Jesse Cook

University of Wisconsin–Madison | UW · Department of Psychology

Background Sleep abnormalities may play a prominent role in the pathogenesis or exacerbation of Alzheimer’s disease (AD). Sleep is considered a modifiable target for prevention and treatment. Racial sleep health disparities exist, and may contribute to the disproportionately increased risk for developing AD associated with being African American. Y...

Introduction Sleep slow oscillations (SOs, 0.5-1.5Hz) during stages N2 and N3 sleep facilitate cortical communication and are important to the restorative properties of sleep. Spatiotemporal clustering analysis of SOs on the electrode manifold has identified 3 topographically distinct patterns of SOs: Frontal, Local, and Global. Global SOs are spat...

Introduction Daytime sleepiness is a risk factor for Alzheimer’s disease (AD) pathology and is associated with more severe cardiometabolic sequalae in persons with obstructive sleep apnea (OSA). However, limited studies have examined objective measures of decreased alertness in the context of AD. Here, we examined performance on the psychomotor vig...

Background Daytime sleepiness is common among individuals with obstructive sleep apnea (OSA), and has been reported among individuals with Alzheimer’s Disease (AD) pathology. However, objective measures of decreased alertness have not been examined in the context of AD. Here, we examined performance on the psychomotor vigilance task (PVT) in relati...

Study Objectives Patients with unexplained hypersomnolence have significant impairment related to daytime sleepiness and excessive sleep duration, the biological bases of which are poorly understood. This investigation sought to examine relationships between objectively measured hypersomnolence phenotypes and epigenetic modification of candidate hy...

Introduction Sleep and circadian factors play an important role in school attendance, academic performance, and daytime behaviors among adolescents. This investigation assessed school night sleep duration (SNSD) and circadian preference (CP) association with first period tardies (FPT) using a middle-aged sample from the Madison (Wisconsin) Metropol...

Introduction Sleep plays an important role in adolescent education and development. Sleep impacts student school attendance, academic performance, and daytime behaviors. There has been limited investigation into the impact on sleep duration (SD) on school suspension risk. Given the growing public health and policy focus on altering school start tim...

Study objectives: The multiple sleep latency test (MSLT) has limitations when evaluating disorders of hypersomnolence with unknown etiology. Alternative measures of hypersomnolence may objectively identify pathology in patients with complaints of daytime sleepiness that may not be captured by the MSLT alone. This study evaluated the impact of a mu...

Purpose of Review Diagnosing patients with central disorders of hypersomnolence (CDH) can be challenging. The emergence of wearable technology, such as actigraphy and consumer sleep trackers (CSTs), allows for objective characterization of habitual sleep-wake behavior, which can greatly assist the CDH diagnostic process. This review considers the c...

Hypersomnia is common in psychiatric disorders, yet there are few self-report measures that adequately characterize this sleep disturbance. The objective of this study was to validate the Hypersomnia Severity Index (HSI), a tool designed to measure severity, distress and impairment of hypersomnia in psychiatric populations. Psychometric properties...

Background: Patient heterogeneity is problematic for the accurate assessment and effective treatment of Hypersomnolence Disorder. Clustering analysis is a preferred approach for establishing homogenous subclassifications. Thus, this investigation aimed to identify more homogeneous subclassifications of Hypersomnolence Disorder through clustering a...

Hypersomnolence is a common and debilitating symptom in mood disorders. However, objective differentiation of excessive daytime sleepiness (EDS) from non-EDS in depression has not yet been achieved. This study compared performance on the Compensatory Tracking Task (CTT) and concurrently recorded high-density (hd)EEG theta power in 22 patients with...

Study objectives: To determine the optimal Actiwatch 2 setting configuration for the estimation of total sleep time (TST) in persons with suspected idiopathic hypersomnia. Methods: Thirty-three patients with a diagnosis of idiopathic hypersomnia (28 female; mean age = 33.7 ± 10.5) underwent ad libitum polysomnography with concurrent use of the A...

Introduction The assessment and treatment of Hypersomnolence Disorder (HD) is burdened by patient heterogeneity. Data-driven subtyping has resolved problematic heterogeneity across various medical conditions. Clustering exists as a preferred technique for establishing homogeneous subdivisions within clinical disorders. Thus, this investigation empl...

Study Objectives To clarify whether hypersomnolence disorder is associated with a specific sleep phenotype and altered neurophysiological function in persons with and without hypersomnolence disorder and major depressive disorder (MDD). Methods Eighty-three unmedicated persons with and without hypersomnolence disorder and/or MDD underwent ad libit...

Measuring sleep duration and early onset rapid eye movement sleep (REMS) is critical in the assessment of suspected central disorders of hypersomnolence (CDH). Current multi‐sensor activity trackers that integrate accelerometry and heart rate are purported to accurately quantify sleep time and REMS; however, their utility in suspected CDH has not b...

Study objectives: To evaluate the ability of a multisensory fitness tracker, the Jawbone UP3 (JB3), to quantify and classify sleep in patients with suspected central disorders of hypersomnolence. Methods: This study included 43 patients who completed polysomnography (PSG) and a Multiple Sleep Latency Test (MSLT) with concurrent wrist-worn JB3 an...

Introduction Objectively measured total sleep time (TST) greater than 11 hours is a diagnostic criterion for idiopathic hypersomnia (IH). Guidelines for quantifying TST using extended duration polysomnography (PSG) are well established, however, optimal actigraphic parameters to quantify excessive sleep time in IH are not clear. Since device settin...

Introduction Objective measurement of hypersomnolence plays a key role in the practice of sleep medicine. The multiple sleep latency test (MSLT) is the current gold standard for quantifying daytime sleepiness and measures the ability to fall asleep under soporific conditions. Since hypersomnolence is a multifaceted construct that includes other asp...

Introduction Sleep disturbance is a core symptom of Pediatric post-traumatic stress disorder (PPTSD). Given the link between sleep and affective processing, disruptions in sleep-dependent processing of emotional material have been suggested to contribute to symptom maintenance. In this study we sought to asses the relationship between sleep and emo...

Background Sleep disturbance is a common and important component of affective illness. Fitness activity trackers are emerging as alternative means to estimate sleep in psychiatric patients; however, their ability to quantify sleep in mood disorders has not been empirically evaluated. Thus, this study sought to evaluate the utility of the Fitbit Fle...

Slow waves are characteristic waveforms that occur during non-rapid eye movement (NREM) sleep that play an integral role in sleep quality and brain plasticity. Benzodiazepines are commonly used medications that alter slow waves, however, their effects may depend on the time of night and measure used to characterize slow waves. Prior investigations...

Objective: Changes in slow waves during non-rapid eye movement (NREM) sleep in response to acute total sleep deprivation are well-established measures of sleep homeostasis. This investigation utilized high-density electroencephalography (hdEEG) to examine topographic changes in slow waves during repeated partial sleep deprivation. Methods: Twent...

Objective: Endogenous neurosteroids that potentiate the gamma-aminobutyric acid type A (GABAA ) receptor are thought to enhance the generation of sleep spindles. This study tested the hypothesis that the 5α-reductase inhibitor finasteride, an agent associated with reductions in neurosteroids, would be associated with reduced sleep spindles in men...

Benzodiazepines are commonly used medications that alter sleep spindles during non-rapid eye movement (NREM) sleep, however the topographic changes to these functionally significant waveforms have yet to be fully elucidated. This study utilized high-density electroencephalography (hdEEG) to investigate topographic changes in sleep spindles and spin...