Jeffrey Karsdon

• M.D.
• M.D., CTO at e-Bio

Preterm birth (PTB) is one of the leading causes of neonatal morbidities and mortalities. Limited methods are available to physicians for mitigating PTB, thus posing an urgent need to develop effective methods for its prevention. In prior research, a benchtop electronic uterine control device (EUCD) was developed for tocolysis through injection of...

Aim: The aim of the study was to test the safety and feasibility of a system designed to decrease the uterine contractions of human preterm labor using a weak electrical current. Methods: Patients in preterm labor had an electrode catheter placed in the posterior vaginal fornix and attached to an electrical pacemaker. Contraction intervals were...

Despite appropriate immunoprophylaxis, up to 10 % of infants born to highly viremic hepatitis B virus (HBV-DNA ≥ 7 log IU/mL) mothers are infected with HBV. Use of TDF to prevent vertical transmission (VT) by such mothers has not been evaluated. To evaluate the efficacy and safety of TDF in preventing VT from highly viremic HBV-infected mothers. Da...

The purpose of this study was to inhibit uterine contractility during parturition with an electrical current, which is called electrical inhibition, in the rabbit and the rat. We studied the electrical inhibition of in vitro spontaneously contracting preterm or term gestational rat myometrium tissue and in vivo spontaneously contracting uterus eith...

Sick neonates often need gastric decompression and various decompression tubes are used. However, on the roentgenograms after tube placement, we noticed the proximal vent hole often is not in the stomach and may even be in the glottis, thus not allowing for efficient decompression and posing a risk of aspiration of any fluids in the tube. We studie...

We studied the efficiency of the Natelson-type tube (NTT), which requires only 0.25 ml of blood, on 11 healthy adult volunteers (HAV) and 42 pediatric patients. Free flow venous and finger stick capillary specimens were taken simultaneously in duplicate. In patients, venous specimens were split to have Westergren method (WM) ESR and NTT ESR done si...

The effects of mechanical changes in loading conditions on the left ventricular end-systolic pressure-volume relation (ESPVR) were studied in nine open-chest dogs, including three dogs studied before and after beta-adrenergic blockade. Left ventricular pressure was measured with a micromanometer, and left ventricular volume was measured with a cond...

We studied, in vitro, different commercially available components for pneumothorax drainage, i.e. drainage tubes, Heimlich flutter valve and vacuum control units. The drainage of a pneumothorax by a drainage tube was, as expected, directly dependent on Poiseuille's law and was influenced more by diameter than length. Of practical importance, a size...

We have examined lymphocytes from human preterm (PT) and fullterm (FT) babies for an effect of gestational age (GA) on chromosomal aberrations either occurring spontaneously or induced by treatment with X-rays (1 Gy) alone; or with caffeine (1,3,7-trimethylxanthine) supplementation (5 X 10(-4) M), in comparison to the lymphocytes of healthy adults...

The effect of an on-line manometer on the variables of ventilation i.e. peak inspiratory pressure (PIP), mean airway pressure (MAP), positive end expiratory pressure (PEEP), and inspiratory to expiratory time ratio (I:E) was studied in vitro. Analysis of PIP, MAP, PEEP, and I:E was made during hand ventilation of a resuscitation mannequin at the pr...

Electrical resistivity of the myocardium is anisotropic and dependent on muscle fiber direction. An effect as yet not studied, is the influence of blood in the capillary vessels on the electrical properties of the myocardial wall. We developed an electrode system consisting of 2 perpendicular arrays of 4 electrodes with an inter-electrode distance...

An in vitro study showed that the use of transparent plastic insulation to decrease heat loss from newborn infants substantially decreases the transmission of phototherapy light. The decrease is proportional to the number of plastic layers between the light source and the baby because of reflection from the surface of the plastic. This increases if...

Several recent reports have suggested that continuous-wave Doppler ultrasonography may be a useful, noninvasive tool in the diagnosis of patent ductus arteriosus (PDA). Detection of PDA was based on the identification of retrograde blood flow in the descending aorta during ventricular diastole. This study was designed to investigate how well contin...