Jeffrey K LuttrullVentura County Retina Vitreous Medical Group / Vision Protection Institutes LLC
Jeffrey K Luttrull
MD
Medical device development; specialty clinics development
About
81
Publications
16,516
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1,982
Citations
Citations since 2017
Introduction
Vitreoretinal subspecialist in private practice, emphasizing clinical research. Research interests include retinal laser; medical retina; diabetic retinopathy; age-related macular degeneration; retinitis pigmentosa; open angle glaucoma; vitreoretinal surgery for complicated glaucomas; vitreoretinal surgery for retinal vein occlusions. Founder & Exec. Director of LIGHT: The International Retinal Laser Society.
Additional affiliations
June 1980 - May 1986
Position
- Research Assistant
Description
- Clinical and basic research as medical student, intern, and ophthalmology resident at University of So. California School of Medicine, Dept of Ophthalmology, Doheny Eye Foundation
Publications
Publications (81)
In a prior retrospective all comers study of eyes with dry AMD, regular periodic panmacular SDM laser as Vision Protection Therapy (VPT) reduced the expected incidence of neovascular conversion by 95-98% per year. (Luttrull JK, Sinclair SH, Elmann S, Glaser BM. Low incidence of choroidal neovascularization following subthreshold diode micropulse la...
Introduction There are 463 million persons worldwide with diabetes mellitus, representing 9.3% of the adult population. This is expected to double in the next 25 years [1], with approximately 37% of US adults older than 20 years and 51% older than 65 having prediabetes with predicted high rates of conversion to type 2DM with aging [2]. Because of t...
Purpose:
To access the impact of regular periodic subthreshold diode micropulse laser (SDM) as Vision Protection Therapy on the rate of neovascular conversion of dry age-related macular degeneration (AMD).
Methods:
Patient unidentified clinical data aggregated by Vestrum Health, LLC (VH) from 300 retina specialists across the United States was a...
Patient unidentified clinical data aggregated by Vestrum Health, LLC (VH) from 300 retina specialists across the United States was analyzed to examine the effect of a program of regular periodic low-intensity/high-density subthreshold diode micropulse laser (SDM) on the incidence of neovascular conversion and visual acuity (VA) in patients with dry...
The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital—King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients with center-involving diabetic...
Purpose:
To determine the effect of panmacular low-intensity/high-density subthreshold diode micropulse laser (SDM) on age-related geographic atrophy (ARGA) progression.
Methods:
The retinal images of all eyes with ARGA in a previously reported database, consisting of all eyes with dry age-related macular degeneration (AMD) active in a vitreoret...
The use of macular laser treatment to attempt to prevent CNV is reviewed in relation to age-related macular degeneration (AMD), the principal cause of visual loss due to CNV. The causes of age-related CNV and ways in which macular laser may interact and influence with those processes for good or ill are reviewed and discussed. In particular, progre...
Guidelines for subthreshold retinal laser treatment from the Annual Meeting of LIGHT: The International Retinal Laser Society, October 2019, Paris, France
Purpose:
To examine the effect of low-intensity/high-density subthreshold diode micropulse laser (SDM) on visual acuity (VA) and macular thickness in eyes with limited visual recovery and persistent macular thickening after epiretinal membrane peeling.
Methods:
A retrospective review of medical records identified all patients undergoing SDM afte...
Purpose:
To compare the safety and efficacy of 810 versus 577 nm laser wavelengths for micropulse subthreshold (sublethal) laser treatment by mathematical analysis.
Methods:
Two different representative laser parameter sets for micropulsed subthreshold diode laser treatment, one employing 810 nm and the other 577 nm, are compared with regard to...
Citation: Chang DB, Luttrull JK. Comparison of subthreshold 577 and 810 nm micropulse laser effects on heat-shock protein activation kinetics: implications for treatment efficacy and safety. Trans Vis Sci Tech. ;0(0):1947, https://doi.org/10.1167/tvst.0.0.1947 Purpose: To compare the safety and efficacy of 810 versus 577 nm laser wavelengths for mi...
Purpose: To examine the rationale for modern laser treatment of the retina to provide neuroprotection in open-angle glaucoma (OAG). Method: The effects of therapeutic thermal laser stimulation of the retinal pigment epithelium (RPE) are reviewed in relation to RPE function in glaucoma and the pathogenesis of OAG. Results: Modern retinal laser thera...
Purpose
To determine the incidence of new choroidal neovascularization (CNV) in eyes with dry age-related macular degeneration (AMD) following subthreshold diode micropulse laser (SDM).
Method
In an observational retrospective cohort study, the records of all patients active in the electronic medical records database were reviewed to identify eyes...
Objectives:
To examine the effect of subthreshold diode micropulse laser (SDM) on pattern electroretinography (PERG) and visual function in retinitis pigmentosa (RP).
Methods:
The records of all patients (pts) undergoing SDM in a vitreoretinal subspecialty practice were reviewed. Inclusion criteria included the presence of RP evaluated before an...
Aim
To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP).
Methods
In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was...
Because of complications and side effects, conventional laser therapy has taken a back seat to drugs in the treatment of macular diseases. Despite this, research on new laser modalities remains active. In particular, various approaches are being pursued to preserve and improve retinal structure and function. These include micropulsing, various expo...
Purpose:
To review the results of low-intensity/high-density subthreshold micropulse laser (SDM) for treatment of central serous chorioretinopathy.
Method:
The records of all patients treated in a retinal subspecialty practice with SDM for central serous chorioretinopathy were reviewed.
Results:
Eleven consecutive eyes of 11 patients treated b...
Purpose: To review the results of retinal function testing in eyes undergoing panmacular subthreshold diode micropulse laser (SDM) prophylaxis for chronic progressive retinal disease.
Setting: A private vitreoretinal subspecialty practice in Ventura, California, USA.
Methods: The records of all patients undergoing prophylactic panmacular SDM for...
Two consecutive cases of symptomatic vitreomacular adhesion with macular hole were treated with intravitreal ocriplasmin. Both were complicated by long-term visual symptoms and chronic serous foveal detachments lasting 17 months post-treatment. These findings suggest direct and long-lasting effects of ocriplasmin on the retinal pigment epithelium a...
Purpose: Drug tolerance is the most common cause of treatment failure in neovascular age-related macular degeneration (NAMD). “Low-intensity / high-density” subthreshold diode micropulse laser (SDM) has been reported effective for a number of retinal disorders without adverse effects. It has been proposed that SDM normalizes RPE function. On this b...
Medicinal lasers are a standard source of light to produce retinal tissue photocoagulation to treat retinovascular disease. The Diabetic Retinopathy Study and the Early Treatment Diabetic Retinopathy Study were large randomized clinical trials that have shown beneficial effect of retinal laser photocoagulation in diabetic retinopathy and have dicta...
Purpose:
To determine the safety of transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema.
Methods:
The records of all patients treated with transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema in two retina clinics were reviewed. The eligibility included fovea-involving...
To review results of vitreous surgery for branch and central retinal vein occlusion (BRVO and CRVO).
All cases of vitrectomy with multiple transvenous chorioretinotomies for retinal vein occlusion at a vitreoretinal subspecialty practice were reviewed.
Twenty eyes of 20 patients (four with BRVO and 16 with CRVO) were included. Mean time from diagno...
In his seminal book on modern education, Closing of the
American Mind, Allan Bloom observed that oftentimes
the things that disturb us most about prior civilizations
are the very things that they took most for granted: Child
sacrifice. Gladiatorial games. Bell‑bottom pants. Modified
ETDRS macular photocoagulation for diabetic macular
oedema (DME)?...
To present the state-of-the-art of subthreshold diode laser micropulse photocoagulation (SDM) as invisible retinal phototherapy for diabetic macular edema (DME).
To review the role and evolution of retinal laser treatment for DME.
Thermal laser retinal photocoagulation has been the cornerstone of treatment for diabetic macular edema for over four d...
To determine the long-term safety of high-density subvisible diode micropulse photocoagulation (810 nm), compare the clinical findings with computational modeling of tissue hyperthermia and to report results for a subset of eyes treated for diabetic macular edema (ME) documented pre- and postoperatively by spectral-domain optical coherence tomograp...
Eye is the official journal of the Royal College of Ophthalmologists. It aims to provide the practising ophthalmologist with information on the latest clinical and laboratory-based research.
To report the visual acuity results in a small case series of eyes undergoing membrane peeling for epiretinal membrane presenting with age-related subfoveal choroidal neovascularization.
Retrospective chart review of all eyes undergoing vitrectomy with epiretinal membrane peeling after intravitreal anti-vascular endothelial growth factor injection...
To report the visual acuity and clinical outcomes of a pilot study of subthreshold diode micropulse (SDM) panretinal photocoagulation (PRP) for treatment of diabetic retinopathy.
A retrospective chart review of all patients undergoing PRP for diabetic retinopathy between April 2000 and February 2003 was performed. Treated conditions ranged from sev...
To determine the incidence and effect of persistent/prolonged choroidal hypofluorescence (PCH) following combined verteporfin photodynamic therapy and intravitreal triamcinolone acetate injection (PDT + IVTA) for age-related subfoveal choroidal neovascularization (CNVM).
A retrospective review of all patients undergoing PDT + IVTA for CNVM from Dec...
Is subthreshold diode micropulse photocoagulation the “Emperor’s new laser”
or a paradigm shift for retinal vascular disease?
To use serial optical coherence tomography (OCT) to evaluate low-intensity, high-density subthreshold diode laser micropulse photocoagulation treatment of clinically significant diabetic macular edema.
Eighteen consecutive eyes of 14 patients with clinically significant diabetic macular edema and a minimum foveal thickness of 223 microm or greater...
To report the visual and clinical outcomes of a pilot study of subthreshold diode micropulse (SDM) laser photocoagulation for clinically significant diabetic macular oedema (CSMO).
The results of infrared (810 nm) SDM laser photocoagulation for CSMO were retrospectively reviewed in 95 eyes of 69 consecutive patients with mild to moderate non-prolif...
To assess the efficacy of pneumatically stented drainage tube implants specially modified for pars plana insertion in the treatment of complicated glaucoma.
Retrospective, non-comparative case series.
50 consecutive patients with refractory complicated glaucoma nonresponsive to medical treatment.
Baerveldt glaucoma implants modified by Hofmann for...
To describe a morphologic variant of the multiple evanescent white-dot syndrome that can mimic other conditions.
We examined three patients with severe cases of unilateral multiple evanescent white-dot syndrome characterized by an atypical progressive circumpapillary discoloration of the fundus.
The confluent circumpapillary lesion progressed towar...
To report a patient with a macular injury caused by a laser pointing device.
Case report. A healthy 34-year-old man was examined 2 days after he deliberately gazed into the beam of a laser-pointing device with his left eye for an estimated 30 to 60 seconds. His uncorrected visual acuity in each eye was 20/20. He reported a transient central scotoma...
This report evaluates the clinical characteristics of surfing-related ocular trauma to learn the nature of such injuries and propose possible preventive measures.
The authors reviewed 11 cases of surfing-related eye injuries caused by direct trauma from the surfboard, studying their mechanism of injury, the associated ocular complications, and the...
To report a patient with a sight-threatening complication of laser-induced chorioretinal venous anastomosis for treatment of central retinal vein occlusion.
A 69-year-old woman with a nonischemic central retinal vein occlusion underwent focal argon laser photocoagulation treatment to create a chorioretinal venous anastomosis.
Massive preretinal fib...
To report a patient with acute retinal pigment epitheliitis examined less than 24 hours after onset of symptoms.
One day after the onset of blurred vision in her left eye, a 33-year-old woman had a best-corrected visual acuity of LE, 20/60 -2. The left eye had classic uniform golden-colored nodules in a honeycomb pattern in the foveal retinal pigme...
We examined a patient with acute retinal pigment epitheliitis before the development of the characteristic pigmentary retinopathy.
Three days after onset of blurred vision in her left eye, a 25-year-old woman had a visual acuity of L.E.: 20/40 -2. There were uniform outer retinal golden-colored vacuoles in the area of subsequent foveal pigmentary a...
Purpose:
We treated five patients who had ocular fungal infections with oral fluconazole to determine its safety and effectiveness.
Methods:
We reviewed the case histories of the five patients. One patient had coccidioidomycosis and four had endogenous Candida endophthalmitis.
Results:
The intraocular fungal infection resolved in all patients....
To evaluate the effectiveness of pars plana implants in the treatment of neovascular glaucoma.
Twenty-two consecutive pars plana implant procedures performed for neovascular glaucoma were retrospectively reviewed.
Preoperative intraocular pressures ranged from 22 to 80 mmHg (mean 46 mmHg) on a mean of three glaucoma medications. With a mean follow-...
THE APPLICATION OF vitreoretinal microsurgical techniques
to disorders of the macula, the central retinal visual area, has
become one of the most exciting and rapidly developing areas
in ophthalmology.
We performed ophthalmologic examinations on 127 subjects with or at risk for human immunodeficiency virus (HIV) infection over a one-year period to determine the prevalence and significance of retinal cotton-wool spots and hemorrhages (AIDS-related retinal microvasculopathy). Of 26 asymptomatic homosexual men, of whom 13 were HIV seronegative and 1...
Twenty-five patients (48 eyes) underwent transantral, surgical decompression of their orbits for treatment of Graves' ophthalmopathy with optic neuropathy. Visual acuity improved in 77%, remained unchanged in 17%, and worsened in 6%. Colour vision improved in 76%, remained unchanged in 20%, and worsened in 4%. Visual fields improved in 67%, remaine...
Contraction of corneal wounds has been the topic of recent speculation, particularly in reference to regression of corneal flattening following radial keratotomy. In an animal model of corneal wound fibroplasia, we offer the first demonstration of in vitro contractility by avascular corneal wound tissue. Three millimeter diameter full-thickness cor...
Butadien-monoxid (I) wird mit Halogenen, Methylhypochlorit, N-Brornsuccinimid, Interhalogeniden oder p-Chlorphenylsulfenylchlorid in die isomeren Adduktionsverbindungen (III) und (IV) umgewandelt.
Ionic reactions of bromine, chlorine, methyl hypochlorite or N-bromosuccinimide with butadiene monoxide (4) give only 1,2-addition products. The Markownikoff (1-halo-2-methoxy-3,4-epoxybutane) and anti-Markownikoff (2-halo-1-methoxy-3,4-epoxybutane) product ratios for ionic reaction of methyl hypochlorite and N-bromosuccinimide in methanol with 4 a...
In Reply.
—We certainly agree that long-term studies to determine the susceptibility of the cornea to blunt trauma following radial keratotomy are important. Our study yielded information only about immediate postoperative weakness in the cornea and was not designed to assess corneal integrity following wound healing.We did refer to an unpublished...
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The usefulness of transillumination and biomicroscopy of the lid margin in assessing meibomian gland dysfunction was studied in a rabbit model. Transillumination of rabbit lids treated with topical epinephrine for 2 to 3 months revealed plugging of the meibomian gland orifice. Plugging appeared to be correlated histopathologically with increased th...
The safety of deep corneal incisions in radial keratotomy was evaluated in a porcine model of blunt trauma. One eye of each enucleated pair (right and left) of porcine eyes was subjected to a variation of radial keratotomy; the fellow eyes served as unoperated-on controls. All eyes were subjected to a standard injury. Control eyes ruptured at the e...
The electrophiles chlorine (Cl2), methyl hypochlorite (CH3OCl), bromine (Br2), methyl hypobromite (CH3OBr), and N-bromosuccinimide (NBS) were added to ethyl sorbate (1) under ionic conditions in methanol as solvent. Addition of CH3OCl and CH3OBr to neat 1 under ultraviolet illumination resulted in molecule-induced homolysis reactions. Under ionic c...
Die Halogenierung von Äthylsorbat (I) wird untersucht,und die Anteile an den Addukten und Substitutionsprodukten (II)-(V) werden ermittelt.
The addition of chlorine and bromine to ethyl sorbate (1a) gave 1,2- and 1,4-dihalo products derived from attack of the halogen across the γ,δ double bond. Chlorination of 1a under ionic conditions proceeds through a tightly bridged chloronium ion intermediate, as indicated by the stereospecific formation of erythro-1,2-dichloride 3a. Stereospecifi...
Questions
Questions (3)
Manuscript attached. SDM produces improvements in PERG, VA, and mesopic VA in every retinopathy including dry AMD and RP, in large part due to rescue of dysfunctional pre-apoptotic cells. I am confident DARC can show reversal of pre-apoptosis within days after SDM in any chronic progressive retinopathy including POAG. I have extensive data on all types of chronic progressive retinopathies (all neurodegenerations). I would like to discuss. Thank you jkluttrull@gmail.com
Suggest "panmacular" treatment for all DME: 1200-1500 (200um) spots confluently throughout the posterior pole between the arcades for best results. If 810, 200um spot, 0.15 sec, 5% DC, 1.45 W. If 577, 100um, 0.2 sec, 5% DC, 0.25 W. Best, Jeff
Projects
Project (1)