Jennifer Spehr

Jennifer Spehr
RWTH Aachen University · Institute for Biology II (Zoology)

Dr. rer. nat.

About

26
Publications
3,974
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585
Citations
Citations since 2017
5 Research Items
292 Citations
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20172018201920202021202220230204060
20172018201920202021202220230204060

Publications

Publications (26)
Article
Full-text available
Spermatogenesis, the complex process of male germ cell proliferation, differentiation, and maturation, is the basis of male fertility. In the seminiferous tubules of the testes, spermatozoa are constantly generated from spermatogonial stem cells through a stereotyped sequence of mitotic and meiotic divisions. The basic physiological principles, how...
Preprint
Full-text available
Spermatogenesis, the complex developmental process of male germ cell proliferation, differentiation, and maturation, is the basis of male fertility and reproductive fitness. In the seminiferous tubules of the testes, spermatozoa are constantly generated from spermatogonial stem cells through a stereotyped sequence of mitotic and meiotic divisions....
Article
Full-text available
Peritubular myoid cells, which form the walls of seminiferous tubules in the testis, are functionally unexplored. While they transport sperm and contribute to the spermatogonial stem cell niche, specifically their emerging role in the immune surveillance of the testis and in male infertility remains to be studied. Recently, cytokine production and...
Article
Full-text available
Spermatogenesis ranks among the most complex, yet least understood, developmental processes. The physiological principles that control male germ cell development in mammals are notoriously difficult to unravel, given the intricate anatomy and complex endo- and paracrinology of the testis. Accordingly, we lack a conceptual understanding of the basic...
Article
Full-text available
Olfactory signals influence food intake in a variety of species. To maximize the chances of finding a source of calories, an animal's preference for fatty foods and triglycerides already becomes apparent during olfactory food search behavior. However, the molecular identity of both receptors and ligands mediating olfactory-dependent fatty acid reco...
Article
Full-text available
The mouse vomeronasal organ (VNO) plays a critical role in semiochemical detection and social communication. Vomeronasal stimuli are typically secreted in various body fluids. Following direct contact with urine deposits or other secretions, a peristaltic vascular pump mediates fluid entry into the recipient's VNO. Therefore, while vomeronasal sens...
Article
Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates and cellular mechanisms of astringency perception are still not well understood. We explored taste and astringency perception in human subjects to study the contribution of th...
Article
Full-text available
Intracellular Cl(-) concentrations ([Cl(-)](i)) of sensory neurons regulate signal transmission and signal amplification. In dorsal root ganglion (DRG) and olfactory sensory neurons (OSNs), Cl(-) is accumulated by the Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1), resulting in a [Cl(-)](i) above electrochemical equilibrium and a depolarizing Cl(-) effl...
Data
Patch clamp characterization of GABA-induced currents in TG neurons. A: Exemplary responses of TG neurons to stimulation with GABA (100 µM). Cells were kept at a holding potential of −60 mV. The total number of responsive cells was 45/45 (newborn WT), 20/20 (adult WT), and 15/15 (newborn NKCC1−/−). Bars signify duration of stimulus application. B,...
Data
FPKM values for different housekeeping, Ca2+-gated Cl− channel, and TRP channel genes in murine neuronal and non-neuronal tissues. (DOCX)
Data
Control PCR for Ano1, Ano8, and tweety3 in different neuronal tissues. For the minus-RT PCR, RNA prior to cDNA synthesis was used as template. PCR was performed under the same condition as for the cDNA analysis. 1: adult female TG, 2: adult brain, 3: adult DRG, 4: newborn mouse (P2-5) TG, and 5: adult male TG. (TIF)
Article
Full-text available
In olfactory sensory neurons (OSNs), cytosolic Ca(2+) controls the gain and sensitivity of olfactory signaling. Important components of the molecular machinery that orchestrates OSN Ca(2+) dynamics have been described, but key details are still missing. Here, we demonstrate a critical physiological role of mitochondrial Ca(2+) mobilization in mouse...
Article
Full-text available
Intimate bidirectional communication between Sertoli cells and developing germ cells ensures the integrity and efficiency of spermatogenesis. Yet, a conceptual mechanistic understanding of the physiological principles that underlie Sertoli cell autocrine and paracrine signalling is lacking. Here, we characterize a purinergic Ca(2+) signalling netwo...
Article
Full-text available
Ca(2+) homeostasis plays a critical role in a variety of cellular processes. We showed previously that stimulation of the prostate-specific G protein-coupled receptor (PSGR) enhances cytosolic Ca(2+) and inhibits proliferation of prostate cells. Here, we analyzed the signaling mechanisms underlying the PSGR-mediated Ca(2+) increase. Using complemen...
Article
Full-text available
The mammalian vomeronasal organ (VNO) mediates the regulation of social behaviors by complex chemical signals. These cues trigger transient elevations of intracellular Ca(2+) in vomeronasal sensory neurons (VSNs), but the functional role of such Ca(2+) elevations is unknown. We show that stimulus-induced Ca(2+) entry plays an essential role as a ne...
Article
Full-text available
The mammalian olfactory system has evolved complex mechanisms to detect a vast range of molecular cues. In rodents, the olfactory system comprises several distinct subsystems. Current interest has focused on the exact role that each of these subsystems plays in detecting molecular information and regulating chemosensory-dependent behaviors. Here, w...
Article
The facial innervation pattern of trigeminal nerve fibres comprises the innervation of the nasal epithelium, where free trigeminal nerve endings contribute to detection and discrimination of chemical stimuli including odourants. The signal transduction mechanisms in sensory nerve endings underlying perception of chemical stimuli remain widely uncov...
Article
Die Chemosensitivität des trigeminalen Systems erlaubt die Detektion und Unterscheidung vieler Duftmoleküle. Hier werden erstmalig molekulare Detektionsmechanismen für die trigeminal wirksamen Dufstoffe Benzaldehyd und Linalool beschrieben. Eine bislang nicht beschriebene trigeminale Population, die durch die Expression ATP-sensitiver P2X2-Rezeptor...

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