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Publications (106)
Objective
To report the study design of a Phase 2, multicenter, randomized, placebo controlled, parallel-group study (ARDA, NCT05225675 ) will assess the safety, efficacy, PK, and PD of ARGX-117 in adults with MMN.
Background
Multifocal motor neuropathy (MMN) is a chronic, immune-mediated neuropathy characterized by progressive asymmetric weakness...
8543
Background: Patients with early stage, non-small cell lung cancer (NSCLC) with solitary pulmonary lesions ≤4 cm typically have favorable outcomes. However, disease recurrence impacts up to 30% of patients, leading to either additional surgical or systemic interventions. New methods to risk stratify patients based on clinical and molecular para...
e24080
Background: Significantly longer OS has been reported in advanced NSCLC pts. who gained weight or maintained (skeletal muscle mass) SMI during treatment with platinum containing chemotherapy. None of these studies evaluated the relationship between OS and both weight and SMI. Sex specific distributions are described for cachexia and muscle w...
e21087
Background: While laboratory parameters including PDL1 expression and NLR are associated with outcomes in patients with metastatic NSCLC treated with ICIs, these measures have not identified patients with rapid progression (RP) defined as progressive disease within 30 days. Clinical factors including patient age and weight loss have been ass...
BACKGROUND: Promacta (eltrombopag; EPAG) and Nplate (romiplostim; ROMI) have not been compared in head-to-head trials for treatment of chronic immune thrombocytopenia (cITP); however, indirect treatment comparisons have indicated similar efficacy and safety outcomes, and the drugs are generally accepted as therapeutic alternatives. OBJECTIVE: To de...
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an open acce...
This paper develops a multi-industry general equilibrium model where entrepreneurs within each industry can decide to operate formally or informally. The model generates a rich set of predictions including productivity cut-offs for formal and informal firms to operate within different industries. We allow fixed costs to vary across industries, resu...
We constructed a lung cancer-specific database housing expression data and clinical data from over 6,700 patients in 56 studies. Expression data from 23 “whole-genome” based platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer database, we created an...
The Oxford Textbook of Neuro-Oncology examines the epidemiology, pathogenesis, clinical features, and management of adult and childhood central nervous system (CNS) tumours. The book is organized according to the World Health Organization (WHO) classification of CNS tumours and includes an introductory chapter discussing the new, revised WHO classi...
A joint including a substrate, optionally a metal substrate, and a body of material joined to the substrate, the body of material typically having a composite portion. An outer surface of the substrate is provided with a fastening projection for fastening the substrate to body of material, where the fastening projection has a stem and a plurality o...
Background:
Overall response rate is frequently used as an end point in phase 2 trials of platinum-treated extensive stage (ES) small-cell lung cancer (SCLC). We hypothesized that disease control rate (DCR) would be a superior surrogate for subsequent survival outcomes.
Methods:
Updated patient-level data from Southwest Oncology Group (SWOG) tri...
The invention relates to a joint including a substrate, optionally a metal substrate, and a body of material joined to the substrate, the body of material typically having a composite portion. An outer surface of the substrate is provided with a fastening projection for fastening the substrate to body of material, wherein the fastening projection h...
The purpose of this study is to determine the accuracy with which a non-Gaussian measure of diffusion, mean kurtosis (MK), predicts the histologic grade of pediatric brain tumors. After institutional review board approval, 21 World Health Organization (WHO) grade I, 7 WHO grade II, and 7 WHO grade IV pathologically-proven intracranial pediatric mal...
A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prostheti...
Extensive-stage small-cell lung cancer (SCLC) patients who progress after platinum-based chemotherapy are traditionally categorized as platinum sensitive (progression ≥ 90 days from last platinum dose) or refractory (progression < 90 days), a practice arising from seminal observations of worse survival in refractory patients. Subsequent trials acco...
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAM consortium launched an open challenge to foster the development of in silico methods to computationally rank 91 compound pairs, from the most synergist...
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Objectives. Environmental factors expose an individual to heavy metals that may stimulate cancer growth preclinically including non-small cell lung cancer (NSCLC) cells. Here, we examine the prevalence of four heavy metals present in postsurgical tissues from individuals with and without NSCLC. Materials and Methods. Thoracic tissue samples from tw...
The quantity of heavy metals analyzed in primary NSCLC tumor compared with non-cancer lung tissue from MMC cases is provided in Supplementary Table S1.
Purpose:
Development of new therapies for previously treated small-cell lung cancer (SCLC) is a major unmet need. Here, we describe a randomized, phase II trial of weekly topotecan with or without ziv-aflibercept (VEGF-trap) in this clinical setting.
Patients and methods:
Patients with previously treated SCLC (one line of platinum-based chemothe...
Predicting the best treatment strategy from genomic information is a core goal of precision medicine. Here we focus on predicting drug response based on a cohort of genomic, epigenomic and proteomic profiling data sets measured in human breast cancer cell lines. Through a collaborative effort between the National Cancer Institute (NCI) and the Dial...
The performance appraisal practices used by industrial firms when evaluating members of the sales force are investigated. A formal model of the relationships among major aspects of the appraisal process is proposed and tested. Results are presented from a survey of 104 senior sales managers. Significant relationships are identified between what is...
Several air shower observatories have established that the number of muons
produced in UHE air showers is significantly larger than that predicted by
models. We argue that the only solution to this muon deficit, compatible with
the observed Xmax distributions, is to reduce the transfer of energy from the
hadronic shower into the EM shower, by reduc...
1068
Background: TNBC are mostly “basal-like” tumors, that have been shown to overexpress Secreted Protein Acidic and Rich in Cysteine (SPARC). Endothelial transcytosis of nab-P via albumin- gp60 -cav1 and binding of albumin to SPARC results in high intratumoral levels of nab-P. Exploiting this and the dysfunctional DNA repair in basal tumors, we h...
7511
Background: ES-SCLC patients (pts) with progressive disease (PD) following plat-based chemo are traditionally categorized as plat-sensitive (PD >/= 90 days from last plat dose) or refractory (PD < 90 days). This practice arose from seminal observations in the early 1980s of worse survival in refractory pts. Subsequent trial designs accounted f...
Purpose:
Prospectively identifying who will benefit from adjuvant chemotherapy (ACT) would improve clinical decisions for non-small cell lung cancer (NSCLC) patients. In this study, we aim to develop and validate a functional gene set that predicts the clinical benefits of ACT in NSCLC.
Experimental design:
An 18-hub-gene prognosis signature was...
We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Con...
As robots continue to enter people's everyday spaces, we argue that it will be increasingly important to consider the robots' movement style as an integral component of their interaction design. That is, aspects of the robot's movement which are not directly related to a task at hand (e.g., pick up a ball) can have a strong impact on how people per...
Background: Cigarettes, food, water, and air pollution can contain toxic heavy metals, such as cadmium (Cd), arsenic (As), mercury (Hg), and lead (Pb). A cigarette contains approximately 1-2 ug of Cd, 40-120 ng of As, 2.95-10.2 ng of Hg, and 1-2 mg/kg of Pb because the tobacco plant concentrates metals from soil and water. The accumulation of toxic...
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL
Background: Approximately 50% of all non-small cell lung carcinoma (NSCLC) cases in the United States are adenocarcinoma histology. While definitive lung cancer resection offers a chance for cure in stage I and II NSCLC, up to 57% of patients will have disease relapse or...
3032
Background: CVX-060 (CVX) is a humanized monoclonal antibody fused to two Ang2 binding peptides. The recommended phase 2 dose (RP2D) is15 mg/kg/wk by intravenous (IV) infusion. Sunitinib (Sun), a kinase with many targets including VEGFR1-3, is dosed 50 mg/day orally x 4/6 wks. Methods: Patients (pts) with solid tumors were to receive CVX at do...
TPS1137
Background: Triple negative breast cancer (TNBC) predominantly clusters with “basal like” subtype on genomic profiling. Over-expression of Secreted Protein Acidic and Rich in Cysteine (SPARC) has been observed in basal like breast cancer (Charaffe-Jaufrett et al. Oncogene 2006; 2273-84). Endothelial transcytosis of nab- paclitaxel occurs vi...
7005
Background: Topotecan (T) (oral and IV) is the only FDA-approved second-line chemotherapy for patients with SCLC. Weekly T is associated with less toxicity than the daily x 5 regimen. AVE0005 (aflibercept) (A) is a novel recombinant human fusion protein which binds to circulating VEGF, thereby inhibiting its interaction with cell surface recep...
It is well known that luminance from photo-chemical reactions of hydroxyl ions in the upper atmosphere (~85 km altitude) produces a significant amount of night time radiation in the short wave infra-red (SWIR) band with wavelength between 0.9 and 1.7 mum. This air glow has been proposed as an illumination source for obtaining imagery in the dark of...
Intensity interferometery holds tremendous potential for remote sensing of space objects. Whereas spatial resolution of imagery obtained from earth-based observatories is typically limited by both the size of the primary mirror and atmospheric effects, intensity interferometers (IIs) are relatively unaffected by atmospheric distortions and their ef...
Airglow luminescence in the SWIR region due to upper atmospheric recombination of solar excited molecules is a well accepted phenomenon. While the intensity appears broadly uniform over the whole sky hemisphere, we are interested in variations in four areas: 1) fine periodic features known as gravity waves, 2) broad patterns across the whole sky, 3...
Febrile neutropenia, a common side effect of myelosuppressive chemotherapy in patients with cancer, can result in prolonged hospitalization and broad-spectrum antibiotic use, often prompting treatment delays or dose reductions of drug regimens. Prophylactic use of myeloid growth factors (mainly the colony-stimulating factors filgrastim and pegfilgr...
For {\theta} \in [0, 2{\pi}), consider the rotation matrix R? and h =
({\lambda}, 0; 0, 0), {\lambda} > 1. Let W_n({\theta}) denote the product of m
R?'s and n h's with the condition m \leq [\epsilon\astn], (0 < \epsilon < 1).
We analyze the measure of the set of {\theta} for which ||W_n({\theta})|| \geq
{\lambda}?^(n*{\delta}), (0 < {\delta} < 1)....
It is well known that luminance from photo-chemical reactions of hydroxyl ions in the upper atmosphere (~85 km altitude) produces a significant amount of night time radiation in the short wave infra-red (SWIR) band of wave length 0.9 to 1.7 mum. Numerous studies of these phenomena have demonstrated that the irradiance shows significant temporal and...
The ageing population is taking an increasing number of both prescribed and non-prescribed medication. Little is known of the potential for adverse drug reactions between these. Warfarin is a commonly prescribed medication, well known for its potential to cause serious adverse reactions in combination with many prescription medicines. It has been s...
An economic model provides a consistent logic for earning profits within a venture. In this research, a four-component framework is developed and tested for capturing the entrepreneur's economic model. The proposed framework argues for integrating these four elements in a logical and consistent manner. Certain combinations of these elements can lea...
Non-small cell lung cancer (NSCLC) continues to be the leading cause of cancer-related mortality in the United States. Current standard care for treating NSCLC is surgical resection, when feasible, followed by adjuvant chemotherapy in stages II and III. Neoadjuvant or induction chemotherapy may have several potential advantages compared with adjuva...
While heavily emphasized within for-profit organizations, little is understood regarding the role of entrepreneurial leadership in the development, growth, and sustainability of non-profit enterprises. The fundamental logic of entrepreneurship is less apparent in this context given the social mission and multiple stakeholders involved. Building on...
How do entrepreneurs experience entrepreneurship, and what are the implications? The cognitive and emotional experiences of the entrepreneur as he/she performs the tasks associated with venture creation and high growth have received limited attention from researchers. The entrepreneurial context can be characterized in terms of peaks and valleys, o...
who generously supported the meeting. Meeting
p75NTR is most abundantly expressed in the nervous system, but is also widely expressed in many other organs and tissues where it primarily functions as a negative regulator of cell survival. In the prostate, p75NTR functions as an inhibitory protein capable of slowing proliferation and inducing apoptosis. It has been shown that p75NTR is expressed...
Attempts to understand the heterogeneous nature of the population of entrepreneurs are relatively few in number, and focus largely on gender, race, ethnicity, age and educational differences. The experiences of many other key cohorts have been ignored, including those of gay, lesbian and bisexual (GLB) individuals. This paper examines the concept o...
Most small engine manufacturers are looking to introduce fuel control technology to reduce engine out emissions, however most available conventional fuel injectors consume high levels of power to achieve controlled injection and suitable atomisation of the fuel. Typical fuel injection pressures of 300kPa are required to achieve pulsed injection and...
The residual stress fields generated within a laser deposition metal component or added feature have the potential to significantly affect its properties and performance. Stresses play a major role in determining the initial levels of distortion, in both the added part and the initial substrate material, and affect both short-time properties, such...
Several major telecommunications companies have made significant investment in either controlled language and/or machine translation
over the past 10 years.
The p75neurotrophin receptor (p75NTR) has been characterized as a tumor suppressor in human prostate cancer. Ectopic re-expression of this cell surface receptor protein in prostate cancer cell lines has been shown to increase the frequency of apoptosis and concurrently reduce the rate of cellular proliferation. Since it is difficult to maintain a t...
This paper describes a new biometric technology based on the optical properties of skin. The new technology can perform both identity verification and sample authenticity based on the optical properties of human skin. When multiple wavelengths of light are used to illuminate skin, the resulting spectrum of the diffusely reflected light represents a...
The DIPLOMAT project at Carnegie Mellon University instantiates a program of rapid-deployment speech-to-speech machine translation; we have developed techniques for quickly producing text-to-speech (TTS) systems for new target languages to support this work. While the resulting systems are not immediately of comparable quality to commercial systems...
The utility of the Clock Drawing Test (CDT) in localizing lesions has not been thoroughly examined to date. In the present
study, six scoring systems (Freedman et al., 1994; Ishiai, Sugishita, Ichikawa, Gono, & Watabiki, 1993; Mendez, Ala, & Underwood,
1992; Rouleau, Salmon, Butters, Kennedy, & McGuife, 1992; Sunderland et al., 1989; Tuokko, Hadjis...
Our position is that when porting a system from one platform to another, there are many non-code aspects of the system that collectively define it, that may or may not be available in some concrete form, but that nevertheless need to be considered and possibly "recycled" in the port. Furthermore, these non-code aspects seem to parallel those aspect...
The extent to which entrepreneurship in established firms is the result of a more individualistic versus collectivistic culture is explored. Hypotheses are tested in which it is proposed that a curvilinear relationship exists between individualism-collectivism and corporate entrepreneurship. Findings are reported from a survey completed separately...
: A 16-year-old boy was noted to have an apparent intradural sacral mass 6 weeks after the excision of a 4th ventricle ependymoma. Although spinal axis radiation was considered, it was decided to make a definitive tissue diagnosis. At sacral laminectomy, only segmental arachnoiditis was found. The implications of this finding are the subject of thi...
Serial echocardiographic (ECHO) studies were obtained on 40 pediatric patients (pts) treated with greater than or equal to 80 mg/kg cyclophosphamide (CPM) (range 80-200 mg/kg) in 1 week. Patients were treated for solid tumors and prior to marrow transplant. Echo changes occurred in 10/13 pts who received CPM greater than or equal to 170 mg/kg over...
The effect of corticosteroid (prednisone) and/or chronic anticholinesterase (neostigmine) treatment on alpha-bungarotoxin binding was examined in the diaphragms of male rats. In endplate regions of the diaphragm, prednisone treatment had no effect on the density of toxin binding sites, either when given alone or when administered in conjunction wit...
Over a one year period, 44 bilirubin binding assays were requested on premature and sick newborns. Total serum bilirubins ranged from 7.6 to 25.4 mg% with reserve bilirubin binding capacities ranging from −4 to 18 mg%. The saturation points ranged from 7.6 to 29.4 mg%. 85% had a saturation point greater than 15 mg%, with 50% greater than 20 mg%. On...
A thermolabile inhibitory factor of mitogen-induced lymphocyte transformation was observed in the fresh plasma of one patient in stage 3 of subacute sclerosing panencephalitis (SSPE) and not in three other patients in various stages of the disease. Thus, its relevance to SSPE is not clear. The plasma factor was removed by adsorption onto human and...
CSAR-X, helicopter competition in late May. USAF is now in the midst of evalu- ating the revised proposals and will determine, for the second time, whether Boeing's HH-47, Lockheed's US101, or Sikorsky's HH-92 is the best-suited rescue platform to replace aging HH- 60G Pave Hawk helicopters. Boeing is the reigning champ, winning the original compet...
The nature and role of entrepreneurship in for-profit companies is fairly well-established. Empirically, the firm’s entrepreneurial orientation (EO) has been associated with various measures of performance, as well as with a number of antecedent variables. In addition, evidence exists of a relationship between EO and the market orientation (MO) of...
Central to most conceptualizations of a business model is the firm’s approach to making money, or its economic model (Rayport & Jaworski, 2001). Surprisingly, no framework exists for capturing the entrepreneur’s economic model (Gunter and McGrath, 2005). In this research, a four-component framework is developed and tested. These four components inc...
Here at GPSolo magazine's Technology & Practice Guide, we often receive requests for guidance about what technology to buy. Even those of us who devote substantial time to staying on top of the latest developments often have a hard time keeping current. The number of choices available within any given category can be overwhelming. For example, woul...
An analysis of the technical and business aspects of the development of Horsepower Trading Platform, an online suite of services that enables members to participate in all phases of agricultural e-commerce. Includes bibliographical references (leaves 126-128). Thesis (M.S.)--California Polytechnic State University, 2002.
Typescript. Thesis (M.S.)--West Virginia University, 1986. Vita. Includes bibliographical references (leaves 73-91).
Typescript. Thesis (M.A.)--West Virginia University, 1984. Vita.
Typescript (photocopy) Thesis (Ph. D.)--Cornell University, June, 1985. Bibliography: leaves 212-222.
Thesis (M.S. - Electrical Engineering)--University of Arizona. Includes bibliographical references.
Thesis (M.S.)--North Carolina State University. Includes bibliographies. Includes vita.
Thesis (Ph. D.)--Cornell University, 1980. Vita.
Ph. D. (Audiology and Hearing Impairment)--Northwestern University, 1989.
Printout. Thesis (Ph. D.)--University of Illinois at Urbana-Champaign, 2000. Vita. Includes bibliographical references.
Thesis (Ph. D.)--North Carolina State University. Bibliography: leaves 137-156. Microfiche. s
Typescript. Vita. Thesis (Ed. D.)--West Virginia University, 1976. Includes bibliographical references (leaves 49-54).
Thesis (Ph. D.)--North Carolina State University. Includes bibliographical references. Includes vita.
University Microfilms order no. UMI00384689. Thesis (M. Sc.)--University of Manitoba, 1992. Includes bibliographical references.
Thesis--Columbia University. Bibliography: leaves 205-217.
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1991. Vita. Abstract. Includes bibliographical references (leaves 69-72).
Thesis (Ph. D.)--New York University, School of Education. Also on microfilm. New York University, Bobst Library.
Photocopy of typescript. Thesis (M.S.)--Cornell University, Jan., 1979. Includes bibliographical references (leaves 110-125).
System requirements: World Wide Web browser and PDF reader. Mode of access: World Wide Web. Title from document title page (viewed on August 22, 2006). Document formatted into pages; contains: vii, 132 p. : ill. (some col.). Thesis (Ph. D.)--University of Kentucky, 2006. Includes abstract and vita. Includes bibliographical references (p. 127-131).
Typescript. Thesis (M.S.)--University of Missouri-Columbia, 2004. Includes bibliographical references (leaves 107-108).
Thesis (M. Ed.)--University of Oklahoma, 2000. Includes bibliographical references (leaves 81-83).
