Jeevithan Elango

Jeevithan Elango
Saint Anthony Catholic University | UCAM · Facultad de Ciencias de la Salud

Professor

About

97
Publications
56,205
Reads
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2,128
Citations
Additional affiliations
November 2016 - March 2017
Shanghai Ocean University
Position
  • Researcher
April 2010 - July 2013
Tamil Nadu Dr. J Jayalalitha Fisheries University
Position
  • Senior Researcher
March 2009 - July 2010
Rajah Serfoji Government college, Tanjore, India
Position
  • Research Associate

Publications

Publications (97)
Article
Full-text available
This study evaluates the influence of conventional versus simplified drilling protocols on bone remodeling after the osteointegration period, marginal bone loss (MBL), and primary implant stability. A randomized, double-blind clinical trial was conducted involving 44 implants in 37 patients over a two-year period. The primary outcome was peri-impla...
Article
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As the focus on green chemistry intensifies, researchers are progressively looking to incorporate biodegradable and environmentally friendly solvents. Given the prevalent use of inorganic solvents in conventional methods for detecting selenium content, this study utilized a mixture design approach to create four deep eutectic solvents (DESs). The e...
Chapter
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Marine-derived natural compounds play a major role in treating several human-related diseases due to their unique chemical diversity, biocompatibility, and excellent medicinal properties. Recent studies have explored the potential of marine organisms, especially microorganisms, as sources for novel bioactive substances that possess fibrinolytic act...
Article
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For several decades, products derived from marine natural sources (PMN) have been widely identified for several therapeutic applications due to their rich sources of bioactive sub-stances, unique chemical diversity, biocompatibility and excellent biological activity. For the past 15 years, our research team explored several PMNs, especially fungi f...
Article
A new procedure for the bioactivation of alumina-based porous ceramic constructs was introduced. The constructs were built with the aim of mimicking the structural and mechanical properties of the human cortical bone. Bioactivation was achieved by adding wollastonite and acidic surface treatment (piranha solution). Structural studies (SEM, CAT) con...
Article
Full-text available
The fibrinolytic kinase identified in the nereid worm (Perinereis aibuhitensis Grub) displays exceptional kinase activity, stability, and specificity, suggesting its potential as a promising candidate for the advancement of new thrombolytic drugs. In this study, a process was optimized for the production of fibrinolytic kinase using Escherichia col...
Research
Full-text available
Abstract: Dentin pulp has a complex function as a major unit in maintaining the vitality of teeth. In this sense, the Wnt/β-Catenin pathway has a vital part in tooth development, maintenance, repair, and regeneration by controlling physiological activities such as growth, differentiation, and migration. This pathway consists of a network of protein...
Article
Full-text available
Dentin pulp has a complex function as a major unit in maintaining the vitality of teeth. In this sense, the Wnt/β-Catenin pathway has a vital part in tooth development, maintenance, repair, and regeneration by controlling physiological activities such as growth, differentiation, and migration. This pathway consists of a network of proteins, such as...
Article
Full-text available
A novel fibrinolytic enzyme, BSFE1, was isolated from the marine bacterium Bacillus sp. S-3685 (GenBank No.: KJ023685) found in the South China Sea. This enzyme, with a molecular weight of approximately 42 kDa and a specific activity of 736.4 U/mg, exhibited its highest activity at 37 °C in a phosphate buffer at pH 8.0. The fibrinolytic enzyme rema...
Article
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Recently, there has been a growing interest in collagen peptides derived from marine sources for their notable ability to protect skin cells against apoptosis induced by oxidants. Therefore, the current study aimed to investigate the fundamental properties of collagen peptides, including their physicochemical, thermal, structural, stem-cell-regener...
Article
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VAT photopolymerization technology was applied to fabricate three-dimensional (3D) porous β-Ca2SiO4 ceramic scaffolds functionalized with graphene oxide (GO) sheets decorated with silver nanoparticles (AgNPs). We achieved this by utilizing commercial resin blends and “customized” resin both loaded with CaCO3 particles. The dual functionality of the...
Preprint
Full-text available
A new procedure for the bioactivation of alumina-based porous ceramic constructs was introduced. The constructs were built with the aim of mimicking the structural and mechanical properties of the human cortical bone. Bioactivation was achieved by adding wollastonite and acidic surface treatment (piranha solution). Structural studies (SEM, CAT) con...
Article
Full-text available
Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is the use of polymer-based systems due to their excellent beneficial properties to the skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin and fibroin, have been tested and have proven the benefits for skin...
Article
Collagens from marine sources have been used widely in food, cosmetics and tissue engineering application due to their excellent functional and biological properties. In the present study, a novel protein, collagen from iris squid skin (SSC) was characterized, grafted with polyethylene-glycol (PEG) and Acid-Green 20 (AG) and was investigated the mo...
Article
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Several approaches have evolved to facilitate the exploration of hydrogel systems in biomedical research. In this sense, poly(vinyl alcohol) (PVA) has been widely used in hydrogel (HG) fabrication for several therapeutic applications. The biological properties of PVA hydrogels (PVA-HGs) are highly dependent on their interaction with protein recepto...
Article
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Nowadays, there exists a huge interest in producing innovative, high-performance, bio-functional, and cost-efficient electrospun biomaterials based on the association of biocompatible polymers with bioactive molecules. Such materials are well-known to be promising candidates for three-dimensional biomimetic systems for wound healing applications be...
Article
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One of the supporting factors behind the biomolecules recently used in anti-aging and skin nourishment is their antioxidant properties. Hydrogen peroxide (H2O2) is a well-known small molecule oxidant that induces apoptosis in human skin fibroblast (HSF) cells through the synthesis of inflammatory cytokines. Hence, this study aimed to investigate th...
Article
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Hydrogels are soft water-rich three-dimensional polymer networks that are fabricated by physical and chemical crosslinking of different polymers. For decades, hydrogels are playing a major role in cosmetics and pharmacological applications. Several kinds of hydrogels are developed by various fabrication techniques. Due to their hydrophilic nature,...
Article
Full-text available
Marine collagen (MC) has recently attracted more attention in tissue engineering as a biomaterial substitute due to its significant role in cellular signaling mechanisms, especially in mesenchymal stem cells (MSCs). However, the actual signaling mechanism of MC in MSC growth, which is highly influenced by their molecular pattern, is poorly understo...
Article
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Numerous studies have shown that type II collagen (CII) has a potential role in the treatment of rheumatoid arthritis. However, most of the current studies have used terrestrial animal cartilage as a source of CII extraction, with fewer studies involving marine organisms. Based on this background, collagen (BSCII) was isolated from blue shark (Prio...
Article
Full-text available
The use of hydrogel (HG) in regenerative medicine is an emerging field and thus several approaches have been proposed recently to find an appropriate hydrogel system. In this sense, this study developed a novel HG system using collagen, chitosan, and VEGF composites for culturing mesenchymal stem cells (MSCs), and investigated their ability for ost...
Preprint
Full-text available
The free radical hypothesis has been accepted in the researching of skin aging. As a small molecule oxidant, hydrogen peroxide (H 2 O 2 ) is easily induce the apoptosis of HSF cells through biofilm system. Oxidative stress caused by H 2 O 2 also leads to the synthesis of inflammatory cytokines, mainly including interleukin-1 (IL-1), interleukin-6 (...
Article
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Several metallic and polymer-based implants have been fabricated for orthopedic applications. For instance, titanium (Ti), zirconia (Zr), and polyetheretherketone (PEEK) are employed due to their excellent biocompatibility properties. Hence, the present study aimed to compare the functional and biological properties of these three biomaterials with...
Article
Hydrogel-based systems are widely used for conventional 3D-cell culture, where cells can be seeded on or embedded in 3D-matrix gels for cultivation. Several new approaches have emerged to develop innovative more performing polymeric biomaterials for tissue regeneration. Within this class of biomaterials, land and marine based-polymers (including am...
Article
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Polyvinyl alcohol (PVA) hydrogels are well-known biomimetic 3D systems for mammalian cell cultures to mimic native tissues. Recently, several biomolecules were intended for use in PVA hydrogels to improve their biological properties. However, retinol, an important biomolecule, has not been combined with a PVA hydrogel for culturing bone marrow mese...
Article
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The development of innovative engineered epoxy composites aiming to manufacture cost‐efficient materials with reduced weight and enhanced physical properties remains as a current industrial challenge. In this work we report an original procedure for manufacturing glass‐fiber epoxy reinforced nanocomposites (GFECs) by employing electrospun fiber‐mat...
Article
The development of innovative engineered epoxy composites aiming to manufacture cost-efficient materials with reduced weight and enhanced physical properties remains as a current industrial challenge. In this work we report an original procedure for manufacturing glass-fiber epoxy reinforced nanocomposites (GFECs) by employing electrospun fiber-mat...
Article
Full-text available
Hydroxyapatite (HA) is a hard mineral component of mineralized tissues, mainly composed of calcium and phosphate. Due to its bioavailability, HA is potentially used for the repair and regeneration of mineralized tissues. For this purpose, the properties of HA are significantly improved by adding natural and synthetic materials. In this sense, the g...
Article
Full-text available
In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. In this case, the administration of oral collagen may play a potential role in returning cells to thei...
Article
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Collagen from fish has been proven to have a low antigenicity that has no difference in the genetic codes compared with mammalian-based collagen. This study was designed to investigate the impact of tilapia skin collagen on immunogenicity and biocompatibility in vivo and in vitro. The structural characteristics of both acid-soluble and pepsin-solub...
Article
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Fish collagen has been widely used in tissue engineering (TE) applications as an implant, which is generally transplanted into target tissue with stem cells for better regeneration ability. In this case, the success rate of this research depends on the fundamental components of fish collagen such as amino acid composition, structural and rheologica...
Article
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Fibrillins are microfibril-associated macro glycoproteins found in connective tissues and structurally related to latent TGF-β-binding proteins (LTBPs). The special cellular immunity and blocking glycoprotein receptors IIb and IIIa of fibrillins are emerging topics in recent years. In this study, Nile Tilapia type IIcollagen (NTCII) was extracted a...
Article
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Collagen, an extracellular protein, covers the entire human body and has several important biological functions in normal physiology. Recently, collagen from non-human sources has attracted attention for therapeutic management and biomedical applications. In this regard, both land-based animals such as cow, pig, chicken, camel, and sheep, and marin...
Article
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FGFC1, an active compound isolated from the culture of marine fungi Stachybotrys longispora FG216, elicits fibrinolytic, anti-oxidative, and anti-inflammatory activity. We have previously reported that FGFC1 inhibited the proliferation, migration, and invasion of the non-small cell lung cancer (NSCLC) cells in vitro. However, the precise mechanisms...
Article
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The present study investigated whether the purified polysaccharide from Cereus sinensis (CSP-1) had beneficial effects on mice with antibiotic-associated diarrhea (AAD). The effects of CSP-1 on gut microbiota were evaluated by 16S rRNA high-throughput sequencing. Results showed that CSP-1 increased the diversity and richness of gut microbiota. CSP-...
Article
Full-text available
Objective This study aimed to investigate the effect of small molecules incorporated into the engineered nanofibrous scaffold to enhance the osteoblast differentiation Materials and methods Poly-ε-caprolactone (PCL) nanofiber matrices with lithium chloride (LiCl) were fabricated using the electrospinning technique. Scaffolds were characterized usi...
Article
Chinese Traditional Medicines (CTMs) are very popular for therapeutic applications to cure several chronic diseases. Many researchers are trying to discover the potential application and actual mechanism of CTMs in order to scientifically prove their effects for commercial use. One of the main functions of CTMs is to aid stem cell regeneration. Sin...
Article
The discovery of cytokine tumor necrosis factor (TNF) in the 20th century revealed numerous secrets about organ development. In particular, the functions identified for the receptor activator of nuclear factor kappa-β (NF-κβ) ligand (also known as the RANKL/osteoprotegerin ligand (OPGL) or RANK ligand/TNFSF11) in the homeostasis of skeletal structu...
Article
The inhibition of α‐glucosidase activity is a prospective approach to prevent postprandial hyperglycemia in the treatment of type 2 diabetes mellitus. Herein, we investigated the inhibition of three triterpenoid compounds ( 1‐3 ) of Akebia trifoliata stem, namely hedragenin, 3‐Epiakebonoic acid, and arjunolic acid on α‐glucosidases by enzyme kineti...
Article
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Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic, non-immunogenicity, and so on. Chitosan can be easily modified owing to its molecular chain that contains abundant active amino...
Article
Collagen is widely used for dental therapy in several ways such as films, 3D matrix, and composites, besides traditional Chinese medicine (TCM) has been used in tissue regeneration and wound healing application for centuries. Hence, the present study was targeted for the first time to fabricate collagen film with TCM such as resveratrol and celastr...
Article
Fabrication of biomaterial that mimics a suitable biological microenvironment is still a major challenge in the field of periodontitis treatment. Hence, in this report, we presented for the first time the fabrication of a novel biomaterial 3D matrix using collagen combined with sodium alginate and titanium oxide (TiO2) to recreate the in-vivo micro...
Article
The present work was developed the pH dependent-aptamer AS1411 (APT) decorated and erlotinib (En) loaded chitosan nanoparticles (CSNPs) for promising non-small-cell lung carcinoma (NSCLC) treatment. The characterization studies revealed that formulated APT-En-CSNPs were spherical in shape with size of 165.95 d. nm and PDI of 0.212. FTIR spectrum re...
Article
The common phenomenon that the non-viral vectors have much lower transfection efficiency in vivo than in vitro greatly restricts its further developments and applications. Possible reasons are lacking targeting ability, elimination by the reticuloendothelial system (RES) and insufficient nuclear transport. Here, a novel flexible and deformable poly...
Article
Full-text available
To investigate the structure and immunomodulatory activity of polysaccharide from Solanum muricatum, a novel acid polysaccharide named SMP-3a was purified from Solanum muricatum pulp through DEAE-52 cellulose column and Sephadex G-200 chromatography. Monosaccharide composition analysis showed that SMP-3a was mainly composed of rhamnose, arabinose,...
Article
This work reports the optimization, synthesis, characterization, anticancer, and antibacterial activity of the Trichoderma-β-D-glucan‑zinc oxide nanoparticles (T-β-D-glu-ZnO NPs). Firstly, the T-ZnO NPs was synthesized using the fungal mycellial water extract (FWME) derived from T. harzianum (SKCGW009) under the optimized condition of extract conce...
Article
Full-text available
A marine fibrinolytic compound was studied for use in thrombolytic therapy. Firstly, the absorption and transportation characteristics of 2,5-BHPA (2,5-BHPA:2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-tertahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid, a novel pyran-isoindolone derivative with bioactivity isolat...
Article
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A recent study reported the expression of receptor activator of nuclear factor-κB (RANK) in mesenchymal stem cells (MSCs) surface that negatively regulates osteogenesis of MSCs. Empirical evidence from the previous study confirmed the role of parathyroid hormone-related protein (PTHrP) in osteoblastogenesis. However, it is necessary to understand t...
Article
Full-text available
Collagen is the most abundant extracellular fibrous protein that has been widely used for biomedical applications due to its excellent biochemical and biocompatibility features. It is believed that the smaller molecular weight collagen, i.e., collagen peptide (CP), has more potent activity than native collagen. However, the preparation of CP from f...
Article
Full-text available
Recent studies have identified the regulatory mechanism of collagen in bone ossification and resorption. Due to its excellent bio-mimicry property, collagen is used for the treatment of several bone and joint disease such as arthritis, osteoporosis, and osteopenia. In bone, the biological action of collagen is highly influenced by the interactions...
Article
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Interleukin 6 (IL-6) supports development of bone-resorbing osteoclasts by acting early in the osteoblast lineage via membrane- bound (cis) or soluble (trans) receptors. Here, we investigated how IL-6 signals and modifies gene expression in differentiated osteoblasts and osteocytes and determined whether these activities can promote bone formation...
Article
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Empirical evidence proves that the antioxidant property plays a main role in the biological activities of biomaterials, which is influenced by several factors. In order to explore in‐depth, the influence of ionic systems on the antioxidant activity of collagen peptides was studied. Type‐I‐collagen peptides (GBB‐10SP and TYPE‐S) contained a high amo...
Article
Full-text available
The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing mat...
Article
The present study aimed to purify and identify the metabolites from T. atroviride using high-performance liquid chromatography (HPLC) and ¹H and ¹³C nuclear magnetic resonance spectrometer (NMR) followed by analyzing their toxicological, antibacterial and anticancer properties. This work identified two metabolites - TM1 and TM2. TM1 was in two form...
Article
Full-text available
Collagen from a marine resource is believed to have more potential activity in bone tissue engineering and their bioactivity depends on biochemical and structural properties. Considering the above concept, pepsin soluble collagen (PSC) and acid soluble collagen (ASC) from blue shark (Prionace glauca) skin were extracted and its biochemical and oste...
Article
Chitosan (CS), a novel biomaterial is widely used as a drug nano-carrier for cancer treatment. Towards this aim, anticancer and antibacterial activities of CS-nanoparticles-linked zinc (Zn-CSNPs) were evaluated. Particle size of CSNPs lowered (113.09 nm) compared to Zn-CSNPs (160.7 nm). Both nanoparticles (CSNPs and Zn-CSNPs) were spherical in shap...
Article
This paper reports the synthesis of chitosan nanoparticles (T-CSNPs) using the fungal enzyme of Trichoderma harzianum and its biocompatibility, antioxidant and bactericidal properties. The T-CSNPs synthesis was confirmed by absorbance at 280 nm using UV–Vis spectrophotometer. T-CSNPs were of spherical shape, as evident by field emission transmissio...
Article
Full-text available
Homeostasis of osteoclast formation from bone marrow macrophages (BMM) is regulated by paracrine signals of the neighbourhood bone cells particularly mesenchymal stem cells (MSC), osteoblasts and osteocytes (OC). Besides paracrine cues, collagen and glycosaminoglycan are involved in controlling bone homeostasis. Towards this approach, different mol...
Article
The physicochemical and in vitro mechanism of immunologic tolerance of pepsin-soluble collagen and its peptide, CII-P, from blue shark cartilage were studied. Protein patterns showed three identical (α1)3 chains, suggesting that it was a type-II collagen (CII). CII-P had high antioxidant activity and low carbohydrate content. Collagens had better b...
Article
Acid-soluble (ASC) and pepsin-soluble (PSC) collagens were isolated from tilapia skin and were characterized as type I collagen. The T d (denaturation temperature) of ASC and PSC was 26.80 and 28.20°C, respectively. CD (circular dichroism) and FTIR (Fourier transform infrared) spectra of ASC and PSC were slightly different, which confirmed that lim...
Article
In the present investigation, an attempt was made to find an alternative to mammalian collagen with better osteogenesis ability. Three types of collagen scaffolds—collagen, collagen-chitosan (C-CH), and collagen-hydroxyapatite (C-HA)—were prepared from the cartilage of Blue shark and investigated for their physico-functional and mechanical properti...
Article
Low molecular weight (LMW) (57, 40 and 25 kDa) collagens were separated and Fas cell surface death receptor activation were investigated based on its MW and glycoprotein content. The biochemical properties such as amino acid pro␣le, FTIR and glycoprotein content of LMW collagens were slightly di␣erent and con␣rmed that limited digestion by proteoly...