Jeffrey Michael Hubbard

Jeffrey Michael Hubbard
NEUROSERVICE · Department of Neurosciences

Ph.D.

About

12
Publications
1,159
Reads
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598
Citations
Introduction
American expat in Aix. Group leader for the Neuroservice in vitro patch-clamp electrophysiology platform. We co-design and perform functional neuronal assays with you that will advance your CNS based projects.
Additional affiliations
May 2019 - present
NEUROSERVICE
NEUROSERVICE
Position
  • Group Leader
Description
  • I lead the in vitro patch-clamp team. Our team provides high quality robust physiological data for CNS based programs.
September 2017 - March 2019
Servier
Position
  • PostDoc Position
January 2013 - July 2017
L'Institut du Cerveau et de la Moelle Épinière
Position
  • Fellow
Education
August 2004 - December 2012
Oregon Health and Science University
Field of study
  • Neuroscience
September 1995 - May 1999
Reed College
Field of study
  • Biochemistry and Molecular Biology

Publications

Publications (12)
Article
Full-text available
In the vertebrate spinal cord, cerebrospinal fluid-contacting neurons (CSF-cNs) are GABAergic neurons whose functions are only beginning to unfold. Recent evidence indicates that CSF-cNs detect local spinal bending and relay this mechanosensory feedback information to motor circuits, yet many CSF-cN targets remain unknown. Using optogenetics, patte...
Article
Full-text available
Significance statement: Use-dependent fatigue accompanies many neuromuscular myasthenic syndromes, including muscle rapsyn deficiency. Here, using a rapsyn-deficient line of zebrafish, we performed paired motor neuron target muscle patch-clamp recordings to investigate the mechanisms causal to this phenomenon. Our findings indicate that the reduce...
Article
Full-text available
A long-held tenet of neuromuscular transmission is that calcium-dependent neurotransmitter release is mediated by N-type calcium channels in frog but P/Q-type channels in mammals. The N-type assignment in frog is based principally on pharmacological sensitivity to ω-conotoxin GVIA. Our studies show that zebrafish neuromuscular transmission is also...
Article
Graphical Abstract Highlights d Optimized, genetically encoded botulinum neurotoxin silences synaptic output in vivo d Excitatory V2a interneurons drive high-frequency components of fast locomotion d Silencing of V2as shifts locomotor frequency downward during the slow regime In Brief Silencing of neuronal populations in moving animals remains a ch...
Article
Full-text available
Background: Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with disease, but the role of this protein in disease pathog...
Article
Full-text available
Asynchronous transmission plays a prominent role at certain synapses but lacks the mechanistic insights of its synchronous counterpart. The current view posits that triggering of asynchronous release during repetitive stimulation involves expansion of the same calcium domains underlying synchronous transmission. In this study, live imaging and pair...
Article
Full-text available
Glutamate transporters (excitatory amino acid transporter (EAATs)) are critical for normal excitatory signaling and maintaining subtoxic glutamate concentrations in mammalian central nervous system. Recently, a crystal structure for a homologous transporter in bacteria was reported. Still, little is understood regarding the mechanism of substrate u...
Article
Full-text available
The emergence and spread of multidrug-resistant gram-positive bacteria represent a serious clinical problem. Telavancin is a novel lipoglycopeptide antibiotic that possesses rapid in vitro bactericidal activity against a broad spectrum of clinically relevant gram-positive pathogens. Here we demonstrate that telavancin's antibacterial activity deriv...

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