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Publications (51)
STUDY QUESTION
What are the current national medically assisted reproduction (MAR) data collection systems across EU Member States, and how can these countries contribute to a unique, cycle-by-cycle registry for the European Monitoring of Medically Assisted Reproduction (EuMAR) project?
SUMMARY ANSWER
The study identified significant variation in...
STUDY QUESTION
How are ART and IUI regulated, funded, and registered in European countries, and how has the situation changed since 2018?
SUMMARY ANSWER
Of the 43 countries performing ART and IUI in Europe, and participating in the survey, specific legislation exists in only 39 countries, public funding varies across and sometimes within countries...
Study question
What are the reported data on cycles in ART, IUI and fertility preservation interventions in 2021 as compared to previous years and what are the main trends over the years?
Summary answer
The 25th ESHRE report on ART and IUI shows a progressive increase in reported treatment cycle numbers in Europe, a small decrease in the number of...
STUDY QUESTION: How does a gonadotrophin-releasing hormone (GnRH) agonist versus a GnRH antagonist protocol affect ovarian
response when using an individualized fixed daily dose of follitropin delta for ovarian stimulation?
SUMMARY ANSWER: The BEYOND trial data demonstrate that individualized fixed-dose follitropin delta is effective when used in a...
STUDY QUESTION: What are the data and trends on ART and IUI cycle numbers and their outcomes, and on fertility preservation (FP) interventions, reported in 2019 as compared to previous years? SUMMARY ANSWER: The 23rd ESHRE report highlights the rising ART treatment cycles and children born, alongside a decline in twin deliveries owing to decreasing...
STUDY QUESTION
What are the data and trends on ART and IUI cycle numbers and their outcomes, and on fertility preservation (FP) interventions, reported in 2019 as compared to previous years?
SUMMARY ANSWER
The 23rd ESHRE report highlights the rising ART treatment cycles and children born, alongside a decline in twin deliveries owing to decreasing...
Background:
The growing field of assisted reproductive techniques, including frozen-thawed embryo transfer (FET), should lead the way to the best sustainable health care without compromising pregnancy chances. Correct timing of FET is crucial to allow implantation of the thawed embryo. Nowadays, timing based on hospital-controlled monitoring of ov...
Study question
What are the reported data on cycles in ART, IUI and fertility preservation interventions in 2020 as compared to previous years and what are the main trends over the years?
Summary answer: author
The 24rd ESHRE report on ART and IUI shows a progressive increase in reported treatment cycle numbers in Europe, a small decrease in the n...
More than 20 years ago, the survey of activities in medically assisted reproduction (MAR) was initiated in Europe and resulted in cross-sectional annual reports, as issued by the European IVF Monitoring (EIM) consortium of ESHRE. Over time, these reports mirror the continuous development of the technologies and contribute to increased transparency...
STUDY QUESTION
What are the data and trends on ART and IUI cycle numbers and their outcomes, and on fertility preservation (FP) interventions, reported in 2018 as compared to previous years?
SUMMARY ANSWER
The 22nd ESHRE report shows a continued increase in reported numbers of ART treatment cycles and children born in Europe, a decrease in transfe...
STUDY QUESTION
Is a single endometrial scratch prior to the second fresh IVF/ICSI treatment cost-effective compared to no scratch, when evaluated over a 12-month follow-up period?
SUMMARY ANSWER
The incremental cost-effectiveness ratio (ICER) for an endometrial scratch was €6524 per additional live birth, but due to uncertainty regarding the incre...
STUDY QUESTIONS
The objective of this trial is to compare the effectiveness and costs of true natural cycle (true NC-) frozen embryo transfer (FET) using urinary LH tests to modified NC-FET using repeated ultrasound monitoring and ovulation trigger to time FET in the natural cycle. Secondary outcomes are the cancellation rates of FET (ovulation bef...
STUDY QUESTION
Does endometrial scratching in women with one failed IVF/ICSI treatment affect the chance of a live birth of the subsequent fresh IVF/ICSI cycle?
SUMMARY ANSWER
In this study, 4.6% more live births were observed in the scratch group, with a likely certainty range between −0.7% and +9.9%.
WHAT IS KNOWN ALREADY
Since the first sugges...
Background:
In many countries, clomifene citrate is the treatment of first choice in women with normogonadotropic anovulation (ie, absent or irregular ovulation). If these women ovulate but do not conceive after several cycles with clomifene citrate, medication is usually switched to gonadotrophins, with or without intrauterine insemination. We ai...
What is the cost-effectiveness of in vitro fertilization (IVF) with conventional ovarian stimulation, single embryo transfer (SET) and subsequent cryocycles or IVF in a modified natural cycle (MNC) compared with intrauterine insemination with controlled ovarian hyperstimulation (IUI-COH) as a first-line treatment in couples with unexplained subfert...
Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous ongoing pregnancy (SOP) than the World Health Organization (WHO) classification system?
The prewash TMSC shows a better correlation with the spontaneous ongoing pregnancy rate (SOPR) than the WHO 2010 classification system.
According to the WHO classific...
STUDY QUESTION What is the effectiveness of continued treatment with clomiphene citrate (CC) in women with World Health Organization (WHO)
type II anovulation who have had at least six ovulatory cycles with CC but did not conceive?
The aim of this study was to investigate the presence of MMP-14 and MMP-2 during human ovarian follicular development using immunohistochemistry, and the activity of MMP-2 in follicular fluid using zymography.
Ovarian tissue collected from the archives of the Department of Pathology was examined and medical records and histopathology were reviewed....
Background:
Clomiphene citrate (CC) is first line treatment in women with World Health Organization (WHO) type II anovulation and polycystic ovary syndrome (PCOS). Whereas 60% to 85% of these women will ovulate on CC, only about one half will have conceived after six cycles. If women do not conceive, treatment can be continued with gonadotropins o...
Objective: To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics, such as female age, in the prediction of excessive response to ovarian hyperstimulation in patients undergoing IVF, and whether their performance differs across clinical subgroups. Design: Authors of studies reporting on basal FSH, antimülle...
Study question:
Do the quality of life (QoL) and the risk factors for emotional problems during and after treatment of infertile women differ from their partners?
Summary answer:
Women have lower levels of fertility-related QoL, and more and differing risk factors for emotional problems during and after treatment than their partners. WHAT IS KNO...
Abstract Background Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decisi...
Long-term effects of ovarian stimulation for IVF on the risk of ovarian malignancies are unknown.
We identified a nationwide historic cohort of 19,146 women who received IVF treatment in the Netherlands between 1983 and 1995, and a comparison group of 6006 subfertile women not treated with IVF. In 1997-1999, data on reproductive risk factors were o...
To produce age-related normograms for serum antimüllerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO).
Retrospective cohort analysis.
Fifteen academic reproductive centers.
A total of 3,871 infertile women.
Blood sampling for AMH level.
Serum AMH levels and correlation between age and different percentiles of AMH.
Ag...
After many years of research, the impact of psychological distress on the IVF treatment outcome is still unclear. This study aimed to determine the influences of anxiety and depression before and during IVF or ICSI treatment on the cancellation and pregnancy rates of inductees.
In a multicentre prospective cohort study, we assessed anxiety and depr...
To assess the glycoform distribution patterns of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) during the menstrual cycle at different ages and FSH levels, after menopause, and with premature ovarian failure (POF).
Controlled clinical study.
Healthy volunteers in an academic research environment.
Women aged 20 to 25 years with nor...
Antimüllerian hormone (AMH) and other markers of ovarian reserve were assessed to determine their predictive value with respect to treatment outcome. In a multivariate regression analysis, AMH was found to be predictive of the number of oocytes and the number of embryos, but not of embryo quality or the chance of a pregnancy, after IVF/ICSI.
The aim of this study was to gain more insight into long-term psychological adjustment to IVF in women.
In a prospective cohort study, 298 women entering their first IVF treatment cycle (including ICSI) completed standardized psychological questionnaires before the start of the treatment, just after the last treatment cycle, and 6 months and 3-5 ye...
This review provides an overview of how women adjust emotionally to the various phases of IVF treatment in terms of anxiety, depression or general distress before, during and after different treatment cycles. A systematic scrutiny of the literature yielded 706 articles that paid attention to emotional aspects of IVF treatment of which 27 investigat...
The objective of this study was to determine the predictive value of FSH isoforms for the outcome of IVF treatment. Although this pilot study comprises only a small number of patients, we conclude that because no statistical differences could be found in the isoform-composition between poor and good responders, it is not likely that FSH isoforms pr...
In the present prospective study, the relationship between autobiographical memory specificity and the emotional reactions to a stressful event was investigated.
The Autobiographical Memory Test (AMT) was administered to 74 women before they underwent an in vitro fertilization (IVF) treatment, which subsequently failed. Symptoms of emotional reacti...
A longitudinal study into the course of the emotional response to IVF from pre-treatment to 6 months post-treatment and factors that contributed to that course.
A total of 148 IVF patients and 71 partners completed self-report questionnaires on anxiety, depression, personality characteristics, meaning of fertility problems, coping, marital relation...
The predictive value of a comprehensive model with personality characteristics, stressor related cognitions, coping and social support was tested in a sample of 187 nonpregnant women. The emotional response to the unsuccessful treatment was predicted out of vulnerability factors assessed before the start of the treatment. The results indicated the...
The aim of this study was to examine the associations between urinary levels of the stress hormones adrenaline, noradrenaline and cortisol during treatment with self reported stress, in order to investigate the mechanism for the previously observed negative association of anxiety and depression with the outcome of IVF/ICSI.
In a multicentre prospec...
Because several studies indicate that psychological factors play a role in dropping out of IVF treatment, the question arises as to whether psychological interference is indicated.
To gain more insight into psychological aspects of dropping out from IVF-ICSI.
Prospective cohort study.
University hospital-based tertiary care fertility clinic.
Women entering their first treatment cycle of IVF or ICSI.
Standardized psychological questionnaires were administered before the start of the treatment and after treatment.
Reasons for d...
This study was designed to prospectively investigate the role of neuroticism, trait anxiety and attentional biases towards threat in the development of anxiety after a failed IVF or ICSI treatment. A subliminal and supraliminal Stroop task was administered to 49 women entering IVF or ICSI treatment as well as self-report measures of neuroticism, tr...
Determination of the emotional burden of the first IVF or ICSI treatment cycle, the effect of the treatment on the marital relationship, and the course of the treatment following a failed and a successful first attempt.
Descriptive longitudinal study with repeated measures before and after the first treatment cycle.
240 women and 219 men filled in...
To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI).
Repeated measurement.
Fertility department at a university and a regional hospital.
Women entering their first treatment cycle of IVF...
The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes.
In a multicentre prospective study, 291 out of 359 (81%) consecu...
This study aimed to externally validate the prognostic model presented by Templeton in 1996 for live births resulting from
IVF treatment. Data were used from the University Hospital, Nijmegen, The Netherlands, from March 1991 to January 1999. The
predictive capacity of the model in our population discriminated between those women with a low probabi...