Jeanne Oiticica

Jeanne Oiticica
University of São Paulo | USP · Faculty of Medicine (FM)

MD PhD

About

58
Publications
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644
Citations
Citations since 2017
23 Research Items
444 Citations
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2017201820192020202120222023020406080100
2017201820192020202120222023020406080100

Publications

Publications (58)
Article
Full-text available
Objective In this study, the Tinnitus Primary Function Questionnaire was translated, culturally adapted and validated for Brazilian Portuguese. Methods This study was carried out in two stages. First, a prospective study of translation and cultural adaptation was carried out with a group of 20 patients. The questionnaire was translated, revised an...
Article
Full-text available
Objective Our study aimed to measure the effectiveness of using HA in reducing the disturbance caused by tinnitus. Methods Study was designed as a within-subjects clinical trial. Nineteen patients with chronic tinnitus and untreated sensorineural hearing loss were under counseling, HA fitting and 6 months follow-up. Tinnitus assessment was perform...
Article
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Hearing loss is one of the most common sensory defects, affecting 5.5% of the worldwide population and significantly impacting health and social life. It is mainly attributed to genetic causes, but their relative contribution reflects the geographical region’s socio-economic development. Extreme genetic heterogeneity with hundreds of deafness genes...
Article
Brain imaging studies have revealed neural changes in chronic tinnitus patients that are not restricted to auditory brain areas; rather, the engagement of limbic system structures, attention and memory networks are has been noted. Hearing aids (HA) provide compensation for comorbid hearing loss and may decrease tinnitus-related perception and annoy...
Article
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Introduction Therapeutic dry needling (DN) is effective in reducing the discomfort of chronic somatosensory tinnitus in patients with myofascial trigger points (MTP)s. Objective To evaluate the efficacy of DN in chronic somatosensory tinnitus discomfort in patients with MTP. Methods Placebo-controlled paired trial that included 16 patients with a d...
Article
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Introduction Tinnitus affects a large portion of the world's population. There are several questionnaires being used for the evaluation of the severity of tinnitus and its impact in quality of life; however, they do not measure treatment-related changes. So, a new self-reported questionnaire was developed, the Tinnitus Functional Index (TFI), which...
Article
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NOTCH pathway proteins, including the transcriptional factor HES1, play crucial roles in the development of the inner ear by means of the lateral inhibition mechanism, in which supporting cells have their phenotype preserved while they are prevented from becoming hair cells. Genetic manipulation of this pathway has been demonstrated to increase hai...
Article
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Hearing loss is a frequent sensory impairment in humans and genetic factors account for an elevated fraction of the cases. We have investigated a large family of five generations, with 15 reported individuals presenting non-syndromic, sensorineural, bilateral and progressive hearing loss, segregating as an autosomal dominant condition. Linkage anal...
Preprint
Full-text available
Hearing loss is a frequent sensory impairment in humans and genetic factors account for an elevated fraction of the cases. We have investigated a large family of five generations, with 15 reported individuals presenting non-syndromic, sensorineural, bilateral and progressive hearing loss, segregating as an autosomal dominant condition. Linkage anal...
Article
Here we define a ~ 200Kb genomic duplication in 2p14 as the genetic signature that segregates with post-lingual progressive sensorineural autosomal dominant hearing loss in 20 affected individuals from the DFNA58 family, first reported in 2009. The duplication includes two entire genes, PLEK and CNRIP1, and the first exon of PPP3R1 (protein-coding)...
Article
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Introduction: Neurotology is a rapidly expanding field of knowledge. The study of the vestibular system has advanced so much that even basic definitions, such as the meaning of vestibular symptoms, have only recently been standardized. Objective: To present a review of the main subjects of neurotology, including concepts, diagnosis and treatment...
Article
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OBJECTIVES Currently, cochlear implant procedures are becoming increasingly broad and have greatly expanded. Bilateral cochlear implants and cochlear implants are more frequently applied in children. Our hypothesis is that the video head impulse test may be more sensitive than the caloric test in detecting abnormal vestibular function before cochle...
Article
Background: Cochlear implantation (CI) is the gold standard therapy for profound or severe sensorineural hearing loss. It is a safe surgical procedure but, because of the proximity of the cochlea and vestibule, postoperative vestibular disorder may occur. Our hypothesis is that the video head impulse test (vHIT) may be a good tool to achieve a top...
Article
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Purpose: to review both the national and international literature as well as to describe the methods used to collect psychoacoustic measurements in tinnitus patients. Methods: the current integrative review was conducted on articles in specialized national and international journals, in both the Portuguese and English languages, available in the P...
Article
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Since somatic or somatosensory tinnitus (ST) was first described as a subtype of subjective tinnitus, where altered somatosensory afference from the cervical spine or temporomandibular area causes or changes a patient’s tinnitus perception, several studies in humans and animals have provided a neurophysiological explanation for this type of tinnitu...
Article
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GJB2 mutations are the leading cause of non-syndromic inherited hearing loss. GJB2 encodes connexin-26 (CX26), which is a connexin (CX) family protein expressed in cochlea, skin, liver, and brain, displaying short cytoplasmic N-termini and C-termini. We searched for CX26 C-terminus binding partners by affinity capture and identified 12 unique prote...
Article
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Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. Objective to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal...
Article
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Introduction Music-based sound therapies become recently a trend in the treatment of tinnitus. Few publications have studied the therapeutic use of fractal tones to treat chronic tinnitus. Objective The aim of this study was to determine the benefits of using fractal tones as a unique sound therapy for chronic tinnitus sufferers. Methods Twelve par...
Article
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Introduction: Tinnitus and sound intolerance are frequent and subjective complaints that may have an impact on a patient's quality of life. Objective: To present a review of the salient points including concepts, pathophysiology, diagnosis and approach of the patient with tinnitus and sensitivity to sounds. Methods: Literature review with bibl...
Article
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OBJECTIVES The aim of this study was to search for evidence of stem or progenitor cells in the adult human cochlea by testing for sphere formation capacity and the presence of the stem cell marker ABCG2. METHODS Cochleas removed from patients undergoing vestibular schwannoma resection (n=2) and from brain-dead organ donors (n=4) were dissociated f...
Article
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We investigated 313 unrelated subjects who presented with hearing loss to identify the novel genetic causes of this condition in Brazil. Causative GJB2/GJB6 mutations were found in 12.7% of the patients. Among the familial cases (100/313), four were selected for exome sequencing. In one case, two novel heterozygous variants were found and were pred...
Article
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Introduction Cervical pain contributes to postural deviations and imbalance. Nanotechnology may be used for the treatment of neck pain by fixing to the skin small rounds silicone patches containing double spiral carbon nanotubes arranged in the form of a coil (Helical), which would then relieve dizziness caused by muscular contraction. Objective Th...
Article
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In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transp...
Article
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Objective: This study aimed to evaluate if hearing performance is a predictor of postural control in cochlear implant (CI) users at least six months after surgery. Methods: Cross-sectional study including (CI) recipients with post-lingual deafness and controls who were divided into the following groups: nine CI users with good hearing performanc...
Article
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Genetic heterogeneity has made the identification of genes related to hearing impairment a challenge. In the absence of a clear phenotypic aetiology, recurrence risk estimates are often based on family segregation and may be imprecise. We profiled by oligonucleotide array-CGH patients presenting non-syndromic hearing loss with presumptive autosomal...
Article
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Introduction Tinnitus is an abnormal perception of sound in the absence of an external stimulus. Chronic tinnitus usually has a high impact in many aspects of patients' lives, such as emotional stress, sleep disturbance, concentration difficulties, and so on. These strong reactions are usually attributed to central nervous system involvement. Neuro...
Article
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Objective: To identify novel genetic causes of syndromic hearing loss in Brazil. Design: To map a candidate chromosomal region through linkage studies in an extensive Brazilian family and identify novel pathogenic variants using sequencing and array-CGH. Study sample: Brazilian pedigree with individuals affected by BO syndrome characterized by...
Article
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This study shows how occurs the diffusion of the anesthetic into the sheath through the axiliary infraclavicular space and hence prove the efficacy of the anesthetic block of the brachial plexus, and may thereby allow a consolidation of this pathway, with fewer complications, previously attached to the anesthesia.
Article
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This study shows how the diffusion of the anesthetic into the sheath occurs through the axillary infraclavicular space and hence proves the efficacy of the anesthetic block of the brachial plexus, and may thereby allow a consolidation of this pathway, with fewer complications, previously attached to the anesthesia. 33 armpits of adult cadavers were...
Article
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OBJECTIVE: This is a cross-sectional epidemiological survey designed to estimate the prevalence of dizziness among the adult population of the city of São Paulo, Brazil, and to describe the clinical features and level of discomfort. METHOD: This population based study was conductedin the city of São Paulo, Brazil, between April and October 2012. A...
Article
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Introduction: The public and private health care in the city of São Paulo has no data on tinnitus prevalence. Objective: Determine tinnitus prevalence in São Paulo city. Study design: Series study. Methods: Cross-sectional study by field questionnaire with 1960 interviews. Predictor variables included gender, age, tinnitus. Results: The pr...
Article
Full-text available
This study shows how occurs the diffusion of the anesthetic into the sheath through the axiliary infraclavicular space and hence prove the efficacy of the anesthetic block of the brachial plexus, and may thereby allow a consolidation of this pathway, with fewer complications, previously attached to the anesthesia.Materials and methods33 armpits of...
Article
Full-text available
Objectives In clinical practice, knowing the epidemiology of dizziness is essential. The aim of the study was to estimate the prevalence of dizziness among the adult population of the city of São Paulo, Brazil and describe the clinical features and level of discomfort. Methods A cross-sectional epidemiological survey was conducted in São Paulo, Br...
Article
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The epidemiology of dizziness is essential in clinical practice. To establish the prevalence of dizziness in the adult population of São Paulo, its clinical characteristics and level of discomfort. A prospective cross-sectional study ran from April to October of 2012 by a field questionnaire, totaling 1,960 interviews. The predictor variables asses...
Article
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Introduction: Sudden hearing loss (SHL) is an ENT emergency defined as sensorineural hearing loss (SNHL) ≥ 30 dB HL affecting at least 3 consecutive tonal frequencies, showing a sudden onset, and occurring within 3 days. In cases of SHL, a detailed investigation should be performed in order to determine the etiology and provide the best treatment....
Article
We ascertained a Brazilian family with nine individuals affected by autosomal dominant nonsyndromic sensorineural hearing loss. The bilateral hearing loss affected mainly mid-high frequencies, was apparently stable with an early onset. Microsatellites close to the DFNA8/DFNA12 locus, which harbors the TECTA gene, showed significant multipoint lod s...
Article
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Objective: Compare conditions and outcomes of otosphere suspension cultures from dissociated organ of Corti of either mouse or guinea pig at postnatal day 3 (P3), and to evaluate the guinea pig as a potential cochlea donor for preclinical cell therapy. Method: Organs of Corti were isolated from P3 guinea pig or mouse cochlea, dissociated, and culti...
Article
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Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who...
Article
Full-text available
Sudden hearing loss is defined as a sensorineural hearing loss, equal to or greater than 30 dB, at three or more consecutive frequencies, which takes place within 72 hours. Both peginterferon and ribavirin are well-known to be associated with significant adverse effects, but sudden hearing loss is uncommon. We report a 65-year-old male patient who...
Article
Full-text available
The aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys. No consensus has been reached regarding the prevalence of metabolic disorders among sudden deafness patients or their influence as associated risk factors. This cross...
Article
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Culturing otospheres from dissociated organ of Corti is an appropriate starting point aiming at the development of cell therapy for hair cell loss. Although guinea pigs have been widely used as an excellent experimental model for studying the biology of the inner ear, the mouse cochlea has been more suitable for yielding otospheres in vitro. The ai...
Article
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The aim of this study was to determine the effects of various treatment modalities employed for patients with sudden sensorineural hearing loss (SHL). We retrospectively evaluated the records of patients treated in the sudden hearing loss section of the Otolaryngology Department at Clinic Hospital, School of Medicine, University of São Paulo, Brazi...
Article
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A reabilitação vestibular (RV) é uma ótima opção terapêutica para tratamento dos pacientes vestibulopatas. Contudo, mesmo quando bem conduzida, algumas vezes não surte os efeitos propostos. OBJETIVO: Avaliar a resposta de pacientes submetidos à RV em relação às etiologias apresentadas. Forma de Estudo: Retrospectivo descritivo. PACIENTES E MÉTODO:...
Article
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Vestibular rehabilitation (VR) is an excellent therapy for dizziness patients. However, despite well managed, sometimes results are not suitable. evaluate VR outcome between patients according to dizziness etiology. Study design: Retrospective review of medical records. Patients records were analyzed between January 2002 and December 2004. As for i...
Article
The aims of the present study were to determine the effect of epidermal growth factor (EGF) and pentoxifylline on subacute tympanic membrane (TM) perforations and to quantify the healing rate of such perforations treated with these drugs alone or in combination. It is known that EGF modulates in vitro and in vivo proliferation of epithelial and end...
Article
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Pacientes com zumbido e audiometria normal constituem um grupo importante, pois seus achados não sofrem influência da perda auditiva. Apesar disso, este grupo é pouco estudado e não sabemos se suas características clínicas e repercussões são semelhantes às dos indivíduos com perda auditiva. OBJETIVOS: Comparar as características clínicas do zumbido...
Article
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Patients with tinnitus and normal hearing constitute an important group, given that findings do not suffer influence of the hearing loss. However, this group is rarely studied, so we do not know whether its clinical characteristics and interference in daily life are the same of those of the patients with tinnitus and hearing loss. To compare tinnit...
Article
Objectives: Tinnitus usually appears in patients with some degree of hearing loss. Just a few papers studied tinnitus in normal hearing patients, usually involving less than 20 cases. The objective of this study is to describe the main characteristics of a significant sample of tinnitus patients with normal pure tone audiometry.Methods: The files o...
Article
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A perda bilateral da função vestibular é rara em pacientes com vertigem e desequilíbrio, porém os sintomas muitas vezes são incapacitantes e seu tratamento é tema controverso na literatura. OBJETIVO: Nosso objetivo foi avaliar e descrever a resposta clínica de pacientes com distúrbio do equilíbrio corporal secundário à arreflexia vestibular pós-cal...
Article
UFAL) mloiticica@hotmail.com Maria de Lourdes Barreto Gomes (UFPB) marilu@producao.ct.ufpb.br Resumo Estudos recentes orientam para os cuidados que se deve ter com o estresse a curtos e longos prazos. O estresse em longo prazo pode provocar reações crônicas no indivíduo. O desgaste, o esgotamento, a ruptura total dos limites, referem-se a reações d...
Article
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Herpetic laryngitis is a rare inflammatory disease caused by herpes simplex or herpes zoster virus. The propensity for spreading along peripheral nerves and within the central nervous system, with frank herpetic meningoencephalitis, is a rare complication. We present one case of herpetic laryngitis by reactivation of varicella zoster, with central...
Article
Herpetic laryngitis is a rare inflammatory disease caused by herpes simplex or herpes zoster virus. The propensity for spreading along peripheral nerves and within the central nervous system, with frank herpetic meningoencephalitis, is a rare complication. We present one case of herpetic laryngitis by reactivation of varicella zoster, with central...
Article
Full-text available
The healing rate of subacute tympanic membrane perforations over a 30-day period showed significant difference between the groups (ANOVA; p < 0.001) and was 30.3% for the epidermal growth factor group, 3.6% for the pentoxifylline group, 16.5% for ears treated with epidermal growth factor and pentoxifylline and 8.7% for untreated controls. Conclusio...
Article
Full-text available
Introduction: Loss of hair cells in mammals causes permanent sensorineural hearing loss, as these cells are terminally-differentiated and their precursors do not reenter the cell cycle.

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Projects (4)
Project
The aim of this project is to identify and characterize the expression of novel genes associated with nonsyndromic hearing loss by studying large families with many affected members.
Project
This project aims to prove that a novel deafness gene is indeed essential to the normal physiology of hearing and to elucidate the underlying defect that leads to hearing impairment, recapitulating the effects the altered expression of this gene in a cellular and animal model.
Project
Identify genes and their respective proteins associated with auditory physiology and their role in deafness. Map biomarkers that can be used in the diagnosis of genetic deafness. Map out possible therapeutic targets for studies to restore hearing.