
Jessica RowleyImperial College London | Imperial · Department of Life Sciences
Jessica Rowley
PhD Inflammation and repair
About
5
Publications
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253
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Introduction
Additional affiliations
Position
- Postdoctoral Research Assistant
Publications
Publications (5)
Objectives: Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af) are the most common bacterial and fungal organisms respectively to infect the airways of cystic fibrosis (CF) patients. We and others have shown in vitro that Pa can inhibit the growth of Af. This is strain-dependent and is observed both in direct co-culture and indirectly, with...
Background: Asthma is characterised by structural changes such as airway smooth muscle (ASM) thickening. Our studies have shown that, in a murine house dust mite (HDM) model of asthma, pericytes detach from the airway microvasculature and accumulate in ASM; however the mechanism is not understood. Pericytes are mural cells that maintain vascular ho...
Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has garnered considerable public attention due to the potential of returning tissues and organs to a normal, healthy state after injury or damage has occurred. To achieve this, progenitor cells such as pericytes and bone marrow-derived mesenchymal stem cells can be...
Myofibroblast accumulation, subepithelial fibrosis and vascular remodeling are complicating features of chronic asthma, but the mechanisms are not clear. Platelet-derived growth factors (PDGFs) regulate the fate and function of various mesenchymal cells and have been implicated as mediators of lung fibrosis. However, it is not known whether PDGF-BB...
Pericytes are mesenchymal cells embedded within the abluminal surface of the endothelium of microvessels such as capillaries, pre-capillary arterioles, post-capillary and collecting venules, where they maintain microvascular homeostasis and participate in angiogenesis. In addition to their roles in supporting the vasculature and facilitating leukoc...
Questions
Question (1)
Hi guys. Does anybody know if it is possible to freeze murine bone marrow, with the intention of analysing MSC via flow cytometry following thawing?
Thanks,
Jess