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Introduction
Jenson Mak PhD FRACP FAFRM FACP BMedSci JP is a clinical academic, consultant internal physician, geriatrician and rehabilitation physician with a special interest in hip fracture, vitamin D, osteoporosis and common disorders of the elderly. He was the lead investigator of the Multisite Randomized Controlled Trial (REVITAHIP) in Sydney and Central Coast, NSW, Australia. He has also been a member of development of several National clinical guidelines and is an active Cochrane review.
Current institution
Additional affiliations
June 2009 - February 2016
Publications
Publications (50)
Background:
Improving mobility outcomes after hip fracture is key to recovery. Possible strategies include gait training, exercise and muscle stimulation. This is an update of a Cochrane Review last published in 2011.
Objectives:
To evaluate the effects (benefits and harms) of interventions aimed at improving mobility and physical functioning af...
Background:
Hip fracture is a major cause of morbidity and mortality in older people, and its impact on society is substantial. After surgery, people require rehabilitation to help them recover. Multidisciplinary rehabilitation is where rehabilitation is delivered by a multidisciplinary team, supervised by a geriatrician, rehabilitation physician...
Background
Disability and falls are common following fall-related lower limb and pelvic fractures.
Objective
To evaluate the impact of an exercise self-management intervention on mobility-related disability and falls after lower limb or pelvic fracture.
Design
Randomized controlled trial.
Participants
Three hundred thirty-six community dwellers...
Background:
Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.
Methods:
A prospective multicentre cohort study was delivered by an international, student-...
Background:
Older people with hip fractures are often malnourished at the time of fracture, and subsequently have poor food intake. This is an update of a Cochrane review first published in 2000, and previously updated in 2010.
Objectives:
To review the effects (benefits and harms) of nutritional interventions in older people recovering from hip...
Background
Improving vitamin D (25-OHD) status may be an important modifiable factor that could reduce disability severity, fall-rates and mortality associated after hip fracture surgery. Providing a loading-dose post-surgery may overcome limitations in adherence to daily supplementation. Method
In this randomized, double-blind, placebo-controlled...
Background:
Older people living in residential aged care facilities (RACFs) are at a higher risk of suffering fractures than the community-dwelling older population. The first Consensus Conference on Treatment of Osteoporosis in RACFs in Australia, held in Sydney in July 2009, aimed to address some of the issues relating to the treatment of older...
Lasting disability and further falls are common and costly problems in older people following fall-related lower limb and pelvic fractures. Exercise interventions can improve mobility after fracture and reduce falls in older people, however the optimal approach to rehabilitation after fall-related lower limb and pelvic fracture is unclear. This ran...
: This study aims to further elucidate the demographic and diabetes characteristics of diabetic patients in Australia who use complementary and alternative medicines (CAM).
: This was a prospective, cross-sectional questionnaire-based study of 149 patients with diabetes attending a general endocrine clinic in a tertiary referral hospital in Sydney,...
Background: Adequate pain management following hip fracture surgery reduces length of stay, reduces incidence of delirium, promotes recovery and improves mobility. Previous research suggests that hip fracture pain is undertreated in some patient subgroups, and that hypovitaminosis D can further aggravate pain which could hinder active rehabilitatio...
Background:
Hypovitaminosis D is particularly common among older people with a proximal femoral (hip) fracture. There are currently no agreed strategies for vitamin D replenishment after hip fracture surgery. The REVITAHIP Study is a multisite, double-blinded randomized-controlled trial investigating the effects of an oral vitamin D loading dose o...
Vitamin D and related compounds have been used to prevent osteoporotic fractures in older people. This is the third update of a Cochrane review first published in 1996.
To determine the effects of vitamin D or related compounds, with or without calcium, for preventing fractures in post-menopausal women and older men.
We searched the Cochrane Bone,...
Background
The objective of this study was to evaluate the evidence for different interventions in the preoperative, perioperative and post-operative care for people undergoing elective total hip (THR) and knee (TKR) replacement surgery. MethodA multidisciplinary working group comprising consumers, managers and clinicians from the areas of orthopae...
BACKGROUND: Hip fracture mainly occurs in older people. Strategies to improve mobility include gait retraining, various forms of exercise and muscle stimulation. OBJECTIVES: To evaluate the effects of different interventions for improving mobility after hip fracture surgery in adults. SEARCH STRATEGY: We searched the Cochrane Bone, Joint and Muscle...
Chan DKY, O’Rourke F, Shen Q, Mak JCS, Hung WT. Meta-analysis of the cardiovascular benefits of intensive lipid lowering with statins. Acta Neurol Scand: 2011: 124: 188–195. © 2010 John Wiley & Sons A/S.
Objective – To evaluate the efficacy of intensive lipid lowering with higher-dose statins.
Methods – Meta-analysis of seven randomized controlled...
Hypovitaminosis D is particularly common among older people with a proximal femoral (hip) fracture and has been linked with poorer lower extremity functioning, falls, and fractures. There is evidence that disability severity and fall rates may be reduced by adequate vitamin D replacement. However, the ideal regimen for vitamin D administration to h...
Hip fracture mainly occurs in older people. Strategies to improve mobility include gait retraining, various forms of exercise and muscle stimulation.
To evaluate the effects of different interventions for improving mobility after hip fracture surgery in adults.
We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the C...
Objectives:
To correlate analgesia use among patients with hip fracture requiring surgery with hip fracture subtype, cognitive status, and type of surgery in the postacute period.
Design and participants:
Prospective review of patients with hip fractures requiring surgical intervention. A total of 415 patients (mean age: 81.2 ± 9.1 years, 74.3%...
A 90-year-old man presented to the emergency department with multiple symptoms including double vision, reduced mobility, dysphagia, recent rapid weight loss, ear discharge and deafness. He had diabetes and other chronic medical problems, including otitis media with mastoiditis. This case highlights the difficulty of investigating weight loss in ol...
Complementary and alternative medicine (CAM) therapies have become increasingly popular and are used regularly by patients with osteoporosis in Australasia and worldwide. This study was done to determine the prevalence and patterns of use of CAM in an Australian osteoporosis clinic.
This was a prospective, cross-sectional questionnaire-based study...
This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party
.
To update evidence-based guidelines for the treatment of proximal femoral fractures published in the Journal in 2003.
Systematic search of MEDLINE, CINAHL and EMBASE for articles published from October 2001 to June 2008, and the Cochrane Database of Systematic Reviews (most recent issue searched - Issue 2, 2008).
Randomised controlled trials and me...
Hip fracture is a major cause of morbidity and mortality in older people and its impact on society is substantial.
To examine the effects of multidisciplinary rehabilitation, in either inpatient or ambulatory care settings, for older patients with hip fracture.
We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register (April...
Problem: There are low rates of treatment of osteoporosis following hip fractures in the elderly.
Design: Controlled before-after trial of the ortho-geriatric-led ‘ICHIBAN’ program. Data were collected by a blinded observer in 2 phases: over the year before and 10-months following intervention. The data is collected from orthopaedic wards in a larg...
The growing demand for complementary and alternative medicine (CAM) is undeniable. We report a first study about the attitudes and behaviour of Australian rehabilitation physicians to CAM.
A prospective cross-sectional survey was undertaken to document the prevalence of, knowledge about and referrals to CAM therapies and their perceived effectivene...
This retrospective file review outlines a case study of an 84 year-old man with a transtibial amputation for vascular disease who underwent an ipsilateral total hip replacement (THR). The question being addressed was how surgical techniques, rehabilitation processes and outcomes of joint arthroplasty would need to vary in a case of an ipsilateral d...
To review the practice of evidence-based medicine with respect to drug treatment given to medical in-patients.
Retrospective study.
Teaching hospital, Hong Kong.
Medical records of 129 consecutive patients who were admitted to the acute adult general medical ward from 1 September 1998 to 30 September 1998 were reviewed.
Primary diagnoses, drug trea...
Histamine, released from activated mast cells, causes bronchoconstriction mediated by H-1 receptors, whereas beta(2)-agonists are widely used for the relief of bronchoconstriction. In this study, we examined the effects of the beta(2)-adrenoceptor agonist, fenoterol, on the expression of H-1 receptors at the mRNA and protein levels, and functional...
Neutral endopeptidase (NEP) may regulate peptide-induced inflammation in the respiratory tract. It is of interest to determine which respiratory resident cells express NEP. Trachea and bronchi from seven nonsmoking, nonasthmatic subjects were examined. NEP messenger ribonucleic acid (mRNA) was characterized by Northern blot hybridization of culture...
Neutral endopeptidase (NEP) may regulate peptide-induced inflammation in the upper respiratory tract. NEP mRNA was detected by Northern blotting in poly(A)+ mRNA prepared from human turbinates. NEP mRNA bands were detected at 3.9 and 1.8 kb. In situ hybridization identified NEP mRNA in epithelial cells, serous cells of submucosal glands, and vessel...
Messenger RNA for rat islet amyloid polypeptide (IAPP) has been identified not only in the pancreas but also, in lesser amounts, in preparations from the stomach and dorsal root ganglia. In the stomach, insulin mRNA was not detectable, ruling out possible contamination by pancreatic tissue. Because IAPP and calcitonin gene-related peptide (CGRP) ar...
Neutral endopeptidase (NEP) may regulate peptide-induced inflam- mation in the respiratory tract. It is of interest to determine which respiratory resi- dent cells express NEP. Trachea and bronchi from seven nonsmoking, nonasthmatic subjects were exam- ined. NEP messenger ribonucleic acid (mRNA) was characterized by Northern blot hybridization of c...
