Jella Wauters

Jella Wauters
Ghent University | UGhent · Department of Pharmacology, Toxicology and Biochemistry

About

53
Publications
5,119
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432
Citations
Citations since 2017
38 Research Items
395 Citations
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (53)
Preprint
The giant panda reproductive physiology shows important similarities with at least six of the eight existing bear species: the occurrence of diapause and/or pseudopregnancy is commonly described in bears. Nevertheless, significant differences including the earlier breeding season with - in general - a single estrus, a shorter delay of implantation...
Article
Full-text available
Graphical abstract: Abstract: Giant pandas are mono-estrus seasonal breeders, with the breeding season typically occurring in the spring. Successful fertilization is followed by an embryonic diapause, of variable length, with birth in the late summer/autumn. There is a need for additional understanding of giant panda reproductive physiology, and...
Article
Full-text available
Progesterone and oestrogen are the main gonadal steroid hormones that regulate the ovarian activity and induce the fertile oestrus period in females. The monitoring of this receptive phase is particularly decisive for captive breeding and is commonly based on the observation of female behavioural patterns that coincide with their hormonal oestrus....
Article
Full-text available
Understanding the causes of range expansions in abundant species can help predict future species distributions. During range expansions, animals are exposed to novel environments and are required to cope with new and unpredictable stressors. Glucocorticoids (GCs) are mediators of the hormonal and behavioural mechanisms allowing animals to cope with...
Article
Full-text available
Testosterone is known to be essential for sexual maturation as well as for the display of behavioural traits linked to reproduction. At the same time, external factors such as the presence of receptive females may affect testosterone levels, stressing the hormone’s substantial role in reproductive success. It is therefore of major interest to inves...
Article
Full-text available
Boar taint is an unpleasant taste and odor that can occur in entire male pigs and is caused by androstenone, skatole, and to a lesser extent indole accumulating in fat tissue. In the present observational study, we evaluated an extensive list of such potential risk factors which influence boar taint: social hierarchy and puberty attainment, housing...
Article
Because of the need to abolish the castration of piglets without anaesthesia/analgesia, the pig industry is searching for a mode of action for the valorisation of meat with boar taint, an off-odour in entire male pigs. Carcasses with boar taint were selected by means of sensory and chemical analysis, after which patties with different levels of tai...
Article
Full-text available
To prevent transmission of the pathogenic chytrid fungi Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal), hygiene protocols prescribe the single use of disposable gloves for handling amphibians. We discovered that rinse water from nitrile gloves instantly kills 99% of Bd and Bsal zoospores. Transmission experiments u...
Article
Full-text available
Trained expert panels are used routinely in boar taint research, with varying protocols for training of panelists and scoring methods. We describe a standardized process for training and scoring, to contribute to standardize the olfactory detection of boar taint. Three experiments are described in which we (1) evaluate the importance of training an...
Article
Full-text available
Knowledge on species’ reproductive biology is a fundamental pre-requisite of every conservation effort, but is often lacking. Sex steroids can provide valuable information for the assessment of reproductive success, whereas glucocorticoids are used to assess adrenocortical activity and stress-related bodily adaption. However, due to their perilous...
Article
Full-text available
Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, there is no confirmatory non-invasive biomarker of blastocyst implantation or pregnancy. This study aimed to monitor urinary estrogens across gestation in pregnancy (n = 4), ps...
Article
Immunocastration (vaccination against boar taint) is an alternative method to prevent boar taint without the need for surgical castration. This study investigates the evolution of boar taint compounds in serum and fat, serum steroid compounds as well as behavior in immunocastrated pigs from 3 sire lines: 15 stress positive Belgian Piétrain (BP), 20...
Article
A generic extraction and UHPLC-Q-OrbitrapTM-HRMS method was developed for four insect species (mealworm, grasshopper, house cricket and black soldier fly) analyzing a large spectrum of organic chemical contaminants, including pesticides (n=25), (veterinary) drugs (n=29), and mycotoxins (n=23). To prove the method as ‘fit-for- purpose’, a successful...
Article
Full-text available
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results requires normalisation due to an animal’s changing hydration. Correction of urinary concentrations based on creatinine is the gold standard. In this study, a largely unexplored, easy...
Data
Faeces, oestrogen and progesterone oestrus profiles (normalised with creatinine and USpG) for Tian TianSB569 (2013, 2015–2017). (TIF)
Data
Faeces, oestrogen and progesterone full-cycle profiles (normalised with creatinine and USpG) for Tian TianSB569 (2013, 2015–2017). (TIF)
Data
Descriptives for Tian Tian’s 2014 reproductive cycle (SB569): USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight. Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine. Different superscripts (a-d; ascending; hor...
Data
Descriptives for Tian Tian’s 2016 reproductive cycle (SB569): USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight. Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine. Different superscripts (a-d; ascending; hor...
Data
Descriptives for Tian Tian’s 2017 reproductive cycle (SB569): USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight. Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine. Different superscripts (a-d; ascending; hor...
Data
Descriptives for Tian Tian’s 2013 reproductive cycle (SB569): USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight. Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine. Different superscripts (a-d; ascending; hor...
Data
Descriptives for Tian Tian’s 2015 reproductive cycle (SB569): USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight. Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine. Different superscripts (a-d; ascending; hor...
Article
In recent years, metabolomics has surfaced as an innovative research strategy in human metabolism, whereby selection of the biological matrix and its inherent metabolome is of crucial importance. However, focusing on a single matrix may imply that relevant molecules of complementary physiological pathways, covered by other matrices, are missed. To...
Poster
Full-text available
The continuously growing world population is expected to more than double the demand for meat products by 2050, creating an urgent need for alternative and safe food supplies from sustainable sources, such as the consumption of insects, or entomophagy. However, health hazards including (organic) chemical contaminants are not sufficiently identified...
Article
One of the challenges in the production of entire male pigs is the occurrence of boar taint. We separately tested the effect of 3 management strategies to reduce boar taint on respectively 2, 3, and 6 Flemish pig farms: 1) adapted feeding strategies, 2) presence of gilts in the compartment, and 3) varying lairage duration at the slaughterhouse. A c...
Article
Full-text available
In the European Union, the use of thyreostats for animal fattening purposes has been banned and monitoring plans have been established to detect potential abuse. However, this is not always straightforward as thyreostats such as thiouracil may also have a semi-endogenous origin. Therefore, this study aimed at defining urinary metabolites, which may...
Data
Ions that were retained as candidate markers for cows. Ions were able to discriminate between TU treated and untreated cows. All ions showed the highest abundance upon TU treatment. (DOCX)
Data
Filtering of candidate markers for cows. Selection of candidate markers based on the sensitivity and specificity as determined for the TU treated cows and those that received the rapeseed-enriched diet. In addition, based on metabolic linkage (correlation coefficient and modelling), additional certainty about the metabolic involvement of the marker...
Data
Tested extraction protocols. Protocols that were tested for the efficient extraction and high metabolome coverage of metabolites from urine, thereby having a particular focus on thyreostats. (DOCX)
Data
Ions that were retained as candidate markers for calves. Ions were able to discriminate between TU treated and untreated calves. All ions showed the highest abundance upon TU treatment. (DOCX)
Data
Filtering of candidate markers for calves. Selection of candidate markers based on the sensitivity and specificity as determined for the TU treated calves and those that received the rapeseed-enriched diet. In addition, based on metabolic linkage (correlation coefficient and OPLS modelling), additional certainty about the metabolic involvement of t...
Data
Chromatograms for the eleven metabolite markers. Chromatograms were acquired from samples from TU treated animals, with characteristic information about the retention time (RT), m/z-value, ionization adduct, intensity, and tentative chemical configuration. (DOCX)
Preprint
This protocol describes the untargeted polar analysis of urine samples from cows and calves, with special emphasis on the coverage of thyreostats. Extraction started with 3 mL urine and was in essence based on liquid-liquid extraction with ethyl acetate. Analysis of extracts was achieved by ultra-high performance liquid chromatography (UHPLC) using...
Article
Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18...
Article
Boar taint is a contemporary off-odor present in meat of uncastrated male pigs. As European Member States intend to abandon surgical castration of pigs by 2018, this off-odor has gained a lot of research interest. In this study, rapid evaporative ionization mass spectrometry (REIMS) was explored for the rapid detection of boar taint in neck fat. Un...
Article
There is a commitment by the European pig sector to ban surgical castration of male piglets in the European Union in 2018. One alternative to castration is to raise entire male pigs, with an increased risk of boar taint. A field study was performed to: (1) evaluate inter- and intra-farm variation in boar taint prevalence, (2) investigate factors me...
Article
Rearing entire male pigs, one of the alternatives for surgical castration, entails the possible occurrence of boar taint. This study aimed at the investigation of the acceptability of meat from entire male pigs in 8 different meat products (cutlets, bacon, blade loin, tenderloin, dry fermented sausage, cooked ham, dry-cured ham and minced meat) by...
Article
One of the main issues related to entire male pigs is the occurrence of boar taint, an off-odour, which compromises meat consumability. In this study, odour thresholds (indole: 24-65 µg kg⁻¹, skatole: 44-89 µg kg⁻¹, androstenone: 121-342 µg kg⁻¹) for the boar taint compounds were estimated in minced meat, dry fermented sausage and dry-cured ham. Af...
Article
Because of animal welfare issues, the voluntary ban on surgical castration of male piglets, starting January 2018 was announced in a European Treaty. One viable alternative is the fattening of entire male pigs. However, this can cause negative consumer reactions due to the occurrence of boar taint and possibly lead to severe economic losses in pig...
Article
Full-text available
Societal pressure to ban surgical castration of male piglets is rising due to animal welfare concerns, thus other methods to prevent boar taint need to be explored. Genetic selection against boar taint appears to be a long-term sustainable alternative. However, as boar taint is linked to reproductive hormones, it is important to consider possible n...
Article
The Asp298Asn polymorphism of the melanocortin-4 receptor (MC4R) in pigs is known to affect economically important traits such as growth rate and backfat thickness. We have assessed the possible use of this polymorphism as a molecular marker to perform genetic selection toward lower boar taint levels without compromising growth performance and carc...
Article
Full-text available
The Asp298Asn polymorphism of the melanocortin-4 receptor (MC4R) in pigs is known to affect economically important traits such as growth rate and backfat thickness. We have assessed the possible use of this polymorphism as a molecular marker to perform genetic selection toward lower boar taint levels without compromising growth performance and carc...
Article
Thiouracil, 1 (Figure 1) is a thyrostat inhibiting the thyroid function, resulting in fraudulent weight gain if applied in the fattening of livestock. The latter abuse is strictly forbidden and monitored in the European Union. Recently, endogenous sources of thiouracil were identified after frequently monitoring low-level thiouracil positive urine...
Article
Full-text available
The use of thyreostatic drugs, like thiouracil (TU), in animal production has been banned for over three decades by the European Union, due to potential teratogenic and carcinogenic effects of its residues upon human consumption. Besides, thyreostats induce water retention in livestock, causing fallacious weight gain and deterioration of meat quali...
Article
Full-text available
In recent years, the frequent detection of the banned thyreostat thiouracil (TU) in livestock urine has been related to endogenous TU formation following digestion of glucosinolate-rich Brassicaceae crops. Recently, it was demonstrated that, upon in vitro digestion of Brassicaceae, fecal bacteria induce TU detection in livestock (porcine livestock...
Article
Reasons for performing study: Equine joint infection is a life-threatening disorder and the confirmation of its diagnosis can be difficult. Synovial fluid biomarkers may assist the discrimination between infectious and non-infectious joint disease. Objectives: The current study investigates whether the immunological detection of total and enzymati...
Article
Myeloperoxidase (MPO) is a protein of interest due to its involvement in equine pathologies. Until now, results in equine diagnostic research were achieved through extracellular MPO detection. However, studying the cellular MPO content in neutrophils has revealed important insights in human diseases. This study aimed to develop a technique for the...
Article
Synovial fluid samples from culture-confirmed infected joints (n=13), joints with pronounced non-infectious synovitis (n=11) and healthy joints (n=14) were collected from 24 equine patients and seven slaughterhouse horses. The samples from the joints with non-infectious synovitis and healthy joints served as negative controls. After isolation, coun...

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