Jeffrey Ruta

Jeffrey Ruta
Temple University | TU · Department of Neurology

About

3
Publications
467
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265
Citations
Citations since 2016
0 Research Items
159 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530

Publications

Publications (3)
Article
The factors influencing sensitization to cocaine are complex and likely include both cellular and neural systems factors. Upregulation of the striatal dopamine cAMP-signaling pathway and enhanced accumbens adenosine tone are two mechanisms that have been proposed to underlie the development of cocaine sensitization. Isobutylmethylxanthine (IBMX) is...
Article
Full-text available
Atypical antipsychotic drugs, such as clozapine and risperidone, have a high affinity for the serotonin 5-HT(2A) G protein-coupled receptor (GPCR), the 2AR, which signals via a G(q) heterotrimeric G protein. The closely related non-antipsychotic drugs, such as ritanserin and methysergide, also block 2AR function, but they lack comparable neuropsych...

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