Jesús Rodríguez Huertas

Jesús Rodríguez Huertas
University of Granada | UGR · Instituto de Nutrición y Tecnología de Alimentos "José Mataix"

Full Professor of Physiology

About

132
Publications
39,468
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2,818
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Introduction
Jesús Rodríguez Huertas currently works at the Instituto de Nutrición y Tecnología de Alimentos "José Mataix", University of Granada. Jesús does research in Physiology, Molecular Biology and Human Biology. Their current project is 'Skeletal muscle mitochondria and exercise. Effects of intensity and antioxidant supplementation'.
Additional affiliations
January 1991 - December 2009
Universidad de Granada
January 1991 - December 1995
University of Bologna
January 1985 - February 2017
University of Granada
Position
  • Managing Director

Publications

Publications (132)
Article
Full-text available
A triathlon is an endurance event in which athletes need an efficient hydration strategy since hydration is restricted at different stages. However, it seems that seawater intake can be a suitable hydration alternative for this type of endurance event. Therefore, the aim of this study was to evaluate the efficacy of seawater hydration during a tria...
Article
Numerous dietary strategies are currently used for the prevention of metabolic diseases and for weight loss. Some of the strategies that are used do not have an appropriate physiological-nutritional basis and do not take into account the genetic changes that have occurred recently. Thus, in certain cases, they can be harmful to human health. This r...
Article
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Resumen Actualmente se utilizan numerosas estrategias dietéticas para la prevención de enfermedades metabólicas y la pérdida de peso. Algunas de las estrategias utilizadas no tienen base fisiológica-nutricional apropiada y no tienen en cuenta los cambios genéticos que han ocurrido de forma reciente, por lo que en ciertos casos pueden resultar perju...
Preprint
Full-text available
Objectives To investigate whether recombinant human erythropoietin (rHuEPO) injections during an altitude training camp impact heart function. Methods Thirty-nine (16 women) moderately trained subjects stayed at 2,320 m altitude for 4 weeks while training. Subjects were randomized to placebo (isotonic saline) or rHuEPO (20 IU/kg body weight) i.v....
Article
Full-text available
We tested whether physiological doses of hydroxytyrosol (HT) may alter the mRNA tran- scription of key metabolic genes in exercised skeletal muscle. Two groups of exercise-trained Wistar rats, HTlow and HTmid, were supplemented with 0.31 and 4.61 mg/kg/d of HT, respectively, for 10 weeks. Another two groups of rats were not supplemented with HT; on...
Article
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Background The purpose of this study was to investigate the inflammatory response, lipid peroxidation and muscle damage in men and women athletes subjected to an acute resistance exercise. Methods Twenty college athletes (10 men and 10 women) performed a half-squat exercise consisting of five incremental intensities: 20%, 40%, 60%, 80% and 100% of...
Article
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The incidence and severity of metabolic diseases can be reduced by introducing healthy lifestyle habits including moderate exercise. A common observation in age-related metabolic diseases is an increment in systemic inflammation (the so-called inflammaging) where mitochondrial reactive oxygen species (ROS) production may have a key role. Exercise p...
Article
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Objective Several working groups (eg, miners, flight crews and soldiers) are subjected to chronic intermittent hypoxic exposure. The cardiovascular implications have been studied but not systematically reviewed with focus on possible negative health implications. The aim of the present review was to systematically evaluate the hypothesis that inter...
Article
Training induces a number of healthy effects including a rise in skeletal muscle (SKM) glucose uptake. These adaptations are at least in part due to the reactive oxygen species produced within SKM, which is in agreement with the notion that antioxidant supplementation blunts some training‐induced adaptations. Here, we tested whether hydroxytyrosol...
Article
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Mitochondrial respiratory complexes assemble into supercomplexes (SC). Q-respirasome (III 2 + IV) requires the supercomplex assembly factor (SCAF1) protein. The role of this factor in the N-respirasome (I + III 2 + IV) and the physiological role of SCs are controversial. Here, we study C57BL/6J mice harboring nonfunctional SCAF1, the full knockout...
Article
Mitochondria are the hub for energy production within living cells. They can undergo morphological changes in response to nutrient availability and cellular stress. Here, we review how exercise chronically and acutely affects mitochondrial dynamics. Moreover, we discuss whether mitochondrial dysfunction observed in elderly subjects is due to the ag...
Article
Bench press (i.e. arm-based) and half-squat (i.e. leg-based) are exercises commonly used to increase and evaluate muscular strength. In addition to differences in the location of the muscles that participate in each exercise, the total muscle mass required for the latter is larger than that involved in the former. The aim of this study is to analyz...
Preprint
Full-text available
Mitochondrial respiratory complexes assemble into different forms of supercomplexes (SC). In particular, SC III 2 +IV require the SCAF1 protein. However, the structural role of this factor in the formation of the respirasome (I+III 2 +IV) and the physiological role of SCs are controversial. Here, we study C57BL/6J mice harbouring either non-functio...
Article
Full-text available
The objective of this study was to determine the acute (one single dose), subacute (14 days), and sub-chronic (90 days) toxicity of an aqueous virgin olive oil (VOO) extract rich in hydroxytyrosol in rats. For acute/subacute toxicity, rats were divided into three groups. The control group received distilled water (n = 9), another experimental group...
Article
Full-text available
The Mediterranean diet is considered as the foremost dietary regimen and its adoption is associated with the prevention of degenerative diseases and an extended longevity. The preeminent features of the Mediterranean diet have been agreed upon and the consumption of olive oil stands out as the most peculiar one. Indeed, the use of olive oil as the...
Article
The main objective of this work was to investigate whether mitochondrial fusion occurs in the skeletal muscle of well-trained athletes in response to high-intensity exercise. Well-trained swimmers (n = 9) performed a duration-matched sprint interval training (SIT) and high-intensity high-volume training (HIHVT) session on separate days. Muscle samp...
Article
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Introduction: Milk and dairy products are key foods during all stages of life within a balanced Western diet. In recent decades, their consumption has decreased significantly. In parallel, an increase in some pathological alterations caused by the deficit of some micronutrients present in dairy products, mainly calcium and vitamin D, has been dete...
Article
Full-text available
Milk and dairy products are key foods during all stages of life within a balanced Western diet. In recent decades, their consumption has decreased significantly. In parallel, an increase in some pathological alterations caused by the deficit of some micronutrients present in dairy products, mainly calcium and vitamin D, has been detected, resulting...
Article
Full-text available
Skeletal muscles require the proper production and distribution of energy to sustain their work. To ensure this requirement is met, mitochondria form large networks within skeletal muscle cells, and during exercise, they can enhance their functions. In the present review, we discuss recent findings on exercise-induced mitochondrial adaptations. We...
Article
Hydroxytyrosol (HT) has been demonstrated to improve mitochondrial function, both in sedentary and in exercised animals. Herein, we assessed the effects of two different doses of HT on exercise-induced mitochondrial respiratory complex (C) assembly into supercomplexes (SCs) and the relation of the potential results to OPA1 levels and oxidative stre...
Article
Full-text available
Background Hydroxytyrosol (HT) is a polyphenol found in olive oil that is known for its antioxidant effects. Here, we aimed to describe the effects of a low and high HT dose on the physical running capacity and redox state in both sedentary and exercised rats. Methods Male Wistar rats were allocated into 6 groups: sedentary (SED; n = 10); SED consu...
Conference Paper
Full-text available
PURPOSE: Polyphenols function as antioxidants due to their chemical structure composed of several hydroxyl groups on aromatic rings. Hydroxytyrosol (HT) is the main phenolic compound of olive oil, responsible for its beneficial effects on health and one of the component most biologically active and metabolized by humans. Accordingly, among other bi...
Article
Full-text available
The aim of the study was to compare myocellular damage, metabolic stress and inflammatory responses as well as circulating sodium (Na⁺) and potassium (K⁺) between a single sprint swimming and running training. Eighteen subjects regularly involved in swimming and running training for at least two years were recruited. The subjects performed 8 x 30 s...
Article
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We aimed to test whether high-intensity high-volume swimming (HIT) would induce more robust signaling than sprint interval training (SIT) swimming within the m. triceps brachii due to lower metabolic and oxidation. Nine well-trained swimmers performed the two training procedures on separate randomized days. Muscle biopsies from m. triceps brachii a...
Article
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Mitochondrial respiratory complexes become assembled into supercomplexes (SC) under physiological conditions. One of the functional roles of these entities is the limitation of reactive oxygen species (ROS) produced by complex I (CI) of the respiratory chain. We sought to determine whether the systemic antioxidant effect of exercise is mediated by...
Article
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Background & Study Aim: Cardiovascular diseases are the first cause of death globally and, although athletes have a longer life expectancy, they are not exempt from these diseases. Thus, the aim of this study was the presence of cardiovascular-risk factors in elite judo athletes amongst weight categories. Material and Methods: Cross-sectional descr...
Chapter
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INTRODUCCIÓN UTILIZACIÓN DE ENERGÍA POR EL MÚSCULO Combustible energético para la contracción muscular Efectos de la duración y la intensidad del ejercicio sobre la utilización metabólica de los depósitos energéticos UTILIZACIÓN DE LOS HIDRATOS DE CARBONO EN EL EJERCICIO Importancia del aporte de hidratos de carbono Técnicas de supercompensación Ef...
Article
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Evaluation of muscular fatigue thresholds in athletes performing short-duration and explosive exercises is difficult due to the fact that classic parameters do not suffer large variations. Therefore, the aim of this study was to develop a new method to estimate the fatigue threshold in single muscles. Our approach is based on electromyographic data...
Conference Paper
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A negative aspect of sport practice, wrestling included, is the elevated production of superoxide radical as a consequence of the high oxygen consumption or by xanthine oxidase activity. According to the mitochondrial theory of aging, elite athletes will be more vulnerable because they are lifelong more exposes to deleterious effect of superoxide r...
Article
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The aim of the present study was to determine the anthropometric variables that best predict Special Judo Fitness Test (SJFT) performance. In addition, anthropometric profiles of elite Spanish judo athletes were compared by sex and age category (seniors and juniors). In this cross-sectional study, a total of 51 (29 females) athletes from the Spanis...
Article
Full-text available
Casuso, Rafael A., Jerónimo Aragón-Vela, Gracia López-Contreras, Silvana N. Gomes, Cristina Casals, Yaira Barranco-Ruiz, Jordi J. Mercadé, and Jesus R. Huertas. Does swimming at a moderate altitude favor a lower oxidative stress in an intensity-dependent manner? Role of nonenzymatic antioxidants. High-Alt Med Biol. 00:000-000, 2016-we aimed to desc...
Article
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Background: The effect of exercise-induced oxidative stress on health and aging is not clearly explained. This study examined the effects of habitual sport practice, age, and submaximal exercise on the blood markers of oxidative stress, muscle damage, and antioxidant response. Methods: Seventy-two healthy men were grouped by their habitual sport pr...
Article
Objective: Controlling antioxidant supplementation in athletes involved in studies related to oxidative stress and muscle damage is the key to ensure results. The aim of this study was to confirm through high-performance liquid chromatography (HPLC) analysis whether well-trained individuals lied during a personal interview when asked if they were...
Chapter
The strong body of scientific evidence has established that the exercise-induced stress promotes the generation of reactive oxygen species (ROS), important biomolecules in cellular homeostasis. On one hand, when the ROS production exceeds cellular antioxidant defense, oxidative stress appears resulting in lipid and protein oxidation, DNA damage, ap...
Conference Paper
Full-text available
RESPUESTA FUNCIONAL DE MITOCONDRIAS MUSCULARES AL EJERCICIO: BIOENERGÉTICA, MORFOMETRÍA, DAÑO TISULAR Y ENVEJECIMIENTO Jesús Francisco Rodríguez Huertas. Catedrático de Fisiología. Departamento de Fisiología. Centro de Investigación Biomédica. Instituto de Nutrición y Tecnología de los Alimentos. Universidad de Granada. El talón de Aquiles de la p...
Article
Full-text available
Background & Study Aim: Cardiovascular diseases are the first cause of death globally and, although athletes have a longer life expectancy , they are not exempt from these diseases. Thus, the aim of this study was the presence of cardiovascular-risk factors in elite judo athletes amongst weight categories.
Article
Full-text available
Background: The aim of the study was to investigate oxidative stress, muscle damage, enzymatic antioxidant defense and body composition in senior adults who have performed different lifelong physical activity practices. Methods: Twenty-three healthy senior men (60±1.88 years old) were divided into three groups according to their lifelong physica...
Article
High intensity intermittent exercise is present in the practice of Judo what could be associated with a high production of reactive species of oxygen. Thereby, oxidative stress evaluation could be useful for detecting imbalance in antioxidant system that can affect to health and performance in judo athletes.PURPOSE: To determine the oxidative stres...
Book
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MÉXICO OBESO es una primera referencia para estudiantes, profesores, investigadores e interesados en indagar acerca de la obesidad y su compleja interacción con factores sociales, epidemiológicos, médicos, biológicos, nutricionales, psicológicos y educativos que han alarmado a todos los sectores de la sociedad de nuestro país. Para el resto del mun...
Conference Paper
The first aim of the study was to describe the muscle damage response to a maximal-intensity intermittent effort in elite athletes. The second aim was to compare the differences in alpha-actin by sex and to relate this marker to the body muscle mass. Twenty judo players from the Spanish National Team (10 males) underwent anthropometric and physical...
Conference Paper
Full-text available
Anthropometry has had centuries of history in many areas such as anthropology, anatomy, health and art. In sport, however, it is only relatively recently that measures other than height and weight have been utilized to better understand the connection between morphology and performance. Though many earlier anthropometrists were very precise in the...
Article
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La exposición aguda a altitud previene el estrés oxidativo por una movilización del -tocoferol plasmático Resumen Introducción: Existe gran controversia sobre el efecto de la hipoxia en el estatus oxidativo de deportistas; por otra parte, la mayoría de estudios analizan los mecanismos de adaptación tras un periodo de aclimatación y no contemplan e...
Article
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Background Judo athletes usually try to maximize muscle mass and to minimize adiposity in each weight category, but few studies focused on comparisons of different age categories and little is known about sexual dimorphism among judo athletes. The aim of the study was to compare anthropometrical variables in male and female judoka from Spanish Nati...
Chapter
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OBJETIVOS Describir los principales sistemas que utiliza el músculo para la obtención de energía. Proporcionar una visión global de la utilización de los hidratos de carbono en el ejercicio y describir las técnicas de supercompensación. Establecer recomendaciones generales acerca de la utilización de hidratos de carbono antes, durante y después del...
Article
Full-text available
The knowledge of coenzyme Q levels in tissues, organs, and subcellular compartments is of outstanding interest. A wide amount of data regarding coenzyme Q distribution and occurrence was collected in the last decades; nevertheless the data are often hard to compare because of the different extraction methods and different analytical techniques used...