Jeff J Guo

Jeff J Guo
University of Cincinnati | UC

About

212
Publications
30,050
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3,132
Citations
Citations since 2017
17 Research Items
1388 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (212)
Article
Full-text available
The use of direct oral anticoagulants (DOACs) is widely increasing in the United States (US). Warfarin has been the conventional anticoagulant used in the past few decades, but it has been gradually replaced by DOACs. The objective of the study was to analyze trends in utilization, reimbursement, and price for those anticoagulants in the US Medicai...
Article
Background Nonalcoholic fatty liver disease (NAFLD) is a silent disease, yet patients might report nonspecific symptoms. The objectives of this study were to examine the effect of polypharmacy on patient-reported symptoms in NAFLD adult patients and to examine the impact of patient-reported symptoms on quality of life (QoL).MethodsA retrospective o...
Article
Background Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used for several indications including hypertension. Our aim is to evaluate the utilization, expenditure, and drug price of ACEIs and ARBs in the US Medicaid population. Methods A retrospective descriptive trend analysis was conducted using Med...
Article
Full-text available
Background Nonalcoholic fatty liver disease (NAFLD) is a significant epidemiological problem with rising prevalence. Due to limited literature, the objective of this study is to examine the association between polypharmacy and health-related quality of life (QoL) in NAFLD adult patients. Methods A retrospective observational study design was condu...
Article
To evaluate the cost-effectiveness of ponatinib compared with second-line TKIs in the treatment of adult patients with CML who failed, or were intolerant to, first-line TKIs. A Markov state transition model was conducted. Model transition, adverse-effect probabilities, utility data and medical costs were obtained from clinical trials and literature...
Article
Many pediatric patients with rare diseases use drugs off-label due to limited data in pediatric patients. Off-label treatment remains an important public health issue for neonates, infants, children, and adolescents, especially for pediatric patients with rare diseases. For patients with rare diseases, the majority of medications have no or limited...
Article
Background Obesity is a globally growing health problem, and its treatment has been challenging. The use of anti-obesity medications (AOMs) has been associated with severe adverse events (AEs). Several AOMs have been withdrawn from the market owing to documented AEs. Aim To describe, estimate and characterize the frequency of AEs attributable to th...
Article
Objective: The aim of this study was to examine patterns of initial prescriptions, investigate time to initiation of biologic disease-modifying anti-rheumatic drugs (bDMARDs), and evaluate the impact of clinical and other baseline factors associated with the time to first bDMARD in treating children with newly diagnosed non-systemic juvenile idiop...
Article
Background: SSRIs and SNRIs are antidepressants that have largely substituted old antidepressants like Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants (TCAs). They have been widely used since 1987 when the FDA approved the first SSRI Fluoxetine and the first SNRI Venlafaxine in 1993. Since then, several new SSRIs and SNRIs have...
Article
Objective To evaluate the persistence and effectiveness of tumor necrosis factor inhibitors (TNFi) vs non-TNFi among newly diagnosed JIA patients after initiation of biologic disease-modifying anti-rheumatic drug (bDMARD). Methods Using longitudinal patient-level data extracted from electronic medical records (EMR) in a large Midwestern pediatric...
Article
Background China has achieved near-universal health coverage (UHC) for 95 percent of its population (>1.3 billion lives) as a result of healthcare reforms that began in 2009. However, one of many remaining issues in the Chinese healthcare system is the need to better optimize the allocation and use of healthcare resources in order to meet growing h...
Article
BACKGROUND: Multiple sclerosis (MS) is a rare, long-standing, and disabling disease that affects the central nervous system and causes several clinical manifestations. As a result, this disease is associated with a high societal economic burden. OBJECTIVE: To analyze the trends in drug expenditure, utilization, and cost of specialty drugs for the...
Article
Full-text available
Objective: This study estimated nationally representative medical expenditures of gynecologic cancers, described treatment patterns and assessed key risk factors associated with the economic burden in the United States. Methods: A retrospective repeated measures design was used to estimate the effect of gynecologic cancers on medical expenditure...
Article
Background: Smoking remains the single largest preventable cause of death and disease. Smoking-cessation medications provide patients a multitude of benefits and can prevent certain diseases, including some cancers. Because of the limited amount of studies on smoking-cessation medications, we wanted to find general trends about the use of these me...
Article
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Background Findings on smoking among pregnant women were mostly from high income countries and were rarely from China. This study aimed to estimate the prevalence of smoking and its influencing factors among pregnant women living in China. Methods A cross-sectional analysis was conducted in this study. Data from pregnant women were collected in th...
Article
Background Simvastatin plus ezetimibe reduced the risk of cardiovascular events in the IMProved Reduction of Outcomes: Vytorin Efficacy International (IMPROVE-IT) study. The aim of this study is to investigate the cost-effectiveness of adding ezetimibe to simvastatin treatment for patients with ACS based on the recently completed IMPROVE-IT trial....
Article
Background Second-hand smoke is a major indoor pollutant that causes serious health problems, especially for pregnant women. The 2010 Global Adult Tobacco Survey in China reported that 65·1% of non-smoking women of childbearing age were exposed to second-hand smoke at home and 52·6% were exposed in the workplace. This study aimed to probe behaviour...
Article
Background Smoking during pregnancy is related to many adverse outcomes on infants. Smoking during pregnancy can cause abortion, premature birth, stillbirth, increased sudden infant death risk, and low birthweight. The aim of this study was to probe the differences in smoking among pregnant women with diverse characteristics. Methods In this cross...
Article
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Background: Bevacizumab is a recombinant, humanized monoclonal antibody that hinders the proliferation of new blood vessels required for malignant progression. The drug is considered safe and tolerable; however, some controversy remains about whether it is linked to venous and arterial thromboembolic events (TEEs). Objective: To evaluate the ris...
Article
Purpose: The aim of this study was to evaluate the practice pattern of off-label use of fluoroquinolones (FQs) in ambulatory settings and to identify the related risk factors. Methods: The National Ambulatory Medical Care Surveys from 2006 through 2012 was used to identify subjects who received FQ off-label prescriptions. We defined off-label us...
Article
Background: Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide. Objectives: To describe patient profile, treatment patterns, and disease burden for patients with ACS. Methods: A retrospective descriptive cohort study was conducted. Data were obtained from electronic medical records from seven Shanghai medical...
Article
Objective: After sumatriptan was approved by the Food and Drug Administration in 1992, triptans became first-line anti-migraine therapies. Rapidly rising triptan expenditures, however, led payers, including Medicaid, to implement cost-containment policies. We describe triptan utilization and reimbursement trends in Medicaid. Methods: Using natio...
Article
Importance Antipsychotics are used increasingly in youth for nonpsychotic and off-label indications, but cardiometabolic adverse effects and (especially) type 2 diabetes mellitus (T2DM) risk have raised additional concern.Objective To assess T2DM risk associated with antipsychotic treatment in youth.Data Sources Systematic literature search of P...
Article
To describe the antiobesity drug-prescribing patterns of US physicians over the past decade. Data for adult patients were obtained from the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey. Obesity was identified using ICD-9 codes, BMI values, and a chronic-obesity-condition variable. For patients wit...
Article
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Previous studies showed inconsistent results on the association of smoking with all-cause dementia and vascular dementia (VaD), and are limited by inclusion of a small number of studies and unexplained heterogeneity. Our review aimed to assess the risk of all-cause dementia, Alzheimer's disease (AD) and VaD associated with smoking, and to identify...
Article
Full-text available
Acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide.
Article
Background: For patients with atrial fibrillation (AF), early treatment is essential to prevent serious complications such as stroke. Several randomized clinical trials have shown that rate-control may be as effective as rhythm-control medications, whereas the latter have serious side effects. Little evidence exists, however, about which class of...
Article
Full-text available
Azithromycin has been used for many years for the treatment of patients with various types of bacterial infections, as well as for the secondary prevention of coronary events. There is a growing concern, however, that azithromycin may be associated with an increased cardiovascular (CV) risk and may lead to CV-related death in high-risk patients. Th...
Data
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BACKGROUND: Cost savings from the use of generic drugs versus brand-name drugs are well known. Both private and public prescription drug plans encourage the use of generic drugs through a variety of mechanisms. The magnitude of cost savings for a given generic drug is dependent on the degree to which the generic market is competitive. Should the co...
Article
Longitudinal Health Insurance Database during 2000-2008. VTE cases were identified based on the disease diagnosis coding and anticoagulant prescription or surgical thrombectomy procedure from the claims of inpatient or emergency care. Using risk set sampling, ten controls were selected for each case, matched on age (± 5 years), entry date (± 180 da...
Article
Full-text available
The entry of generic drugs into markets previously monopolized by patented, branded drugs often represents large potential savings for healthcare payers in the USA. Our objectives were to describe and explain the trends in drug reimbursement by public Medicaid programmes post-generic entry for as many drug markets and for as long a time period as p...
Article
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PURPOSE: Several investigations have shown that the risk of childhood overweight and obesity may be associated with excessive gestational weight gain (GWG), but the study samples were limited and results were mixed; hence we conducted this meta-analysis to assess the explicit association between them and present evidence. METHODS: We searched PubMe...
Article
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Introduction Asthma, a chronic inflammatory disorder associ-ated with variable airflow obstruction and bron-chial hyperresponsiveness, is the most common chronic lower respiratory disease in children worldwide. It presents with recurrent episodes of wheeze, cough, shortness of breath, and chest tightness [Papadopoulos et al. 2012]. In the United St...
Article
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1) To compare the Food and Drug Administration's (FDA's) Risk Evaluation and Mitigation Strategies (REMS) and European Medicines Agency's (EMA's) Risk Management Plan (RMP) guidances and 2) to compare REMS and RMPs for specific chemical entities and biological products. FDA, EMA, and pharmaceutical company Web sites were consulted for details perta...
Article
Full-text available
An orphan drug is a drug developed specifically to treat a rare medical condition. With a combined population of less than 400 million, about 2.8 million patients are estimated to be suffering from a rare disease in the Middle East. Some disorders such as hemoglobinopathy, glucose-6-phosphate dehydrogenase deficiency, autosomal recessive syndromes,...
Article
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Objective: To observe the effect of electronic medical record (EMR) system sophistication on preventive women's healthcare. Materials and methods: Providers in the National Ambulatory Medical Care Survey (NAMCS), 2007-8, were included if they had at least one visit by a woman at least 21 years old. Based on 16 questions from NAMCS, the level of...
Article
The incidence of invasive fungal infections (IFIs) has increased substantially in the recent past. Advances in medical technology, including broad-spectrum antibiotics, may increase the risk for fungal infections. Moreover, immunocompromised patients with cancer, HIV/AIDS, and/or transplants are susceptible to IFIs. Meanwhile, superficial fungal in...
Article
Full-text available
Cost savings from the use of generic drugs versus brand-name drugs are well known. Both private and public prescription drug plans encourage the use of generic drugs through a variety of mechanisms. The magnitude of cost savings for a given generic drug is dependent on the degree to which the generic market is competitive. Should the competitive st...
Article
Objective: Antipsychotic drug therapy is the cornerstone of treatment of persons with schizophrenia. Because most antipsychotics are metabolized by the hepatic cytochrome P450 system, concomitant use of an antipsychotic and medications that are competitively metabolized by the same system may cause a potentially harmful drug-drug interaction. This...
Conference Paper
The article is intended to launch a discussion on a new method to quantify associations between drugs and adverse drug reactions (ADRs). Based on the contingency table for a drug and ADR, we proposed a method to evaluate the strength of a pairwise association using a hypergeometric distributions-based hypothesis test. In contrast to existing freque...
Article
Background: The U.S. Agency for Healthcare Research and Quality (AHRQ) developed, in the context of a national pediatric discharge database, 18 pediatric quality indicators (PDIs) for assessing pediatric care. These measures have not yet been adapted for and applied to claims databases. Objectives: The objectives of this study were to (1) adapt...
Article
Background: Pompe disease is a rare condition, with an incidence rate estimated to be between 1 in 40,000 and 1 in 300,000 live births worldwide. For an infant who contracts the disease, which is an inherited metabolic myopathy caused by deficiency of the acid alpha-glucosidase (GAA) enzyme in lysosomal cells, the survival rate to age 1 year is es...
Article
Full-text available
Although it is well-known that drug costs in the US have risen precipitously over the last 25 years, what is much less appreciated is how this rise in cost has occurred across so many seemingly distinct drug markets. To describe trends in the utilization, spending, and average per-prescription cost of benzodiazepines individually, in subgroups, and...
Article
This study compared actual use of individual statin drugs to expected use based on their efficacy and safety profiles. Five panels covering the years 1999 to 2008 from the National Health and Nutrition Examination Survey provided interview, demographic, and laboratory data for 8769 (365,503,838 weighted) people aged 20 years or older who were not t...