Jesus Simal-Gandara

Jesus Simal-Gandara
University of Vigo | UVIGO · Department of Analytical and Food Chemistry

Highly-Cited Researcher

About

821
Publications
222,511
Reads
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Introduction
Jesus Simal-Gandara, Professor in Nutrition and Food Science at the Faculty of Food Science and Technology, University of Vigo (Spain) He was 1st Spanish Award of Completion of Pharmacy and PhD Prize at the Faculty of Pharmacy, University of Santiago de Compostela (Spain). He also was Associate Professor in 1991 at the University of Vigo, where he is Full Professor since 1999. He now leads a research group of excellence at NW Spain, in addition to CIA3 (Environmental, Agricultural and Food Research Center) formed by 10 research groups from different fields (botany, plant physiology, soil science and agricultural chemistry, biochemistry and molecular biology, nutrition and food science, biotechnology, food technology, food rheology, chemical engineering, and colloidal chemistry), and also is the Head of the Department of Analytical Chemistry and Food Science at the University of Vigo. He performed research stays at the Université de Paris-Sud (Paris, France), University of Delaware (Newark, USA), Fraunhofer-Institut für Lebensmitteltechnologie und Verpackung (Munich, Germany), Central Science Laboratory (Norwich and York, UK), TNO-Voeding (Zeist, Netherlands), Packaging Industries Research Association (Leatherhead, UK) and The Swedish Institute for Food and Biotechnology (Gothenburg, Sweden). He is editor of 4 national books. He published book chapters in 10 national and 14 international books. He directed 15 doctoral theses and participated in lots of competitive research projects, of which he was principal investigator at 20. He has numerous publications in international journals (http://scholar.google.es/citations?user=rmeHFXIAAAAJ&hl=es&oi=ao). His research group is specialized in chromatographic separations (GC-MS and LC-MS) and molecular biology and proteomics. He investigates the distribution of agricultural and environmental organic chemical contaminants in the food production chain, and how improving the sensory and functional quality of food, with an eye on the food chain globally, integrating environment, agriculture and food with nutrition and public health issues. His focus today is on the study of persistent organic pollutants (POPs) from the point of view of public health (epidemiology, toxicity of mixtures, metabolites ...), and on the study of secondary metabolites in plant foods, exploring the molecular mechanisms that explain their activity.
Additional affiliations
November 1991 - present
University of Vigo
Position
  • Head of Department
Education
September 1988 - July 1991
University of Santiago de Compostela
Field of study
  • Analytical Chemistry, Nutrition, and Food Science

Publications

Publications (821)
Article
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Inducing natural resistance against pathogen infection in postharvest citrus by exogenous elicitor is a promising alternative to reduce postharvest losses. Here, the potential induced resistance mechanism of blended cinna-maldehyde, carvacrol and eugenol nano-emulsion against P. digitatum in 'Newhall' navel orange (Citrus sinensis (L.) Osbeck) was...
Article
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The sea is a vast ecosystem that has remained primarily unexploited and untapped, resulting in numerous organisms. Consequently, marine organisms have piqued the interest of scientists as an abundant source of natural resources with unique structural features and fascinating biological activities. Marine macrolide is a top-class natural product wit...
Article
Gels refer to the soft and flexible macromolecular polymeric materials retaining a large amount of water or biofluids in their three-dimensional network structure. Gels have attracted increasing interest in the food discipline, especially proteins and polysaccharides, due to their good biocompatibility, biodegradability, nutritional properties, and...
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This study aims to determine the impact of dietary energy levels on rumen microbial composition and its relationship to the quality of Black Tibetan sheep meat by applying metabolomics and Pearson's correlation analyses. For this purpose, UHPLC-QTOF-MS was used to identify the metabolome, whereas 16S rDNA sequencing was used to detect the rumen mic...
Article
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Introduction Fenofibrate is an agonist of peroxisome proliferator activated receptor alpha (PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties. Fenofibrate is effective against a variety of viral infections and different inflammatory disorders. Therefore, the aim of critical review was to overview the potential r...
Article
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In the past few years, phytochemicals from natural products have gotten the boundless praise in treating cancer. The promising role of cruciferous vegetables and active components contained in these vegetables, such as isothiocyanates, indole-3-carbinol, and isothiocyanates, has been widely researched in experimental in vitro and in vivo carcinogen...
Poster
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The continuous increased resistance of pathogenic microorganisms to antibiotics is a serious public health problem worldwide. In the last decades, numerous studies have been focused on exploring and developing effective natural additives with antimicrobial potential based on natural matrices such as plants and new strategies to prevent this multi-r...
Article
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Breast cancer (BC) is the most prevalent neoplasm among women. Genetic and environmental factors lead to BC development and on this basis, several preventive – screening and therapeutic interventions have been developed. Hormones, both in the form of endogenous hormonal signaling or hormonal contraceptives, play an important role in BC pathogenesis...
Article
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Macroalgae have been recently used for different applications in the food, cosmetic and pharmaceutical industry since they do not compete for land and freshwater against other resources. Moreover, they have been highlighted as a potential source of bioactive compounds. Red algae (Rhodophyta) are the largest group of seaweeds, including around 6000...
Article
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A method for the simultaneous determination of 19 succinate dehydrogenase inhibitor (SDHI) fungicide residues in 8 kinds of cereals was established by combining UHPLC-MS/MS with the improved QuEChERS method. MgSO4 and octadecylsilane (C18) were used as the dispersive-solid phase extraction sorbent. The proposed method had good linearity in the rang...
Article
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Fisetin (Fis), quercetin (Que), and myricetin (Myr) are flavonols with similar structure but different number of hydroxyl groups. The present research focused on the anti-inflammatory effect of these three flavonols in lipopolysaccharide-stimulated RAW264.7 cells. The number and site of hydroxyl group in flavonols obviously affected their anti-infl...
Conference Paper
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Commonly used antibiotics use multiple administrations for providing a continuous bac-tericidal effect but can increase systemic toxicity, as well as lead to bacterial drug resistance [1,2]. The use of plant-based antibacterial compounds in combination with conventional antibiotics to treat drug-resistant infections could be an alternative to overc...
Article
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Brown macroalgae are a potential source of natural pigments. Among them, Undaria pinnatifida is recognized for its high concentration of fucoxanthin (Fx), which is a pigment with a wide range of bioactivities. In this study, three independent parameters were optimized for conventional heat extraction (CHE) to maximize the recovery of Fx from Undari...
Article
Fruits contain enormous source of vitamins that provides energy to the human body. These are also affluent in essential and vital vitamins, minerals, fiber, and health-promoting components, which has led to an increase in fruit consumption in recent years. Though fruit consumption has expanded considerably in recent years, the use of synthetic chem...
Conference Paper
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Nowadays, medicinal plants have different uses since they can play an important role in the design of modern medicines and new healthy foods. Although their consumption is not high, these plants are attributed pharmacological properties with beneficial properties such as antioxi-dant, anti-inflammatory, or antimicrobial, among others [1]. The study...
Conference Paper
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Ascophyllum nodosum (Linnaeus) Le Jolis is a brown alga from the Fucaceae family and the unique species from the Ascophyllum genus. This brown alga is an edible macroalga from the North Atlantic Ocean, commonly found on the European northwestern coast. High-value bioactive molecules such as pigments, polyphenols, and phlorotannin [1,2] have been fo...
Conference Paper
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The increased resistance of pathogenic microorganisms to a wide range of antibiotics has driven recent research efforts towards exploring and developing effective preservatives with better potential and new strategies to prevent this multi-resistance. Many of these studies have been on natural matrices such as plants [1]. This is in line with consu...
Article
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Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phyto-chemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties...
Article
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The goal of this study was to investigate the effects of three different extracts of Saussurea costus roots (ethanol, methanol, and water) as a food additive in alleviating the harmful effect of sodium nitrite in rat meals. Thirty-five adult male rats were divided into five groups as follows: control, sodium nitrite (NaNO2; 75 mg/kg BW, single oral...
Article
For persons who survive with progressive cancer, nutritional therapy and exercise may be significant factors to improve the health condition and life quality of cancer patients. Nutritional therapy and medications are essential to managing progressive cancer. Cancer survivors, as well as cancer patients, are mostly extremely encouraged to search fo...
Article
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Background The demand of maize crop is increasing day by day, hence to reduce the production and demand gap, there is a need to extract the high yielding parental lines to improve per se yield of the hybrids, which could help to enhance the productivity in maize crops. Methods and results The present investigation was carried out to select the bes...
Article
Recent studies have explored the field of extracellular vesicles (evs), driving an increasing interest in their application to human health. evs have unique physicochemical traits to participate in intercellular communication, thus fostering the idea of using evs to yield synergistic, preventive, and therapeutic effects. Many reports have shown tha...
Article
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The global prevalence of prediabetes is on the rise, and it is of value to manage prediabetes and predisposal to diabetes at an early stage. Myricetin is a natural poly-hydroxyflavonoid, found in planta with several health benefits. This study aimed to evaluate the effects of myricetin on prediabetes. In vitro assay indicated that the cell viabilit...
Article
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Biofilm has been a point of concern in hospitals and various industries. They not only cause various chronic infections but are also responsible for the degradation of various medical appliances. Since the last decade, various alternate strategies are being adopted to combat the biofilm formed on various biotic and abiotic surfaces. The use of enzy...
Article
Background The food industry constantly searches for natural derived bioactive molecules with preventive and therapeutic effects using innovative and sustainable strategies. Fig production and processing generate a considerable amount of by-products (leaves, pulp, peels, seeds, and latex) with limited commercial exploitation and negative impact on...
Article
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Quercetin is evidently unstable in Dulbecco's modified Eagle's medium (DMEM) at 37°C. However, the underlying mechanism of this instability is not clear yet. The stability and new degradation products of quercetin in DMEM at 37°C were investigated via in UPLC‐MS‐MS analysis. With increasing incubation time, quercetin formed various degradation prod...
Article
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The chemical content of plant excerpts can be efficiently employed to reduce the metal ions to nanoparticles in the one-pot green production method. Here, green production of silver nanoparticles (AC-AgNPs) is performed by means of Allium cepa var. Aggregatum (shallot) extract as a stabilizer and reducer. The shape, size, and morphology of resultan...
Article
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Myristica fragrans (Houtt.) is an evergreen tree native to the Maluku Islands, Indonesia. M. fragrans kernel is extensively used in Indian traditional medicines to treat various diseases. Several studies attempt to compile and interpret the pharmacological potential of Myristica fragrans (Houtt.) aqueous and various chemical extracts. Thus, the pha...
Article
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The emergence of several novel SARS-CoV-2 variants regarded as variants of concern (VOCs) has exacerbated pathogenic and immunologic prominences, as well as reduced diagnostic sensitivity due to phenotype modification-capable mutations. Furthermore, latent and more virulent strains that have arisen as a result of unique mutations with increased evo...
Article
The field of analytical sciences has witnessed emergent techniques for efficient detection of clinical and industrial food adulterants. In this review, the contributions made by the paper-based devices are highlighted for an efficient and rapid detection of food adulterants and additives, which is the need of the hour and how different categories o...
Article
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Cancer accounted for almost ten million deaths worldwide in 2020. Metastasis, characterized by cancer cell invasion to other parts of the body, is the main cause of cancer morbidity and mortality. Therefore, understanding themolecular mechanisms of tumor formation and discovery of potential drug targets are of great importance. Gene editing techniq...
Article
Mycotoxins are produced primarily as secondary fungal metabolites. Mycotoxins are toxic in nature and naturally produced by various species of fungi, which usually contaminate food and feed ingredients. The growth of these harmful fungi depends on several environmental factors, such as pH, humidity, and temperature; therefore, the mycotoxin distrib...
Poster
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In recent decades, the interest of compounds with antioxidant properties has increased due to their involvement in biological systems and their implicit functions in a variety of chronic disorders. The genus Camellia is a genus rich in antioxidant compounds, so products derived from camellias such as teas and oils have been used in a traditional wa...
Article
This study aimed to explore the effects of different feeding regimes on muscle metabolism and its association with meat quality of Tibetan sheep through correlation analysis of meat quality and differential metabolites using untargeted and targeted metabolomics. The untargeted metabolome was detected by UHPLC-QTOF-MS, and the targeted metabolome wa...
Article
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Cadmium (Cd) is one of the potent occupational and environmental toxicants, which induces oxidative stress to the multiple organs of the body, including liver. The present investigation was planned to evaluate the protective role of vitexin against Cd-prompted hepatotoxicity in rats. 24 male rats were divided into 4 groups viz. control, Cd-induced...
Article
Cardiometabolic diseases (CMD) have a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis interacting and feedbacking each other. The natural flavonoid chrysin, has been shown to possess a broad spectrum of therapeutic activities...
Article
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This study focuses on the determination of the chemical profile of 24 non-aged Brazilian artisanal sugarcane spirits (cachaça) samples through chromatographic quantification and chemometric treatment via principal component analysis (PCA) and Kohonen's neural network. In total, forty-seven (47) chemical compounds were identified in the samples of n...
Article
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Background The plant growth is influenced by multiple interactions with biotic (microbial) and abiotic components in their surroundings. These microbial interactions have both positive and negative effects on plant. Plant growth promoting bacterial (PGPR) interaction could result in positive growth under normal as well as in stress conditions. Met...
Article
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Background With the globalization of trade, the current fresh fruit supply chain now incorporates multiple entities, wide distribution, and intricate transactions. This brings about the issues of information tamper resistance, supply-demand relationship, and traceable supervision. Blockchain is a distributed ledger technology with advantages of tam...
Article
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Meat constitutes one the main protein sources worldwide. However, ethical and health concerns have limited its consumption over the last years. To overcome this negative impact, new ingredients from natural sources are being applied to meat products to obtain healthier proteinaceous meat products. Algae is a good source of unsaturated fatty acids,...
Poster
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Type 2 diabetes mellitus is a complex metabolic disorder described by hyperglycemia and glucose intolerance. It is considered a new pandemic and its control involves numerous challenges[1]. Currently, the most common treatments consist of the use of oral hypoglycemic agents and insulin, treatments that have shown side effects(cardiovascular problem...
Poster
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Medicinal plants have been traditionally used throughout time as therapeutic treatments. These plants possess different compounds with antioxidant, anti-inflammatory and antimicrobial properties of industrial interest. In particular, the plants Achillea millefolium L., Arnica montana L., Calendula of icinalis L., Chamaemelum nobile L. All. and Tara...
Article
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Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subj...
Conference Paper
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Agroindustry generates different types of waste every year, among which are food suitable for human consumption, but without commercial value since they do not meet the strict marketing parameters. In this sense, the Food and Agriculture Organization of the United Nations (FAO) estimates that food losses reach 1,300 million tons, 44% corresponding...
Article
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Background FSGS (focal and segmental glomerulosclerosis) is a clinical-pathologic condition marked by segmental and localized glomerular damages. Despite investigations, the molecular mechanisms behind FSGS development remain to be more clarified. By a comprehensive analysis of a FSGS related array set, the aim of this study was to unravel the top...
Conference Paper
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Sargassum muticum is an invasive brown macroalga in Galicia (Spain). Thus, exploitation of this biomass for the extraction of bioactive compounds could be an interesting strategy to add value to food supplements and functional foods. Among these compounds, fucoxanthin (Fx) has been gaining attention for its promising biological activities such as a...
Conference Paper
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Current research has shown that oily fish, specifically pelagic species like blue shark (Pri-onace glauca), shortfin mako (Isurus oxyrinchus), swordfish (Xiphias gladius) and bluefin tuna (Thunnus thynnus), are a rich source of essential nutrients like proteins (15-21%), lipids (0.5-3.3%), carbohydrates, vitamins A and D and minerals, like calcium...
Conference Paper
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The scarcity of natural resources and a higher incidence of diseases related to inappropriate eating habits have focused research on the search for food and nutraceutical products with functional properties that are respectful of the environment. Agro-industrial by-products are a profitable source for obtaining bioactive compounds, with various bio...
Conference Paper
Full-text available
The scarcity of natural resources and a higher incidence of diseases related to inappropriate eating habits have focused research on the search for food and nutraceutical products with functional properties that are respectful of the environment. Agro-industrial by-products are a profitable source for obtaining bioactive compounds, with various bio...
Conference Paper
Full-text available
Sargassum muticum is an invasive brown macroalga and several attempts have been made to control and eradicate this species with little success because its time consuming and costly. Thus, exploitation of this biomass for the extraction of bioactive compounds could be an interesting strategy to add value to food supplements and functional foods [1]....
Article
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Coriandrum sativum (coriander) is an edible herb in the family Q1 Q2 Apiaceae. The leaves, fruits, and stems of C. sativum have long been used as culinary spice due to their favorable odor. Traditional practitioners used this plant for treating different diseases like blepharitis, scabies, aphthous stom-atitis, laryngitis, headache, and palpitation...
Article
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The world population is expected to reach almost 10,000 million in 2050, which entails the need to focus on sustainability and its three pillars: the economy, the environment, and society [...]
Article
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Among the various types of cancer, lung cancer is the second most-diagnosed cancer worldwide. The kinesin spindle protein, Eg5, is a vital protein behind bipolar mitotic spindle establishment and maintenance during mitosis. Eg5 has been reported to contribute to cancer cell migration and angiogenesis impairment and has no role in resting, non-divid...