Jelena Cvejic

Jelena Cvejic
University of Novi Sad · Department of Pharmacy

PhD Chemistry

About

90
Publications
17,851
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1,208
Citations
Additional affiliations
March 2002 - present
University of Novi Sad
Position
  • Professor (Full)

Publications

Publications (90)
Chapter
This chapter outlines the current trends and innovative techniques in processing of natural polyphenolic compounds, and how new emerging technologies affect the functionality of these nutraceutical and functional food components. Bioavailability of polyphenols as nutrients, their transformations by intestinal microbiota and specific interactions ar...
Article
Full-text available
Grape processing by-products (particularly grape pomace) are known to contain high amounts of phenolic compounds. To improve the extraction of phenols from this by-product, it is necessary to develop a method and set and model optimal conditions for their extraction. By applying the design of experiments (DoE) approach, optimal experimental factors...
Chapter
The term “edible oils” (EO) refers to complex mixtures of lipids including main triacylglycerols (TAGs) or triglycerides, lower amounts of monoacylglycerols (MAGs), diacylglycerols (DAGs), phospholipids (PLs), free fatty acids (FAs), sterols and other minor components such as vitamins and antioxidants (Indelicato et al., 2017). They have several fu...
Chapter
The positive effects of certain dietary nutrients and phytochemicals on human health include the prevention of a non-communicable diseases (NCD) as well as the enhancement of the healing processes by decreasing the time needed for healing and improving the outcomes. A diet that is low in saturated fats and carbohydrates and that is high in fiber, a...
Article
Isoflavones are phytoestrogens with various types of biological activity. Soybean (Glycine max (L.) Merr.) is the most abundant source of isoflavones in human nutrition. The present study aims to classify the different soybean genotypes according to their isoflavone contents. HPLC analysis of isoflavone content in 22 soybean genotypes was performed...
Article
Full-text available
Trans-resveratrol is a phytoalexin from the stilbene class, polyphenolic compound from non-flavonoid group. In vitro and animal studies have shown that trans-resveratrol may exert a wide range of potential beneficial effects to human health, which involves antioxidant, anti-inflammatory, cardioprotective, neuroprotective, anti-diabetic and anti-can...
Chapter
Resveratrol, a naturally occurring stilbene, is the subject of intense research due to its numerous pharmacological effects. The most common form of resveratrol is trans-isomer, but it can also exist in cis-form, and as glucoside (piceid) and oligomer. Resveratrol is widely spread among different plant species, with Arachis hypogea, Vitis vinifera,...
Article
Full-text available
Since its discovery in 1945, methotrexate has become a standard therapy for number of diseases, including oncological, inflammatory and pulmonary ones. Major physiological interactions of methotrexate include folate pathway, adenosine, prostaglandins, leukotrienes and cytokines. Methotrexate is used in treatment of pulmonary sarcoidosis as a second...
Article
Full-text available
Objectives: Considering high prevalence of use of dietary supplements and their easy access on the internet, the aim of this research was to examine and assess the prevalence of the internet marketing of heart-protective supplements as the most popular supplements of today, and to investigate the quality and quantity of information that are availab...
Chapter
Microalgae are a promising future source for sustainable edible oils. They already represent a valuable alternative for healthy long chain polyunsaturated fatty acids. Microalgal oil can become a cost-effective alternative to existing vegetable oils from terrestrial crops providing that triglyceride productivity is enhanced and the process is inten...
Article
Methotrexate is an anti-inflammatory and anticancer drug that has been used in the treatment of various oncological and inflammatory diseases (such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, sarcoidosis, etc.). Scientists are working on finding optimal formulation that will maintain its efficacy and improve safety and nanoparti...
Poster
Marine n-3 PUFAs (widely known as ‘omega-3’ fatty acids), specially eicosapentaenoic acid (20:5 n-3; EPA), docosahexaenoic acid (22:6 n-3; DHA) and α-linolenic acid (C18:3 n-3; ALA), are known for their numerous benefits on human health. It is generally recognized that regular consumption of n-3 LCPUFAs from fatty fish or from dietary supplements r...
Poster
Full-text available
Every year thousands of tons of by-products and wastes (FBW) deriving from the agro-food industry are disposed worldwide loosing nutrients and energy. Some biotechnological approaches are in place to use them in biomass cultivation, the main ones to produce bacteria, yeast and fungi. Also microalgae are in the spotlight for this kind of application...
Article
Full-text available
Resveratrol was recognized as the major factor responsible for the beneficial properties of red wine. Several resveratrol-based dietary supplements are available, but their efficacy has not been sufficiently tested. This study was designed to examine the effect of resveratrol supplementation, using a commercially available product, on the metabolic...
Article
Full-text available
Isoflavones are a group of phytoestrogens, naturally-occurring substances important for their role in human health. Legumes, particularly soybeans (Glycine max (L.) Merr.), are the richest source of isoflavones in human diet. Since there is not much current data on genetics of isoflavones in soybean, particularly in the aglycone form, elucidation o...
Article
Full-text available
N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An “inflammation-suppressive” effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic im...
Article
Full-text available
Phenolic compounds are frequently present in various natural products, and they can have different beneficial biological potentials. The most widely used method for determination of individual phenolic compounds is high-performance liquid chromatography (HPLC). In this paper, a method for simultaneous determination of 16 phenolic compounds (gallic...
Article
The measurement of pH value of solutions is crucial in many fields of modern science. We deposited MWCNTs coating on a planar capacitive structure consisting of interdigitated gold and aluminium electrodes on a flexible Kapton foil substrate, to develop the pH sensors. MWCNTs coating acts as an H+ ion sensing layer. The complete structural, mechani...
Article
Full-text available
This paper summarizes published literature concerning different factors that could affect the content and composition of isoflavones in red clover (Trifolium pratense L., Fabaceae). Influence of genotype, plant part, geographic origin, ontogeny and storage conditions of raw material are discussed. Statistical analysis of available data on the profi...
Preprint
Full-text available
Specific nutrients including n-3 long chain polyunsaturated fatty acids (LCPUFAs), flavonoids, vitamin A, D and E are considered to possess protective properties on human health by impacting on immunological reactions. An ‘inflammation-suppressive’ effect appears to be the common denominator of the beneficial effects of most of these dietary compon...
Article
Full-text available
Dietary supplements based on soybean extracts are widely used for a myriad of indications, but there is evidence that isoflavones, components of these supplements affect cytochrome activity. Alteration in pharmacodynamics of cytochrome-substrate drugs after co-administration with dietary supplements based on soybean extracts offers information on c...
Chapter
Dietary polyphenols have been recently studied in relation to a variety of chronic noncommunicable diseases. Due to their high content in foods and beverages commonly consumed worldwide, they have been the focus of major attention as mediators of the potential beneficial effects of various functional foods and investigated for their potential globa...
Chapter
This chapter outlines the current trends and innovative techniques in the processing of natural polyphenolic compounds and how emerging technologies affect the functionality of these nutraceutical and functional food components. The bioavailability of polyphenols as nutrients, their transformations by intestinal microbiota as well specific interact...
Chapter
This chapter denotes the main conventional methodologies for the extraction of valuable, biologically active compounds from grape processing by-products. Grape processing by-products are rich source of various biologically active compounds which can be successfully recovered. Extraction techniques, currently in use, are highlighted in this chapter....
Article
The operations applied in plum processing and in the production of plum wine can significantly affect the content and activity of biologically active compounds extracted from the raw material. The aim of this study was to assess the composition of phenolic compounds, chromatic characteristics and antiradical activity of plum wines produced from thr...
Article
Full-text available
The influence of soybean seed coat color and genotype on antioxidant capacity, phenolic content and isoflavone profile was investigated. Isoflavone content and composition of 21 seed samples - yellow, green, brown, black and rarely mentioned ocher and reddish, were determined by high-performance liquid chromatographic analysis. Antioxidant capacity...
Article
Full-text available
The roles of the pharmacist were transformed throughout the history and modern pharmacist as we know now beside providing products and playing in optimization of medicines has a crucial role in ensuring the efficacy and safety of applied drugs. A better life quality, global health and safety is the major goal of the 21st century and to achieve that...
Chapter
This chapter discusses the current trends for the optimization of food waste recovery strategies in the food industry and how this process affects the sustainability of the food systems. The so-called “Universal Recovery Strategy” for the commercial recapture of valuable compounds from food wastes is briefly described, prior to the assessment of co...
Article
Full-text available
Red wine is a rich source of different phenolic compounds which contribute to sensorial characteristics and can exhibit various biological properties. The amount of phenolics in wine depends on various factors such as grape variety, environmental conditions and production technology. The extraction of individual polyphenolic compounds during macera...
Article
Full-text available
Plant-growth promoting rhizobacteria (PGPR) elicit activation of phenylpropanoid pathway in plants which leads to phenolics production and enhanced antioxidant capacity. The purpose of this work was to assess the antioxidant activity of soybean plants, Glycine max L., inoculated with PGPR (isolates of Azotobacter chroococcum, Streptomyces sp. and m...
Chapter
Red wine is a rich source of different phenolic compounds which contribute to sensorial wine characteristics and can exhibit various biological properties. In vitro and animal studies have suggested that phenolics present in wine may exert a wide range of potential beneficial effects to human health, which involves antioxidant, anti-inflammatory, c...
Chapter
Resveratrol and phenolics are mainly responsible for the beneficial effects of wine consumption on human health. Their amount in wine depends on various factors such as grape variety, environmental factors, and extraction parameters. The winemaking process is one among these factors that can be controlled, and mainly includes a range of modificatio...
Article
Full-text available
Herb-drug interactions are an important safety concern and this study was conducted regarding the interaction between the natural top-selling antidepressant remedy Hypericum perforatum (Hypericaceae) and conventional drugs. This study examined the influence of acute pretreatment with different extracts of Hypericum perforatum from Serbia on pentoba...
Article
Full-text available
In this study we investigated resveratrol (trans-3,5,4'-trihydroxystilbene) solubilization with sodium 3 α ,12 α -dihydroxy-7-oxo-5 β -cholanoate (S7-OD) and sodium dodecyl sulfate (SDS). The investigation was aimed at determining whether large spherical micelles (SDS) or small longitudinal micelles (S7-OD) are more convenient for incorporation of...
Article
Full-text available
Soybean [Glycine max (L.) Merr.] cultivars (Meli, Alisa, Sava and 1511/99) were grown up to V1 phase (first trifoliate and one node above unifoliate) and then inoculated with Sclerotinia sclerotiorum (Lib.) de Bary under controlled conditions. Changes in L-phenylalanine ammonia-lyase (PAL) activity and isoflavone phytoalexins were recorded 12, 24,...
Article
Full-text available
Seven elements, namely, arsenic, lead, cadmium, copper, zinc, iron and manganese were determined in 31 samples of Serbian plum brandies by application of atomic spectrometry techniques. Flame atomic absorption spectrometry was used for the quantification of copper, iron, zinc, manganese, lead and cadmium, and hydride generation atomic spectrometry...
Conference Paper
Full-text available
Wines and beers are a rich source of different compounds that show beneficial effects to the human body and their consummation in reasonable amounts can improve health. Among them, the most important are phenolic compounds (nonflavonoids, flavonoids, tannins), which possess antioxidative properties and could be responsible for prevention of many di...
Article
In this paper, the influence of winemaking techniques and cultivars on the resveratrol content, total phenolic content and antioxidant potential of red wines was studied. Wines were made from the cultivars Merlot, Cabernet Sauvignon, Pinot Noir and Prokupac. Applied winemaking technologies included thermovinification and separation of must from pom...
Article
Full-text available
Twenty F1 soybean progenies were analyzed for isoflavone content in order to investigate whether this attribute can be translated from parents to the corresponding hybrids. Content of total isoflavones in analyzed samples was ranged from 1.56 to 3.66 mg/g of dried soybean. Ten analyzed F1 progenies in one group had a mutual parent while the rest in...
Article
Full-text available
The antioxidant activity and contents of various polyphenol classes in the seeds of seven soybean varieties of different seed color and one yellow seed cultivar, representing a reference genotype, were evaluated. Total polyphenols and tannins were determined after extraction of plant material with 70% aqueous acetone, and total flavonoids were extr...
Article
Red clover (Trifolium pratense L., Fabaceae) is important source of isoflavones, among which the most present are: daidzein, genistein, formononetin and biochanin A [1]. These substances are considered to be beneficial for reduction of menopausal symptoms, prevention of osteoporosis, cancer and cardiovascular diseases. Since red clover extracts are...
Article
Objective: The aim of this study was to investigate the extent of variations in lamotrigine serum concentrations between two immediate-release tablet formulations. Data were compared with in vitro difference and similarity tests on dissolution profiles of the two formulations. Methods: Dissolution characteristics of formulations A (reference) and B...
Article
In order to discover an agent that can prevent spasm of the human radial artery, the aim of our study was to evaluate the effect of the K(+) channel opener, pinacidil, on contractions in the radial artery. Contractions of the radial artery were evoked by exogenously applied noradrenaline or by electrical field stimulation (EFS, 20Hz, neurogenic). P...
Article
Full-text available
Background: Since 2005, the antiepileptic drug lamotrigine has been present in the market in various generic products, in addition to the original brand of Lamictal®. The linear pharmacokinetics and wide therapeutic window of lamotrigine enable seizure-free patients to easily switch from brand to generic antiepileptic drugs. Objective: The aim o...
Article
Full-text available
Twenty soybean cultivars, originating from the United States, Russia, Serbia, and China, were analyzed for their isoflavone composition, total polyphenolic content, and antioxidant activity. Isoflavones were extracted by aqueous methanol (80%) and analyzed by high-performance liquid chromatography/diode array detection. Precision and linearity of t...
Article
Full-text available
Resveratrol (trans-3,5,4'-trihydroxystilbene) is a phytoalexin produced by grapevines in response to fungal infection, particularly to Botrytis cinerea. It has been shown that it possess various biological effects such as prevention of cardiovascular diseases and anti-inflammatory and anticancerogenic properties. Red wines are a primary source of r...
Article
Full-text available
Pinacidil, a prevously studied potassium channel opener (PCO), is a potent antihypertensive agent in animals and humans. Its mechanism of action is not completly defined. The aim of our study was to investigate the antivasoconstricting effect of pinacidil on the isolated RA and to study whether this effect is endothelium-dependent. Contractions of...
Article
Full-text available
The growing clinical interest and use of soybean-based food products and extracts to increase dietary phytoestrogen intake have led to medical interest in the precise determination of the phytoestrogen composition of soybean products. We have analyzed the composition of these compounds in 20 domestic and introduced varieties of genetically non-modi...