Jean-Philippe Miron

Jean-Philippe Miron
Université de Montréal | UdeM · Department of Psychiatry

MD PhD FRCPC

About

42
Publications
5,588
Reads
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178
Citations
Citations since 2016
40 Research Items
164 Citations
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Additional affiliations
August 2018 - present
University of Toronto
Position
  • Fellow
Description
  • Fellow in brain stimulation at the MRI-Guided rTMS Clinic with Dr. Jonathan Downar MD PhD FRCPC
July 2013 - June 2018
Université de Montréal
Position
  • Psychiatry resident
Education
August 2018 - April 2020
University of Toronto
Field of study
  • Non-invasive brain stimulation in mood disorders
July 2013 - June 2018
Université de Montréal
Field of study
  • Psychiatry
September 2009 - June 2013
Université de Montréal
Field of study
  • Medicine

Publications

Publications (42)
Article
Full-text available
2022) Transcranial magnetic stimulation and intravenous ketamine combination therapy for treatment-resistant bipolar depression: A case report. Front. Psychiatry 13:986378. About a third of patients suffering from major depression develop treatment-resistant depression (TRD). Although repetitive transcranial magnetic stimulation (rTMS) and intraven...
Preprint
Full-text available
Background The role of inflammation in major depression is increasingly recognized. Vagal neurostimulation (VNS) is used for the treatment of epilepsy and major medical-refractory depression. VNS has neuropsychiatric functions and systemic anti-inflammatory activity. The objective of this study is to measure the clinical efficacy and assess the imp...
Article
Background Alcohol use disorder is highly prevalent and has important economical, societal, psychiatric, and medical consequences. All currently approved therapeutic approaches targeting alcohol dependence have relatively modest effects and high relapse rates. Recent evidence suggests that ketamine may be an effective intervention to treat alcohol...
Article
Background and objective Repetitive transcranial magnetic stimulation (rTMS) is an effective and safe treatment for major depressive disorder (MDD). rTMS is in need of a reliable biomarker of treatment response. High frequency (HF) dorsolateral prefrontal cortex (DLPFC) rTMS has been reported to induce significant changes in the cardiac activity of...
Article
Intermittent theta burst stimulation (iTBS) using 600 pulses is an effective and FDA-cleared transcranial magnetic stimulation (TMS) protocol for major depressive disorder (MDD). Prolonged iTBS (piTBS) using 1,800 pulses could increase the effectiveness of TMS for MDD, but its real-world effectiveness is still debated. We assessed the safety, toler...
Article
Full-text available
Treatment resistant depression is challenging because patients who fail their initial treatments often do not respond to subsequent trials and their course of illness is frequently marked by chronic depression. Repetitive transcranial magnetic stimulation (rTMS) is a well-established treatment alternative, but there are several limitations that dec...
Article
Full-text available
Citation: Noiseux, C.; Miron, J.-P.; Desbeaumes Jodoin, V.; Chu, T.R.; Chouinard, S.; Lespérance, P. Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder Comorbid with Huntington's Disease: A Case Report. NeuroSci 2021, 2, 400-404. https://doi. Abstract: Huntington's disease (HD) is a rare genetic disorder resulting in progres...
Article
Full-text available
BACKGROUND Major depressive disorder (MDD) is now the first cause of disability worldwide. So far, no validated and scalable biomarker has been identified to help with response prediction to antidepressant treatment. Cardiac biomarkers such as heart rate variability (HRV) have been studied in MDD, but few studies have examined its potential use for...
Article
Full-text available
Background: Pathological rumination is a cardinal symptom of major depressive disorder (MDD), resulting from default-mode network (DMN) hyperactivity. Higher baseline rumination have been associated with onset of MDD, and therapies aiming at reducing rumination lead to clinical improvement. Repetitive transcranial magnetic stimulation (rTMS) is eff...
Article
Full-text available
Background Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention for major depressive disorder (MDD). Completing a full treatment course, however, is costly and time-consuming. Biomarkers of clinical outcome such as baseline resting-state brain activity measured with electroencephalography (EEG) may spare people futile tr...
Article
Full-text available
Repetitive transcranial magnetic stimulation (rTMS) is a safe and well-tolerated intervention for major depressive disorder (MDD). Over 150 randomized controlled trials (RCTs) have been carried out, and its efficacy has been confirmed in dozens of meta-analyses. Real world data has also confirmed the effectiveness of rTMS for MDD in clinical practi...
Article
Although effective in major depressive disorder (MDD), repetitive transcranial magnetic stimulation (rTMS) is costly and complex, limiting accessibility. To address this, we tested the feasibility of novel rTMS techniques with cost-saving opportunities, such as an open-room setting, large non-focal parabolic coils, and custom-built coil arms. We em...
Article
Full-text available
BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD) but requires daily travel to a treatment clinic over several weeks. Shorter rTMS courses retaining similar effectiveness would thus increase the practicality and scalability of the technique, and therefore its accessibility...
Article
Background This work describes the clinical symptoms associated with end of service (EOS) of the batteries of vagus nerve stimulation (VNS) generators in treatment-resistant depression (TRD). Because neurostimulator software may not provide reliable information on battery depletion, careful monitoring of clinical symptoms during the EOS period is a...
Preprint
Full-text available
BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD) but requires daily travel to a treatment clinic over several weeks. Shorter rTMS courses retaining similar effectiveness would thus increase the practicality and scalability of the technique, and therefore its accessibility...
Preprint
Full-text available
BACKGROUND Repetitive transcranial magnetic stimulation (rTMS) is effective in major depressive disorder (MDD). However, technical complexity and operational costs might have been barriers for its wide use and implementation in some jurisdictions, thereby decreasing accessibility. OBJECTIVE Our main goal was to test the feasibility of a novel rTMS...
Article
Full-text available
This work describes a clinical case in which we used telemedicine to monitor at-home ketamine treatment in TRD. Ketamine has been shown to be a promising and safe treatment for TRD in elderly patients. However, the COVID-19 pandemic is clearly impacting the world and this disease is recognized as being particularly dangerous for the elderly and vul...
Article
Introduction: Recent studies have revealed a possible link between heart rate variability (HRV) and major depressive disorder (MDD), with decreased HRV in MDD compared with healthy subjects. Corrected Q-T interval (QTc) has been suggested to represent an indirect estimate of HRV, as QTc length is inversely correlated to parasympathetic activity in...
Article
Full-text available
Aim: No previous study has investigated interventions for homeless youth suffering from first episode psychosis and comorbid substance use disorder (HYPS). An intensive assertive community intervention team (IACIT) offering outreach interventions, housing support as well as integrated care for early psychosis and substance use disorder (SUD) was c...
Article
Full-text available
Among healthy volunteers in psychiatric brain functional magnetic resonance imaging (fMRI) research studies, the prevalence of incidentalomas can be as high as 34%, of which 10% show clinical significance. An incidentaloma is a lesion found by coincidence without clinical symptoms or suspicion. Like lesions and other types of accidental findings, i...
Article
Full-text available
Introduction Heart rate variability (HRV) and depression are correlated, suggesting a pathophysiological relationship between depressive symptoms and the modulation of cardiovagal activity. It has been suggested that the corrected Q-T interval (QTc) represents an indirect estimate of HRV. Furthermore, recent depression research has emphasized the i...
Article
Full-text available
Introduction The relationship between sleep and depression is complex and well-established. About three quarter of patients with major depressive disorder (MDD) have comorbid sleep dysregulations. Current research has emphasized the importance of establishing biologically relevant subtypes of MDD with treatment specificity and prognostic value. Pol...
Article
Full-text available
Objective: Major depressive disorder (MDD) is a prevalent condition in older adults. Although antidepressant drugs are commonly prescribed, efficacy is variable, and older patients are more prone to side effects. Repetitive transcranial magnetic stimulation (rTMS) is an alternative therapy used increasingly in the treatment of MDD. Even though rec...
Article
Full-text available
Background: Treatment-resistant depression (TRD) is a serious chronic condition disabling patients functionally and cognitively. Chronic vagus nerve stimulation (VNS) is recognized for the management of TRD, but few studies have examined its long-term effects on cognitive dysfunction in unipolar and bipolar resistant depression. Objective: The p...
Article
Full-text available
FROM: Ising HK, Kraan TC, Rietdijk J, et al. Four-year follow-up of cognitive behavioral therapy in persons at ultra-high risk for developing psychosis: the Dutch Early Detection and Intervention Evaluation (EDIE-NL) trial. Schizophr Bull 2016;42:1243–52. Major efforts have been made to prevent ultra-high-risk (UHR) participants from transitioning...
Article
Full-text available
We tested the hypothesis that the same spinal interneuronal pathways are activated by the reticulospinal system during locomotion and reaching. If such were the case, we expected that microstimulation within the pontomedullary reticular formation (PMRF) would evoke qualitatively similar responses in muscles active during both behaviors. To test thi...

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Projects

Project (1)
Project
Refine and enhance the effects of existing NIBS technologies in various psychiatric disorders, mostly depression