Jess Millar

Jess Millar
University of Michigan | U-M · Department of Computational Medicine & Bioinformatics

MS Bioinformatics, MS Biology, MS Statistics
Looking for postdoc opportunities

About

48
Publications
4,792
Reads
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396
Citations
Additional affiliations
February 2018 - present
University of Michigan
Position
  • Assistant Grader
August 2017 - present
University of Michigan
Position
  • Research Assistant
Description
  • Transmission and evolution of antibiotic resistant bacteria in hospitals.
April 2016 - June 2017
Oregon Health and Science University
Position
  • Research Assistant
Description
  • Oncological prognostic modeling using machine learning techniques.
Education
September 2017 - April 2022
University of Michigan
Field of study
  • Bioinformatics
September 2017 - April 2022
University of Michigan
Field of study
  • Hospital & Molecular Epidemiology
September 2014 - August 2017
Portland State University
Field of study
  • Biology

Publications

Publications (48)
Article
Full-text available
The ongoing COVID-19 pandemic is causing significant morbidity and mortality across the US. In this ecological study, we identified county-level variables associated with the COVID-19 case-fatality rate (CFR) using publicly available datasets and a negative binomial generalized linear model. Variables associated with decreased CFR included a greate...
Article
Computational and mathematical models in biology rely heavily on the parameters that characterize them. However, robust estimates for their values are typically elusive and thus a large parameter space becomes necessary for model study, particularly to make translationally impactful predictions. Sampling schemes exploring parameter spaces for model...
Preprint
Full-text available
The ongoing COVID-19 pandemic is causing significant morbidity and mortality across the US. In this ecological study, we identified county-level variables associated with the COVID-19 case-fatality rate (CFR) using publicly available datasets and a negative binomial generalized linear model. Variables associated with decreased CFR included a greate...
Article
Full-text available
Regulatory RNAs contribute to gene expression control in bacteria. Antisense RNAs (asRNA) are a class of regulatory RNAs that are transcribed from opposite strands of their target genes. Typically, these untranslated transcripts bind to cognate mRNAs and rapidly regulate gene expression at the post-transcriptional level. In this article, we review...
Article
Full-text available
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines and treatment require a 2better understanding of the immune response to infection with Mycobacterium tuberculosis (Mtb). In many infectious diseases, pathogen-specific T cells that are recruited to infection sites are highly responsive and clear infection. Ye...
Article
Abnormally increased angiotensin II activity related to maternal angiotensinogen (AGT) genetic variants, or aberrant receptor activation, is associated with small-for-gestational-age (SGA) babies and abnormal uterine spiral artery remodeling in humans. Our group studies a murine AGT gene titration transgenic (TG; 3-copies of the AGT gene) model, wh...
Article
Full-text available
In the wake of COVID-19, there is an urgent need for a diverse public health work force to address problems presented or exacerbated by the global pandemic. Educational programs that create our work force both train and shape the makeup of access through graduate applications. The Graduate Record Exam has a number of standing issues, with additiona...
Preprint
Full-text available
In the wake of COVID-19, there is an urgent need for a diverse public health work force to address problems presented or exacerbated by the global pandemic. Educational programs that create our work force both train and shape the makeup of access through graduate applications. The Graduate Record Exam has a number of standing issues, with additiona...
Article
Full-text available
Abstract Background Vancomycin-resistant Enterococcus (VRE) is a leading cause of healthcare-associated infections, and asymptomatic colonization precedes infection. VRE continues to spread despite widespread application of pathogen-specific control guidelines. A better understanding of the risk factors for transmission is needed. Methods A retros...
Article
Full-text available
The most commonly studied prokaryotic sensory signal transduction systems include the one-component systems, phosphosignaling systems, extracytoplasmic function (ECF) sigma factor systems, and the various types of second messenger systems. Recently, we described the regulatory role of two separate sensory systems in Streptococcus mutans that jointl...
Data
Comparison of hdrRM luciferase reporter strains. The specific activities of the reporter strains described in Fig 2 of the text are shown for a direct comparison of their expression characteristics. The dashed red line indicates the average background luminescence measured in the assay. The blue bars represent strains listed in Fig 2B. For these re...
Data
Comparison of LRS membrane protein topologies. Protter [36, 37] was used to illustrate the protein topologies of each S. mutans LRS membrane protein as well as putative LRS membrane proteins from other species. For A-E, the predicted protein topology of each S. mutans LRS membrane protein was compared to its corresponding weakest similarity protein...
Data
Insertion sites of brsRM-activating transposon mutations. Red arrows mark the locations of transposon insertions resulting in activation of the brsRM-gusA reporter strain. Open reading frames are drawn to scale. Note: two identical, but independent tilS transposon insertion mutants were isolated. (TIF)
Data
Strains and plasmids used in this study. *Em—erythromycin; Sp—spectinomycin; Km—kanamycin; Cm—chloramphenicol; 4-CP—p-chlorophenylalanine. (XLSX)
Data
Primers used in this study. (XLSX)
Data
Comparison of conserved residues in S. mutans response regulators vs. LRS regulators. A) Clustal Omega was used to align the S. mutans LytTR Family response regulators ComE and LytR along with the well characterized response regulators VicR and CiaR. Residues marked with an asterisk indicate conserved residues. The residues shown in red font repres...
Data
Global analysis of prokaryotic LRS operons. (XLSX)
Article
Immune responses to pathogens are complex and not well understood in many diseases, and this is especially true for infections by persistent pathogens. One mechanism that allows for long‐term control of infection while also preventing an over‐zealous inflammatory response from causing extensive tissue damage is for the immune system to balance pro‐...
Article
Herein, we report an efficient combinatorial therapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin. DJ-1 protein modulates, either directly or indirectly, different oncogenic pathways that support and promote survival, growth, and invasion of ovarian cancer cells. To evaluate...
Chapter
Full-text available
Prognostic models for disease occurrence, tumor progression and survival are abundant for most types of cancers. Physicians and cancer patients are utilizing these models to make informed treatment decisions and corresponding arrangements. However, not all cancer prognostic models are built and validated rigorously. Some are more useful and reliabl...
Thesis
Full-text available
Coxiella burnetii, the etiologic agent of acute Q fever and chronic endocarditis, has a unique biphasic life cycle, which includes a metabolically active intracellular form that occupies a large lysosome-derived acidic vacuole. C. burnetii is the only bacterium known to thrive within such a hostile intracellular niche, and this ability is fundament...
Article
Full-text available
Here, we report the whole-genome sequence of Coxiella burnetii Nine Mile RSA439 (phase II, clone 4), a laboratory strain used extensively to investigate the biology of this intracellular bacterial pathogen. The genome consists of a 1.97-Mb chromosome and a 37.32-kb plasmid.
Article
Full-text available
Coxiella burnetii , the etiologic agent of acute Q fever and chronic endocarditis, has a unique biphasic life cycle, which includes a metabolically active intracellular form that occupies a large lysosome-derived acidic vacuole.C. burnetiiis the only bacterium known to thrive within such an hostile intracellular niche, and this ability is fundament...
Article
Full-text available
We explored the bacterial diversity of untreated sewage influent samples of a wastewater treatment plant in Tucson, AZ and discovered that Arcobacter cryaerophilus , an emerging human pathogen of animal origin, was the most dominant bacterium. The other highly prevalent bacteria were members of the phyla Bacteroidetes and Firmicutes, which are majo...
Data
Combined supplemental files
Article
Full-text available
Non-coding small RNAs (sRNAs) are critical to post-transcriptional gene regulation in bacteria. However, unlike for protein-coding genes, the evolutionary forces that shape sRNAs are not understood. We investigated sRNAs in enteric bacteria and discovered that recently emerged sRNAs evolve at significantly faster rates than older sRNAs. Concomitant...
Article
Full-text available
INTRODUCTION: Our transgenic (TG) model has elevated maternal angiotensinogen expression (120% of WT controls), resulting in fetal growth restriction and abnormal uteroplacental angiogenesis that disproportionately affects male offspring. We hypothesized that placental pathways involved in angiogenic regulation may be negatively impacted by materna...
Article
Full-text available
Plant associations with root microbes represent some of the most important symbioses on earth. While often critically promoting plant fitness, nitrogen-fixing rhizobia and arbuscular mycorrhizal fungi (AMF) also demand significant carbohydrate allocation in exchange for key nutrients. Though plants may often compensate for carbon loss, constraints...
Data
Raw data on effects of light availability (L+ = full light, L- = 50% light), rhizobial (R+ = with rhizobia, R- = no rhizobia) and mycorrhizal (M+ = with AMF fungi, M- = no AMF fungi) colonization on production and viability of seeds in lima bean (Phaseolus lunatus). (DOCX)
Article
Full-text available
Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV. As Coxiella and Leishmania are highly divergent organisms that cause different diseases, we reasoned that their respective infection...
Article
Small RNAs (sRNAs) are short, transcribed regulatory elements that are typically encoded in the intergenic regions (IGRs) of bacterial genomes. Several sRNAs, first recognized in Escherichia coli, are conserved among enteric bacteria, but because of the regulatory roles of sRNAs, differences in sRNA repertoires might be responsible for features tha...
Article
Full-text available
Intestinal parasites pose a burden to the livestock industry throughout the world. Since the discovery of macrocyclic lactones, Ivermectin has been a popular choice to combat nematode (roundworm) infectious due to its broad spectrum of action and high efficacy. Widespread use of this drug has led to the development of resistance in many parasitic n...
Article
Full-text available
Plants can respond with sink stimulation of photosynthesis when colonized with fungal or bacterial root symbionts, compensating costs of carbohydrate allocation to the microbes. However, constraints may arise under light limitation when plants cannot extensively increase photosynthesis. We hypothesize that under such conditions the costs for mainta...
Article
Full-text available
Our goal was to determine the diversity and abundance of Staphylococcus bacteria on different components of a public transportation system in a mid-sized US city (Portland, Oregon) and to examine the level of drug resistance in these bacteria. We collected 70 samples from 2 cm × 4 cm sections from seven different areas on buses and trains in Portla...

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