Jesus Gomez

Jesus Gomez
University of Barcelona | UB

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70
Publications
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1,411
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Publications

Publications (70)
Article
Full-text available
The aim of this study was to develop a rabbit neurosphere culture to characterize differences in basic processes of neurogenesis induced by intrauterine growth restriction (IUGR). A novel in vitro neurosphere culture has been established using fresh or frozen neural progenitor cells from newborn (PND0) rabbit brains. After surgical IUGR induction i...
Article
Full-text available
The antioxidant effect of compounds is regularly evaluated by in vitro assays that do not have the capability to predict in vivo protective activity or to determine their underlying mechanisms of action. The aim of this study was to develop an experimental system to evaluate the in vivo protective effects of different antioxidant compounds, based o...
Article
The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse effects on human and rodent dev...
Article
The inclusion of a read-out to detect functional consequences of craniofacial alterations in the zebrafish embryotoxicity test will allow to evaluate these alterations which are difficult to assess morphologically, and to detect alterations in cranial nerves functions leading to impairment of jaw movements. In this study we have established an inge...
Article
Full-text available
The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we exposed zebrafish embryos t...
Article
Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic su...
Chapter
The principal aim of this work was to optimize and apply a zebrafish experimental model for the screening of anti-inflammatory substances present in the Mediterranean diet. The zebrafish is an organism widely used in various fields of experimental biology. The inflammation is easily inducible, reproducible and visualized in their early stages of de...
Article
Objetivos: Durante los últimos años, los profesores del Departamento de Farmacología, Toxicología y Química Terapéutica hemos puesto en marcha un conjunto de acciones docentes con el objetivo de promover en los alumnos del grado de Farmacia la mejora de capacidades de integración de los conocimientos de las materias impartidas, así como un modelo d...
Chapter
Full-text available
Triclabendazole (TCBZ) is a veterinary drug used against Fasciola hepatica in cattle. The Cajamarca Valley in Peru is an endemic area of fascioliasis with a high infection rate in animals producing milk for human consumption. The administration of TCBZ during the lactating period can lead to TCBZ derivative residues in milk and cheese entering the...
Chapter
Full-text available
The zebrafish embryo has emerged as promising alternative model for traditional in vivo developmental toxicological screening due to their advantageous characteristics as their small size and transparency. In this paper, we reviewed the applicability of the zebrafish embryo model in some relevant areas to human toxicology as developmental toxicity,...
Article
The present study was aimed at estimating the current (2012) dietary intake of arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb) by the population of Catalonia, Spain. The temporal trends with respect to previous surveys, performed in 2000, 2005, and 2008, were also determined. For that purpose, metal concentrations were analyzed in a number...
Article
In the last years, consumption of organic foods has become increasingly popular. Nevertheless, safety of organic foods is still unclear, and needs to be thoroughly evaluated. Patulin is a mycotoxin mainly present in rotten apples and apple-based products. The aim of this study is to analyse the content of patulin in apple juices and purees derived...
Poster
Full-text available
The developing cardiovascular system of zebrafish is a sensitive target of many environmental pollutants, including dioxin like compounds and pesticides. It has been demonstrated that some PCBs can compromise the cardiovascular endothelial function by activating oxidative stress-sensitive signaling pathways. Therefore, we attempt to modulate the de...
Poster
Se analizaron 46 muestras de purés de manzana comercializados en Cataluña, 24 convencionales y 22 ecológicos. Dos de las muestras analizadas presentaron un nivel de patulina superior al máximo establecido por la legislación Europea. Los resultados mostraron una mayor incidencia de muestras positivas en los productos ecológicos respecto a los conven...
Article
Full-text available
El Grup d'Innovació Docent Orfila, en el seu projecte per millorar la qualitat de la docència, està assajant la utilització del cinema amb finalitat didàctica. El material didàctic que hem desenvolupat en aquest projecte són petites seqüències de pel·lícules comercials de 3 a 5 minuts, per ser utilitzades com a elements il·lustratius del procés add...
Chapter
Organic foods are promoted as environmentally friendly and its consumption has become increasingly popular. Nevertheless, organic farming practices could produce commodities more susceptible to fungal attack and as a result, food with higher levels of mycotoxins. Patulin is a mycotoxin mainly present in apples and apple-based products. In this pape...
Poster
A total of 47 apple juice samples marketed in Catalonia were analysed, 25 of which were derived from conventional and 22 from organic farming. Juices from the same brand but from different batch were considered as different samples. Patulin was extracted with ethyl acetate and then purified with sodium carbonate. After evaporation of organic extrac...
Article
In this study we analyzed some aspects of the assessment of developmental delay in the zebrafish embryotoxicity/teratogenicity test and explored the suitability of acetylcholinesterase (AChE) activity as a biochemical marker and as a higher throughput alternative to morphological endpoints such as head-trunk angle, tail length and morphological sco...
Article
In 2000 and 2006, we determined the dietary intake of hexachlorobenzene (HCB) by the population of Catalonia, Spain. In order to establish the temporal trend in the levels of HCB in foodstuffs, as well as in the dietary exposure to that environmental pollutant, the concentrations were again analyzed by HRGC/HRMS in 65 composite food samples widely...
Article
Full-text available
Se ha puesto en marcha un proyecto de innovación docente basado en el desarrollo de casos clínicos transversales a lo largo de las diferentes asignaturas del Grado de Farmacia. El objetivo es favorecer un aprendizaje integrador entre materias del grado, durante la carrera universitaria de los alumnos, mediante la elaboración de material docente ade...
Article
The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), as well as those of 18 polychlorinated biphenyls (PCBs), including 12-dioxin like (DL)-PCBs, were measured in foodstuffs randomly acquired in Catalonia (Spain) in November-December 2008. A total of 65 composite samples, belonging to various food groups were analyze...
Article
3,4-Methylenedioxymethamphetamine, MDMA or "ecstasy" is consumed mainly by young population at childbearing age. Therefore, there may be a risk of exposure of some pregnant women. The effects of the developmental exposure to MDMA on the sexual development and long-term sexual behaviour/fertility were assessed in Sprague-Dawley rats. MDMA was admini...
Article
Full-text available
Amb la finalitat d’adaptar-nos a l’EEES, vàrem desenvolupar una eina que ens permetés realitzar un procés d’avaluació continua de l’assignatura troncal de Toxicologia. A continuació, presentem els resultats d’aquest model en el que utilitzem els seminaris com a elements integradors del procés d’avaluació, així com la seva estructura, desenvolupamen...
Article
Full-text available
The human health risks derived from the multipathway/multipollutant exposure to various chemicals were assessed in an area with significant petrochemical activity (Tarragona, Catalonia, Spain). Environmental exposure to several Persistent Organic Pollutants (POPs) (PCDD/Fs, PCBs, PCNs, and PAHs) and metals (As, Cd, Cr, Hg, Mn, Pb, and V) was determ...
Article
Full-text available
Los objetivos de este proyecto fueron: a) Identificación de los contenidos fisiológicos y fisiopatológicos que los alumnos deben conocer para el seguimiento de la asignatura de toxicología. b) Unificación terminológica. c) Realización de un conjunto de preguntas básicas sobre estos contenidos. d) Detección, a través de estas preguntas, de los temas...
Article
Learning is a continuous process that should be still performed once a particular subject has been passed. In the university, many subjects require prior knowledge of others subjects for better understanding. During the Pharmacy curriculum of 2002, toxicology teachers observed that students did not seem to remember the basic concepts presumably acq...
Article
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is consumed mainly by young population. For this reason, it is especially relevant to take into consideration the effects on the reproductive system. The influence of MDMA on the fertility and reproduction of the male rat was assessed in this study. MDMA was administered subcutaneously at 0 mg/k...
Article
A fast and easy to perform method for the routine determination of aflatoxins in medicinal herbs was developed. The described method involves a single-step extraction with a non-chlorinated solvent, an immunoaffinity clean-up and HPLC with fluorescence detection. Whilst assays with naturally contaminated and with spiked samples of several herbs sho...
Article
alpha-Amino acids are important building blocks for the synthesis of a large number of bioactive compounds and pharmaceutical drugs. However, a literature survey revealed that no theoretical conformational study of a-amino acids with cage carbon frameworks has been performed to date. This paper reports the results of a conformational study on the (...
Article
Objective: To determine the levels of arsenic (As), cadmium (Cd), mercury (Hg) and lead (Pb) in a number of samples of the most consumed species of medicinal plants in Catalonia, Spain. To calculate the daily intake of these elements and to assess potential health risks. Materials and methods: A total of 115 samples of 15 different species were ana...
Article
Two polymorphic sites of the microsomal epoxide hydrolase gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer (N=204) and in a group of healthy controls (N=203), all Spanish caucasians. After adjusting for gender, age, and tobac...
Article
The conformational profile of the eight stereoisomeric 2-amino-3-phenylnorbornane-2-carboxylic acids (2-amino-3-phenylbicyclo[2.2.1]heptane-2-carboxylic acids) has been assessed by computational methods. These molecules constitute a series of four enantiomeric pairs that can be considered as rigid analogues of either L- or D-phenylalanine. The conf...
Article
Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3) and 139His-->139Arg (exon 4)....
Article
The conformational profile of the conformationally constrained cyclohexane analogs of phenylalanine (1-amino-2-phenylcyclohexanecarboxylic acids, c6Phe) was assessed using computational methods. For this purpose, the conformational space of the N-acetyl methylamide derivatives of the stereoisomers (2S,3R)c6Phe and (2S,3S)c6Phe was explored by compu...
Article
We have synthesized the model dipeptides Piv-l-Pro-c6Phe-NHiPr, incorporating each of the two cis cyclohexane analogues of phenylalanine:  (S,S)- and (R,R)-1-amino-2-phenylcyclohexanecarboxylic acid. Their structural analysis has been carried out in solution by 1H NMR and FTIR absorption spectroscopy and in the solid state by X-ray diffraction. In...
Article
1-Aminocyclopropanecarboxylic acid (Ac3c) is a constrained α amino acid residue that exhibits peculiar conformational characteristics. The aim of the present study is to provide a deeper understanding of these features to be used as guidance to decide when to choose Ac3c as a building block for the design of peptide and protein surrogates. The whol...
Article
GSTM3 is one of five mu-class genes (M1-M5) belonging to a cluster located in chromosome 1. GSTM3 has been found to be polymorphic in humans with a number of individuals presenting a 3 bp deletion within intron 6 (GSTM3*B). In this study we have addressed the possible role of the GSTM3 polymorphism on lung cancer susceptibility. GSTM3 was genotyped...
Article
The present work reports the results of a conformational study performed on seven unnatural amino acid residues and on its natural precursor, investigated by means of computational methods at the molecular mechanics level. Amino acid residues selected for the present study are derivatives of L-phenylalanine substituted at the alpha and/or beta carb...
Article
The human GSTTP1 gene is polymorphic with an A-->G transition in exon 5 causing a replacement 105 Ile-->Val in the GSTP1 protein. The two isoforms, encoded by the alleles GSTP1*A and GSTP1*B, respectively, show different catalytic efficiencies towards some carcinogenic epoxides. In this study we have addressed the possible role of the Ile105Val GST...
Article
The present work reports the results of a conformational study performed on seven unnatural amino acid residues and on its natural precursor, investigated by means of computational methods at the molecular mechanics level. Amino acid residues selected for the present study are derivatives of l-phenylalanine substituted at the α and/or β carbons. Th...
Article
Full-text available
Several polymorphic genes including those encoding for glutathione S-transferases (GST) have been reported to be involved in modifying lung cancer risk in smokers. The gene GSTM1 is frequently deleted in humans and a possible association between the null genotype and lung cancer risk is controversial. Another polymorphic gene of the same supergene...
Article
Several polymorphic genes have been reported to be possibly involved in modifying lung cancer risk in smokers. The gene GSTM1 is frequently deleted in human populations, and the null genotype has been reported to be a risk factor for developing lung carcinoma. A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino...
Article
Organochlorine residues (OCR) in adipose tissue of the general population of Navarra Region (Northem Spain) have been determined as indicators of the environmental and food related exposition to these ubiquitous pollutants. The main organochlorine insecticides, hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) have been identified and qu...
Article
1 Hexachlorobenzene (HCB) internal dose in the general population of Barcelona (Spain) was estimated after new indications of the carcinogenicity of this chemical in humans were recently reported. Hospital blood bank facilities and randomly selected volunteers were used for HCB analyses in serum ( n=100) and cerumen ( n=25). Other main organochlori...
Article
Protamines are among the most variable nuclear proteins known in eukaryotes. In order to learn more about their evolution and function in humans and to explore the possibility of potential applications in forensic medicine we have developed a rapid method to amplify and directly sequence the protamine P1 gene simultaneously in many different sample...
Article
Due to the great number of congeners, the use of the correct nomenclature for PCBs is a difficult task, and unfortunately errors in the assignment of chemical denominations are not unusual. We suggest in this paper to correctly apply the rules initially introduced by Ballschmiter and Zell in 1980, which differ from those of the IUPAC. A simple algo...
Article
Pentachlorothiophenol, a sulphur derivative of the widespread environmental pollutant hexachlorobenzene (HCB) has been detected and quantified in the urine of a human general population with high body burden of HCB. The sulphur derivative was analysed by GLC-MS as pentachlorothioanisole (PCTA) after hydrolysis and methylation of the respective conj...
Article
Polychlorinated biphenyls (PCBs) are a class of aryl halides widely distributed in the environment. Although production has virtually ceased, and most industrial applications (capacitors, transformers, hydraulic fluids, lubricants, etc) are severely restricted, they are one of the most ubiquitous and persistent environmental pollutants. Several tox...
Article
The appearance of sex-related differences in the excretion of sulphur derivatives of hexachlorobenzene (HCB) and pentachloronitrobenzene (PCNB) was studied in vitro and in vivo. Sexually immature rats given HCB showed initially no differences in the excretion of N-acetyl-S-(pentachlorophenyl)cysteine, but 5-8 days after weaning the urinary levels o...
Article
Organochlorine residues (OCR)2 are poorly soluble in water and are transported in the organism bound by the blood components. The distribution among blood fractions (cells/plasma, lipoproteins/rest of plasma proteins) were variable depending on the residue (HCB, p p'-DDE, HCH, Aroclor 1260, PCP) and on the species (rat, man). Differences were not f...
Article
The sex related difference in the urinary excretion of pentachlorothiophenol (PCThP) was investigated in rats after a single oral dose of hexachlorobenzene (HCB) and compared to that obtained after a single oral dose of pentachloronitrobenzene (PCNB). A ten fold difference was obtained in both cases in favour of females. The effect of phenobarbital...
Article
The environmental pollution by persistent organochlorine residues has received much attention in the last years because of its possible effects on wildlife and human health. These residues - organochlorine insecticides, hexa-chlorobenzene (HCB), polychlorinated biphenyls (PCBs) and, in minor levels, polychlorinated dibenzofurans (PCDFs) and dibenzo...
Article
Hexachlorobenzene (HCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) kinetics were compared in rats before, during and after partial starvation. Food restriction produced a drastic mobilization of the residues stored in the adipose tissue resulting in symptoms of neurotoxicity. The redistribution was reversible and did not produce a signifi...
Article
1 Urinary chlorophenols of the general population of Barcelona, Spain were determined. Pentachlorophenol (PCP: 25.0 ± 3.9 ng/ml; x ± s.e.m., n = 50) and tetrachlorophenol (TCP: 6.2 ± 1.6 ng/ml; x ± s.e.m., n = 25) were found in all samples. 2 Pentachlorophenol and hexachlorobenzene were also determined in serum. Both were present in all samples (PC...
Article
Adult female rats were given a single oral dose of hexachlorobenzene (HCB) (100 mg/kg, 1% carboxy methyl cellulose) by stomach tube. Six days after HCB dosage the diet of the animals was restricted to 30% of their normal intakes for 7 days. Following dosage and during partial starvation faecal elimination of HCB was monitored. The animals were kill...

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Els objectius plantejats van ser els següents: 1. Caracteritzar la ingesta de patulina que representa el consum d’aliments sòlids (purés i compotes) a base de poma tant ecològics com convencionals en els infants; així com el consum de sucs a base de poma (ecològics i convencionals) en els adults. 2. Avaluar el risc per a la salut que suposa aquesta ingesta 3. Comparar la seguretat dels aliments ecològics respecte als convencionals en relació al contingut de patulina.