Jeremy Antonyshyn

Jeremy Antonyshyn
University of Toronto | U of T · Institute of Biomaterials and Biomedical Engineering

Doctor of Philosophy

About

8
Publications
352
Reads
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63
Citations
Citations since 2016
7 Research Items
53 Citations
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20162017201820192020202120220246810

Publications

Publications (8)
Article
Full-text available
Considerable effort has been directed toward deriving endothelial cells (ECs) from adipose-derived mesenchymal stem cells (ASCs) since 2004, when it was first suggested that ECs and adipocytes share a common progenitor. While the capacity of ASCs to express endothelial markers has been repeatedly demonstrated, none constitute conclusive evidence of...
Article
Tissue engineering has garnered significant attention for its potential to address the predominant modes of failure of small diameter vascular prostheses, namely mid-graft thrombosis and anastomotic intimal hyperplasia. In this review, we describe two main features underpinning the promise of tissue-engineered vascular grafts: the incorporation of...
Article
Full-text available
Endothelial cells are among the fundamental building blocks for vascular tissue engineering. However, a clinically viable source of endothelium has continued to elude the field. Here, we demonstrate the feasibility of sourcing autologous endothelium from human fat – an abundant and uniquely dispensable tissue that can be readily harvested with mini...
Article
Adipose tissue is an abundant, accessible, and uniquely dispensable source of cells for vascular tissue engineering. Despite its intrinsic endothelial cells, considerable effort is directed at deriving endothelium from its resident stem and progenitor cells. Here, we investigate the composition of human adipose tissue and characterize the phenotype...
Article
Human adipose tissue-resident microvascular endothelial cells are not only garnering attention for their emergent role in the pathogenesis of obesity-related metabolic disorders, but are also of considerable interest for vascular tissue engineering due, in part, to the abundant, accessible, and uniquely dispensable nature of the tissue. Here, we de...
Chapter
Chronic wounds that do not heal with standard wound care are a growing public healthcare concern. Wound care costs associated with lower extremity ulcers, such as venous leg ulcers, pressure ulcers, and diabetic foot ulcers, place a signifi cant burden on healthcare systems and severely lower the quality of life for patients. Advanced wound care th...
Article
Severe thermal injury is associated with extreme and prolonged inflammatory and hypermetabolic responses, resulting in significant catabolism that delays recovery or even leads to multiple organ failure and death. Burned patients exhibit many symptoms of stress-induced diabetes, including hyperglycemia, hyperinsulinemia, and hyperlipidemia. Recentl...

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