Jens-Bastian Eppler

Centre de Recerca Matemàtica | CRM

Recent evidence indicates that even under stable environmental and behavioural conditions responses to sensory stimuli undergo continuous reformatting over the course of days, a condition described as representational drift. However, the processes underlying this phenomenon remain poorly understood. Examining the dynamics of signal and noise correl...

Dendritic spines are considered a morphological proxy for excitatory synapses, rendering them a target of many different lines of research. Over recent years, it has become possible to simultaneously image large numbers of dendritic spines in 3D volumes of neural tissue. In contrast, currently no automated method for 3D spine detection exists that...

A MATLAB preprocessing pipeline for 2-photon imaging data recorded in mouse cortex. Data was recorded in two channels: a structural marker and an activity marker. The structural marker was used to reliably track neurons across time. Then, the activity marker is read out. It comes with a fully functional demo version (including example data), calle...

In this repository is a dataset of chronically imaged neuronal populations in the auditory cortex of mice being exposed to a set of short sound stimuli. The imaging was performed on four timepoints two days apart each over the course of seven days. Two different experimental conditions, one cohort was imaged under baseline conditions without any be...

Cortical function and the processing of sensory stimuli is remarkably robust against the continuous loss of neurons during aging, but also accelerated loss during prodromal stages of neurodegeneration. Population activity of neurons in sensory cortices builds a representation of the environment in form of a map that is structured in an informative...

Dendritic spines are considered a morphological proxy for excitatory synapses, rendering them a target of many different lines of research. Over recent years, it has become possible to image simultaneously large numbers of dendritic spines in 3D volumes of neural tissue. In contrast, currently no automated method for spine detection exists that com...

Recent long-term measurements of neuronal activity have revealed that, despite stability in large-scale topographic maps, the tuning properties of individual cortical neurons can undergo substantial reformatting over days. To shed light on this apparent contradiction, we captured the sound response dynamics of auditory cortical neurons using repeat...

Sensory stimuli have long been thought to be represented in the brain as activity patterns of specific neuronal assemblies. However, we still know relatively little about the long-term dynamics of sensory representations. Using chronic in vivo calcium imaging in the mouse auditory cortex, we find that sensory representations undergo continuous reco...

Population imaging in mouse auditory cortex revealed clustering of neural responses to brief complex sounds: the activity of a local population typically falls close to one out of a small number of observed states [1]. These clusters appear to group sets of auditory stimuli into a discrete set of activity patterns and could thereby form the basis f...