Jeeva Sankar

Jeeva Sankar
All India Institute of Medical Sciences | AIIMS · Department of Paediatrics

MD (Pediatrics); DM (Neonatology)

About

230
Publications
156,828
Reads
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13,120
Citations
Citations since 2017
116 Research Items
11850 Citations
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201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
201720182019202020212022202305001,0001,5002,0002,500
Additional affiliations
July 2020 - present
All India Institute of Medical Sciences
Position
  • Professor
July 2017 - June 2020
All India Institute of Medical Sciences
Position
  • Professor (Associate)
May 2014 - June 2017
All India Institute of Medical Sciences
Position
  • Professor (Assistant)
Education
July 2004 - June 2007
September 1993 - January 1999

Publications

Publications (230)
Article
Full-text available
India, with a population of more than 1 billion people, has many challenges in improving the health and nutrition of its citizens. Steady declines have been noted in fertility, maternal, infant and child mortalities, and the prevalence of severe manifestations of nutritional deficiencies, but the pace has been slow and falls short of national and M...
Article
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To synthesize the evidence for effects of optimal breastfeeding on all-cause and infection-related mortality in infants and children aged 0-23 months. We conducted a systematic review to compare the effect of predominant, partial, or no breastfeeding versus exclusive breastfeeding on mortality rates in the first 6 months of life and effect of no ve...
Article
Full-text available
The importance of breastfeeding in low-income and middle-income countries is well recognised, but less consensus exists about its importance in high-income countries. In low-income and middle-income countries, only 37% of children younger than 6 months of age are exclusively breastfed. With few exceptions, breastfeeding duration is shorter in high-...
Article
Background: Vascular endothelial growth factor (VEGF) plays a key role in angiogenesis in foetal life. Researchers have recently attempted to use anti-VEGF agents for the treatment of retinopathy of prematurity (ROP), a vasoproliferative disorder. The safety and efficacy of these agents in preterm infants with ROP is currently uncertain. Objectiv...
Article
Full-text available
M Jeeva Sankar and colleagues call for urgent action to improve quality of care at birth and implement antimicrobial stewardship in health facilities in South Asia to reduce neonatal deaths from sepsis. © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to.
Article
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Background: Infant massage is commonly practiced in many parts of the world. However, the effectiveness of this intervention has not been reviewed for term, healthy newborns. Methods: This systematic review of randomized and quasi-randomized controlled trials assessed the effect of whole-body massage with or without oil, compared to no massage i...
Article
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Objective To study the growth and neurodevelopmental outcome of very and moderate preterm infants (VMPT) compared to term appropriate-for-age (term AGA) infants at 18-months corrected age. Methods This prospective cohort study enrolled consecutively born 212 VMPT infants and 250 term AGA controls delivered during study period. Outcome measures Ma...
Preprint
Importance The Cochrane review (2016) on kangaroo mother care (KMC) demonstrated a significant reduction in the risk of mortality in low birth weight (LBW) infants. New evidence from large multi-center randomized trials has been available since its publication. Objective The objective of the systematic review was to compare the effects of KMC vs....
Chapter
Sepsis is a highly heterogeneous, life-threatening organ dysfunction primarily caused by a dysregulated immune response to counter bacterial, viral, or fungal infections, resulting in haemodynamic changes and significant morbidity and mortality across all ages. In recent times, it has become one of the foremost causes of morbidity and mortality amo...
Article
Objective: To assess whether simulation based education (SBE) improves the practices and knowledge of junior residents for stabilization of a preterm neonate in delivery room as compared to Conventional education (CE). Methods: This randomized trial randomized 24 pediatric residents to SBE (n=12) or CE (n=12).One-time SBE was imparted to the SBE...
Article
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Background: This systematic review of intervention trials and observational studies assessed the effect of delaying the first bath for at least 24 hours after birth, compared to conducting it within the first 24 hours, in term healthy newborns. Methods: We searched MEDLINE via PubMed, Cochrane CENTRAL, Embase, CINAHL (updated till November 2021)...
Article
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Background: This systematic review of randomized trials assessed the effect of emollient application compared to no emollient application in term or near-term healthy newborns. Methods: We searched MEDLINE via PubMed, Cochrane CENTRAL, Embase, and CINAHL (updated until November 2021), clinical trials databases, and reference lists of retrieved a...
Article
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Background: Though recommended by numerous guidelines, adherence to supine sleep position during the first year of life is variable across the globe. Methods: This systematic review of randomized trials and observational studies assessed the effect of the supine compared to non-supine (prone or side) sleep position on healthy newborns. Key outco...
Article
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Background Surge of SARS CoV-2 infections ascribed to omicron variant began in December 2021 in New Delhi. We determined the infection and reinfection density in a cohort of health care workers (HCWs) along with vaccine effectiveness (VE) against symptomatic infection within omicron transmission period (considered from December 01, 2021 to February...
Article
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Objective: To compare the average birthweights and the weight centiles of the 'new' growth charts with the 'old' (1974) charts developed in the same unit four decades ago. Methods: Birthweight and gestation data of the eligible 12,355 singleton neonates born between 2009 and 2016 at a level-3 neonatal unit at a public sector hospital were used t...
Article
Objective: To compare the performance of regional versus global charts for identifying small-for-gestational age (SGA) neonates with short-term adverse outcomes. Design: Prospective cohort study. Setting: Level-3 neonatal unit in India. Patients: Neonates were categorised into SGA and appropriate-for-gestational age (AGA; 10th-90th centile)...
Article
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Evidence from randomized controlled trials (RCTs) suggests that three-hourly feeding is safe and might help achieve full feeds earlier in preterm infants. We systematically compared the benefits and harms of three-hourly and two-hourly feeding schedules in preterm infants. We searched electronic databases (MEDLINE, CINAHL, Embase, Web of Science, a...
Article
Full-text available
Importance Carboplatin increases the pathological complete remission (pCR) rate in triple negative breast cancer (TNBC) when added to neoadjuvant chemotherapy, however, evidence on its effect on survival outcomes is controversial. Methods The study was prospectively registered at PROSPERO (CRD42021228386). We systematically searched PubMed, Embase...
Article
Background: This meta-analysis provides a quantitative measure of the otorhinolaryngological manifestations of coronavirus disease 2019 in children. Methods: A structured literature review was carried out using PubMed, Embase and Cochrane Central, employing pertinent search terms. The statistical analysis was performed using Stata version 14.2 s...
Preprint
Full-text available
Background Delta variant transmission resulted in surge of SARS CoV-2 cases in New Delhi, India during the early half of year 2021. Health Care Workers (HCWs) received vaccines on priority for prevention of infection. Real life effectiveness of BBV152 vaccine against severe disease including hospitalization and death was not known. Objective To es...
Article
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Importance A surge of COVID-19 occurred from March to June 2021, in New Delhi, India, linked to the B.1.617.2 (Delta) variant of SARS-CoV-2. COVID-19 vaccines were rolled out for health care workers (HCWs) starting in January 2021. Objective To assess the incidence density of reinfection among a cohort of HCWs and estimate the effectiveness of the...
Article
Full-text available
Background: Surge of SARS CoV-2 infections ascribed to omicron variant began in December 2021 in New Delhi. We determined the infection and reinfection density in a cohort of health care workers (HCWs) along with vaccine effectiveness (VE) against symptomatic infection within omicron transmission period (considered from December 01, 2021 to Februar...
Article
Full-text available
We evaluated effect of sequentially introducing four WHO-recommended interventions to promote hand-hygiene compliance in tertiary-care NICU. Four dedicated research nurses directly observed doctors and nurses to record success in hand-hygiene opportunities at randomly selected NICU beds and randomly sampled time-slots in four phases (of 4-weeks eac...
Article
(N Engl J Med. 2021;384:2028–2038. doi: 10.1056/NEJMoa2026486. PMID: 34038632; PMCID: PMC810848) While preterm, low–birth-weight infants make up ~15% of neonates, they account for the vast majority of neonatal deaths (70%). “Kangaroo Mother Care,” where the mother or caregiver provides continuous skin-to-skin contact with the neonate, has been show...
Article
Objective: To determine the incidence and risk factors of preterm white matter injury [WMI; periventricular-intraventricular hemorrhage (PIVH) and/or periventricular leukomalacia (PVL)]. Design: Prospective cohort study. Setting: Level-3 neonatal intensive care unit. Patients: Inborn preterm neonates (n=140) delivered at <32 weeks gestation...
Preprint
Full-text available
Evidence from randomized controlled trials (RCTs) suggests that three-hourly feeding is safe and might help achieve full feeds earlier in preterm infants. We systematically compared the benefits and harms of three-hourly and two-hourly feeding schedules in preterm infants. We searched electronic databases (MEDLINE, CINAHL, Embase, Web of Science, a...
Article
Full-text available
Objectives To investigate if intravenous fentanyl or intravenous ketamine can provide adequate analgesia in preterm infants undergoing laser photocoagulation for retinopathy of prematurity (ROP). Design Open-label randomised trial. Setting Tertiary care institution. Participants Preterm infants who underwent laser photocoagulation for ROP. Inte...
Article
In Reply We thank Alshaikh et al and Mukhopadhyay for their thoughtful comments on our study.¹ We would like to reply to each of their concerns as follows:
Article
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Despite lack of evidence, the practice of routine prefeed gastric residue aspiration before the next feed is common. Recent studies suggest that this practice might be even harmful. Therefore, we aimed to evaluate the effect of avoiding routine prefeed gastric residue aspiration as compared to routine aspiration, on various clinical outcomes in pre...
Article
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Background A systematic understanding of the burden of neurological disorders at the subnational level is not readily available for India. We present a comprehensive analysis of the disease burden and trends of neurological disorders at the state level in India. Methods Using all accessible data from multiple sources, we estimated the prevalence or...
Article
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Objective To evaluate whether 1% aqueous chlorhexidine gluconate (CHG) when compared with 2% aqueous chlorhexidine gluconate is non-inferior for neonatal skin antisepsis. Design Parallel, blinded, non-inferiority randomised trial. Setting Level III, academic, neonatal intensive care unit. Patients Infants born at 26 0/7 to 42 6/7 weeks of gestat...
Article
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Background: Algorithms for predicting retinopathy of prematurity (ROP) requiring treatment need to be validated in Indian settings to determine if the burden of screening can be reduced without compromising the sensitivity of existing gestation and weight-based cut offs. Objective: To evaluate the performance of the available algorithms namely,...
Article
Importance Fortification of expressed breast milk (EBM) using commercially available human milk fortifiers (HMF) increases short-term weight and length in preterm very low-birth-weight (VLBW) neonates. However, the high cost and increased risk of feed intolerance limit their widespread use. Preterm formula powder fortification (PTF) might be a bett...
Article
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The aim of this prospective observational study was to compare the incidence of endotracheal tube (ETT) malposition using weight-based (Tochen), gestation-based (Kempley), and nasotragal length (NTL) methods in deceased neonates and fresh stillbirths. We enrolled deceased neonates and fresh stillbirths within 2 ± 1 h of death or delivery, respectiv...
Article
Background: There is great global variation in the sleeping arrangements for healthy newborn infants. Bed sharing is a type of sleeping practice in which the sleeping surface (e.g. bed, couch or armchair, or some other sleeping surface) is shared between the infant and another person. The possible physiological benefits include better oxygen and c...
Article
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Background: Knowledge and practices of postnatal mothers is very crucial in providing care to newborns. Aim was to assess determinants of the knowledge and practices of postnatal mothers on essential newborn care.Methods: A community based cross-sectional study was conducted among 150 postnatal mother - neonate dyads in one of the selected Primary...
Article
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Background: Home based new-born care (HBNC) is a strategy implemented by the Government of India to overcome the problem of new-born deaths and reach the unreached new-borns in the community. Aim was to assess the knowledge and skills of ASHA workers and factors influencing the skills.Methods: In an observational study, a total of 48 accredited soc...
Article
Objective: To compare the risk of mortality and other clinical outcomes in children with sepsis/severe sepsis/septic shock who received antibiotics within the first hour of recognition ('early antibiotics' group) with those who received antibiotics after the first hour ('delayed antibiotics' group). Study design: In this prospective cohort study...
Article
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Background: Home-based newborn care has been found to reduce neonatal mortality in rural areas. Study evaluated effectiveness of home-based care delivered by specially recruited newborn care workers- Shishu Rakshak (SR) and existing workers- anganwadi workers (AWW) in reducing neonatal and infant mortality rates. Methods: This three-arm, communi...
Article
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Background Properly fitting continuous positive airway pressure (CPAP) interface is critical to the efficacy and safety of nasal CPAP therapy in preterm. Unfortunately, there is a perception that CPAP interfaces being used in Indian neonatal intensive care units do not fit well and cause a high rate of nasal injury. Objectives To determine the nasa...
Article
Objective: To compare the effect of intact umbilical cord milking (MUC) and delayed cord clamping (DCC) on venous hematocrit at 48 (±6) hours in late preterm and term neonates (350/7- 426/7 wk). Study design: Randomized trial. Setting and participants: All late preterm and term neonates (350/7 - 426/7 wk) neonates born in the labor room and ma...
Article
Segmental ileal dilatation is an uncommon cause of neonatal intestinal obstruction. This report highlights a rare combination of abnormal distribution of muscles in the muscularis propria and partial loss of interstitial cells of Cajal as causative factors for segmental intestinal dilatation.
Conference Paper
Objectives: To highlight 2 rare cases of neonatal intestinal obstruction (NIO) and the importance of swift evaluation and prompt surgery to prevent catastrophic consequences. Case Report: Case 1: A full-term boy was admitted to the NICU for observation for a birth injury. On the 7th day of life, he started having bilious vomiting and abdominal dis...
Article
Objectives: To study the profile of retinopathy of prematurity (ROP) among outborn and inborn babies at a tertiary-care centre. Methodology: In a prospective observational study from 2015-2016, outborn and inborn babies eligible for ROP screening were evaluated for ROP profile and treatment results. Results: 532 outborns and 38 inborns had ROP...
Article
Full-text available
Despite advancement in medical care, Rh alloimmunisation remains a major cause of neonatal hyperbilirubinaemia, neuro-morbidity, and late-onset anaemia. Delayed cord clamping (DCC), a standard care now-a-days, is yet not performed in Rh-alloimmunised infants due to paucity of evidence. Hence, we randomised these infants of 28- to 41-week gestation...
Article
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Background To inform actions at the district level under the National Nutrition Mission (NNM), we assessed the prevalence trends of child growth failure (CGF) indicators for all districts in India and inequality between districts within the states. Methods We assessed the trends of CGF indicators (stunting, wasting and underweight) from 2000 to 20...
Article
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To evaluate mortality and short-term morbidities in extremely low birth weight (ELBW) infants (<1000 g) in a birth cohort in North India. In-hospital data of 231 ELBW infants (Jan 2013 to Sept 2018) were collected from a prospectively maintained electronic database by using standard definitions. The mean (SD) gestation and birth weight were 27.9 (2...
Article
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Justification: During the current rapidly evolving pandemic of COVID-19 infection, pregnant women with suspected or confirmed COVID-19 and their newborn infants form a special vulnerable group that needs immediate attention. Unlike other elective medical and surgical problems for which care can be deferred during the pandemic, pregnancies and chil...
Article
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Objective: To evaluate the clinical profile and outcome of neonates with non-immune hydrops (NIH). Methods: Data of all the NIH cases admitted to neonatal intensive care unit at our center, New Delhi from January 2010 to October 2017 were extracted from hospital records, which included clinical profile and outcomes. Results: Of the 17,299 tota...
Article
Full-text available
To compare the efficacy of low dose fentanyl infusion and 24% oral sucrose in providing optimal pain relief during laser for retinopathy of prematurity (ROP), we enrolled fifty-eight spontaneously breathing preterm infants undergoing laser. The preterm infants were randomized to either fentanyl infusion (1 mcg/kg/hr) or 24% oral sucrose (2 ml). We...
Article
Objectives: Infliximab (IFX) or adalimumab (ADA) use in patients with inflammatory bowel disease (IBD) leads to increased risk of tuberculosis (TB). This meta-analysis evaluated the factors which determine this risk, with special focus on local TB incidence. Methods: All studies until January 31, 2019, which reported the development of TB in pat...
Technical Report
NNF Clinical Practice Guidelines (CPG) on Health care acquired infections (HAI)
Technical Report
Feeing of low birth weight infant- clinical practice guidelines 2020
Article
Full-text available
Objective: To evaluate the clinical profile and predictors of mortality in neonates with congenital diaphragmatic hernia (CDH). Methods: Demographic and clinical parameters of neonates with congenital diaphragmatic heria (n=37) between January 2014 and October, 2017 were reviewed, and compared among those who survived or expired in hospital. Re...