Jerome J Schentag

Jerome J Schentag
University at Buffalo, The State University of New York | SUNY Buffalo · Department of Pharmacy Practice

Doctor of Pharmacy

About

412
Publications
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Introduction
I retired from the University at Buffalo in 2015. I now live the challenging life of an inventor, with my major focus on a novel means of drug delivery. Working with colleagues from Niagara University, we have developed the Cholestosome, a way to use chylomicrons to achieve intracellular delivery of macromolecules such as proteins, peptides and nucleic acids. Patents have issued. There is much more information at https://schentag.com

Publications

Publications (412)
Article
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Background: Serious but rare side effects associated with immunotherapy pose a difficult problem for regulators and practitioners. Immune checkpoint inhibitors (ICIs) have come into widespread use in oncology in recent years and are associated with rare cardiotoxicity, including potentially fatal myocarditis. To date, no comprehensive model of myo...
Article
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Background Immune checkpoint inhibitors (ICI) have emerged as a front-line therapy for a variety of solid tumors. With the widespread use of these agents, immune-associated toxicities are increasingly being recognized, including fatal myocarditis. There are limited data on the outcomes and prognostic utility of biomarkers associated with ICI-associ...
Article
The importance of glucose metabolic changes and inflammatory responses to these changes connect diabetes and Alzheimer’s disease (AD). The role intracellular insulin may have in this process could provide for alternative therapeutic approaches. In this study a novel cholesteryl ester based vesicle called a CholestosomeTM, that encapsulates payloads...
Article
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Introduction Risk assessment tools are utilized to estimate the risk for stroke and need of anticoagulation therapy for patients with atrial fibrillation (AF). These risk stratification scores are limited by the information inputted into them and a reliance on time-independent variables. The objective of this study was to develop a time-dependent n...
Patent
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the patent address the fatty liver and NASH , in isolation or combined with other viral infection ,showing that it is intimately associated with metabolic syndrome . as per our previous patents, were the discovery and proof that damage to the L-cell system , and the proven rescue with Aphoeline/brake as a mean to resuscitate the L-cells secretion b...
Article
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p>This study was carried out to determine the types of Methicillin-Resistant Staphylococcus aureus (MRSA) by two typing systems, Coagulase typing and spa typing and to identify relationship between types of MRSA strains isolated from patients and hospital staff carriers. A total of 40 MRSA strains, 33 from cases of wound infection and 7 from anteri...
Article
Levofloxacin (LVFX) has different effects depending on the area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ratio. While AUC can be expressed as dose/clearance (CL), we measured serial concentrations of LVFX in Koreans and tried to set a Korean-specific equation, estimating the CL of the antibiotic. In total, 38...
Article
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Although antibiotics whose epithelial lining fluid (ELF) concentrations are reported high tend to be preferred in treatment of pneumonia, measurement of ELF concentrations of antibiotics could be misled by contamination from lysis of ELF cells and technical errors of bronchoalveolar lavage (BAL). In this review, ELF concentrations of anti-methicill...
Article
Elevated minimum inhibitory concentrations (MICs) of vancomycin against meticillin-resistant Staphylococcus aureus (MRSA) and the emergence of heteroresistant S. aureus strains have led to increased use of anti-MRSA antibiotics other than vancomycin. Ceftaroline fosamil is a novel cephalosporin with activity against MRSA, but there are limited clin...
Article
Comparison of Weight and Metabolic Profiles in Patients Treated with an Oral Mimetic of the Roux-en-Y Gastric Bypass Effect David M. Jacobs, PharmD1,2, Joseph Fayad, MD3, Scott V. Monte, PharmD1,2, Ashley Toale, PharmD4, Anthony Perna, MD1, Mark Bryniarski1, Jerome J. Schentag, PharmD1,2 1University at Buffalo School of Pharmacy and Pharmaceutica...
Article
Infections in critically ill patients are associated with persistently poor clinical outcomes. These patients have severely altered and variable antibiotic pharmacokinetics and are infected by less susceptible pathogens. Antibiotic dosing that does not account for these features is likely to result in suboptimum outcomes. In this Review, we explore...
Article
Objective: To determine whether the expression of key asthma related genes, IL-4, LIGHT, LTBR, MMP-9, CCR-2, and ADAM-33 in mononuclear cells and the plasma concentration of nitric oxide metabolites (NOM) and MMP-9 are increased in the obese, obese type 2 diabetics (T2DM) and in morbidly obese patients prior to and after gastric bypass surgery (RY...
Article
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In treatment of pneumonia, microorganisms sometimes persist, appear or reappear despite good clinical responses. On the other hand, recent increasing antibiotic resistance emphases the goal of rapid eradication of pathogen in severe infection. This study was planned to evaluate the correlations between microbiological outcomes and clinical response...
Article
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Purpose: Underlying Metabolic Syndrome (MS) has many diff erent manifestations such as Type 2 Diabetes, hyperlipidemia, obesity or NAFLD, but there is no means of tracking progression of MS in patient populations that may have any or all of these conditions to varying degree. It was our hypothesis that improved risk scoring could be accomplished vi...
Article
Roux-en-Y gastric bypass (RYGB) results in profound weight loss and resolution of type 2 diabetes mellitus (T2DM). The mechanism of this remarkable transition remains poorly defined. It has been proposed that endotoxin (lipopolysaccharide [LPS]) sets inflammatory tone, triggers weight gain, and initiates T2DM. Because RYGB may diminish LPS from end...
Article
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Previously our group has developed neural net progression models to characterize the development of organ failure in an ovine only as well as an integrated human/ovine model of acute lung injury using early clinical information. The goal of this study was to expand our model of disease progression using clinically available data as well as more exp...
Article
Despite pharmacological advances, delivery of drugs to the posterior segment of the eye remains problematic. We investigated the ability of hydrogel contact lenses to deliver small-molecule steroids, as well as larger biological molecules to the posterior segment. Release characteristics of steroid-instilled lenses were studied in vitro. Drug deliv...
Article
Aminoglycosides and penicillins chemically interact when they are combined in vitro or in vivo. The resulting adducts are considered to be biologically inactive. The major adducts formed in he interaction between tobramycin and ticarcillin have been recently isolated in pure form in our laboratory. On the basis of mass, infrared, and proton magneti...
Article
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Having the ability to predict organ failure could impact treatment decisions and potentially lessen the consequences of acute lung injury (ALI) and sepsis. While Acute Physiology and Chronic Health Evaluation (APACHE II) and the Pneumonia Severity Index are useful in predicting the risk of morbidity and mortality, they do not predict the risk of de...
Article
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Acute lung injury (ALI) caused by smoke inhalation with or without bacterial pneumonia remains a significant cause of morbidity and mortality among burn patients. Bacterial pneumonia in an ALI patient is particularly worrisome because it often leads to sepsis. Although much of the literature surrounding ALI and pneumonia-induced sepsis has rightful...
Article
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Methicillin-resistant Staphylococcus aureus (MRSA) is an invasive pathogen in critically ill patients, and is commonly the cause of nosocomial pneumonia. Infection with MRSA can lead to bacteremia, septic shock, and multisystem dysfunction. Previous work has demonstrated that a MRSA pneumonia-sepsis model in sheep mimics the vascular state in human...
Article
To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting. A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are...
Article
This study evaluated the species differences in microbiological outcomes of Gram-negative bacteria (GNB) causing severe pneumonia from the viewpoint of area under the concentration-time curve/MIC ratio (AUC/MIC). In total, 111 strains of GNb from 74 patients were analyzed. Overall, microbiological eradication was achieved in 88% of the cases with i...
Article
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Background: For microvascular outcomes, there is compelling historical and contemporary evidence for intensive blood glucose reduction in patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). There is also strong evidence to support macrovascular benefit with intensive blood glucose reduction in T1DM. Similar evi...
Article
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Background: The nonsignificant reduction in macrovascular outcomes observed in Action to Control Cardiovascular Risk in Diabetes; Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation; and the Veterans Affairs Diabetes Trial have collectively created uncertainty with respect toward the proper extent...
Conference Paper
Background: As clinical and microbiological failures are becoming frequent in traditional dose VAN therapy, increasing VAN trough concentrations is recommended for serious MRSA infections. However, there has been no prospective clinical report on the high dose VAN therapy. In addition, despite in vitro studies demonstrating synergy with Q/D and VAN...
Article
Adequate data on the pharmacokinetics of once-daily administration of ertapenem in critically ill patients are largely lacking. This single-centre, prospective, open-label study was performed on a cohort of eight critically ill patients with severe sepsis with normal renal function treated with 1g of ertapenem once daily. Samples of venous blood an...
Conference Paper
Background: Imipenem monotherapy has been unreliable for severe gram negative bacteria (GNB) pneumonia, and we often empirically combine aminoglycosides or fluoroquinolones with imipenem to improve outcomes. In this study, we used PK/PD data to examine the efficacy of imipenem, alone and in combination for severe GNB pneumonia. Methods: Time-relate...
Article
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Patients with chronic obstructive pulmonary disease (COPD) may progress to community-acquired pneumonia (CAP), but there has been no formal study of the factors responsible. We studied the influence of severity of underlying lung disease, pathogen characteristics and the ratio of the area under the concentration-time curve from 0-24h to minimum inh...
Article
The influence of extended- spectrum beta-lactams on gram-negative bacterial resistance was studied. Hospital pharmacists were asked to provide data on antimicrobial use and bacterial susceptibilities. Defined daily doses per 1000 patient-days of cefepime, ceftazidime, ceftriaxone, and piperacillin-tazobactam were assessed for significant associatio...
Article
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To determine the direct medical costs of treating lower respiratory tract infections (LRTIs) in a managed care organization (MCO). Retrospective analysis of a regional MCO identifying adults diagnosed with acute exacerbation of chronic bronchitis (AECB) or community- acquired pneumonia (CAP). A claims database examination of International Classific...
Article
The objective of this study was to evaluate the relationship of the predicted pharmacodynamic parameters 24-h area under the inhibitory curve (AUIC=area under the concentration-time curve for 24h of dosing/minimum inhibitory concentration (AUC0-24/MIC) and time above the minimum inhibitory concentration (T>MIC) with clinical and microbiological out...
Article
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To evaluate the economic impact of performing rapid testing for Staphylococcus aureus colonization before admission for all inpatients who are scheduled to undergo elective surgery and providing subsequent decolonization therapy for those patients found to be colonized with S. aureus. A budget impact model that used probabilistic sensitivity analys...
Article
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This was a retrospective, multi-center study of patients admitted to hospital with community-acquired pneumonia, caused by Streptococcus pneumoniae, after failing to respond to >2 days of outpatient macrolide therapy. 122 cases, treated between 2000-2004, were enrolled from 31 North American sites between January 2004 - March 2005. Non-susceptible...
Conference Paper
Background: To assess the prevalence of S. aureus infections and evaluate its incremental impact on in-hospital mortality in U.S. hospitals in 2003. Methods: Data from the 2003 Nationwide Inpatient Sample were analyzed. Hospital discharges were classified as either a S. aureus-related infection stay or a non-S. aureus-related infection stay using a...
Article
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There are few data on macrolide pharmacodynamics in pneumococcal infections. We evaluated pneumococcal area under the inhibitory concentration-time curve (AUIC) values at the point of hospital admission in 59 bacteraemic patients failing in the community and in 98 bacteraemic controls without macrolide exposure. The area under the 24-h concentratio...
Article
Current knowledge and policies regarding vancomycin use and the clinical performance of vancomycin in U.S. hospitals were assessed. A questionnaire was sent to interested hospital pharmacists. An observational study of hospitalized adults who received at least 72 hours of i.v. vancomycin for a culture-confirmed gram-positive infection followed. Hos...
Article
The pharmacokinetics of oseltamivir and oseltamivir carboxylate in healthy Japanese (n = 14) and Caucasian (n = 14) males were compared. Subjects in each ethnic group were randomized to twice-daily oral oseltamivir 75 mg, 150 mg, or placebo for 13 doses. Oseltamivir was well tolerated across doses and ethnic groups. Oseltamivir was rapidly absorbed...
Article
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We examined the relationship between the time to clearance of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia while patients were receiving vancomycin therapy and the in vitro bactericidal activity of vancomycin. Vancomycin killing assays were performed with 34 MRSA bloodstream isolates (17 accessory gene regulator group II [agr-II] a...
Article
To compare once-daily intramuscular cefepime with ceftriaxone controls. Double-blind study. Six skilled nursing facilities. Residents aged 60 and older with nursing home-acquired pneumonia. Cultures were obtained, and patients were randomized to cefepime or ceftriaxone 1 g intramuscularly every 24 hours. Clinical success: cure or improvement. Cure...
Article
Antibacterial cost-containment programmes emphasise the use of narrow-spectrum generic agents whenever possible. The use of these agents is driven by their lower purchase prices; the consequences of treatment failure are rarely considered. This study was conducted to identify the costs of treating patients hospitalised with community-acquired pneum...
Article
The pharmacokinetics and pharmacodynamics of angiotensin-converting enzyme inhibitors (ACE) in elderly patients and patients with renal and hepatic impairment were examined, and a role for an AUC/EC50 ratio to guide dosing was evaluated. A Medline and International Pharmaceutical Abstracts search was used to identify human studies and abstracts. Re...
Article
Although minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) have been used as the most popular prediction tools for antimicrobial action, they have shortcomings. The MIC and MBC do not consider time-related antimicrobial effects, such as killing rate and postantibiotic effect. In this regard, the concept of pharmaco...
Conference Paper
Background: Oral β-lactams (β-l) & macrolides (mac) are frequently used in the outpatient treatment of CAP. Insurance companies’ tiered prescription plans encourage use of generics and older agents while penalizing newer & more potent agents with higher co-pay amounts. Consideration is limited to drug price while ignoring costs of treatment failure...
Article
Full-text available
Previous studies have investigated the impact of Staphylococcus aureus infections on individual hospitals, but to date, no study using nationally representative data has estimated this burden. This is a retrospective analysis of the 2000 and 2001 editions of the Agency for Healthcare Research and Quality's Nationwide Inpatient Sample database, whic...
Article
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Efflux of cytotoxic agents mediated by P-glycoprotein is believed to be an important mechanism of multidrug resistance, which remains a serious limitation to successful chemotherapy in cancers such as metastatic breast cancer. A series of 4-aryl-1,4-dihydropyridines and corresponding aromatized 4-arylpyridines have been synthesized based on structu...
Chapter
Ventilator-associated pneumonia (VAP) is characterized by its high prevalence, and more importantly, by its fatal consequences. Although the overall incidence of nosocomial respiratory infections including VAP is lower than urinary tract infection, accounting for 15-20% of the total, it is the most common infection in intensive care unit (ICU) sett...