In this work, a simple optical setup was built to record the fixative drop spreading and evaporation process. Dro...
Article
We report the design and performance validation of microfluidic separation technologies for human identification using a disposable plastic device suitable for integration into an automated rapid DNA analysis system. A fabrication process for a 15-cm long hot-embossed plastic microfluidic devices with a smooth semielliptical cross section out of cy...
Article
Though many aspects of contact printing have been explored extensively since its invention, there are still hurdles to overcome for multilayer printing in the nanometer regime. Here we report on an aligned nanocontact printing (nCP) system that has demonstrated a sub-100 nm alignment capability by means of moiré fringes and microspacers. To address...
Chapter
This chapter will focus on development of DNA sequencing technologies. In the first section, we will review those next generation DNA sequencing (NGS) technologies presently on the market. While NGS has significantly reduced the time and cost of genome sequencing, there is great room for improvement and new technologies. The cycling process involve...
Article
Full-text available
We introduce a new scheme of nanocontact printing that fabricates nanoarrays using stamps generated by ultraviolet nanoimprint lithography. Array patterns can be generated by this printing technique in a high-density (number of features per unit area) fashion with a feature size as low as 30 nm and period of 100 nm. Sub-500 nm alignment accuracy fo...
Article
We present a simple sealing method to fabricate nanofluidic channels, where plasma treated polysilsesquioxane (PSQ) thin film on a rigid support is used to bond to a hydrophilic glass surface permanently at room temperature. This method shows precise dimension control below 10 nm with easy experimental setup. Using this method, one dimensional conf...
Article
In der Mitte getroffen: Regelmäßige Anordnungen selbstorganisierter funktioneller DNA-Nanoröhren sind mithilfe einer Kombination aus „Bottom-up“- und „Top-down“-Methoden zugänglich. Diese wiederum ermöglichen den Aufbau von Anordnungen aus Quantenpunkten, Proteinen und DNA-Zielmolekülen (siehe Bild; grün: DNA-Nanoröhre, rot: Streptavidin-Quantenpun...
Article
Meeting in the middle: Well-organized arrays of self-assembled functional DNA nanotubes can be constructed by combining bottom-up and top-down methods. Such DNA-nanotube arrays allow the construction of arrays of quantum dots, proteins, and DNA targets (see picture; green: DNA nanotube, red: streptavidin–quantum dot conjugate; scale bar: 20 μm).
Article
All polymer field effect transistors have been fabricated combining nanoimprint lithography and inkjet printing. Trenches with hydrophilic bottoms confined by hydrophobic walls with considerable height are patterned by nanoimprint lithography. Conducting polymer solutions were then delivered into these trench liquid containers by inkjet printing. D...
Article
We have constructed nanoscale molecular traps using electrodeless, or insulator-based, dielectrophoresis [1, 2]. The molecular traps consist an array of nanoscale dielectric constrictions defined using electron-beam lithography on nanofluidic passages. The device was then sealed using an extremely simple room-temperature sealing process with virtua...
Article
We report for the first time the use of orientation dependent etching (ODE) of (110) c-Si in sidewall thin film technology for imprint mask fabrication with low line edge roughness (LER) over a large area. Oxidation is used for sidewall thin film formation with a good critical dimension control. 2-dimensional oxidation effects are discussed. Featur...
Article
We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse...
Article
Nano optical biosensors employ the interaction between biomolecules and light confined in nanometer scale structures to report the bio-recognition events. This small scale sensing area/volume can ensure that small amount of biorecognition events could be detected. The exceptional sensitivity and high spatial density of nano optical biosensors make...
Article
Full-text available
We report the design, fabrication, and characterization of room-temperature Si single-electron memories using nanoimprint lithography (NIL). The devices consist of a narrow channel metal–oxide–semiconductor field-effect transistor and a sub-10-nm storage dot, which is located between the channel and the gate. The memories operate at room temperatur...
Article
Full-text available
Single-crystal silicon has been achieved by patterning amorphous silicon film on silicon dioxide substrate into nanoscale lines and nickel-induced lateral crystallization. Line width affects the single-crystal silicon formation significantly. Narrow line widths, 30 nm or less, resulted in little lateral crystallization; while for line widths above...
Article
The fabrication of micrometre- and nanometre-scale devices in silicon typically involves lithography and etching. These processes are costly and tend to be either limited in their resolution or slow in their throughput. Recent work has demonstrated the possibility of patterning substrates on the nanometre scale by 'imprinting' or directed self-asse...
Conference Paper
In this work, we report the fabrication of high performance thin-film transistors (TFTs) down to sub-100 nm regime using Pattern-controlled crystallization of Thin channel layer and High temperature annealing (PaTH). High temperature is used to improve the film quality. Thin body thickness (Tsi) is used to suppress the short channel effects. The de...
Article
Full-text available
Metal–oxide–semiconductor field-effect transistors (MOSFETs) with a wire-channel and wrap-around-gate (WW) structure were fabricated using electron beam lithography and reactive ion etching. The smallest devices have a 35 nm channel width, a 50 nm channel thickness, and a 70 nm channel length. Measurements showed that as the channel width of WW MOS...
Article
rapid STR typing. STR typing has been demonstrated on glass(1-3) and plastic(4, 5) microchip devices. However, sample preparation (DNA extraction and PCR) must still be done off chip. We are currently developing an integrated microfluidic system that integrates all of the necessary processing steps of forensic DNA STR marker analysis and performs t...

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