Jessica Lynn Verpeut

Jessica Lynn Verpeut
Arizona State University | ASU · Department of Psychology

PhD

About

37
Publications
7,366
Reads
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402
Citations
Introduction
My research interests include the complex neural pathways involved in neural development and how the brain performs computations that result in behavior.
Additional affiliations
September 2015 - December 2020
Princeton University
Position
  • Instructor
Description
  • In this class students learn to read and critique scientific papers. I focused this tutorial on the neuroscience of stress.
July 2015 - December 2020
Princeton University
Position
  • PostDoc Position
September 2011 - May 2015
Rutgers, The State University of New Jersey
Position
  • Research Assistant
Education
September 2005 - May 2010
August 2005 - July 2015
Rutgers, The State University of New Jersey
Field of study
  • Endocrinology and Animal Biosciences

Publications

Publications (37)
Article
Full-text available
Introduction: Obesity is a known health risk for the development of several preventable diseases. Obesity-related metabolic alterations negatively impact different physiological mechanisms, which supports the rationale for the use of combined drug therapy. Naltrexone is an opioid antagonist for the treatment of opioid and alcohol dependency, where...
Article
Full-text available
Clinical studies indicate alternate day, intermittent fasting (IMF) protocols result in meaningful weight loss in obese individuals. To further understand the mechanisms sustaining weight loss by IMF, we investigated the metabolic and neural alterations of IMF in obese mice. Male C57/BL6 mice were fed a high-fat diet (HFD; 45 fat) ad libitum for 8...
Article
Full-text available
Prolonged consumption of ketogenic diets (KD) has reported neuroprotective benefits. Several studies suggest KD interventions could be useful in the management of neurological and developmental disorders. Alterations in the Engrailed (En) genes, specifically Engrailed 2 (En2), have neurodevelopmental consequences and produce autism-related behavior...
Poster
Cerebellar lobules form reciprocal loops with neocortical regions associated with executive functions, but the functional significance of those connections is not well explored. We hypothesized that disrupting activity in of these cerebellar regions would perturb one or more executive domains: (1) social choice and behavioral inhibition (2) cogniti...
Article
Full-text available
Transsynaptic viral tracing requires tissue sectioning, manual cell counting, and anatomical assignment, all of which are time intensive. We describe a protocol for BrainPipe, a scalable software for automated anatomical alignment and object counting in light-sheet microscopy volumes. BrainPipe can be generalized to new counting tasks by using a ne...
Article
Full-text available
Adeno-associated viruses (AAVs) are one of the most widely used types of viral vectors for research and gene therapy. AAV vectors are safe, have a low immunogenic profile, and provide efficient and long-term transgene expression in a variety of tissues and organs targeted by a specific serotype. Despite these unique features, therapeutic applicatio...
Article
Adeno‐associated viruses (AAVs) are one of the most widely used types of viral vectors for research and gene therapy. AAV vectors are safe, have a low immunogenic profile, and provide efficient and long‐term transgene expression in a variety of tissues and organs targeted by a specific serotype. Despite these unique features, therapeutic applicatio...
Article
Full-text available
Background Repetitive action, resistance to environmental change and fine motor disruptions are hallmarks of autism spectrum disorder (ASD) and other neurodevelopmental disorders, and vary considerably from individual to individual. In animal models, conventional behavioral phenotyping captures such fine-scale variations incompletely. Here we obser...
Preprint
Full-text available
The cerebellum regulates nonmotor behavior, but the routes by which it exerts its influence are not well characterized. Here we report a necessary role for posterior cerebellum in guiding flexible behavior, acting through a network of diencephalic and neocortical structures. After chemogenetic inhibition of Purkinje cells in lobule VI or crus I, hi...
Article
Women are vulnerable to developing mental disorders that are associated with circulating estrogens. Estrogens, especially 17β-estradiol (E2), have a wide array of effects on the brain, affecting many behavioral endpoints associated with mental illness. By using a total estrogen receptor (ER) α knockout (KO), an ERα knock in/knock out (KIKO) that la...
Preprint
Full-text available
Recombinant adeno-associated viruses (AAVs) allow rapid and efficient gene delivery in the nervous system. AAVs are widely used in research and are the basis of multiple FDA-approved gene therapies. Here, we find that the immune response to AAV's genome reduces dendritic complexity in mammalian cortex. Dendritic loss associated with AAV-mediated ge...
Article
Full-text available
Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipeline. With retrograde tracing, we find that most descending paths originate from the somatomotor cortex. Ante...
Preprint
Full-text available
Background: Repetitive action, resistance to environmental change, and fine motor disruptions are hallmarks of autism spectrum disorder (ASD) and other neurodevelopmental disorders, and vary considerably from individual to individual. In animal models, conventional behavioral phenotyping captures such fine-scale variations incompletely. Here, we ai...
Article
Full-text available
Adeno-associated viral (AAV) vectors are an established and safe gene delivery tool to target the nervous system. However, the payload capacity of <4.9 kb limits the transfer of large or multiple genes. Oversized payloads could be delivered by fragmenting the transgenes into separate AAV capsids that are then mixed. This strategy could increase the...
Preprint
A bstract Autism is noted for both its genotypic and phenotypic diversity. Repetitive action, resistance to environmental change, and motor disruptions vary from individual to individual. In animal models, conventional behavioral phenotyping captures such fine-scale variations incompletely. Here we use advances in computer vision and deep learning...
Article
Full-text available
Recombinant adeno-associated viruses (rAAV) are used as gene therapy vectors to treat central nervous system (CNS) diseases. Despite their safety and broad tropism, important issues need to be corrected such as the limited payload capacity and the lack of small gene promoters providing long-term, pan-neuronal transgene expression in the CNS. Common...
Preprint
Full-text available
Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here we quantify pathways between cerebellum and forebrain using transsynaptic tracing viruses and a whole-brain quantitative analysis pipeline. Retrograde tracing found a majority of descending paths originating from somatomotor cortex. Anter...
Preprint
Full-text available
Recombinant adeno-associated viral vectors (rAAV) are used as gene therapy vectors to treat central nervous system (CNS) diseases. Despite their safety and broad tropism, important issues need to be corrected such as the limited payload capacity and the lack of small gene promoters providing long-term, pan-neuronal transgene expression in the CNS....
Article
Full-text available
Development of brain circuitry requires precise regulation and timing of proliferation and differentiation of neural progenitor cells. The p75 neurotrophin receptor (p75NTR) is highly expressed in the proliferating granule cell precursors (GCPs) during development of the cerebellum. In a previous paper we showed that proNT3 promoted GCP cell cycle...
Article
Full-text available
Cognitive and social capacities require postnatal experience, yet the pathways by which experience guides development are unknown. Here we show that the normal development of motor and nonmotor capacities requires cerebellar activity. Using chemogenetic perturbation of molecular layer interneurons to attenuate cerebellar output in mice, we found th...
Article
Full-text available
Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increased risk of addiction-associated phenotypes in humans yet little is known the underlying neural basis. Induced pluripotent stem cells (iPSCs) were derived from donors homozygous for either the major (D398) or the minor (N398) allele of the nonsynonymous single n...
Poster
A ketogenic diet (KD) improves pediatric epilepsy and has beneficial neural effects by unknown mechanisms. The following studies used Engrailed 2 (En2-/-) knockout (KO) male mice, which have provided insight into neural systems affected by this transcription factor and autistic-like behaviors. En2-/- mice have reduced social behavior, low body weig...
Article
Full-text available
Stress is often associated with binge eating. A critical component of the control of stress is the central norepinephrine system. We investigated how dietary-induced binge eating alters central norepinephrine and related behaviors. Young male Sprague Dawley rats received calorie deprivation (24 h) and /or intermittent sweetened fat (vegetable short...
Article
Full-text available
White-throated sparrows increase fat deposits during pre-migratory periods and rely on these fat stores to fuel migration. Adipose tissue produces hormones and signaling factors in a rhythmic fashion and may be controlled by a clock in adipose tissue or driven by a master clock in the brain. The master clock may convey photoperiodic information fro...
Data
Shown is a segment of a video recording taken during the night under infrared illumination. Video images show intense activity, including wing-whirring, features which were used to determine whether a bird was exhibiting nocturnal migratory restlessness. (WMV)
Article
Full-text available
Central noradrenergic pathways are involved in feeding and cardiovascular control, physiological processes altered by obesity. The present studies determined how high-fat feeding and body weight gain alter the sensitivity to the feeding suppression and neural activation to a selective norepinephrine reuptake inhibitor, nisoxetine. Acute administrat...
Poster
Background: Binge eating is often accompanied with a “sense of loss of control” over feeding. These episodes are sometimes triggered by stressful situations in humans. Brain norepinephrine (NE) has a critical role to regulate stress and food intake. These experiments examined whether dietary-induced binge eating altered brain NE. Methods: Male SD r...
Poster
Adolescence is a critical period of development. These experiments were designed to determine how adolescent dietary experiences affect adult feeding and metabolism. For our initial experiments, body weight and feeding behavior were measured in adolescent rats. Four groups of male Sprague Dawley rats (PND 32) were exposed to the following dietary c...
Poster
Seasonal rhythms of hyperphagia and fat deposition provide migratory birds with the energy needed to complete seasonal migration events which may last thousands of miles. Fat is an endocrine organ; consequently, the amounts of fat hormones in the blood could indicate the status of fat stores. These signals could be seasonal cues for timing rhythms...

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