Jesús M. González-Jartín

University of Santiago de Compostela | USC · Pharmacology, Pharmacy and Pharmaceutical Technology

Background Given the recent detection of TTX in bivalve molluscs but the absence of a full collaborative validation study for TTX determination in a large number of shellfish samples, interlaboratory assessment of method performance was required to better understand current capabilities for accurate and reproducible TTX quantitation using chemical...

Mycotoxins can produce toxic effects on humans; hence, it is of high importance to determine their presence in food products. This work presents a reliable method for the quantification of 32 mycotoxins in cheese. The analysis procedure was optimized based on a QuEChERS extraction process and the ultra-high performance liquid chromatography coupled...

Extracellular cyclophilins (eCyps) A and B are chemotactic mediators in several illnesses in which inflammation plays an important role such as diabetes and cardiovascular diseases. Recently, eCypC has been reported as a potential biomarker for coronary artery disease but its effect in endothelium has not been determined. Moreover, there is a lack...

Enniatins (ENNs) A1 and B1 are non-regulated mycotoxins produced by Fusarium spp. that commonly occur in different types of food. These toxins are cytotoxic in several cell lines, but their mechanism of action is unclear. In this study, the cytotoxic effects of ENNs A1 and B1 in SH-SY5Y human neuroblastoma cells were analysed. Moreover, to better u...

The emergent cyclic imine toxins produced by marine dinoflagellates are potent antagonists of nicotinic acetylcholine receptors. Shellfish accumulate cyclic imine toxins following filter-feeding on toxic dinoflagellates vectoring them to humans. Herein is presented a lateral flow test for the detection of cyclic imine toxins based on three new conc...

Maize and grass silages are important dietary components for ruminant livestock that influence the quality of animal products for human consumption, such as milk, in many parts of the world. Infection of plants by fungi able to produce mycotoxins, either in the field or post-harvest, can result in a decrease of silage nutritional quality and, conse...

Co-occurrence of emerging and regulated mycotoxins in contaminated samples has been widely documented, but studies about their combined toxicity are scarce. In this report, the regulated mycotoxins deoxynivalenol, fumonisin B1 and zearalenone, and the emerging ones enniatin A, enniatin B and beauvericin were tested in SH-SY5Y human neuroblastoma ce...

A simple method for the quantification of 40 mycotoxins in milk was developed. This method is based on a QuEChERS extraction followed by the ultra-high liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) detection, and allows the simultaneous analysis of regulated, emerging, and modified compounds. A sample treatment procedure was optimize...

A new multi-mycotoxin analysis method was developed to identify and quantify 22 mycotoxins in multiple feed matrices. This method is based on a QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction procedure followed by the ultra-high liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) detection. The QuEChERS extraction proc...

Marine and freshwater toxins contaminate water resources, shellfish and aquaculture products, causing a broad range of toxic effects in humans and animals. Different core-shell nanoparticles were tested as a new sorbent for removing marine and freshwater toxins from liquid media. Water solutions were contaminated with 20 μg/L of marine toxins and u...

Mycotoxins are toxic compounds that can be present in feed, food and beverages. In this work, 25 magnetic nanostructured materials were developed to remove the main types of mycotoxins from liquid food matrices. The efficiency for binding mycotoxins from contaminated aqueous solutions was studied. Nanocomposites (diameters lower to 15 μm) composed...

Fusarium foetens, a pathogen of Begonia plants, has been recently described as a new fungal species. This Fusarium species causes a destructive vascular wilt disease which leads to the death of the plant. Moreover, Fusarium species are known to produce a huge variety of secondary metabolites such as mycotoxins and phytotoxins. Here, we studied the...

A new method based on a QuEChERS extraction followed by the ultra-high liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detection has been developed for the analysis of mycotoxin in beer. The method allows the identification and quantification of 23 mycotoxins with different chemical characteristic including regulated, emerging and maske...

A UPLC-MS/MS method has been developed for identification and quantification of hydrophilic and lipophilic marine toxins. The method included the determination of 14 toxins of STX group, 15 lipophilic toxins, 15 toxins of the TTX group and DA. LODs and LOQs for STX group were significantly improved in comparison to the official validated methods an...

Bunch rot of Vitis vinifera is frequently caused by a complex of filamentous fungi. In a study on non-Botrytis fungi associated with bunch rot at harvest in northwestern Spain, rotting berries showing pink masses were observed in bunches of V. vinifera Albariño in one vineyard that experienced prolonged warm, moist conditions before harvest. The ai...

This chapter focuses on the analysis of the main natural toxins associated with food safety. Mycotoxins are produced primarily by fungi of the genera Fusarium, Aspergillus, Penicillium, Claviceps, and Alternaria. The main representatives are aflatoxins, ochratoxin A, patulin, trichothecenes, zearalenone, fumonisins, and ergot alkaloid. Marine toxin...

The large impacts of global warming projected on crops worldwide will subsequently influence not only food security, by reducing yields and thus food availability, but food and feed safety, mycotoxins being considered one of the most important food safety hazards affected by climate change. Future changes in temperature, precipitation, and atmosphe...

Mycotoxins occur naturally as agricultural contaminants all over the world. The toxic effects of some of their metabolites are known and their presence regulated in food and feed. This paper describes two methods for the detection of toxins of type-A trichothecenes group, and their modified forms, using mass spectrometry. Ultra-performance liquid c...

A method based on the combined use of ultra performance liquid chromatography coupled to mass spectrometry – ion trap – time of flight (UPLC-MS-IT-TOF) detection was employed to identify the metabolite production of Aspergillus ochraceus, which is the major cause of food and feed contamination due to ochratoxin A (OTA). Under the proposed chromatog...