Jérôme Laurin

Aix-Marseille Université | AMU · Institut de Neurobiologie de la Méditerranée (UMR_1249 INMED)

Although the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prominent positive effects on the pathophysiology of many neurological disorders, the mechanism of action is obscure. Attention for elucidating the role of Nkcc1 has been mainly focused on neurons. Recent single cell mRNA sequencing analysis has demonstrated that the major cellular...

The optimal endurance exercise parameters remain to be defined to potentiate long-term functional recovery after stroke. We aim to assess the effects of individualized high-intensity interval training (HIIT) with either long or short intervals on neurotrophic factors and their receptors, apoptosis markers and the two-main cation-chloride cotranspor...

Background. Traumatic brain injury (TBI) is the main cause of disabilities over the industrialized countries. Cognitive decline appears in the chronic phase of the pathology consecutively to cellular and molecular processes. Here we described the use of KCC2, a neuronal-specific potassium-chloride transporters as potent biomarker to predict cogniti...

Objective The Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide has prominent positive effects on the pathophysiology of many neurological disorders. Here we studied whether bumetanide could influence post-traumatic cognitive decline and inflammatory processes by regulating astrocyte and microglia activation. Method Controlled cortical impacted (...

Rey, O. ; Rossi, D., Nicol, C., Laurin, J., Hugues, N., (2022). Choisir un test intermittent progressif et maximal propice à la construction de repères d’effort en EPS : le 15-15 Spartacus, Revue EPS, 394.

Nicol C., Laurin J., Rey O., Robert O., Cecconi J., (2022). Articuler la mesure des capacités physiques à la formation en STAPS, Revue EPS, 394.

Mitochondria is an autonomous organelle that plays a crucial role in the metabolic aspects of a cell. Cortical Spreading Depression (CSD) and fluctuations in the cerebral blood flow have for long been mechanisms underlying migraine. It is a neurovascular disorder with a unilateral manifestation of disturbing, throbbing and pulsating head pain. Migr...

The temporal pattern of cortical plasticity induced by high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) is required to clarify their relative benefits to prevent neurological disorders. The purpose of this study is to define the time-dependent effects of work-matched HIIT and MICT on cortical plasticity, end...

Introduction & Objective: Apoptosis, one of the most important mechanisms explaining stroke-induced functional deficit severity, might be reduced by physical rehabilitation. The purpose of this study is to assess effects of an 8-week endurance training both on apoptosis-related genes and proteins expression levels after a transient common carotid a...

Stroke-induced cognitive impairments affect the long-term quality of life. High-intensity interval training (HIIT) is now considered a promising strategy to enhance cognitive functions. This review is designed to examine the role of HIIT in promoting neuroplasticity processes and/or cognitive functions after stroke. The various methodological limit...

Background and purpose: The objective is to compare the effects of high-intensity interval training (HIIT) with long versus short intervals on endurance and motor performance. Their influence on neuroplasticity markers is assessed in the ipsilesional and contralesional cortex and hippocampus since their remodeling could improve functional recovery...

Combining aerobic, coordination and cognitive training allows better improving physical and cognitive performance than when performed separately. A Nordic walking (NW) and two cognitive-motor circuits training programs (CT-c and CT-fit) are compared. Ct-c and CT-fit stimulates cognition differently: CT-c, through conventional complex coordination t...

This study was designed to compare work-matched high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) based on lactate threshold on aerobic performance, brain plasticity markers and cognitive functions following 8 weeks in healthy rats. Muscular plasticity and grip strength were also investigated. Rats performe...

Introduction: We compared Nordic walking training (NW) to a multi-component training (MCT) program of an equivalent intensity, in older adults. Our main hypothesis was that MCT would result in larger effects on cognitive processes than NW. Methods: Thirty-nine healthy older adults, divided in two groups (NW and MCT), took part to study (17 males,...

Injectable hydrogels are promising platforms for tissue engineering and local drug delivery as they allow minimal invasiveness. We have here developed an injectable and biodegradable hydrogel based on an amphiphilic PNIPAAm-b-PLA-b-PEG-b-PLA-b-PNIPAAm pentablock synthesized by ring-opening polymerization/nitroxide-mediated polymerization (ROP/NMP)...

The purpose of the present study was to examine the contribution of group III and IV metabosensitive afferents at spinal and supraspinal levels in rats subjected to middle cerebral artery occlusion (MCAO) with reperfusion during the acute phase. Animals were randomized in Control (n = 23), SHAM (n = 18), MCAO-D1 (n = 10), and MCAO-D7 (n = 20) group...

Background and purpose: This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity aerobic training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks after cerebral ischemia. Methods: Rats were randomized as follows: control (n=15), SHAM (n=9), middle cerebral arter...

Background: Animal models of spinal cord injuries aim to utilize controlled and reproducible conditions. However, a literature review reveals that mouse contusion studies using equivalent protocols may show large disparities in the observed impact force vs. cord compression relationship. The overall purpose of this study was to investigate possibl...

La fibromyalgie est une maladie douloureuse chronique pour laquelle le reconditionnement physique est le traitement de première intention d’après les recommandations (HAS 2010, EULAR 2016, Rapport Députés 2016). « Fibromyactiv », étude monocentrique, prospective et randomisée, évalue l’efficacité d’un programme d’activité physique adaptée organisé...

After more than 20 years since the introduction of ecological and dynamical approaches in sports research, their promising opportunity for interdisciplinary research has not been fulfilled yet. The complexity of the research process and the theoretical and empirical difficulties associated with an integrated ecological-dynamical approach have been...

While the call for interdisciplinary studies has been loud and clear over the last decade or so, the number of interdisciplinary publications in sport sciences is rather limited. One of the reasons for this scarcity is the complexity of the research process itself. Still, the combination and integration of information from different scientific disc...

Stroke often aggravated age-related cognitive impairments that strongly affect several aspects of quality of life. However, few studies are, to date, focused on rehabilitation strategies that could improve cognition. Among possible interventions, aerobic training is well known to enhance cardiovascular and motor functions but may also induce benefi...

Stroke often aggravated age-related cognitive impairments that strongly affect several aspects of quality of life. However, few studies are, to date, focused on rehabilitation strategies that could improve cognition. Among possible interventions, aerobic training is well known to enhance cardiovascular and motor functions but may also induce benefi...

Purpose: This study was designed to highlight the functional impairments and the neuromuscular adaptations following an anterior cruciate ligament (ACL) injury in rat. Methods: Animals were randomized into 5 groups: Control (n=8), SHAM-1wk (n=6), SHAM-5wk (n=8), ACL-1wk (n=8) and ACL-5wk (n=8). Rats performed 3 behavioral tests (the ladder-climb...

Stroke remains a leading cause of adult motor disabilities in the world and accounts for the greatest number of hospitalizations for neurological disease. Stroke treatments/therapies need to promote neuroplasticity to improve motor function. Physical exercise is considered as a major candidate for ultimately promoting neural plasticity and could be...

The present review is focused on neural mechanisms responsible of group III and IV muscle afferent actions on central motor drive during physical exercise in both healthy and pathological populations. It seems that these mechanisms contribute to improve muscle performance by regulating the peripheral fatigue development and by avoiding excessive mu...

The present study is designed to assess the properties of a new degradable PLA-b-PHEMA block copolymer hydrogel and its therapeutic effectiveness after implantation following a thoracic spinal cord hemisection on rats. Degradable characteristics and porous aspect of the scaffold are respectively analyzed by the evaluation of its mass loss and by el...

Background: To date, fibrin sealant is considered to be one of the most effective substitutes to prevent post-operative fibrosis and to limit neuroma formation after nerve suture. Because fibrin sealant presents a number of drawbacks, more suitable techniques should be considered. The aim of this study was to functionally and histologically compar...

The endurance training is considered as an integral part of stroke rehabilitation. However, medical institutions did not systematically include aerobic exercises because of the lack of scientific evidence. It is mainly the case for high-intensity interval training (HIT) for which very few experiments were focused on after stroke. This review was de...

The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respective...

Currently, autologous nerve implantation to bridge a long nerve gap presents the greatest regenerative performance in spite of substantial drawbacks. In this study, we evaluate the effect of two different collagen conduits bridging a peroneal nerve gap. Rats were divided into four groups: (1) the gold standard group, in which a 10-mm-long nerve seg...

The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respective...

The endurance training is considered as an integral part of stroke rehabilitation. However, medical institutions did not systematically include aerobic exercises because of the lack of scientific evidence. It is mainly the case for high-intensity interval training (HIT) for which very few experiments were focused on after stroke. This review was de...

The aim of the present study is to assess the relevance of weight-bearing distribution (DWB) measurement in freely moving rats after stroke and thoracic spinal cord injuries. Animals were divided in 2 experiments: 1) The middle cerebral artery occlusion-reperfusion (MCAO-r) experiment containing the MCAO group in which focal brain ischemia was indu...

MR spectroscopy allows a noninvasive assessment of metabolic information in healthy and pathological central nervous system. Whereas MR spectroscopy has been extensively applied in the brain, only few spectroscopic studies of the spinal cord (SC) have been performed so far. For mice, due to additional technical challenges, in vivo (1) H SC MRS has...

There have been considerable interests in attempting to reverse the deficit due to a spinal cord injury by restoring neural pathways through the lesion and by rebuilding tissue network. In order to provide an appropriate micro-environment for regrowing axotomized neurons and proliferating and migrating cells, we have implanted small block of pHPMA...

We aimed at determining the recovery pattern of neural properties of soleus muscle after a single bout of neuromuscular electrical stimulation (NMES) session. Thirteen subjects performed an NMES exercise (75 Hz, 40 contractions, 6.25 s per contraction). Maximal voluntary contraction (MVC), H-reflex at rest and during voluntary contraction fixed at...

Medial collateral ligament (MCL) rupture of the knee joint frequently occurs during sport activities. However, the optimal rehabilitation strategy after such lesion is unknown. The aim of this study was to assess the effects of progressive eccentric rehabilitation program on neuromuscular deficits induced by MCL transection. Rats were randomized as...

The aim of this study is to describe the eŠects of transcutaneous muscular electrical stimulation on vertical jump performance (jumping height). Electromyostimulation (30 min/day, 10 sessions during 4 weeks) was applied, using a symmetric and biphasic rectangular pulses, with ramp modulation of both pulse duration and stimulation frequency. Ten hea...

The aim of this study was to identify the effect of chemical activation of muscle metabosensitive afferent fibers from groups III and IV on Hoffmann (H-) reflex modulation in the vastus medialis muscle. The experiment was conducted in rats and was divided into two experiments. The first experiment consisted of recording the metabosensitive afferent...

The purpose of this study was to test the hypothesis that group III and IV muscle afferent activity would differ after concentric- and eccentric-type fatiguing tasks. Tibialis anterior afferent activities from adult rats were measured in three conditions: before and after a rest period (C), and after concentric (CC) or eccentric (EC) exercise. Spec...

The medial collateral ligament (MCL) is one of the most injured ligaments during sport activities. The resulting joint damage effects on neuromuscular system remain unclear. Thus this study was designed to assess the changes in neuromuscular properties of vastus medialis muscle after MCL transection. Complete rupture of MCL was performed on rats, a...

In previous studies, the effect of tenotomy had been focused mainly on muscle properties (typology, capillarity, force, etc.). Little attention was paid to the metabosensitive fibers from groups III and IV (also called 'ergoreceptors' or 'exercise receptors'). In the current study, we assessed the metabosensitive responses in a rat model with tenot...