Jesús de Frutos

• PhD
• Hospital Clínico Universitario de Valladolid

Purpose: Brachytherapy (BT) has been used for many years for disease control in tumours of the head and neck area (H&N). It is currently performed with high dose rate (HDR) or pulsed dose rate (PDR), but its use has been reduced due to the implementation of new non-invasive external beam radiotherapy techniques such as intensity modulation (IMRT)...

Purpose The aim of this study was to analyze the course of visual acuity (VA) in visual outcomes of patients treated with iodine-125 (¹²⁵I) brachytherapy in our center, based on original VA before treatment. Material and methods Visual acuity was prospectively assessed using a case series of 305 patients treated with ¹²⁵I between 1996 and 2022. To...

AimDescribe the results of brachytherapy in the prevention of recurrences in conjunctival melanoma (CM) and describe a dosimetric protocol.Methods Retrospective and descriptive case report. Eleven consecutive patients with a confirmed histopathological diagnosis of CM treated with brachytherapy between 1992 and 2023 were reviewed. Demographic, clin...

Purpose: The aim of this study was to analyze regression rates and local control of uveal melanoma patients treated with iodine-125 (125I) brachytherapy based on initial tumor apical height. Material and methods: Patients treated in a single institution from January 1st, 1996 to 2019 with 125I plaques (ROPES and COMS) for uveal melanoma were inc...

Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general proce...

Purpose The aim of this study is to investigate the impact of anatomical changes in prostate cancer patients on the target coverage when using 6 MV beams-VMAT therapy and to propose strategies that allow us to evaluate the dose or correct it by normalization without having to perform a new simulation. Methods and materials Ten patients of high-ris...

The aim of this study is to assess the results of episcleral brachytherapy as treatment of retinal vasoproliferative tumors (RVTs) in a referral Intraocular Tumors Unit (ITU). A retrospective review of all patients diagnosed with vasoproliferative tumors of the retina and treated with episcleral brachytherapy in the ITU, University Hospital of Vall...

Purpose The main objective is to obtain a method to validate the dosimetry of the VMAT treatment plans when these have several arcs with different isocenters and those arcs overlap. The main interest is to check that no hot or cold dose regions are produced when the treatment is delivered. Methods The dosimetry was calculated with the Eclipse radi...

Purpose The aim of this work is to compare Acuros and Analytical Anisotropic Algorithm (AAA), focussing on tissue interfaces. Methods 20 head and neck pathology treatment plans were calculated with both algorithms. Density heterogeneities and air tissue interfaces in the lungs and oral cavity have been analysed. Radiotherapy Treatment Planning Sys...

Purpose To assess the influence of the radiobiological doses, tumor, and treatment features on retinopathy, cataracts, retinal detachment, optic neuropathy, vitreous hemorrhage, and neovascular glaucoma at the authors’ institution after brachytherapy for posterior uveal melanoma. Material and methods Medical records of 243 eyes with uveal melanoma...

Purpose To assess influence of the radiobiological doses, tumor, and treatment features on local control, enucleation rates, overall and disease-specific survival rates after brachytherapy for posterior uveal melanoma. Material and methods Local control, enucleation, overall and disease-specific survival rates were evaluated on the base of 243 pat...

Purpose To assess the long-term influence of radiobiological doses in the evolution of visual acuity (VA) in patients with uveal melanoma treated by episcleral brachytherapy. Material and methods Visual acuity was evaluated prospectively from a case series of 243 patients in 2016 treated with ¹²⁵I. Data analysis was applied to trend VA outcome and...

Purpose To describe the time, frequency, and clinical characteristics of treatment failure after I-125 brachytherapy in patients with uveal melanoma treated and followed in a Spanish referral ocular oncology unit. Design Prospective, consecutive, interventional case series. Methods Patients diagnosed with uveal melanoma from 1995 to 2016 and trea...

A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40 mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary melanomalytic gla...

A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachythe...

Clinical case: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Gonioscopy revealed extension into the anterior chamber angle. Excisional biopsy was performed and consistent with iris melanoma and secondary me...

Introduction Contrast agents for radiotherapy are used to improve accuracy in delineating organ at risk and treatment volumes. These agents modify Hounsfield Units (HU) and tissues electron densities relative to water (EDRW) what are used for determining absorbed dose in external radiotherapy by treatment planning systems (TPS). Purpose To evaluat...

Purpose To report on an unusual form of adult onset iris melanoma as melanomalytic glaucoma. Methods A 35‐year‐old white male with a history of unilateral ocular hypertension and visual loss for six months. Results At first visit,Best Corrected Visual Acuity was 80/20 in the right eye (OD) and 20/20 in the left one (OS).Intraocular pressure was 40...

We report the cases of 2 women with a pigmented tumour in the ciliary body, one a melanocytoma and the other a melanoma, with different clinical manifestations. The first one presented with decreased visual acuity associated with recent growth of the tumour, as well as sectorial opacities of the lens and subluxation. The second one is asymptomatic...

Cases report We report the cases of 2 women with a pigmented tumour in the ciliary body, one a melanocytoma and the other a melanoma, with different clinical manifestations. The first one presented with decreased visual acuity associated with recent growth of the tumour, as well as sectorial opacities of the lens and subluxation. The second one is...

To analyse the clinical features, treatment and survival of uveal melanoma patients diagnosed in a referral Intraocular Tumours Unit over a twenty-year period. A prospective study was performed including five hundred patients, diagnosed between January 1992 and December 2011. Clinical tumour characteristics and treatment were collected in a databas...

Objective To analyse the clinical features, treatment and survival of uveal melanoma patients diagnosed in a referral Intraocular Tumours Unit over a twenty-year period. Methodology A prospective study was performed including five hundred patients, diagnosed between January 1992 and December 2011. Clinical tumour characteristics and treatment were...

Purpose To describe the efficacy of episcleral brachytherapy in a choroidal melanoma and circumscribed hemangioma arising in both eyes of the same patient. Case report We present the case of a 47 year old man who presented decreased visual acuity a few months preceding initial consult. On fundoscopy, he presented a melanotic lesion in the right ey...

To assess the results of I-125 episcleral brachytherapy (EB) in uveal melanoma: tumour control, visual acuity (VA), eye preservation and survival. Prospective and consecutive study of patients with a diagnosis of uveal melanoma at the Ocular Oncology Unit in the Valladolid University Teaching Hospital treated with EB between September 1997 and June...

The aim of this study was to determine the prevalence of ocular and oculodermal melanocytosis (ODM) among patients with uveal melanoma (UM) in a Spanish population. Retrospective review of the medical records of patients with ODM among patients with UM. Ten (11 eyes) of 400 patients (2.7%) with UM associated had ODM. The mean age at diagnosis of UM...

Purpose To analyze the time course of diagnosis and treatment of uveal melanomas in an ocular referral unit in a period of 20 years. Methods Prospectively collected data on consecutive patients diagnosed of uveal melanoma, from 1990 to 2010, were analyzed. Epidemiologic and general data, clinical and tumor characteristics at the time of diagnosis (...

Purpose Ocular melanocytosis, is a congenital condition characterized by hyperpigmentation of the episclera and uvea.. There is a clear association between this condition and uveal melanoma in Caucasian populations. We report a case of a patient affect of bilateral ocular malanocytosis whom has recently been diagnosticated of bilateral choroidal me...

Purpose The management of suspected small choroidal melanomas is controversial. The purpose of the present study is to assess tumor growth, visual acuity changes, activity factors and survival on choroidal melanoma patients under observation in our Intraocular Tumors Unit. Methods Prospective, consecutive and non‐interventional case series. Patient...

To evaluate episcleral plaque radiotherapy with high-dose (125)I for the treatment of circumscribed choroidal haemangioma (CCH). A retrospective review was performed of patients treated for CCH between 1995 and 2007. Brachytherapy was performed with ROPES plaques loaded with (125)I seeds with a target apex dose of 48 Gy. Main outcome measures were...

to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities. Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study. 273 patients were included. 193 were treated with conservative treatment...

Objective: to analyze ocular survival in eyes with uveal melanoma treated with conservative therapies, in a centre that applies all treatment modalities. Methods: Patients diagnosed with uveal melanoma and treated between September 1990 and April 2007 were included in an historical cohorts study. Results: 273 patients were included. 193 were treate...

Purpose To develop the clinical pathway of episcleral brachytherapy as developed in our center. Methods 1 .‐ Recruitment multidisciplinary team 2 .‐ A critical review of clinical practice guidelines applicable 3 .‐ Combining the expertise of professionals with revisions to guidelines previously outlined and the rest of literature applicable 4 .‐ de...

Purpose To evaluate the clinical pathway for electronic episcleral brachytherapy and their comparison with the paper‐based format. Methods Patients: Patients diagnosed with choroidal melanoma or angioma treated with epiescleral brachytherapy in our hospital since the entry into operation of the clinical pathway. The electronic clinical pathway was...

Purpose To assess the results of I125 Episcleral Brachytherapy (EB) in uveal melanoma: tumor control, visual acuity, eye preservation and survival Methods Prospective and consecutive study of patients with the diagnosis of uveal melanoma at the ocular oncology unit in the Valladolid University Hospital treated with EB between september 1997 and jun...

Purpose To compare the doses calculated from the measurements of the tumour obtained by different imaging techniques. Methods It is a retrospective study of 50 enucleated eyes corresponding to 50 patients with diagnosis of choroidal melanoma. For every case, there was recorded information about height of the tumour obtained by means of studies of p...

Purpose: To analyse eye survival in patients with uveal melanoma with a multimodality approach to treatment Methods: 273 patients with uveal melanoma diagnosed at Ocular Oncology Unit of the University Hospital of Valladolid from 1997 September to 2007 April. Pearson’s Chi‐square test was used to identify between variables and primary enucleation....

Purpose: The treatment of choroidal melanoma and other ocular tumors can be approached by means of epiescleral brachytherapy. The process involves several specialiced professionals, different methods to obtain measurements (radioactive sources, tumor) and a complex process to apply every treatment. A program of quality assurance would minimize the...

To present a series of patients with uveal melanoma masquerading as ocular hypertension. Patients diagnosed with uveal melanoma were reviewed, selecting those cases with initial presentation as secondary unilateral glaucoma. Clinical and histopathological information useful for prognosis was examined, such as anterior border localization, size and...

Objetivo: Presentar una serie de casos de pacientes con melanoma uveal cuya forma de presentación fue la hipertensión ocular (HTO). Métodos: Se revisaron los pacientes con diagnóstico de melanoma uveal seleccionando los casos cuya forma inicial de presentación del tumor fuera un glaucoma unilateral secundario. Se examinaron los datos clínicos e his...

The main aim of this paper is to make a study of dose‐rate distributions obtained around the 15mm, radiation oncology physics and engineering services, Australia (ROPES) eye plaque loaded with I125 model 6711 radioactive seeds. In this study, we have carried out a comparison of the dose‐rate distributions obtained by the algorithm used by the Plaqu...

Cases: We present four cases of ocular melanosis. Choroidal melanoma was detected in all of them. Three eyes had decreased visual acuity and were enucleated because of their large, active tumours. In the fourth case the melanoma was detected in a routine examination and we were able to apply a preserving treatment with I125 brachytherapy. Discuss...

Casos clínicos: Se presentan cuatro casos de pacientes con signos clínicos de melanosis óculi. En todos se diagnosticó melanoma de coroides. Tres acudieron con disminución de visión en ojo afecto y fueron enucleados por presentar tumores grandes y activos. En el cuarto caso el melanoma fue descubierto en una revisión rutinaria y se pudo aplicar un...

A termoluminiscence dosimetry system (TLD) has been assessed as a tool to verify radiotherapy treatment dose prescription by exit dose measurements. LiF chips (TLD- 100, Harsaw), irradiated with a 6 MV x-ray beam and calibrated in a monitored ionisation chamber acrylic phantom, are placed at the exit surface of a slab phantom and a set of irradiati...

A tool for comparing contours in different image sets is been made to use with a Radiotherapy planning system. The aim is delineating GTV in a non-simulation image set and translating it into a simulation one where GTV cannot be easily segmented. To do so, a singular value decomposition mathematical method is used. We have two image sets per patien...

Checks in photon beams in linear accelerators are part of the quality assurance program in Medical Physics Departments. Water phantom checks are common, but faster alternatives could be possible for routine measurements. The purposes of this work are to found reference value for photon profiles in routine measurements, to asses variations from wate...