Jeffrey Treiber

University of California, San Diego | UCSD · Department of Medicine

IntroductionConflicting results have been reported in the association between glioblastoma proximity to the subventricular zone (SVZ) and enrichment of cancer stem cell properties. Here, we examined this hypothesis using magnetic resonance (MR) images derived from 217 The Cancer Imaging Archive (TCIA) glioblastoma subjects.Methods Pre-operative MR...

Mass effect has demonstrated prognostic significance for glioblastoma, but is poorly quantified. Here we define and characterize a novel neuroimaging parameter, lateral ventricle displacement (LVd), which quantifies mass effect in glioblastoma patients. LVd is defined as the magnitude of displacement from the center of mass of the lateral ventricle...

The biologic processes that contribute to contrast enhancement on magnetic resonance imaging of glioblastoma patients remain poorly understood. Glioblastoma tumors from The Cancer Imaging Archive were segmented using iterative probabilistic voxel labeling. Three parameters of contrast enhancement (CE) were calculated: intensity (CEi), heterogeneity...

The physiologic processes underlying MRI contrast enhancement in glioblastoma patients remain poorly understood. MRIs of 148 glioblastoma subjects from The Cancer Imaging Archive were segmented using Iterative Probabilistic Voxel Labeling (IPVL). Three aspects of contrast enhancement (CE) were parametrized: the mean intensity of all CE voxels (CEi)...

Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1) leads to cancer immune evasion via inhibition of T cell function. One of the defining characteristics of glioblastoma, a universally fatal brain cancer, is its profound local and systemic immunosuppression. Glioblastoma has also been shown to generate extracellula...

Autism postmortem studies have shown various cytoarchitectural anomalies in cortical and limbic areas including increased cell packing density, laminar disorganization, and narrowed minicolumns. However, there is little evidence on dendritic and axonal organization in ASD. Recent imaging techniques have the potential for non-invasive, in vivo studi...

Objective: Many past studies have suggested atypical functional and anatomical hemispheric asymmetries in autism spectrum disorder (ASD). However, almost all of these have examined only language-related asymmetries. Here, we conduct a comprehensive investigation of microstructural asymmetries across a large number of fiber tracts in ASD. Method:...

Introduction: Diffusion Weighted Imaging (DWI), which is based on Echo Planar Imaging (EPI) protocols, is becoming increasingly important for neurosurgical applications. However, its use in this context is limited in part by significant spatial distortion inherent to EPI. Method: We evaluated an efficient algorithm for EPI distortion correction...

INTRODUCTION: The subventricular zone (SVZ) has been implicated in the pathogenesis of the molecularly diverse neoplasm, glioblastoma. Whether molecular subtypes arise from unique niches of the brain remains largely unknown. Here, we tested whether these subtypes of glioblastoma occupy distinct regions of the cerebrum and examined glioblastoma loca...

Objective: Growing evidence indicates that autism spectrum disorder (ASD) stems from abnormal structural and functional connectivity of neural networks. Although diagnostic symptoms are sociocommunicative, motor-related functions (beyond repetitive mannerisms) are also impaired. However, evidence on connectivity at the level of basic motor executi...

We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enhanced the cytotoxic effects of the DNA damaging ag...

Robust, automated segmentation algorithms are required for quantitative analysis of large imaging datasets. We developed an automated method that identifies and labels brain tumor-associated pathology by using an iterative probabilistic voxel labeling using k-nearest neighbor and Gaussian mixture model classification. Our purpose was to develop a s...

Introduction: The subventricular zone (SVZ) has been implicated in the pathogenesis of glioblastoma. Whether molecular subtypes of glioblastoma arise from unique niches of the brain relative to the SVZ remains largely unknown. Here, we tested whether these subtypes of glioblastoma occupy distinct regions of the cerebrum and examined glioblastoma l...

Clinical efficacy of EGFR inhibitors (EGFRi) in glioblastoma patients has been limited by a multitude of resistance mechanisms. We hypothesized that these mechanisms emerge upstream of the interface between EGFR signaling and fundamental cellular processes, such as DNA damage response (DDR), without altering this interface. Thus, synthetic lethal i...

The clinical efficacies of molecularly targeted glioblastomas therapies have been vastly disappointing. The multitudes of resistance mechanisms suggest that glioblastomas possess highly dynamic molecular circuits grounded in functional redundancy. Emerging data suggests that the expression of functionally redundant oncogenes induced similar forms o...

Stereotactic radiosurgery (SRS) refers to the delivery of a single, high dose of radiation to a precisely defined target.1 This is achieved by using multiple, noncoplanar radiation beams that converge on the target lesion.2,3 The goal of SRS is to deliver highly conformal radiation therapy in an attempt to ablate the lesion, while minimizing damage...

The thalamus plays crucial roles in the development and mature functioning of numerous sensorimotor, cognitive and attentional circuits. Currently limited evidence suggests that autism spectrum disorder may be associated with thalamic abnormalities, potentially related to sociocommunicative and other impairments in this disorder. We used functional...

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterized by atypical behavioral profiles including deficits in social reciprocity and communication. While many studies have reported abnormal long-distance functional connectivity in ASD, much less is known about local connectivity. We used the regional homogeneity (ReH...

Background: A number of studies have shown abnormal volume, neuronal integrity, perfusion, and metabolism of the thalamus in autism spectrum disorder (ASD). However, evidence on thalamocortical connectivity remains scant, except for a few functional studies. This lack of evidence is surprising, given the important role of thalamocortical connectivi...

Background: Individuals with autism spectrum disorder (ASD) exhibit early and lifelong abnormalities in adaptive allocation of visual attention. Previous studies have shown white matter compromise in children and adults with ASD, which may relate to impaired function in distributed networks. Objectives: The goals of the present study were to...