Jennifer L. Rollo

University College London | UCL · Queen Square Institute of Neurology

Alzheimer’s disease (AD) is a spatially dynamic pathology that implicates a growing volume of multiscale data spanning genetic, cellular, tissue, and organ levels of the organization. These data and bioinformatics analyses provide clear evidence for the interactions within and between these levels. The resulting heterarchy precludes a linear neuron...

Background Systems biology approaches to Alzheimer’s disease (AD) are comparatively rare and reductionist concepts still prevail. We challenge the idea that either tau or Aß are the causal agents in the pathology of AD, and instead consider the role systemic factors play in its neurodegenerative spread through the brain. Method In a new systems pat...

Background: Systems biology approaches to Alzheimer’s disease(AD) are comparatively rare and reductionist concepts still prevail. We challenge the idea that either tau or A-beta the causal agents in the pathology of AD, and instead consider the role systemic factors play in its neurodegenerative spread through the brain. Methods: In a new systems...

Alzheimer's disease (AD) is a complex, multifactorial disease that has reached global epidemic proportions. The challenge remains to fully identify its underlying molecular mechanisms that will enable development of accurate diagnostic tools and therapeutics. Conventional experimental approaches that target individual or small sets of genes or prot...

Background: Comorbidity and multimorbidity are common in older people. Here we used a novel analytic approach called Association Rules together with network analysis to evaluate multimorbidity (two or more disorders) and comorbidity in old age. Methods: A population-based cross-sectional study was undertaken where 17 morbidities were analyzed us...

To better understand the mechanisms of Alzheimer’s disease (AD) conventional experimental methodologies have commonly targeted individual, or small sets of genes/proteins. However, the strong message from computational systems biology (CSB) approaches in other applications, such as cancer, indicate control is distributed across the cell network and...

Axotomy of the rodent facial nerve represents a well-established model of synaptic plasticity. Post-traumatic "synaptic stripping" was originally discovered in this system. We report upregulation of matrix metalloproteinase MMP12 in regenerating motor neurons of the mouse and rat facial nucleus. Matrix metalloproteinases (matrix metallopeptidases,...

Thesis (M.Sc.)--Victoria University of Wellington, 1992. Includes bibliography.

A study has been conducted to visualise the flow pattern over the blades of a novel fan – the AXTRA fan, for the first time, in an attempt to explain its reduced noise levels in comparison to conventional axial flow fans. Previously, the performance of the AXTRA fan had only been described using experimental data, from handmade balsa wood prototype...

The numerical and experimental results of the AXTRA® turbine – a new generation wind turbine, indicate its ability to produce greater power output in comparison to conventional horizontal axis wind turbines (HAWT). With a three-dimensional streamlined geometry, the AXTRA® turbine can produce up to three times more torque than a HAWT with the same r...

A revolutionary new concept wind turbine is presented with the capacity to generate substantially more power when compared to conventional horizontal axis wind turbines (HAWT), while at the same time potentially emitting lower noise levels. With a more streamlined geometry, preliminary results show the new AXTRA® turbine can produce approximately n...