Jeffrey T Duda

University of Pennsylvania | UP · Department of Radiology

The ventromedial prefrontal cortex (vmPFC) to nucleus accumbens (NAc) circuit has been implicated in impulsive reward-seeking. This disinhibition has been implicated in obesity and often manifests as binge eating, which is associated with worse treatment outcomes and comorbidities. It remains unclear whether the vmPFC-NAc circuit is perturbed in im...

Ramey, C. (2021). Randomized manipulation of early cognitive exper ience impacts adult brain structure. Jour nal of Cognitive Neuroscience, 33, 1197-1209. The study reported by Farah et al. revealed large effects of a period of intense cognitive stimulation in early childhood on adult brain morphology. How ever, the effect on male brains was substa...

Automated quantitative and probabilistic medical image analysis has the potential to improve the accuracy and efficiency of the radiology workflow. We sought to determine whether AI systems for brain MRI diagnosis could be used as a clinical decision support tool to augment radiologist performance. We utilized previously developed AI systems that c...

The Advanced Normalizations Tools ecosystem, known as ANTsX, consists of multiple open-source software libraries which house top-performing algorithms used worldwide by scientific and research communities for processing and analyzing biological and medical imaging data. The base software library, ANTs, is built upon, and contributes to, the NIH-spo...

Sustained differences in early life cognitive and linguistic stimulation were found to impact adult brain structure. Starting in infancy, groups of very low SES children were randomized to either 5 years of cognitively and linguistically stimulating high-quality center-based care or a comparison condition. The intervention resulted in large and sta...

The Advanced Normalizations Tools ecosystem, known as ANTsX, consists of multiple open-source software libraries which house top-performing algorithms used worldwide by scientific and research communities for processing and analyzing biological and medical imaging data. The base software library, ANTs, is built upon, and contributes to, the NIH-spo...

Traumatic brain injury (TBI) is a leading cause of morbidity worldwide, for which biomarkers are needed to better understand the underlying pathophysiology. Microvascular injury represents a subset of pathological mechanisms contributing to cognitive dysfunction following TBI, which may also impair subsequent neural repair thereby inhibiting cognit...

Longitudinal studies of development and disease in the human brain have motivated the acquisition of large neuroimaging data sets and the concomitant development of robust methodological and statistical tools for quantifying neurostructural changes. Longitudinal-specific strategies for acquisition and processing have potentially significant benefit...

Longitudinal studies of development and disease in the human brain have motivated the acquisition of large neuroimaging data sets and the concomitant development of robust methodological and statistical tools for quantifying neurostructural changes. Longitudinal-specific strategies for acquisition and processing have potentially significant benefit...

The present study examined the relationship between childhood socioeconomic status (SES), childhood maltreatment, and the volumes of the hippocampus and amygdala between the ages of 25 and 36 years. Previous work has linked both low SES and maltreatment with reduced hippocampal volume in childhood, an effect attributed to childhood stress. In 46 ad...

α-Mannosidosis (AMD) is an autosomal recessively inherited lysosomal storage disorder affecting brain function and structure. We performed ex vivo and in vivo diffusion tensor imaging (DTI) on the brains of AMD-affected cats to assess gray and white matter abnormalities. A multi-atlas approach was used to generate a brain template to process the ex...

Introduction: Alpha-mannosidosis (AMD) is an autosomal recessively inherited lysosomal storage disorder, which is caused by deficiency of the enzyme α-D-mannosidase. This enzyme is involved in the degradation of glycoproteins, thus its deficiency leads to accumulation of oligosaccharides in cells including that of the brain, kidney and liver

Magnetic resonance imaging (MRI) captures the dynamics of brain development with multiple modalities that quantify both structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder. The Pediatric Template of Brain Perfusion (PTBP) is...

Autism spectrum disorders (ASD) comprise an etiologically heterogeneous set of neurodevelopmental disorders. Neuroligin-3 (NL-3) is a cell adhesion protein that mediates synapse development and has been implicated in ASD. We performed ex-vivo high resolution magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI) and behavioral (...

Many studies of the human brain have explored the relationship between cortical thickness and cognition, phenotype, or disease. Due to the subjectivity and time requirements in manual measurement of cortical thickness, scientists have relied on robust software tools for automation which facilitate the testing and refinement of neuroscientific hypot...

Recent interest in human brain connectivity has led to the application of graph theoretical analysis to human brain structural networks, in particular white matter connectivity inferred from diffusion imaging and fiber tractography. While these methods have been used to study a variety of patient populations, there has been less examination of the...

We contribute a novel multivariate strategy for computing the structure of functional networks in the brain from arterial spin labeling (ASL) MRI. Our method fuses and correlates multiple functional signals by employing an interpretable dimensionality reduction method, sparse canonical correlation analysis (SCCA). There are two key aspects of this...

Childhood socioeconomic status (SES) predicts executive function performance and measures of prefrontal cortical function, but little is known about its anatomical correlates. Structural MRI and demographic data from a sample of 283 healthy children from the NIH MRI Study of Normal Brain Development were used to investigate the relationship between...

There is a long history and a growing interest in the canine as a subject of study in neuroscience research and in translational neurology. In the last few years, anatomical and functional magnetic resonance imaging (MRI) studies of awake and anesthetized dogs have been reported. Such efforts can be enhanced by a population atlas of canine brain an...

To evaluate the longitudinal repeatability and accuracy of cerebral blood flow (CBF) measurements by using pseudo-continuous arterial spin-labeled (pCASL) perfusion magnetic resonance (MR) imaging in typically developing children. Institutional review board approval with HIPAA compliance and informed consent were obtained. Twenty-two children aged...

Measures from event-related functional MRI, diffusion tensor imaging tractography and cognitive performance in a language-based task were used to test the hypothesis that both functional and structural connectivity provide independent and complementary information that aids in the identification of network components most related to the neurobiolog...

The human brain is a system of neurons that provides great computational capacity via a complicated communication network. A complete description of this network, also known as the human connectome, is an active topic of research as it would provide invaluable knowledge to cognitive neuroscience. Historically, the study of brain connectivity has be...

Diffusion tensor (DT) and T1 structural magnetic resonance images provide unique and complementary tools for quantifying the living brain. We leverage both modalities in a diffeomorphic normalization method that unifies analysis of clinical datasets in a consistent and inherently multivariate (MV) statistical framework. We use this technique to stu...

Diffusion tensor (DT) images quantify connectivity patterns in the brain while the T1 modality provides high-resolution images of tissue interfaces. Our objective is to use both modalities to build subject-specific, quantitative models of fiber connections in order to discover effects specific to a neural system. The health of this thalamo-cortical...

Current clinical and research neuroimaging protocols acquire images using multiple modalities, for instance, T1, T2, diffusion tensor and cerebral blood flow magnetic resonance images (MRI). These multivariate datasets provide unique and often complementary anatomical and physiological information about the subject of interest. We present a method...

Recently, concerns have been raised that the correspondences computed by volumetric registration within homogeneous structures are primarily driven by regularization priors that differ among algorithms. This paper explores the correspondence based on geometric models for one of those structures, midsagittal section of the corpus callosum (MSCC), an...

Current clinical and research neuroimaging protocols acquire images using multiple modalities, for instance, T1, T2, diffusion tensor and cerebral blood flow magnetic resonance images (MRI). These multivariate datasets provide unique and often complementary anatomical and physiological information about the subject of interest. We present a method...

The continuous medial representation (cm-rep) is an approach that makes it possible to model, normalize, and analyze anatomical structures on the basis of medial geometry. Having recently presented a partial differential equation (PDE)-based approach for 3-D cm-rep modeling [1], here we present an equivalent 2-D approach that involves solving an or...

Since the 1970’s B-splines have evolved to become the de facto standard for use in curve and surface representation. This resulted in a relatively recent proliferation of nonrigid image registration techniques based on B-splines. These techniques fall under the general Free-Form Deformation (FFD) approach in which the object to be registered is emb...

In this chapter, we consider the task of anatomically labeling diffusion tensor images of cerebral white matter to facilitate visualization as well as quantitative comparison of these data. The analogous labeling problem for structural magnetic resonance images of the brain has been extensively studied and we propose that advances in atlas-based te...

Diffusion tensor magnetic resonance imaging (DTI) provides data concerning water diffusion in the spinal cord, from which white matter tracts may be inferred, and connectivity between spinal cord segments may be determined. We evaluated this potential application by imaging spinal cords from normal adult rats and rats that received cervical lateral...

The aim of this study was to examine the registration of diffusion tensor magnetic resonance images. A method for estimating a smooth, continuous mapping between two tensor images is presented. This method includes a tensor-to-tensor measure of similarity as well as a neighborhood similarity measure intended to preserve the relative position of adj...

The aim of this work was to develop a reliable semi-automatic method for quantifying carotid atherosclerotic lesion burden using black-blood high-resolution MR images. Vessel wall volume was quantified by measuring its cross-sectional area in adjacent slices. Two methods for obtaining this measure are presented. The first method approximates the ou...

In this paper, we describe work on the non-rigid registration of diffusion tensor magnetic resonance (DT-MR) images. The registration task for DT-MR images is complicated by the fact that DTs contain orientational information, which is affected by the registration transformation. We discuss how to properly account for this effect in the implementat...

Diffusion-weighted MR imaging (DWI) is a novel technique to delineate focal areas of cytotoxic edema of various etiologies. We hypothesized that DWI may also detect the epileptogenic region and adjacent areas during the ictal and early postictal periods in patients with temporal lobe epilepsy (TLE). We studied patients with intractable TLE (n = 9),...

Brain atrophy is a relevant surrogate marker of the disease process in multiple sclerosis (MS) because it represents the net effect of various pathological processes leading to brain tissue loss. There are various approaches to quantifying central nervous system atrophy in MS. We have focused on a normalized measure of whole brain atrophy, the brai...

Brain atrophy is a relevant surrogate marker of the disease process in multiple sclerosis (MS) because it represents the net effect of various pathological processes leading to brain tissue loss. There are various approaches to quantifying central nervous system atrophy in MS. We have focused on a normalized measure of whole brain atrophy, the brai...

Fiber tract trajectories in coherently organized brain white matter pathways were computed from in vivo diffusion tensor magnetic resonance imaging (DT-MRI) data. First, a continuous diffusion tensor field is constructed from this discrete, noisy, measured DT-MRI data. Then a Frenet equation, describing the evolution of a fiber tract, was solved. T...

Diffusion-weighted MR imaging (DWI) has been used for the early diagnosis of acute ischemic lesions in humans and in animal models of focal status epilepticus. We hypothesized that DWI may be a sensitive, noninvasive tool for the localization of the epileptogenic area during the periictal period. A periictal DWI study was performed on a 35-year-old...