Jessica Rosenholm

Jessica Rosenholm
Åbo Akademi University · Faculty of Science and Engineering

Doctor of Science (Technology)

About

229
Publications
75,885
Reads
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7,530
Citations
Introduction
PI of the BioNanoMaterials research group (https://www.pharmscilab.fi/bionanomaterials) the main objectives of which are to: 1) develop nanoparticles for specific biomedical applications by smart design, and 2) synthesize composite nanostructures for improved bio-visibility and theranostic activity, and 3) evaluate the potential and applicability of the developed nanomaterials for in vitro and in vivo drug delivery and biomedical imaging together with our collaborators.
Additional affiliations
January 2015 - present
Åbo Akademi University
Position
  • Professor
April 2013 - March 2018
Åbo Akademi University
Position
  • Adjunct Professor (Title of Docent) in Biomedical Nanotechnology
May 2010 - December 2014
Åbo Akademi University
Position
  • Principal Investigator (Group leader)
Description
  • www.fyke.fi/bionano
Education
January 2003 - May 2008
Åbo Akademi University
Field of study
  • Biomaterials research
September 1996 - November 2002
Åbo Akademi University
Field of study
  • Chemical Engineering

Publications

Publications (229)
Article
New approaches in pharmaceutical chemistry have resulted in more complex drug molecules in the quest to achieve higher affinity to their targets. However, these ‘highly active’ drugs can also suffer from poor water solubility. Hence, poorly water soluble drugs became a major challenge in drug formulation, and this problem is increasing, as currentl...
Article
Recent progress in the development of silica- and silicon-based multimodality imaging nanoprobes has advanced their use in image-guided drug delivery, and the development of novel systems for nanotheranostic and diagnostic applications. As biocompatible and flexibly tunable materials, silica and silicon provide excellent platforms with high clinica...
Article
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Nanodiamond (ND) has emerged as an intriguing material in recent years both industrially and in research. During the last decade, ND has furthered its way into the biomedical field, mainly due to its inherent photoluminescent properties. In parallel, the development of advanced biomedical imaging methods and techniques has faced a steep upswing, ma...
Article
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The threats posed by the impending “postantibiotic era” have put forward urgent challenges to be overcome by providing new diagnostic and therapeutic regimes for improved diagnosis and treatment of bacterial infections. Antibiotic resistance and incurable bacterial infections are especially important in a society faced with rapid demographic change...
Article
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Zoledronic acid (ZOL) is a nitrogen-containing bisphosphonate used for the treatment of bone diseases and calcium metabolism. Anticancer activity of ZOL has been established, but its extraskeletal effects are limited due to its rapid uptake and accumulation to bone hydroxyapatite. In this work, we report on the development of tethered lipid bilayer...
Article
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Plastics are one of the most widely used polymeric materials. However, they are often undegradable and non‐recyclable due to the very stable covalent bonds of macromolecules, causing environmental pollution and health problems. Here, we report that liquid‐liquid phase separation (LLPS) could drive the formation of robust, stable, and sustainable pl...
Article
Plastics are one of the most widely used polymeric materials. However, they are often undegradable and non‐recyclable due to the very stable covalent bonds of macromolecules, causing environmental pollution and health problems. Here, we report that liquid‐liquid phase separation (LLPS) could drive the formation of robust, stable, and sustainable pl...
Article
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Antibody-mediated rejection (ABMR) is a major cause of dysfunction and loss of transplanted kidney. The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells. However, the prognosis of patients following current treatment is poor. T follicular helper cells (Tfh) play an important role in allograft-spe...
Article
Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve...
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Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product development. The use of lipids in designing formulations provides an opportunity to enhance the aqueous solubility and consequently bioavailability of drugs. Pre-dissolution of drugs in lipids, surfactants, or mixtures of lipid excipients and surfactants elimin...
Article
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Orodispersible films (ODFs)are ultra-thin, stamp-sized, rapidly disintegrating, and attractive oral drug delivery dosage forms best suited for the pediatric and geriatric patient populations.They can be fabricated by different techniques, but the most popular, simple, and industrially applicable technique is the solvent casting method (SCM). In add...
Article
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In recent years, polymer-based advanced drug delivery and tissue engineering have grown and expanded steadily. At present, most of the polymeric research has focused on improving existing polymers or developing new biomaterials with tunable properties. Polymers with free functional groups offer the diverse characteristics needed for optimal tissue...
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Biofilms are currently responsible for 80% of human chronic bacterial infections, being composed of bacterial communities within self‐produced extracellular polymeric substances (EPS) that can resist various adverse factors in the bacterial microenvironment. Therefore, the development of powerful antibacterial systems by disrupting biofilms first a...
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Microfluidics has become a popular method for constructing nanosystems in recent years, but it can also be used to coat other materials with polymeric layers. The polymeric coating may serve as a diffusion barrier against hydrophilic compounds, a responsive layer for controlled release, or a functional layer introduced to a nanocomposite for achiev...
Article
Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype. In the presented work, we have combined several emerging technologies to build up a nanoplatform for TNBC treatment: photothermal therapy, prodrug design and tumor cell camouflage formulation. First, we synthesized a paclitaxel (PTX) based prodrug PTX-SS, and t...
Article
Lithography-based digital light processing (DLP) 3D printing has gained increasing interest in the fabrication of custom-designed hydrogel scaffolds. Current research development calls for the versatility of the bio-based resin formulations...
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Abstract Zeta potential is an essential surface parameter in the characterization of nanoparticles, determined at the interface of loosely bound ions (diffuse layer) at the nanoparticle surface and free ions in solution. The ionic concentration and pH of the solution are known to, by definition, influence the composition of the diffuse layer and ze...
Preprint
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Supramolecular polymers self-assembled by small molecules are a type of new material with adaptive and biocompatible properties. However, the mechanical property of these materials is always weak, impeding their applications in practice. Here, we reported that coacervation can be used to explore robust and stable bulk materials without the compromi...
Article
Due to its modular and flexible design options, mesoporous silica provides ample opportunities when developing new strategies for combinatory antibacterial treatments. In this study, antibacterial ceria (CeO2) nanoparticles (NP) were used as core material, and were further coated with a mesoporous silica shell (mSiO2) to obtain a [email protected]...
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Nanoemulsions are a rapidly growing drug delivery technology capable of increasing a drug's aqueous solubility and stability. A novel oil-in-water nanoemulsion using a polymer, poly(decalactone) (PDL), instead of a conventional oil was recently reported. The amount of drug loading in a polymer-based formulation is mainly governed by the drug's solu...
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Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, t...
Article
Appropriate tuning of robust artificial coatings can not only enhance intracellular delivery but also preserve the biological functions of genetic molecules in gene based therapies. Here, we report a strategy to synthesize controllable nanostructures in situ by encapsulating CRISPR/Cas9 plasmids into metal-organic frameworks (MOFs) via biomimetic m...
Article
Orodispersible films (ODFs) are ultra-thin, stamp-sized, elegant, portable and patient-centric pharmaceutical dosage forms that do not need water to be ingested. They are particularly useful for paediatric and geriatric patient populations with special needs such as dysphagia, Parkinson's disease, and oral cancer. Accordingly, they hold tremendous...
Article
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Public awareness of infectious diseases has increased in recent months, not only due to the current COVID-19 outbreak but also because of antimicrobial resistance (AMR) being declared a top-10 global health threat by the World Health Organization (WHO) in 2019. These global issues have spiked the realization that new and more efficient methods and...
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Instances of synthetic polymers obtained from renewable feedstock with the possibility of post‐synthesis functionalization are scarce. Herein, the first ever synthesis and drug delivery application of amphiphilic block copolymer (mPEG‐b‐PJL) derived from renewable jasmine lactone with free allyl groups on the backbone is presented. The polymer is s...
Article
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Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remain elusive. We show that STIM1 and ORAI1 expression is elevated in thyroid cancer cell lines, compared to primary thyroid c...
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Citation: Trivedi, P.; Liu, R.; Bi, H.; Xu, C.; Rosenholm, J.M.; Åkerfelt, M. 3D Modeling of Epithelial Tumors-The Synergy between Materials Engineering, 3D Bioprinting, High-Content Imaging, and Nanotechnology. Int. J. Mol. Sci. Abstract: The current statistics on cancer show that 90% of all human cancers originate from epithelial cells. Breast an...
Article
Integrating multiple materials with different functionalities in a single nanostructure enables advances in many scientific and technological applications. However, such highly sophisticated nanomaterials usually require complex synthesis processes that complicate their preparation in a sustainable and industrially feasible manner. Herein, we desig...
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Local minimally invasive injection of anticancer therapies is a compelling approach to maximize the utilization of drugs and reduce the systemic adverse drug effects. However, the clinical translation is still hampered by many challenges such as short residence time of therapeutic agents and the difficulty in achieving multi-modulation combination...
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Glioblastoma (GB) is the most frequent malignant tumor originating from the central nervous system. Despite breakthroughs in treatment modalities for other cancer types, GB remains largely irremediable due to the high degree of intratumoral heterogeneity, infiltrative growth, and intrinsic resistance towards multiple treatments. A sub-population of...
Article
Obesity is one of the most important public health problems that is associated with an array of metabolic disorders linked to cardiovascular disease, stroke, type 2 diabetes, and cancer. A sustained therapeutic approach to stop the escalating prevalence of obesity and its associated metabolic comorbidities remains elusive. Herein, we developed a no...
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Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PD...
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After hydrogen and oxygen, carbon is the third most abundant component present in the cosmos with excellent characteristic features of binding to itself and nearly all elements. Since ancient times, carbon-based materials such as graphite, charcoal, and carbon black have been utilized for writing and drawing materials. As these materials possess ex...
Chapter
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Mesoporous silica nanoparticles (MSNs) offer many advantageous properties for applications in the field of nanobiotechnology. Loading of small molecules into MSNs is straightforward and widely applied, but with the upswing of both research and commercial interest in biological drugs in recent years, also biomacromolecules have been loaded into MSNs...
Preprint
Full-text available
Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. The identity and function of these proteins in thyroid cancer remained elusive. We show that STIM1 and ORAI1 expression is elevated in thyroid cancer cell lines, compared with primary thyro...
Article
Full-text available
The aim of the current study was to fabricate naturally derived polymer based hydrogels for controlled release of diclofenac sodium (DS) for a long duration of time. In this research work, sodium alginate-co-poly(2-acrylamido-2-methyl propane sulphonic acid) (SA-co-poly(AMPS)) hydrogels were prepared by the free radical polymerization technique, wh...
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Nanogels (Ng) are crosslinked polymer-based hydrogel nanoparticles considered to be next-generation drug delivery systems due to their superior properties, including high drug loading capacity, low toxicity, and stimuli responsiveness. In this study, dually thermo-pH-responsive plasmonic nanogel (AuNP@Ng) was synthesized by grafting poly (N-isoprop...
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Three-dimensional correlative light and electron microscopy (3D CLEM) is attaining popularity as a potential technique to explore the functional aspects of a cell together with high-resolution ultrastructural details across the cell volume. To perform such a 3D CLEM experiment, there is an imperative requirement for multi-modal probes that are both...
Preprint
Full-text available
Glioblastoma (GB) is the most frequent malignant tumor originating from the central nervous system. Despite breakthroughs in treatment modalities for other cancer types, GB remains largely irremediable due to its high degree of intratumoral heterogeneity, infiltrative growth, and intrinsic resistance towards multiple treatments. These resistant and...
Article
Full-text available
Correlative light and electron microscopy (CLEM) is revolutionizing how cell samples are studied. CLEM provides a combination of the molecular and ultrastructural information about a cell. For the execution of CLEM experiments, multimodal fiducial landmarks are applied to precisely overlay light and electron microscopy images. Currently applied fid...
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In this study, we used electrospun polycaprolactone (PCL) or a mixture of PCL and gelatin (Gel) in a mixed acidic solvent to develop antimicrobial electrospun nanofibers. Carboxyl-modified mesoporous silica nanoparticles (CMSNs) or CMSNs loaded with antibiotic drugs polymyxin B and vancomycin (CMSNs/ABs) were mixed with the electrospinning solution...
Chapter
Silica nanoparticles are a type of colloidal amorphous metal oxide, which can be synthesized by a bottom‐up approach via the sol‐gel process. This chapter presents different architectures of silica nanoparticles (NPs), including nonporous silica NPs, mesoporous silica NPs, hollow silica NPs, and porous silica NPs, along with case studies of drug de...
Article
Molecular self‐assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli‐responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spo...
Article
Dynamic combinatorial chemistry was employed to explore an ideal carrier molecule for anti‐cancer drug delivery. Driven by thermodynamics, the carrier molecule was quantitatively yielded by its co‐self‐assembly with a template and a drug doxorubicin (DOX). The self‐assembled nanocarrier with a drug‐loading content of 40 % was stable yet pH‐ and red...
Article
Full-text available
Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular drug delivery potential is not...
Article
Full-text available
Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular drug delivery potential is not...
Article
Full-text available
The topical route is the most preferred one for administering drugs to eyes, skin and wounds for reaching enhanced efficacy and to improve patient compliance. Topical administration of drugs via conventional dosage forms such as solutions, creams and so forth to the eyes is associated with very low bioavailability (less than 5%) and hence, we canno...
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Several bioactive compounds are in use for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. Historically, willow (salix sp.) bark has been an important source of salisylic acid and other natural compounds with anti-inflammatory, antipyretic and analgesic properties. Among these, picein isolated from hot wat...
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Traditional chemotherapy, along with antiangiogenesis drugs (combination cancer therapy), has shown reduced tumor recurrence and improved antitumor effects, as tumor growth and metastasis are often dependent on tumor vascularization. However, the effect of combination chemotherapy, including synergism and additive and even antagonism effects, depen...
Article
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In this study, direct and effective intracellular delivery of CRISPR/Cas9 plasmids for homology‐directed repair is achieved by functionalized mesoporous silica nanoparticles (MSNs). The functionalized MSNs (Cy5.5‐MSNs‐NLS) are synthesized by in situ labeling of a fluorescent dye (Cy5.5) and surface conjugation of nuclear localization sequence (NLS,...
Article
This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections; of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative...
Article
Polymicrobial biofilms are major complications of various chronic infections. Therefore, in vitro biorelevant polymicrobial biofilm models are essential tools for medical studies. This study presents a dual species biofilm of Pseudomonas aeruginosa and Staphylococcus aureus developed on cell-derived matrices (CDMs), in order to simulate the microen...
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The aim of this study was to study an AMP, aurein 1.2, which substantially increased protein delivery directly into multiple mammalian inner ear cell types in vivo. Different concentrations of aurein 1.2 with superpositively charged GFP (+36-GFP) protein fused with Cre recombinase were delivered to P1-2 and adult cochleae of Cre reporter transgenic...
Article
The supplementation of stem cell culture medium with fetal bovine serum (FBS) for maintenance and propagation of cell lines in vitro is associated with immunogenicity and disease transmission by prions, bacteria, and viruses. Therefore, establishing xenogenic-free cell culture media for the benefit of rational testing conditions for stem cells in t...
Article
Polymers and more specifically, polyesters have gained a significant position within biomedical applications, mainly owing to their well-controlled biodegradability. They play a prominent role within nanomedicine in improving the safety and efficacy of therapeutic agents. In recent years, polymers obtained from renewable resources have attracted mu...