Jhakeshwar Prasad Chandel

• Doctor of Pharmacy
• Professor (Assistant) at Shri Shankaracharya College of Pharmaceutical Sciences Bhilai Chhattisgarh

Alzheimer's disease (AD) is characterized by the central feature of dysregulated metabolism of β-amyloid peptide (Aβ). BACE1, which is the enzyme responsible for the production of Aβ, has been identified as a promising therapeutic target. Recent research has uncovered a regulatory correlation between BACE1 and Clusterin, a glycoprotein that plays a...

Alzheimer's disease (AD), a neurological condition that worsens over time, affects millions of individuals worldwide. Because of this, effective intervention and therapy depend on early and precise detection. In recent years, encouraging findings have been obtained using data science and artificial intelligence (AI) techniques in the field of medic...

Sorrel tree leaf extract reduced silver nanoparticles (AgNPs) in the lab. The extract's phytochemicals slowed and stabilised silver nanoparticles. Characterising nanoparticle size, shape, and morphology required many approaches. UV-visible, FT-IR, XRD, and SEM were used. All synthesised nanoparticles were spherical and monodisperse. FTIR spectrum s...

To create once-daily composition, the floating microspheres were used to provide extended and uniform release in the stomach. Short processing times, little exposure of materials to high temperatures, and high encapsulation effectiveness are main benefits of this technique. The manufacture of metformin hydrochloride floating microspheres, assessmen...

Introduction: Cancer kills most of the people. Breast cancer will have the highest cases in 2020. Geography, genetics, hormones, oral contraceptives, and lifestyle may cause breast cancer, which may be treated in many ways. Radiation, chemotherapy, hormone treatment, and immunotherapy for breast cancer. Due to non-selectivity, multidrug resistance,...

Endometriosis is regarded as a spectrum disease with a wide range of subtypes and clinical manifestations. Endometriosis must be found to be present outside of (ectopic) the uterus in order to be defined histologically. These ectopic lesions are frequently found in the peritoneum and pelvic organs. They may occasionally exist in the bladder, kidney...

A METHOD OF PIMELIE KELONE COMPOUNDS ON THE CONSTITUENT FOR THE PREPARATION FOR THE TREATMENT OF DIABETES OF UTILIZING Establishing a connection between a first electrode 5 and subepithelial parenchymal tissue in the breast of the individual. Placing over the nipple of a breast a cup having an interior, and first and second openings, and an electro...

Lately, diabetic retinopathy (DR) is deliberated to be the major cause of blindness in today's world. There are various reasons for loss of eyesight but DR has greatly contributed to blindness. The main challenge of DR is that it is incurable at an early stage, therefore basic analysis is of great significance. Consequently, it is mentioned as a cl...

Abstract—Lately, diabetic retinopathy (DR) is deliberated to bethe major cause of blindness in today’s world. There are variousreasons for loss of eyesight but DR has greatly contributed toblindness. The main challenge of DR is that it is incurable at an earlystage, therefore basic analysis is of great significance. Consequently,it is mentioned as...

SYSTEMATIC FRAMEWORK INTEGRATED WITH MACHINE LEARNING APPROACHES FOR IDENTIFICATION AND DIRECTED DELIVERY OF NANOPARTICLES TO TUMORS Systematic framework integrated with Machine Learning approaches for Identification and Directed Delivery of Nanoparticles to Tumors is the proposed invention . The invention focuses on designing an efficient framewor...

MACHINE LEARNING BASED APPROACH TO PREDICT THE VARIOUS MYELOSUPPRESSION AGENT THAT CAN BE USED ALONG WITH HYDROXYUREA IN IMPROVING THE CONDITION OF SICKLE CELL ANAEMIA Machine Learning based approach to Predict the Various Myelosuppression Agent that can be used along with Hydroxyurea in improving the condition of Sickle Cell Anaemia is the propose...

ARTIFICIAL INTELLIGENCE BASED APPROACH TO STUDY THE IMPACT OF TOPICAL NANO ADJUVANTS FOR ERADICATION OF SKIN CANCER Eradication of Skin Cancer is the proposed invention. The proposed invention focuses on analysing the properties of nano adjuvants in eradicating skin cancer. The intention of the proposed invention Artificial Intelligence based appro...

ARTIFICIAL INTELLIGENCE BASED APPROACH TO ANALYSE THE THERAPEUTIC EFFECT OF DRUGS THAT ARE OBTAINED FROM MARINE IN THE TREATMENT OF CANCER Artificial Intelligence based approach to analyse the Therapeutic Effect of Drugs that are obtained from Marine in the Treatment of Cancer is the proposed invention. The invention aims at implementing algorithms...

MACHINE LEARNING BASED APPROACH TO STUDY AND ANALYSE THE ANTIBACTERIAL EFFECTS OF SILVER NANOPARTICLES FOR HEALING DENTAL ISSUES Machine learning based approach to study and analyse the antibacterial effects of silver nanoparticles for healing dental issues is the proposed invention. The proposed invention focuses on analysing the properties of sil...

Cardiovascular diseases (CVDs) have emerged as a major danger to human life and health. Despite the fact that numerous medicines working through various mechanisms of action are available in the market as traditional formulations for the treatment of CVDs, they are still far from adequate due to poor water solubility, limited biological activity, n...

A MACHINE LEARNING BASED APPROACH FOR EARLY PREDICTION OF NEURODEGENERATIVE DISORDER A machine learning based approach for early prediction of neurodegenerative disorder is the proposed invention. The proposed invention focuses on implementing a module of machine learning to identify the early onset of neurodegenerative disorders. Studying the phys...

Artificial intelligence-based approach to analyse the neurological disorder that erupt during covid 19 pandemic is the proposed invention. The invention focuses on designing an artificial intelligence model to analyse the cause and effect of neurological disorder. The pandemic was a very huge impact on the mindset of the human population across the...

MACHINE LEARNING BASED BIG DATA ANALYTICS OF PATIENTS SUFFERING FROM CANCER Machine learning based big data analytics of patients suffering from cancer is the proposed invention. The invention focuses on implementing a machine learning based approach to analyze and dig the big data sets. The proposed invention aims at achieving higher efficacy in t...

ABSTRACT A RETROSPECTIVE DATA ANALYSIS OF LUNG CANCER RELATED ASPECTS A retrospective data analysis of lung cancer related aspects is the proposed invention that focuses on identifying the actual cause of the disease. The proposed invention concentrates on two p’s i.e., prevention and prediction. The invention will analyze the parameters of data se...

Floating drug delivery systems are planned for the less soluble, unbalanced and they have small bulk density than the gastric content similarly they float in the stomach for an extended period of time. From this the planning of floating microspheres is one of the method in conveying a dosage form to the target site in sustained controlled release m...

Diabetes mellitus has become a global epidemic over the past few decades and is one among the major causes of death worldwide. Although various modern medicines are in the market, herbal medicines have usually maintained worldwide popularity in achieving the primary health care needs of the diabetic population because of the multiple adverse effect...

Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% and half-life of about 3 hrs, and is soluble only at acidic pH. Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers a...

Background: Bacopa monnieri Linn. an important medicinal plant in Indian system of alternative medicine belonging to Scrophulariaceae family. It is distributed in the wet and marshy lands throughout India, Nepal and many other parts of world. This study was carried out to evaluate the natural and micropropagated Bacopa monnieri plant extract for an...

Diabetes mellitus has become a global epidemic over the past few decades and is one among the major causes of death worldwide. Although various modern medicines are in the market, herbal medicines have usually maintained worldwide popularity in achieving the primary health care needs of the diabetic population because of the multiple adverse effect...

The objective of the study was to evaluate anti-bacterial and anti-Inflammatory activities of polymeric microparticles. In vitro antibacterial activity was performed for prepared microparticles followed by in vivo anti-inflammatory activity on rats. From the present study, it was observed that the microparticles developed were appropriate in their...

Transdermal drug delivery system is a novel approach in drug delivery system. Human skin is the largest organ of the body and TDDS take it into scene for the administration of drug. Present work focuses on describing about TDDS, components of TDDS such as drug, polymers and penetration enhancers. It also describes the different types of TDDS along...

The aim of the present research work was to formulate, characterized and evaluate the Acacia arabica microparticles for therapeutic influence. In this research we have developed Acacia arabica microparticles. Microparticles were prepared by solvent diffusion evaporation technique. Particle size and size distribution of prepared microparticles was d...

Philosophers, cognitive and social psychologists and laypeople frequently subscribe to the view that self control (will power) is one of anthers approach to recovery from addiction. But there are reasons to suspect that willpower is a good deal less crucial to explaining recovery than this view shows. Methods Here we report findings from a qualitat...

The corona virus disease 2019 (COVID-19) pandemic reason for worldwide outbreak of respiratory illness. We are enriched with herbal drugs. Impaired immune function is one of the important factors for key role for pathogenesis of COVID-19. A number of studies have been carried out for establishment of remedies for corona by using anti-virals or immu...

G protein coupled receptors (GPCRs) moreover called as metabotropic receptor addresses the greatest gathering of film proteins in the human genome. GPCRs share a regular essential characteristic of seven hydrophobic transmembrane (TM) sections (heptahelical structure), with an extracellular amino end and an intracellular carboxyl end their assistan...

Background: Bacopa monnieri Linn. an important medicinal plant in Indian system of alternative medicine belonging to Scrophulariaceae family. It is distributed in the wet and marshy lands throughout India, Nepal and many other parts of world. This study was carried out to evaluate the natural and micropropagated Bacopa monnieri plant extract for an...

In these present study, two different series of experiments such as evaluation for toxicity and therapeutic of effectiveness of Aesculus hippocastanum co-administered low viscosity of sodium alginate has been carried out by using rat model (Acetic acid-induced ulcerative colitis). Acute and subacute toxicities were performed according to OECD guide...

The present study has been undertaken to evaluate antihyperlipidemic and antioxidant activities of Terminalia Arjuna (TA) and Commiphoramukul (CM) standardized extracts in combination at their predetermined doses. The hyperlipidemia in animals (rats) was induced by high fat diet by mixing Indian vanaspati ghee and coconut oil in the ratio of 3:1 (v...

In these present study, two different series of experiments such as evaluation for toxicity and therapeutic of effectiveness of Aesculus hippocastanum co- administered low viscosity of sodium alginate has been carried out by using rat model (Acetic acid-induced ulcerative colitis). Acute and subacute toxicities were performed according to OECD guid...

In current research work our aim was to formulation conniving, characterization, and in vitro and in vivo anti-inflammatory activity in rats. During this research we have formulated Acacia arabica microparticles by solvent diffusion evaporation technique. From prepared microparticle particle of size and size of distribution study was done. It was e...

Peptic ulcer disease (PUD) is an uncommon disorder of early life. Peptic ulceration of the stomach or duodenum is usually associated with abnormalities of the gastric mucosa such as gastritis and/or gastropathy. Gastritis and ulcers of the stomach and duodenum can be classified into either primary or secondary depending on their aetiologies. The ma...

The aim of the present research work was to formulate, characterized and evaluate the Acacia arabica microparticles for therapeutic influence. In this research we have developed Acacia arabica microparticles. Microparticles were prepared by solvent diffusion evaporation technique. Particle size and size distribution of prepared microparticles was d...

Objective: The present study was performed to determine in vitro antidiabetic effect of neohesperidin. To evaluate inhibitory effect of neohesperidin on α-amylase and α-glucosidase diabetes causing enzyme. Methods and Materials: Invitro carbohydrate metabolizing enzyme based inhibitory methods were used to determine antidiabetic effect of neohesper...

The aim of this work was to develop and evaluate curcumin loaded liposome and its bio- enhancement. Curcumin was selected as a natural drug for liposome formulation. Curcumin show variety of biological activity but it also shows poor bioavailability due to low aqueous solubility (1 µg/ml), poor absorption and rapid metabolism so that piperine was s...

This book defining the medicinal value of Terminalia Arjuna and Commiphora Mukul. Readers will find exhaustive note on mechanism and pharmacological actions of plants. Toxicity evaluation of plants will provide the safety level of consumption for medicinal purposes. The work was based on determination of therapeutic potential of plants against hype...

ABSTRACT: Wound is an injury to living tissue caused by a cut, blow or broken mainly the outer membrane. Wound healing requires a precised control for derivative and regenerative processes, which is involved in several types of cell and complex interactions between multiple biological processes in the living body. It is achieved throughout four pre...

Novel approaches of drug delivery such as formulating the polymeric nanoparticles is revolutionizing the future of medicines. However there are several methods to prepare polymeric nanoformulation such as thin film hydration, Solid dispersion, Emulsion polymerization, Fessi method, emulsion-diffusion-evaporation method, interfacial polymerization m...

ABSTRACT The systemic use of cytotoxic agents to disrupt mitosis in rapidly dividing cancer cells, with foreseeable dose-limiting haematological toxicities. Targeted therapies affect specific cellular molecular mechanisms promoting cancer cell survival and proliferation, enabling treatment tailored to specific tumour characteristics. The key pathwa...

The investigations on economic feasibility of intercropping arvi (Colocassia esculenta var. antiquarum), bunda (C. esculenta var. esculenta), suran (Amarphophallus companulatus) and turmeric (Curcuma domestica) were conducted under guava (cv. L-49) plantation. Guava + Suran cropping system provided highest net return (Rs. 123.80 thousands per ha),...

The investigation on suitability of vegetable crops as intercrops was conducted at the Main Experiment Station, Department of Horticulture, N.D.U.A. & T., Kumargaj, Faizabad (U.P.). The maximum plant height (93.71 cm), plant spread (71.13 cm) and stem diameter (3.62 cm) were observed in suran followed by turmeric and bunda. The maximum fresh and dr...

Shear strength of concrete especially fibre based is a complex phenomenon involving number of variables giving rise to lengthy equations with cumbersome calculations thereby making it difficult to use these equations in practice in design offices and thus rendering fibre based concrete unpopular in construction industry from users'point of view. In...